TY  - CONF
AU  - Vukašinović-Sekulić, Maja
AU  - Đošić, Marija
AU  - Janković, Ana
AU  - Stevanović, Milena
AU  - Grujić, Svetlana
AU  - Matić-Bujagić, Ivana
AU  - Kojić, Vesna
AU  - Mišković-Stanković, Vesna
PY  - 2024
UR  - https://ritnms.itnms.ac.rs/handle/123456789/1244
AB  - INTRODUCTION: Following orthopedic surgery, bacterial infection may lead to significant complications related to
inflammation in the peri-implant region, including the potential for implant loosening. To address this concern, the
surface of metallic implants was modified through the application of bioactive and antibacterial coatings, aiming to
mitigate these issues.
EXPERIMENTAL: HAP/PVA/CS/Gent coatings was single-step electrophoretically deposited from four-component
aqueous suspension containing 1 wt.% hydroxyapatite powder (HAP, particles < 200 nm particle size, Sigma-Aldrich),
0.1 wt.% poly(vinyl alcohol) (PVA, medium molecular weight 89 to 98 kDa, 99 % hydrolysed, Sigma-Aldrich), 0.05 wt%
chitosan powder (CS, medium molecular weight, 190 to 310kDa with 75 to 85 % deacetylation degree, Sigma-Aldrich), and
aqueous gentamicin sulfate solution (Gent, concentration 50 mg/ml, Sigma-Aldrich) on titanium plates (Sigma-Aldrich).
Antibacterial activity of HAP/PVA/CS/Gent coating was evaluated against Staphylococcus aureus TL (culture collection-
FTM, University of Belgrade, Serbia) and Escherichia coli ATCC 25922, while kinetics of antibacterial activity was monitored
according to our previously published data [1]. In vitro cytotoxicity assay was performed towards two fibroblast cell lines
of different origin-mouse origin cell line (L929 (ATCC CRL-6364)) and human lung origin cell line (MRC-5 (ATCC CCL-171)) [2].
To evaluate the statistical significance of the biological assay results (antibacterial activity, cytotoxicity and ALP activity),
one-way analysis of variance (ANOVA) followed by a multiple comparisons posthoc test was used.
RESULTS AND DISCUSSION: HAP/PVA/CS/Gent coating exhibited strong antibacterial effect against both S. aureus
and E. coli, especially pronounced against S. aureus, causing bactericidal effect. Cytotoxic effect of HAP/PVA/CS/Gent
coating was not pronounced in investigated MRC-5 and L929 cell lines. MRC-5 fibroblast cells in contact with
HAP/PVA/CS/Gent doubled alkaline phosphatase levels compared to their contact with the control samples
(HAP/PVA/CS), indicating good osteogenic properties.
CONCLUSIONS: Electrophoretically deposited HAP/PVA/CS/Gent bioceramic coatings on titanium, demonstrated
significant potential as implants in orthopedic practice, functioning as drug carriers. Not only do they possess
antibacterial properties, but they also exhibit no adverse effects on living tissue.
PB  - Beograd : Savez hemijskih inženjera Srbije
C3  - ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices
T1  - Bioactivity of gentamicin-loaded hydroxyapatite/poly(vinyl alcohol)/chitosan composite coatings aimed for orthopedic application
EP  - 59
IS  - 1s
SP  - 59
VL  - 78
ER  - 

@conference{
author = "Vukašinović-Sekulić, Maja and Đošić, Marija and Janković, Ana and Stevanović, Milena and Grujić, Svetlana and Matić-Bujagić, Ivana and Kojić, Vesna and Mišković-Stanković, Vesna",
year = "2024",
abstract = "INTRODUCTION: Following orthopedic surgery, bacterial infection may lead to significant complications related to
inflammation in the peri-implant region, including the potential for implant loosening. To address this concern, the
surface of metallic implants was modified through the application of bioactive and antibacterial coatings, aiming to
mitigate these issues.
EXPERIMENTAL: HAP/PVA/CS/Gent coatings was single-step electrophoretically deposited from four-component
aqueous suspension containing 1 wt.% hydroxyapatite powder (HAP, particles < 200 nm particle size, Sigma-Aldrich),
0.1 wt.% poly(vinyl alcohol) (PVA, medium molecular weight 89 to 98 kDa, 99 % hydrolysed, Sigma-Aldrich), 0.05 wt%
chitosan powder (CS, medium molecular weight, 190 to 310kDa with 75 to 85 % deacetylation degree, Sigma-Aldrich), and
aqueous gentamicin sulfate solution (Gent, concentration 50 mg/ml, Sigma-Aldrich) on titanium plates (Sigma-Aldrich).
Antibacterial activity of HAP/PVA/CS/Gent coating was evaluated against Staphylococcus aureus TL (culture collection-
FTM, University of Belgrade, Serbia) and Escherichia coli ATCC 25922, while kinetics of antibacterial activity was monitored
according to our previously published data [1]. In vitro cytotoxicity assay was performed towards two fibroblast cell lines
of different origin-mouse origin cell line (L929 (ATCC CRL-6364)) and human lung origin cell line (MRC-5 (ATCC CCL-171)) [2].
To evaluate the statistical significance of the biological assay results (antibacterial activity, cytotoxicity and ALP activity),
one-way analysis of variance (ANOVA) followed by a multiple comparisons posthoc test was used.
RESULTS AND DISCUSSION: HAP/PVA/CS/Gent coating exhibited strong antibacterial effect against both S. aureus
and E. coli, especially pronounced against S. aureus, causing bactericidal effect. Cytotoxic effect of HAP/PVA/CS/Gent
coating was not pronounced in investigated MRC-5 and L929 cell lines. MRC-5 fibroblast cells in contact with
HAP/PVA/CS/Gent doubled alkaline phosphatase levels compared to their contact with the control samples
(HAP/PVA/CS), indicating good osteogenic properties.
CONCLUSIONS: Electrophoretically deposited HAP/PVA/CS/Gent bioceramic coatings on titanium, demonstrated
significant potential as implants in orthopedic practice, functioning as drug carriers. Not only do they possess
antibacterial properties, but they also exhibit no adverse effects on living tissue.",
publisher = "Beograd : Savez hemijskih inženjera Srbije",
journal = "ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices",
title = "Bioactivity of gentamicin-loaded hydroxyapatite/poly(vinyl alcohol)/chitosan composite coatings aimed for orthopedic application",
pages = "59-59",
number = "1s",
volume = "78"
}

Vukašinović-Sekulić, M., Đošić, M., Janković, A., Stevanović, M., Grujić, S., Matić-Bujagić, I., Kojić, V.,& Mišković-Stanković, V.. (2024). Bioactivity of gentamicin-loaded hydroxyapatite/poly(vinyl alcohol)/chitosan composite coatings aimed for orthopedic application. in ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices
Beograd : Savez hemijskih inženjera Srbije., 78(1s), 59-59.

Vukašinović-Sekulić M, Đošić M, Janković A, Stevanović M, Grujić S, Matić-Bujagić I, Kojić V, Mišković-Stanković V. Bioactivity of gentamicin-loaded hydroxyapatite/poly(vinyl alcohol)/chitosan composite coatings aimed for orthopedic application. in ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices. 2024;78(1s):59-59..

Vukašinović-Sekulić, Maja, Đošić, Marija, Janković, Ana, Stevanović, Milena, Grujić, Svetlana, Matić-Bujagić, Ivana, Kojić, Vesna, Mišković-Stanković, Vesna, "Bioactivity of gentamicin-loaded hydroxyapatite/poly(vinyl alcohol)/chitosan composite coatings aimed for orthopedic application" in ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices, 78, no. 1s (2024):59-59.

TY  - CONF
AU  - Stevanović, Milena
AU  - Đošić, Marija
AU  - Janković, Ana
AU  - Sprecher, Christoph Martin
AU  - Vukašinović-Sekulić, Maja
AU  - Mišković-Stanković, Vesna
PY  - 2024
UR  - https://ritnms.itnms.ac.rs/handle/123456789/1243
AB  - INTRODUCTION: Tissue engineering strives for innovative solutions in addressing challenges associated with
contemporary bone tissue implants. This study focuses on the electrophoretic deposition (EPD) of hydroxyapatite-based
bioceramic composites containing antibacterial agents onto titanium surfaces. Two composite coatings, hydroxyapatite/
chitosan (HAP/CS) and hydroxyapatite/chitosan/gentamicin (HAP/CS/Gent) were developed to combat issues such as
poor adhesion, limited antibacterial potential, limited bioactivity, and potential toxicity of implant materials [1].
EXPERIMENTAL: EPD was performed at constant voltage (5 V, 12 min) on pure Ti plates from aqueous (HAP/CS and
HAP/CS/Gent) suspensions. The uniformity and functionality of the deposited coatings were assessed through
comprehensive physico-chemical characterization using X-ray diffraction (XRD) (Philips PW 1710, Netherlands) and
scanning electron microscopy (SEM, Hitachi S-4700, J) equipped with energy dispersive X-Ray spectroscopy (EDS, X-Max,
Oxford Instruments, UK). Antibacterial activity was evaluated against Staphylococcus aureus TL and Escherichia coli ATCC
25922 by quantitatively monitoring changes in the viable number of bacterial cells in suspension. Cytotoxicity against
MRC-5 and L929 cell lines was investigated using trypan blue dye-exclusion test (DET) and MTT assay for assessing cell
metabolic activity. Statistical significance was determined for antibacterial and cytotoxicity results by one-way analysis
of variance (ANOVA), followed by multiple comparisons post-hoc test.
RESULTS AND DISCUSSION: XRD revealed broadened diffraction maximums corresponding to fine HAP crystallites.
Porous surface with homogeneously distributed spherical HAP agglomerates embedded in wax-like polymers' matrix of
CS was observed for both coatings by SEM. The addition of gentamicin significantly enhanced the antibacterial activity
of the HAP/CS/Gent coating – complete reduction of S. aureus bacterial cells was achieved within 1 h of exposure. MTT
and DET tests indicated low cytotoxicity against MRC-5 and L929 tested cell line for both samples. Slightly decreased
cell percentage viability due to gentamicin presence was observed for HAP/CS/Gent.
CONCLUSIONS: Single-step EPD yielded antibacterial composite coatings with potential for biomedical applications.
HAP/CS/Gent showed successful gentamicin loading, favorable crystalline structure, and strong antibacterial effects.
The presence of fine HAP crystallites yielded a larger surface area, favorable for new bone growth and improved
osseointegration. HAP/CS/Gent exhibited good antibacterial activity against both tested bacteria (especially
pronounced against S. aureus – bactericidal effect), while preserving low cytotoxicity, indicating the high potential for
biomedical applications.
PB  - Beograd : Savez hemijskih inženjera Srbije
C3  - ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices
T1  - Innovative hydroxyapatite-based coatings for bone implants: A multifaceted approach
EP  - 58
IS  - 1s
SP  - 58
VL  - 78
ER  - 

@conference{
author = "Stevanović, Milena and Đošić, Marija and Janković, Ana and Sprecher, Christoph Martin and Vukašinović-Sekulić, Maja and Mišković-Stanković, Vesna",
year = "2024",
abstract = "INTRODUCTION: Tissue engineering strives for innovative solutions in addressing challenges associated with
contemporary bone tissue implants. This study focuses on the electrophoretic deposition (EPD) of hydroxyapatite-based
bioceramic composites containing antibacterial agents onto titanium surfaces. Two composite coatings, hydroxyapatite/
chitosan (HAP/CS) and hydroxyapatite/chitosan/gentamicin (HAP/CS/Gent) were developed to combat issues such as
poor adhesion, limited antibacterial potential, limited bioactivity, and potential toxicity of implant materials [1].
EXPERIMENTAL: EPD was performed at constant voltage (5 V, 12 min) on pure Ti plates from aqueous (HAP/CS and
HAP/CS/Gent) suspensions. The uniformity and functionality of the deposited coatings were assessed through
comprehensive physico-chemical characterization using X-ray diffraction (XRD) (Philips PW 1710, Netherlands) and
scanning electron microscopy (SEM, Hitachi S-4700, J) equipped with energy dispersive X-Ray spectroscopy (EDS, X-Max,
Oxford Instruments, UK). Antibacterial activity was evaluated against Staphylococcus aureus TL and Escherichia coli ATCC
25922 by quantitatively monitoring changes in the viable number of bacterial cells in suspension. Cytotoxicity against
MRC-5 and L929 cell lines was investigated using trypan blue dye-exclusion test (DET) and MTT assay for assessing cell
metabolic activity. Statistical significance was determined for antibacterial and cytotoxicity results by one-way analysis
of variance (ANOVA), followed by multiple comparisons post-hoc test.
RESULTS AND DISCUSSION: XRD revealed broadened diffraction maximums corresponding to fine HAP crystallites.
Porous surface with homogeneously distributed spherical HAP agglomerates embedded in wax-like polymers' matrix of
CS was observed for both coatings by SEM. The addition of gentamicin significantly enhanced the antibacterial activity
of the HAP/CS/Gent coating – complete reduction of S. aureus bacterial cells was achieved within 1 h of exposure. MTT
and DET tests indicated low cytotoxicity against MRC-5 and L929 tested cell line for both samples. Slightly decreased
cell percentage viability due to gentamicin presence was observed for HAP/CS/Gent.
CONCLUSIONS: Single-step EPD yielded antibacterial composite coatings with potential for biomedical applications.
HAP/CS/Gent showed successful gentamicin loading, favorable crystalline structure, and strong antibacterial effects.
The presence of fine HAP crystallites yielded a larger surface area, favorable for new bone growth and improved
osseointegration. HAP/CS/Gent exhibited good antibacterial activity against both tested bacteria (especially
pronounced against S. aureus – bactericidal effect), while preserving low cytotoxicity, indicating the high potential for
biomedical applications.",
publisher = "Beograd : Savez hemijskih inženjera Srbije",
journal = "ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices",
title = "Innovative hydroxyapatite-based coatings for bone implants: A multifaceted approach",
pages = "58-58",
number = "1s",
volume = "78"
}

Stevanović, M., Đošić, M., Janković, A., Sprecher, C. M., Vukašinović-Sekulić, M.,& Mišković-Stanković, V.. (2024). Innovative hydroxyapatite-based coatings for bone implants: A multifaceted approach. in ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices
Beograd : Savez hemijskih inženjera Srbije., 78(1s), 58-58.

Stevanović M, Đošić M, Janković A, Sprecher CM, Vukašinović-Sekulić M, Mišković-Stanković V. Innovative hydroxyapatite-based coatings for bone implants: A multifaceted approach. in ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices. 2024;78(1s):58-58..

Stevanović, Milena, Đošić, Marija, Janković, Ana, Sprecher, Christoph Martin, Vukašinović-Sekulić, Maja, Mišković-Stanković, Vesna, "Innovative hydroxyapatite-based coatings for bone implants: A multifaceted approach" in ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices, 78, no. 1s (2024):58-58.

TY  - CONF
AU  - Janković, Ana
AU  - Đošić, Marija
AU  - Stevanović, Milena
AU  - Vukašinović-Sekulić, Vesna
AU  - Kojić, Vesna
AU  - Mišković-Stanković, Vesna
PY  - 2024
UR  - https://ritnms.itnms.ac.rs/handle/123456789/1242
AB  - INTRODUCTION: Electrochemical methods were employed for synthesizing composites intended for applications in
medicine as antibacterial coatings on titanium bone implants or as highly efficient antibacterial hydrogels for
accelerated wound healing.
EXPERIMENTAL: Hydroxyapatite-based coatings were single-step electrophoretically deposited from fourcomponent
aqueous suspension containing 1 wt% hydroxyapatite powder (HAP, particles < 200 nm particle size, Sigma-
Aldrich), 0.1 wt% poly(vinyl alcohol) (PVA, medium molecular weight, Sigma-Aldrich), 0.05 wt% chitosan powder (CS,
medium molecular weight, Sigma-Aldrich), and aqueous gentamicin sulfate solution (Gent, concentration 50 mg/ml,
Sigma-Aldrich) on titanium plates (Sigma-Aldrich). Antibacterial activity of HAP/PVA/CS/Gent coating was evaluated
against Staphylococcus aureus TL (culture collection-FTM, University of Belgrade, Serbia) and Escherichia coli ATCC
25922. For poly(vinyl alcohol)/chitosan (PVA/CHI) hydrogel synthesis poly(vinyl alcohol) powder (PVA, Sigma Aldrich,
USA), chitosan powder (CHI, Sigma Aldrich, USA), graphene (Graphene Supermarket, USA), glacial acetic acid (Beta
Hem), silver nitrate (MP Hemija), potassium nitrate (Centrohem, Serbia) were used. For antibacterial properties
evaluation, monobasic and dibasic (Sigma Aldrich, USA) potassium phosphates were used. Cell culture suspensions for
cytotoxicity tests were prepared using MTT tetrazolium salt, EDTA, fetal calf serum and antibiotic-antimycotic solution
(Sigma Aldrich, USA).
RESULTS AND DISCUSSION: Surface modification of titanium with innovative bioactive coatings enhances
biomineralization and reduces post-operation pain and infection risk. Using powerful single-step electrophoretic
deposition (EPD) at a constant voltage we have produced various hydroxyapatite-based composite bioceramic coatings
in combination with polymers (lignin, chitosan), graphene, and antibacterial agents (silver, gentamicin).
Electrochemical methods enable in situ synthesis of AgNPs inside polymer matrices, with the main advantage being
the complete absence of any chemical reducing agents that are often toxic and difficult to remove from the material.
The electrochemical reduction of Ag+ ions is achieved only using electrical current or pure hydrogen gas that is generated
at the cathode in aqueous electrolytes, which allows for obtaining completely green and non-toxic product.
Modifications in the synthesis process also enable the control of AgNPs properties, such as size and concentration.
CONCLUSIONS: Composite antibacterial coatings were obtained on titanium plates using EPD. Strong antibacterial
activity against E. coli and S. aureus was found. Biocompatibility was confirmed using in vitro MTT testing since a noncytotoxic
effect was shown towards healthy human peripheral blood mononuclear cells PBMC, fibroblast cell lines MRC-5
and L929, suggesting high potential for bone tissue engineering and medical applications. Hydrogels composed of physically
cross-linked poly(vinyl alcohol)/chitosan with embedded AgNPs were successfully developed for applications as antibacterial
wound dressings due to their highly favorable properties of silver release, antibacterial activity, and non-toxicity.
PB  - Beograd : Savez hemijskih inženjera Srbije
C3  - ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices
T1  - Electrochemically synthesized biomaterials
EP  - 57
IS  - 1s
SP  - 57
VL  - 78
ER  - 

@conference{
author = "Janković, Ana and Đošić, Marija and Stevanović, Milena and Vukašinović-Sekulić, Vesna and Kojić, Vesna and Mišković-Stanković, Vesna",
year = "2024",
abstract = "INTRODUCTION: Electrochemical methods were employed for synthesizing composites intended for applications in
medicine as antibacterial coatings on titanium bone implants or as highly efficient antibacterial hydrogels for
accelerated wound healing.
EXPERIMENTAL: Hydroxyapatite-based coatings were single-step electrophoretically deposited from fourcomponent
aqueous suspension containing 1 wt% hydroxyapatite powder (HAP, particles < 200 nm particle size, Sigma-
Aldrich), 0.1 wt% poly(vinyl alcohol) (PVA, medium molecular weight, Sigma-Aldrich), 0.05 wt% chitosan powder (CS,
medium molecular weight, Sigma-Aldrich), and aqueous gentamicin sulfate solution (Gent, concentration 50 mg/ml,
Sigma-Aldrich) on titanium plates (Sigma-Aldrich). Antibacterial activity of HAP/PVA/CS/Gent coating was evaluated
against Staphylococcus aureus TL (culture collection-FTM, University of Belgrade, Serbia) and Escherichia coli ATCC
25922. For poly(vinyl alcohol)/chitosan (PVA/CHI) hydrogel synthesis poly(vinyl alcohol) powder (PVA, Sigma Aldrich,
USA), chitosan powder (CHI, Sigma Aldrich, USA), graphene (Graphene Supermarket, USA), glacial acetic acid (Beta
Hem), silver nitrate (MP Hemija), potassium nitrate (Centrohem, Serbia) were used. For antibacterial properties
evaluation, monobasic and dibasic (Sigma Aldrich, USA) potassium phosphates were used. Cell culture suspensions for
cytotoxicity tests were prepared using MTT tetrazolium salt, EDTA, fetal calf serum and antibiotic-antimycotic solution
(Sigma Aldrich, USA).
RESULTS AND DISCUSSION: Surface modification of titanium with innovative bioactive coatings enhances
biomineralization and reduces post-operation pain and infection risk. Using powerful single-step electrophoretic
deposition (EPD) at a constant voltage we have produced various hydroxyapatite-based composite bioceramic coatings
in combination with polymers (lignin, chitosan), graphene, and antibacterial agents (silver, gentamicin).
Electrochemical methods enable in situ synthesis of AgNPs inside polymer matrices, with the main advantage being
the complete absence of any chemical reducing agents that are often toxic and difficult to remove from the material.
The electrochemical reduction of Ag+ ions is achieved only using electrical current or pure hydrogen gas that is generated
at the cathode in aqueous electrolytes, which allows for obtaining completely green and non-toxic product.
Modifications in the synthesis process also enable the control of AgNPs properties, such as size and concentration.
CONCLUSIONS: Composite antibacterial coatings were obtained on titanium plates using EPD. Strong antibacterial
activity against E. coli and S. aureus was found. Biocompatibility was confirmed using in vitro MTT testing since a noncytotoxic
effect was shown towards healthy human peripheral blood mononuclear cells PBMC, fibroblast cell lines MRC-5
and L929, suggesting high potential for bone tissue engineering and medical applications. Hydrogels composed of physically
cross-linked poly(vinyl alcohol)/chitosan with embedded AgNPs were successfully developed for applications as antibacterial
wound dressings due to their highly favorable properties of silver release, antibacterial activity, and non-toxicity.",
publisher = "Beograd : Savez hemijskih inženjera Srbije",
journal = "ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices",
title = "Electrochemically synthesized biomaterials",
pages = "57-57",
number = "1s",
volume = "78"
}

Janković, A., Đošić, M., Stevanović, M., Vukašinović-Sekulić, V., Kojić, V.,& Mišković-Stanković, V.. (2024). Electrochemically synthesized biomaterials. in ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices
Beograd : Savez hemijskih inženjera Srbije., 78(1s), 57-57.

Janković A, Đošić M, Stevanović M, Vukašinović-Sekulić V, Kojić V, Mišković-Stanković V. Electrochemically synthesized biomaterials. in ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices. 2024;78(1s):57-57..

Janković, Ana, Đošić, Marija, Stevanović, Milena, Vukašinović-Sekulić, Vesna, Kojić, Vesna, Mišković-Stanković, Vesna, "Electrochemically synthesized biomaterials" in ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices, 78, no. 1s (2024):57-57.

TY  - CONF
AU  - Đošić, Marija
AU  - Nikolić, Jelena
AU  - Stojanović, Jovica
AU  - Vuković, Nikola
AU  - Marković, Marija
AU  - Savić, Veljko
AU  - Topalović, Vladimir
PY  - 2024
UR  - https://ritnms.itnms.ac.rs/handle/123456789/1241
AB  - INTRODUCTION: Owing to its similarity to the inorganic part of the natural bone, excellent bioactivity, biocompatibility,
and ability to stimulate the osteoconductive process, synthetic hydroxyapatite (HAP) is very often the material of
choice for biomedical applications. Diverse ions can be found as substitutes within natural bone structures, each playing
a distinct and crucial role in the physiological processes governing the lifecycle of bones [1]. Among them, strontium ion
has a very important role for the acceleration of osteogenesis and the inhibition of osteoclasts activity [2]. Current
research aims to provide physico-chemical characterization of synthesized HAP and strontium substituted HAP (Sr-HAP)
powders obtained by varying strontium concentration (10, 20 and 40 mol.%) in the starting solutions.
EXPERIMENTAL: HAP powder was synthesized by wet chemical precipitation, using aqueous solutions of Ca(NO3)2
4H2O (Merck, p.a.) and (NH4)2HPO4 (Sigma-Aldrich, ≥99 %). By adding NH4OH (CENTROHEM, p.a.), pH value was adjusted
to 10. The obtained precipitate was heated up to 90 °C. The same procedure was followed for Sr-HAP powder syntheses,
by adding Sr(NO3)2 (Sigma-Aldrich ≥99.0 %) and maintaining the (Ca + Sr)/P ratio at 1.67 in the mixed Ca2+/Sr2+ solution.
Synthesized powders were characterised by FTIR spectroscopy (Nicolet IS-10, Thermo Fisher Scientific), XRD analysis
(Philips PW 1710, Philips, The Netherlands), TG analysis (Netzsch STA 449 F5 Jupiter instrument), and FE-SEM analysis
(JSM-7001F, JEOL Ltd, Japan).
RESULTS AND DISCUSSION: FTIR spectra revealed the presence of carbonate-substituted hydroxyapatite in both pure
and Sr-substituted HAP powders. The powders showed a granular, homogeneous morphology without the Sr separation.
XRD analysis revealed that the amount of incorporated Sr in the HAP structure increased with increased Sr concentration
in the starting solutions. Thermal stability of the Sr-HAP powders decreased with increased Sr concentration.
CONCLUSIONS: Physico-chemical characteristics of Sr-HAP powders are directly dependent on Sr ion concentration
in powders.
PB  - Beograd : Savez hemijskih inženjera Srbije
C3  - ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices
T1  - Characterisation of strontium-substituted hydroxyapatite as potential biomedical material
EP  - 40
IS  - 1s
SP  - 40
VL  - 78
ER  - 

@conference{
author = "Đošić, Marija and Nikolić, Jelena and Stojanović, Jovica and Vuković, Nikola and Marković, Marija and Savić, Veljko and Topalović, Vladimir",
year = "2024",
abstract = "INTRODUCTION: Owing to its similarity to the inorganic part of the natural bone, excellent bioactivity, biocompatibility,
and ability to stimulate the osteoconductive process, synthetic hydroxyapatite (HAP) is very often the material of
choice for biomedical applications. Diverse ions can be found as substitutes within natural bone structures, each playing
a distinct and crucial role in the physiological processes governing the lifecycle of bones [1]. Among them, strontium ion
has a very important role for the acceleration of osteogenesis and the inhibition of osteoclasts activity [2]. Current
research aims to provide physico-chemical characterization of synthesized HAP and strontium substituted HAP (Sr-HAP)
powders obtained by varying strontium concentration (10, 20 and 40 mol.%) in the starting solutions.
EXPERIMENTAL: HAP powder was synthesized by wet chemical precipitation, using aqueous solutions of Ca(NO3)2
4H2O (Merck, p.a.) and (NH4)2HPO4 (Sigma-Aldrich, ≥99 %). By adding NH4OH (CENTROHEM, p.a.), pH value was adjusted
to 10. The obtained precipitate was heated up to 90 °C. The same procedure was followed for Sr-HAP powder syntheses,
by adding Sr(NO3)2 (Sigma-Aldrich ≥99.0 %) and maintaining the (Ca + Sr)/P ratio at 1.67 in the mixed Ca2+/Sr2+ solution.
Synthesized powders were characterised by FTIR spectroscopy (Nicolet IS-10, Thermo Fisher Scientific), XRD analysis
(Philips PW 1710, Philips, The Netherlands), TG analysis (Netzsch STA 449 F5 Jupiter instrument), and FE-SEM analysis
(JSM-7001F, JEOL Ltd, Japan).
RESULTS AND DISCUSSION: FTIR spectra revealed the presence of carbonate-substituted hydroxyapatite in both pure
and Sr-substituted HAP powders. The powders showed a granular, homogeneous morphology without the Sr separation.
XRD analysis revealed that the amount of incorporated Sr in the HAP structure increased with increased Sr concentration
in the starting solutions. Thermal stability of the Sr-HAP powders decreased with increased Sr concentration.
CONCLUSIONS: Physico-chemical characteristics of Sr-HAP powders are directly dependent on Sr ion concentration
in powders.",
publisher = "Beograd : Savez hemijskih inženjera Srbije",
journal = "ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices",
title = "Characterisation of strontium-substituted hydroxyapatite as potential biomedical material",
pages = "40-40",
number = "1s",
volume = "78"
}

Đošić, M., Nikolić, J., Stojanović, J., Vuković, N., Marković, M., Savić, V.,& Topalović, V.. (2024). Characterisation of strontium-substituted hydroxyapatite as potential biomedical material. in ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices
Beograd : Savez hemijskih inženjera Srbije., 78(1s), 40-40.

Đošić M, Nikolić J, Stojanović J, Vuković N, Marković M, Savić V, Topalović V. Characterisation of strontium-substituted hydroxyapatite as potential biomedical material. in ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices. 2024;78(1s):40-40..

Đošić, Marija, Nikolić, Jelena, Stojanović, Jovica, Vuković, Nikola, Marković, Marija, Savić, Veljko, Topalović, Vladimir, "Characterisation of strontium-substituted hydroxyapatite as potential biomedical material" in ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices, 78, no. 1s (2024):40-40.

TY  - JOUR
AU  - Mišković-Stanković, Vesna
AU  - Janković, Ana
AU  - Grujić, Svetlana
AU  - Matić-Bujagić, Ivana
AU  - Radojević, Vesna
AU  - Vukašinović-Sekulić, Maja
AU  - Kojić, Vesna
AU  - Đošić, Marija
AU  - Atanasković, Teodor
PY  - 2024
UR  - https://ritnms.itnms.ac.rs/handle/123456789/1229
AB  - This study presents comparison of our recently formulated two compartmental model with General fractional derivative (GFD) and Korsmeyer-Peppas, Makoid-Banakar and Kopcha diffusion models. We have used our GFD
model to study the release of gentamicin in poly (vinylalcohol)/chitosan/gentamicin (PVA/CHI/Gent) hydrogel aimed for wound dressing in medical treatment of deep chronical wounds. The PVA/CHI/Gent hydrogel was prepared by physical cross linking of poly(vinyl alcohol)/chitosan dispersion using freezing-thawing method, and then was swollen for 48 h in gentamicin solution, at 37 °C. Different physico-chemical (FTIR, SEM), mechanical and biological (cytotoxicity, antibacterial activity) properties have been determined. The concentration of released gentamicin was determined
using a high-performance liquid chromatography (HPLC) coupled with mass spectrometry (MS). The ratio between concentration of released gentamicin and initial concentration of gentamicin in the hydrogel was monitored for the
prolonged time period in order to obtain gentamicin release profile. It was proven that our novel diffusion GFD model better fitted with experimental data, and enabled the determination of diffusion coefficient precisely for the entire time period.
PB  - Belgrade :  Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel
DO  - 10.2298/JSC231207010M
ER  - 

@article{
author = "Mišković-Stanković, Vesna and Janković, Ana and Grujić, Svetlana and Matić-Bujagić, Ivana and Radojević, Vesna and Vukašinović-Sekulić, Maja and Kojić, Vesna and Đošić, Marija and Atanasković, Teodor",
year = "2024",
abstract = "This study presents comparison of our recently formulated two compartmental model with General fractional derivative (GFD) and Korsmeyer-Peppas, Makoid-Banakar and Kopcha diffusion models. We have used our GFD
model to study the release of gentamicin in poly (vinylalcohol)/chitosan/gentamicin (PVA/CHI/Gent) hydrogel aimed for wound dressing in medical treatment of deep chronical wounds. The PVA/CHI/Gent hydrogel was prepared by physical cross linking of poly(vinyl alcohol)/chitosan dispersion using freezing-thawing method, and then was swollen for 48 h in gentamicin solution, at 37 °C. Different physico-chemical (FTIR, SEM), mechanical and biological (cytotoxicity, antibacterial activity) properties have been determined. The concentration of released gentamicin was determined
using a high-performance liquid chromatography (HPLC) coupled with mass spectrometry (MS). The ratio between concentration of released gentamicin and initial concentration of gentamicin in the hydrogel was monitored for the
prolonged time period in order to obtain gentamicin release profile. It was proven that our novel diffusion GFD model better fitted with experimental data, and enabled the determination of diffusion coefficient precisely for the entire time period.",
publisher = "Belgrade :  Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel",
doi = "10.2298/JSC231207010M"
}

Mišković-Stanković, V., Janković, A., Grujić, S., Matić-Bujagić, I., Radojević, V., Vukašinović-Sekulić, M., Kojić, V., Đošić, M.,& Atanasković, T.. (2024). Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel. in Journal of the Serbian Chemical Society
Belgrade :  Serbian Chemical Society..
https://doi.org/10.2298/JSC231207010M

Mišković-Stanković V, Janković A, Grujić S, Matić-Bujagić I, Radojević V, Vukašinović-Sekulić M, Kojić V, Đošić M, Atanasković T. Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel. in Journal of the Serbian Chemical Society. 2024;.
doi:10.2298/JSC231207010M .

Mišković-Stanković, Vesna, Janković, Ana, Grujić, Svetlana, Matić-Bujagić, Ivana, Radojević, Vesna, Vukašinović-Sekulić, Maja, Kojić, Vesna, Đošić, Marija, Atanasković, Teodor, "Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel" in Journal of the Serbian Chemical Society (2024),
https://doi.org/10.2298/JSC231207010M . .

TY  - JOUR
AU  - Jaćimović, Nevena
AU  - Đošić, Marija
AU  - Janković, Ana
AU  - Grujić, Svetlana
AU  - Matić-Bujagić, Ivana
AU  - Stojanović, Jovica
AU  - Vukašinović-Sekulić, Maja
AU  - Kojić, Vesna
AU  - Mišković-Stanković, Vesna
PY  - 2023
UR  - https://ritnms.itnms.ac.rs/handle/123456789/1228
AB  - Biocomposite hydroxyapatite/poly(vinyl alcohol)/chitosan/gentamicincoatings were fabricated on titanium by an electrophoretic deposition process (EPD) from an aqueous suspension using  the  constant voltage  method. Characterization of  the  deposited coatings  was performed by scanning electron  micros-copy with field emission (FE–SEM), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffrac-tion  (XRD)  after  immersion  in  simulated  body  fluid  (SBF)  at  37°C.  The  concentration  of  the  released gentamicin was determined using high-performance liquid chromatography (HPLC) coupled with a mass spectrometer (MS). The release profile confirmed an initial “burst-release effect”with ~ 30% of the gen-tamicin released in the first 48 h, which could be of assistance in the prevention of biofilm formation. An-tibacterial activity was proven by the agar diffusion method on Staphylococcus aureusTL and Escherich-ia coliATCC 25922 bacterial strains. Cytotoxicity was tested by the dye exclusion test (DET) on MRC-5 and L929 fibroblast cell lines, with both coatings expressing nontoxicity. The results showed the high ap-plicability potential of a poly(vinyl alcohol)-based biocomposite coating for medical purposes.
PB  - Skopje : Society of Chemists and Technologists of Macedonia
PB  - Skopje : Ss. Cyril and Methodius University in Skopje
T2  - Macedonian Journal of Chemistry and Chemical Engineering
T1  - Single-step, electrophoretically deposited  Hydroxyapatite/Poly(Vinyl Alcohol)/Chitosan/Gentamicin coating for biomedical applications
EP  - 262
IS  - 2
SP  - 249
VL  - 42
DO  - 10.20450/mjcce.2023.2775
ER  - 

@article{
author = "Jaćimović, Nevena and Đošić, Marija and Janković, Ana and Grujić, Svetlana and Matić-Bujagić, Ivana and Stojanović, Jovica and Vukašinović-Sekulić, Maja and Kojić, Vesna and Mišković-Stanković, Vesna",
year = "2023",
abstract = "Biocomposite hydroxyapatite/poly(vinyl alcohol)/chitosan/gentamicincoatings were fabricated on titanium by an electrophoretic deposition process (EPD) from an aqueous suspension using  the  constant voltage  method. Characterization of  the  deposited coatings  was performed by scanning electron  micros-copy with field emission (FE–SEM), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffrac-tion  (XRD)  after  immersion  in  simulated  body  fluid  (SBF)  at  37°C.  The  concentration  of  the  released gentamicin was determined using high-performance liquid chromatography (HPLC) coupled with a mass spectrometer (MS). The release profile confirmed an initial “burst-release effect”with ~ 30% of the gen-tamicin released in the first 48 h, which could be of assistance in the prevention of biofilm formation. An-tibacterial activity was proven by the agar diffusion method on Staphylococcus aureusTL and Escherich-ia coliATCC 25922 bacterial strains. Cytotoxicity was tested by the dye exclusion test (DET) on MRC-5 and L929 fibroblast cell lines, with both coatings expressing nontoxicity. The results showed the high ap-plicability potential of a poly(vinyl alcohol)-based biocomposite coating for medical purposes.",
publisher = "Skopje : Society of Chemists and Technologists of Macedonia, Skopje : Ss. Cyril and Methodius University in Skopje",
journal = "Macedonian Journal of Chemistry and Chemical Engineering",
title = "Single-step, electrophoretically deposited  Hydroxyapatite/Poly(Vinyl Alcohol)/Chitosan/Gentamicin coating for biomedical applications",
pages = "262-249",
number = "2",
volume = "42",
doi = "10.20450/mjcce.2023.2775"
}

Jaćimović, N., Đošić, M., Janković, A., Grujić, S., Matić-Bujagić, I., Stojanović, J., Vukašinović-Sekulić, M., Kojić, V.,& Mišković-Stanković, V.. (2023). Single-step, electrophoretically deposited  Hydroxyapatite/Poly(Vinyl Alcohol)/Chitosan/Gentamicin coating for biomedical applications. in Macedonian Journal of Chemistry and Chemical Engineering
Skopje : Society of Chemists and Technologists of Macedonia., 42(2), 249-262.
https://doi.org/10.20450/mjcce.2023.2775

Jaćimović N, Đošić M, Janković A, Grujić S, Matić-Bujagić I, Stojanović J, Vukašinović-Sekulić M, Kojić V, Mišković-Stanković V. Single-step, electrophoretically deposited  Hydroxyapatite/Poly(Vinyl Alcohol)/Chitosan/Gentamicin coating for biomedical applications. in Macedonian Journal of Chemistry and Chemical Engineering. 2023;42(2):249-262.
doi:10.20450/mjcce.2023.2775 .

Jaćimović, Nevena, Đošić, Marija, Janković, Ana, Grujić, Svetlana, Matić-Bujagić, Ivana, Stojanović, Jovica, Vukašinović-Sekulić, Maja, Kojić, Vesna, Mišković-Stanković, Vesna, "Single-step, electrophoretically deposited  Hydroxyapatite/Poly(Vinyl Alcohol)/Chitosan/Gentamicin coating for biomedical applications" in Macedonian Journal of Chemistry and Chemical Engineering, 42, no. 2 (2023):249-262,
https://doi.org/10.20450/mjcce.2023.2775 . .

TY  - CONF
AU  - Lopičić, Zorica
AU  - Antanasković, Anja
AU  - Šoštarić, Tatjana
AU  - Đošić, Marija
AU  - Milojković, Jelena
AU  - Bourgerie, Sylvain
AU  - Morabito, Domenico
PY  - 2023
UR  - https://ritnms.itnms.ac.rs/handle/123456789/1209
AB  - The concerns over the environmental and economic issues of the phosphates as eutrophication agents are continiously rising, due to their toxic
effects on the whole environment. The greatest risk arises from entering phosphates into water streams as the runoff from agricultural lands and
those from sewage water. Among the conventional methods used for phosphate removal, adsorption technology appeared as the most promising
one, due to its simplicity and economical feasibility. Another advantage of this technique is the possibility of sorbent regeneration with low amounts
of by-products, and possible reuse of regenerated sorbate in different applications, including agriculture. Amongst many sorbents widely used,
modified activated carbon (AC) is mostly used, but the application of modified AC raises costs of AC production/application. In the sense of this,
the search for cheaper sorbents with higher phosphate removal capacity is still needed. Biochar (BC) is a cost-effective and environmental friendly
stable solid material rich in carbon, resistant to decomposition and mineralization [1]. Although BC and AC are made from similar raw materials, BC
is usually produced at lower temperatures, resulting in a price of BC that is app. 1/6 of the price of the commercial AC [2]. In the last decade, BC is
receiving great attention as a promising sorbent for different pollutants from water streams, but the use of BC also supports the reduction of
greenhouse gases and its application into soils enhance the soil fertility. Many recent studies with unmodified BCs [3] have shown lower phosphate
removal ability, indicating negative surface charge as one of the factors influencing lower removal of negatively charged ions over a wide pH range.
In order to increase BCs sorption capacity toward phosphates, the introduction of some cationic species is often required. In this paper, synthesis
of MgO-biochar from waste lignocellulosic biomass was applied, in order to create highly porous nanocomposite material with efficient phosphate
removal. For this purpose, feedstock used to make the MgO-biochar nanocomposites were plum stones (PmS) obtained from the local factory,
where they have been disposed as a waste. After receiving, feedstock was air dried and milled into 0.1-0.5 mm particles. MgCl2·6H2O was used to
prepare a solution to pre-treat the PmS feedstock according to the procedure described in [4]. After immersing procedure, the oven dried mixture
was heated at 10 °C/min up to 500 °C under Ar flow for 1,5 h. For the purpose of sorbent characterisation, pHpzc, XRD, TG-DTG and FTIR analysis
were performed. The existence of Mg nanoparticles shifts the pHPZC from 6.7 to highly alkaline value of 10.7 which facilitates the electrostatic
interactions between the negatively charged PO43- ions and PmS-M-B. The diffraction peaks identified as MgO revealed that MgO particles were
highly crystalline, and uniformly deposited across the entire PmS-M-B surface. TGA analyses revealed four stage degradation, where the peaks for
the PmS-M-B shifted to the higer temperatures compared to the unmodified biochar (PmS-B) and higher residual mass after final combustion stage.
FTIR spectra have showed most band differences in the 1800–600 cm−1 range. The characterised MgO-biochar nanocomposite produced from
pyrolysis (PmS-M-B) was further used in sorption experiments. A stock phosphate solution was prepared using KH2PO4 and diluted to the required
concentrations. The adsorption isotherm of phosphate on the PmS-M-B was determined using the batch sorption technique by mixing 0.1 g of the
biochar sample with 50 mL of phosphate solutions of different concentrations ranging from 10 to 500 mg/L. The reaction vessels were shaken (150
rpm, 25 °C) and after the desired contact times (from 5 min to 24 h), the samples were filtered, phosphate concentrations in the liquid phase samples
were determined using MD 610 colorimeter (Lovibond, Germany), and the amount of PO43- adsorbed onto PmS-M-B was calculated. Data obtained
through the isothermal experiments were fitted using three commonly applied isotherms: Langmuir, Freundlich and Sips. Isotherm equilibrium
modelling revealed that the Sips isotherm provided the best model fit with maximum sorption capacity of 181.46 mg/g. This sorption capacity is
much higher than the most of the others reported in literature [5, 6] .A possible sorption mechanism of PO43 removal might be assigned to
electrostatic attraction and hydrogen bonding, Obtained results demonstrated that engineered MgO-biochar derived from waste PmS can be used
as a promising green material for removing phosphates from contaminated waters, providing opportunities in developing low-cost and highly
efficient material to resolve eutrophication issue. In the same time, environmental benefits might be multiple: decreasing environmental hazards by
reducing waste landfills, and also using exhausted sorbate in soil remediation and as a slow release fertilizer, confirming advantages of the biochars
amongst the other available adsorbents.
PB  - PROTEOMASS Scientific Society
C3  - 5th International Caparica Conference on Pollutant Toxic Ions and Molecules 2023
T1  - Engineered Biochar Made from Waste Plum Stones as Efficient Sorbent in Phosphate Removal
EP  - 176
SP  - 176
ER  - 

@conference{
author = "Lopičić, Zorica and Antanasković, Anja and Šoštarić, Tatjana and Đošić, Marija and Milojković, Jelena and Bourgerie, Sylvain and Morabito, Domenico",
year = "2023",
abstract = "The concerns over the environmental and economic issues of the phosphates as eutrophication agents are continiously rising, due to their toxic
effects on the whole environment. The greatest risk arises from entering phosphates into water streams as the runoff from agricultural lands and
those from sewage water. Among the conventional methods used for phosphate removal, adsorption technology appeared as the most promising
one, due to its simplicity and economical feasibility. Another advantage of this technique is the possibility of sorbent regeneration with low amounts
of by-products, and possible reuse of regenerated sorbate in different applications, including agriculture. Amongst many sorbents widely used,
modified activated carbon (AC) is mostly used, but the application of modified AC raises costs of AC production/application. In the sense of this,
the search for cheaper sorbents with higher phosphate removal capacity is still needed. Biochar (BC) is a cost-effective and environmental friendly
stable solid material rich in carbon, resistant to decomposition and mineralization [1]. Although BC and AC are made from similar raw materials, BC
is usually produced at lower temperatures, resulting in a price of BC that is app. 1/6 of the price of the commercial AC [2]. In the last decade, BC is
receiving great attention as a promising sorbent for different pollutants from water streams, but the use of BC also supports the reduction of
greenhouse gases and its application into soils enhance the soil fertility. Many recent studies with unmodified BCs [3] have shown lower phosphate
removal ability, indicating negative surface charge as one of the factors influencing lower removal of negatively charged ions over a wide pH range.
In order to increase BCs sorption capacity toward phosphates, the introduction of some cationic species is often required. In this paper, synthesis
of MgO-biochar from waste lignocellulosic biomass was applied, in order to create highly porous nanocomposite material with efficient phosphate
removal. For this purpose, feedstock used to make the MgO-biochar nanocomposites were plum stones (PmS) obtained from the local factory,
where they have been disposed as a waste. After receiving, feedstock was air dried and milled into 0.1-0.5 mm particles. MgCl2·6H2O was used to
prepare a solution to pre-treat the PmS feedstock according to the procedure described in [4]. After immersing procedure, the oven dried mixture
was heated at 10 °C/min up to 500 °C under Ar flow for 1,5 h. For the purpose of sorbent characterisation, pHpzc, XRD, TG-DTG and FTIR analysis
were performed. The existence of Mg nanoparticles shifts the pHPZC from 6.7 to highly alkaline value of 10.7 which facilitates the electrostatic
interactions between the negatively charged PO43- ions and PmS-M-B. The diffraction peaks identified as MgO revealed that MgO particles were
highly crystalline, and uniformly deposited across the entire PmS-M-B surface. TGA analyses revealed four stage degradation, where the peaks for
the PmS-M-B shifted to the higer temperatures compared to the unmodified biochar (PmS-B) and higher residual mass after final combustion stage.
FTIR spectra have showed most band differences in the 1800–600 cm−1 range. The characterised MgO-biochar nanocomposite produced from
pyrolysis (PmS-M-B) was further used in sorption experiments. A stock phosphate solution was prepared using KH2PO4 and diluted to the required
concentrations. The adsorption isotherm of phosphate on the PmS-M-B was determined using the batch sorption technique by mixing 0.1 g of the
biochar sample with 50 mL of phosphate solutions of different concentrations ranging from 10 to 500 mg/L. The reaction vessels were shaken (150
rpm, 25 °C) and after the desired contact times (from 5 min to 24 h), the samples were filtered, phosphate concentrations in the liquid phase samples
were determined using MD 610 colorimeter (Lovibond, Germany), and the amount of PO43- adsorbed onto PmS-M-B was calculated. Data obtained
through the isothermal experiments were fitted using three commonly applied isotherms: Langmuir, Freundlich and Sips. Isotherm equilibrium
modelling revealed that the Sips isotherm provided the best model fit with maximum sorption capacity of 181.46 mg/g. This sorption capacity is
much higher than the most of the others reported in literature [5, 6] .A possible sorption mechanism of PO43 removal might be assigned to
electrostatic attraction and hydrogen bonding, Obtained results demonstrated that engineered MgO-biochar derived from waste PmS can be used
as a promising green material for removing phosphates from contaminated waters, providing opportunities in developing low-cost and highly
efficient material to resolve eutrophication issue. In the same time, environmental benefits might be multiple: decreasing environmental hazards by
reducing waste landfills, and also using exhausted sorbate in soil remediation and as a slow release fertilizer, confirming advantages of the biochars
amongst the other available adsorbents.",
publisher = "PROTEOMASS Scientific Society",
journal = "5th International Caparica Conference on Pollutant Toxic Ions and Molecules 2023",
title = "Engineered Biochar Made from Waste Plum Stones as Efficient Sorbent in Phosphate Removal",
pages = "176-176"
}

Lopičić, Z., Antanasković, A., Šoštarić, T., Đošić, M., Milojković, J., Bourgerie, S.,& Morabito, D.. (2023). Engineered Biochar Made from Waste Plum Stones as Efficient Sorbent in Phosphate Removal. in 5th International Caparica Conference on Pollutant Toxic Ions and Molecules 2023
PROTEOMASS Scientific Society., 176-176.

Lopičić Z, Antanasković A, Šoštarić T, Đošić M, Milojković J, Bourgerie S, Morabito D. Engineered Biochar Made from Waste Plum Stones as Efficient Sorbent in Phosphate Removal. in 5th International Caparica Conference on Pollutant Toxic Ions and Molecules 2023. 2023;:176-176..

Lopičić, Zorica, Antanasković, Anja, Šoštarić, Tatjana, Đošić, Marija, Milojković, Jelena, Bourgerie, Sylvain, Morabito, Domenico, "Engineered Biochar Made from Waste Plum Stones as Efficient Sorbent in Phosphate Removal" in 5th International Caparica Conference on Pollutant Toxic Ions and Molecules 2023 (2023):176-176.

TY  - JOUR
AU  - Đošić, Marija
AU  - Janković, Ana
AU  - Stevanović, Milena
AU  - Stojanović, Jovica
AU  - Vukašinović-Sekulić, Maja
AU  - Kojić, Vesna
AU  - Mišković-Stanković, Vesna
PY  - 2023
UR  - https://ritnms.itnms.ac.rs/handle/123456789/666
AB  - Electrophoretic deposition (EPD) was employed to fabricate composite coatings aimed for orthopedic implants.
Hydroxyapatite (HAP), poly(vinyl alcohol) (PVA) and chitosan (CS) coatings, with or without antibiotic gentamicin
(Gent) were deposited in a single-step process from aqueous suspension, using EPD. Polymer/mineral
composite coatings were formed with the aim to mimic the natural composition of bone tissue, along with
improved coatings antibacterial properties, at the same time serving as a drug carrier, allowing local administration
of antibiotic. Structural and morphological characterization of HAP/PVA/CS and HAP/PVA/CS/Gent
coatings was investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric
analysis (TG/DTG), and scanning electron microscopy (SEM) proving carbonate-substituted HAP.
The presence of gentamicin contributed to the bactericidal activity of composite HAP/PVA/CS/Gent coating
against Staphylococcus aureus and Escherichia coli. Cytotoxicity studies were performed towards human MRC-5
and mice L929 fibroblast cell lines, and both investigated samples (HAP/PVA/CS and HAP/PVA/CS/Gent)
expressed good biocompatibility, without causing toxic effect on tested cells. Biomineralization potential was
investigated by measuring the alkaline phosphatase activity, demonstrating high potential of HAP/PVA/CS/Gent
to induce the growth of new HAP layer. Therefore, the present investigation proposes the production of nents,
along with antibiotic gentamicin, improving the antibacterial coatings’ properties.
PB  - Elsevier
T2  - Materials Chemistry and Physics
T1  - Hydroxyapatite/poly(vinyl alcohol)/chitosan coating with gentamicin for orthopedic implants
IS  - 127766
VL  - 303
DO  - 10.1016/j.matchemphys.2023.127766
ER  - 

@article{
author = "Đošić, Marija and Janković, Ana and Stevanović, Milena and Stojanović, Jovica and Vukašinović-Sekulić, Maja and Kojić, Vesna and Mišković-Stanković, Vesna",
year = "2023",
abstract = "Electrophoretic deposition (EPD) was employed to fabricate composite coatings aimed for orthopedic implants.
Hydroxyapatite (HAP), poly(vinyl alcohol) (PVA) and chitosan (CS) coatings, with or without antibiotic gentamicin
(Gent) were deposited in a single-step process from aqueous suspension, using EPD. Polymer/mineral
composite coatings were formed with the aim to mimic the natural composition of bone tissue, along with
improved coatings antibacterial properties, at the same time serving as a drug carrier, allowing local administration
of antibiotic. Structural and morphological characterization of HAP/PVA/CS and HAP/PVA/CS/Gent
coatings was investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric
analysis (TG/DTG), and scanning electron microscopy (SEM) proving carbonate-substituted HAP.
The presence of gentamicin contributed to the bactericidal activity of composite HAP/PVA/CS/Gent coating
against Staphylococcus aureus and Escherichia coli. Cytotoxicity studies were performed towards human MRC-5
and mice L929 fibroblast cell lines, and both investigated samples (HAP/PVA/CS and HAP/PVA/CS/Gent)
expressed good biocompatibility, without causing toxic effect on tested cells. Biomineralization potential was
investigated by measuring the alkaline phosphatase activity, demonstrating high potential of HAP/PVA/CS/Gent
to induce the growth of new HAP layer. Therefore, the present investigation proposes the production of nents,
along with antibiotic gentamicin, improving the antibacterial coatings’ properties.",
publisher = "Elsevier",
journal = "Materials Chemistry and Physics",
title = "Hydroxyapatite/poly(vinyl alcohol)/chitosan coating with gentamicin for orthopedic implants",
number = "127766",
volume = "303",
doi = "10.1016/j.matchemphys.2023.127766"
}

Đošić, M., Janković, A., Stevanović, M., Stojanović, J., Vukašinović-Sekulić, M., Kojić, V.,& Mišković-Stanković, V.. (2023). Hydroxyapatite/poly(vinyl alcohol)/chitosan coating with gentamicin for orthopedic implants. in Materials Chemistry and Physics
Elsevier., 303(127766).
https://doi.org/10.1016/j.matchemphys.2023.127766

Đošić M, Janković A, Stevanović M, Stojanović J, Vukašinović-Sekulić M, Kojić V, Mišković-Stanković V. Hydroxyapatite/poly(vinyl alcohol)/chitosan coating with gentamicin for orthopedic implants. in Materials Chemistry and Physics. 2023;303(127766).
doi:10.1016/j.matchemphys.2023.127766 .

Đošić, Marija, Janković, Ana, Stevanović, Milena, Stojanović, Jovica, Vukašinović-Sekulić, Maja, Kojić, Vesna, Mišković-Stanković, Vesna, "Hydroxyapatite/poly(vinyl alcohol)/chitosan coating with gentamicin for orthopedic implants" in Materials Chemistry and Physics, 303, no. 127766 (2023),
https://doi.org/10.1016/j.matchemphys.2023.127766 . .

TY  - CONF
AU  - Topalović, Vladimir
AU  - Matijašević, Srđan
AU  - Nikolić, Jelena
AU  - Savić, Veljko
AU  - Đošić, Marija
AU  - Grujić, sn
PY  - 2023
UR  - https://ritnms.itnms.ac.rs/handle/123456789/786
AB  - Polyphosphate glasses are a class of bioactive glasses that have gained significant attention in recent years due to their unique properties and potential applications in various fields, particularly in the area of biomedical engineering. These glasses exhibit excellent biocompatibility, which is a crucial requirement for biomaterials. Furthermore, their dissolution and degradation rates can be tailored by modifying their composition, allowing for control over their bioactivity and biodegradability. Polyphosphate glasses also have the ability to form a hydroxyapatite-like layer on their surface when in contact with biological fluids, which facilitates their integration with surrounding tissues. The unique properties of polyphosphate glasses make them promising candidates for various biomedical applications, including bone tissue engineering, drug delivery, and wound healing. This paper presents the thermal characterization of two bioactive polyphosphate glass compositions with the addition of strontium, to investigate the sintering and crystallization processes. The samples were synthesized using the melt-quenching method and then sintered at various temperatures. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to analyze the thermal behavior and crystalline phases formed during sintering. Our results showed that sintering and crystallization are separate processes for both compositions. The addition of strontium to the glass improved its sintering behavior, resulting in a denser glass structure. Moreover, strontium incorporation did not affect the formation of the crystalline phase during sintering. These findings provide useful insights into the design and development of bioactive polyphosphate glass compositions for bone tissue engineering applications.
PB  - Belgrade : Materials Research Society of Serbia
C3  - THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023
T1  - Thermal characterization of bioactive polyphosphate glass with strontium addition
EP  - 163
SP  - 163
ER  - 

@conference{
author = "Topalović, Vladimir and Matijašević, Srđan and Nikolić, Jelena and Savić, Veljko and Đošić, Marija and Grujić, sn",
year = "2023",
abstract = "Polyphosphate glasses are a class of bioactive glasses that have gained significant attention in recent years due to their unique properties and potential applications in various fields, particularly in the area of biomedical engineering. These glasses exhibit excellent biocompatibility, which is a crucial requirement for biomaterials. Furthermore, their dissolution and degradation rates can be tailored by modifying their composition, allowing for control over their bioactivity and biodegradability. Polyphosphate glasses also have the ability to form a hydroxyapatite-like layer on their surface when in contact with biological fluids, which facilitates their integration with surrounding tissues. The unique properties of polyphosphate glasses make them promising candidates for various biomedical applications, including bone tissue engineering, drug delivery, and wound healing. This paper presents the thermal characterization of two bioactive polyphosphate glass compositions with the addition of strontium, to investigate the sintering and crystallization processes. The samples were synthesized using the melt-quenching method and then sintered at various temperatures. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to analyze the thermal behavior and crystalline phases formed during sintering. Our results showed that sintering and crystallization are separate processes for both compositions. The addition of strontium to the glass improved its sintering behavior, resulting in a denser glass structure. Moreover, strontium incorporation did not affect the formation of the crystalline phase during sintering. These findings provide useful insights into the design and development of bioactive polyphosphate glass compositions for bone tissue engineering applications.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023",
title = "Thermal characterization of bioactive polyphosphate glass with strontium addition",
pages = "163-163"
}

Topalović, V., Matijašević, S., Nikolić, J., Savić, V., Đošić, M.,& Grujić, s.. (2023). Thermal characterization of bioactive polyphosphate glass with strontium addition. in THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023
Belgrade : Materials Research Society of Serbia., 163-163.

Topalović V, Matijašević S, Nikolić J, Savić V, Đošić M, Grujić S. Thermal characterization of bioactive polyphosphate glass with strontium addition. in THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023. 2023;:163-163..

Topalović, Vladimir, Matijašević, Srđan, Nikolić, Jelena, Savić, Veljko, Đošić, Marija, Grujić, sn, "Thermal characterization of bioactive polyphosphate glass with strontium addition" in THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023 (2023):163-163.

TY  - CONF
AU  - Savić, Veljko
AU  - Topalović, Vladimir
AU  - Nikolić, Jelena
AU  - Đošić, Marija
AU  - Matijašević, Srđan
AU  - Grujić, Snežana
PY  - 2023
UR  - https://ritnms.itnms.ac.rs/handle/123456789/785
AB  - Open loop glass recycling is a process where the glass is recycled into a new product. Glass recycling helps reduce landfill waste. Glass takes up significant space in landfills and does not decompose. In many countries, landfills are filling up faster than we can create new ones. Recycling glass reduces the volume of waste, and increases the lifespan of landfills. One of examples of open loop recycling of glass is glass foam produciton. Glass foam production is a process that involves the creation of a light-weight glass material with a foam-like consistency. This type of glass is made by mixing a foaming agent with glass powder and heating to temperatures where decomposition of a foaming agent and sintering of glass happens. This results in the creation of a material that is light, strong, and has thermally-insulating properties. Milled flat glass was mixed with sugar beet factory lime, a CaCO3 – rich waste wich has role of a foaming agent, in order to enter 5% CaCO3 in mixture and pressed at 20 MPa in hydraulic press. Raw pellets were sintered at 800 °C for 30 min. In obtained glass foam phase composition, pore size distribution, compressive strength and thermal conducitivity were determined. Glass foam is emerging as a flexible, cost-effective, and sustainable material that can be utilized in numerous applications to promote sustainable development. Its features such as high insulation capacity, lightweight, and durability make it an ideal material for a wide range of industries.
PB  - Belgrade : Materials Research Society of Serbia
C3  - THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023
T1  - Recycling of flat glass for glass foam production
EP  - 98
SP  - 98
ER  - 

@conference{
author = "Savić, Veljko and Topalović, Vladimir and Nikolić, Jelena and Đošić, Marija and Matijašević, Srđan and Grujić, Snežana",
year = "2023",
abstract = "Open loop glass recycling is a process where the glass is recycled into a new product. Glass recycling helps reduce landfill waste. Glass takes up significant space in landfills and does not decompose. In many countries, landfills are filling up faster than we can create new ones. Recycling glass reduces the volume of waste, and increases the lifespan of landfills. One of examples of open loop recycling of glass is glass foam produciton. Glass foam production is a process that involves the creation of a light-weight glass material with a foam-like consistency. This type of glass is made by mixing a foaming agent with glass powder and heating to temperatures where decomposition of a foaming agent and sintering of glass happens. This results in the creation of a material that is light, strong, and has thermally-insulating properties. Milled flat glass was mixed with sugar beet factory lime, a CaCO3 – rich waste wich has role of a foaming agent, in order to enter 5% CaCO3 in mixture and pressed at 20 MPa in hydraulic press. Raw pellets were sintered at 800 °C for 30 min. In obtained glass foam phase composition, pore size distribution, compressive strength and thermal conducitivity were determined. Glass foam is emerging as a flexible, cost-effective, and sustainable material that can be utilized in numerous applications to promote sustainable development. Its features such as high insulation capacity, lightweight, and durability make it an ideal material for a wide range of industries.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023",
title = "Recycling of flat glass for glass foam production",
pages = "98-98"
}

Savić, V., Topalović, V., Nikolić, J., Đošić, M., Matijašević, S.,& Grujić, S.. (2023). Recycling of flat glass for glass foam production. in THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023
Belgrade : Materials Research Society of Serbia., 98-98.

Savić V, Topalović V, Nikolić J, Đošić M, Matijašević S, Grujić S. Recycling of flat glass for glass foam production. in THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023. 2023;:98-98..

Savić, Veljko, Topalović, Vladimir, Nikolić, Jelena, Đošić, Marija, Matijašević, Srđan, Grujić, Snežana, "Recycling of flat glass for glass foam production" in THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023 (2023):98-98.

TY  - CONF
AU  - Savić, Veljko
AU  - Topalović, Vladimir
AU  - Nikolić, Jelena
AU  - Matijašević, Srđan
AU  - Đošić, Marija
AU  - Zildžović, Snežana
AU  - Grujić, Snežana
PY  - 2023
UR  - https://ritnms.itnms.ac.rs/handle/123456789/784
AB  - Waste glass can be transformed into a foam by addition of suitable substance (foaming agent) which generated gaseous products by decomposition or reaction at temperatures above its softening temperature (corresponding to a viscosity of 106.6 Pas). This paper provides a concise overview of the latest research in the field of improving the glass foam production process. Some of the possibilities for reducing the environmental impact of glass foam production are also presented. Some of the new production techniques, new foaming agents as well as the possibility of including other solid waste in the composition of glass foams are presented. At the end, the glass foam produced in the Laboratory for glass and ceramics, Institute for Technology of Nuclear and other Mineral Raw Materials, was shown.
PB  - Belgrade : University of Belgrade, Faculty of Mining and Geology
C3  - 9th International Conference Mining and Environmental Protection MEP-23
T1  - Recycling of glass waste into foam glass: A review
EP  - 272
SP  - 267
ER  - 

@conference{
author = "Savić, Veljko and Topalović, Vladimir and Nikolić, Jelena and Matijašević, Srđan and Đošić, Marija and Zildžović, Snežana and Grujić, Snežana",
year = "2023",
abstract = "Waste glass can be transformed into a foam by addition of suitable substance (foaming agent) which generated gaseous products by decomposition or reaction at temperatures above its softening temperature (corresponding to a viscosity of 106.6 Pas). This paper provides a concise overview of the latest research in the field of improving the glass foam production process. Some of the possibilities for reducing the environmental impact of glass foam production are also presented. Some of the new production techniques, new foaming agents as well as the possibility of including other solid waste in the composition of glass foams are presented. At the end, the glass foam produced in the Laboratory for glass and ceramics, Institute for Technology of Nuclear and other Mineral Raw Materials, was shown.",
publisher = "Belgrade : University of Belgrade, Faculty of Mining and Geology",
journal = "9th International Conference Mining and Environmental Protection MEP-23",
title = "Recycling of glass waste into foam glass: A review",
pages = "272-267"
}

Savić, V., Topalović, V., Nikolić, J., Matijašević, S., Đošić, M., Zildžović, S.,& Grujić, S.. (2023). Recycling of glass waste into foam glass: A review. in 9th International Conference Mining and Environmental Protection MEP-23
Belgrade : University of Belgrade, Faculty of Mining and Geology., 267-272.

Savić V, Topalović V, Nikolić J, Matijašević S, Đošić M, Zildžović S, Grujić S. Recycling of glass waste into foam glass: A review. in 9th International Conference Mining and Environmental Protection MEP-23. 2023;:267-272..

Savić, Veljko, Topalović, Vladimir, Nikolić, Jelena, Matijašević, Srđan, Đošić, Marija, Zildžović, Snežana, Grujić, Snežana, "Recycling of glass waste into foam glass: A review" in 9th International Conference Mining and Environmental Protection MEP-23 (2023):267-272.

TY  - CONF
AU  - Stevanović, Milena
AU  - Đošić, Marija
AU  - Janković, Ana
AU  - Kojić, Vesna
AU  - Mišković-Stanković, Vesna
PY  - 2023
UR  - https://ritnms.itnms.ac.rs/handle/123456789/750
AB  - Kompozitna prevlaka hidroksiapatita (HAP) sa prirodnim polimerima hitozanom (CS) i polivinil-alkoholom (PVA), kao i sa antibiotikom gentamicinom (Gent) je elektroforetski taložena na titanu, pri konstantnom naponu. Formiranje nove kompozitne HAP/PVA/CS/Gent prevlake je potvrđeno infracrvenom spektroskopijom sa Furijeovom transformacijom. Necitotoksični efekat istaložene HAP/PVA/CS/Gent prevlake je dokazan MTT testom prema dve ćelijske linije (MRC-5 i L929). Sposobnost HAP/PVA/CS/Gent prevlake da indukuje i promoviše osteointegraciju je pokazana ALP testom.
AB  - Composite coating of hydroxyapatite (HAP) with natural polymers chitosan (CS) and poly(vinyl alcohol) (PVA) with the antibiotic gentamicin (Gent) was electrophoretically deposited on titanium from an aqueous suspension, at a constant voltage. Formation of a new composite HAP/PVA/CS/Gent coating was confirmed by Fourier transform infrared spectroscopy. Non-cytotoxicity of deposited HAP/PVA/CS/Gent coating was demonstrated by MTT assay towards two types of cell lines (MRC-5 and L929). HAP/PVA/CS/Gent coating ability to induce and promote the osseointegration process was proved by the ALP assay.
PB  - Belgrade : Serbian Chemical Society
C3  - 59. Savetovanje Srpskog hemijskog društva
T1  - Bioaktivne kompozitne prevlake na bazi hidroksiapatita na titanu za primene u ortopediji / Bioactive hydroxyapatite-based composite coatings on titanium for orthopedic applications
EP  - 64
SP  - 64
ER  - 

@conference{
author = "Stevanović, Milena and Đošić, Marija and Janković, Ana and Kojić, Vesna and Mišković-Stanković, Vesna",
year = "2023",
abstract = "Kompozitna prevlaka hidroksiapatita (HAP) sa prirodnim polimerima hitozanom (CS) i polivinil-alkoholom (PVA), kao i sa antibiotikom gentamicinom (Gent) je elektroforetski taložena na titanu, pri konstantnom naponu. Formiranje nove kompozitne HAP/PVA/CS/Gent prevlake je potvrđeno infracrvenom spektroskopijom sa Furijeovom transformacijom. Necitotoksični efekat istaložene HAP/PVA/CS/Gent prevlake je dokazan MTT testom prema dve ćelijske linije (MRC-5 i L929). Sposobnost HAP/PVA/CS/Gent prevlake da indukuje i promoviše osteointegraciju je pokazana ALP testom., Composite coating of hydroxyapatite (HAP) with natural polymers chitosan (CS) and poly(vinyl alcohol) (PVA) with the antibiotic gentamicin (Gent) was electrophoretically deposited on titanium from an aqueous suspension, at a constant voltage. Formation of a new composite HAP/PVA/CS/Gent coating was confirmed by Fourier transform infrared spectroscopy. Non-cytotoxicity of deposited HAP/PVA/CS/Gent coating was demonstrated by MTT assay towards two types of cell lines (MRC-5 and L929). HAP/PVA/CS/Gent coating ability to induce and promote the osseointegration process was proved by the ALP assay.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "59. Savetovanje Srpskog hemijskog društva",
title = "Bioaktivne kompozitne prevlake na bazi hidroksiapatita na titanu za primene u ortopediji / Bioactive hydroxyapatite-based composite coatings on titanium for orthopedic applications",
pages = "64-64"
}

Stevanović, M., Đošić, M., Janković, A., Kojić, V.,& Mišković-Stanković, V.. (2023). Bioaktivne kompozitne prevlake na bazi hidroksiapatita na titanu za primene u ortopediji / Bioactive hydroxyapatite-based composite coatings on titanium for orthopedic applications. in 59. Savetovanje Srpskog hemijskog društva
Belgrade : Serbian Chemical Society., 64-64.

Stevanović M, Đošić M, Janković A, Kojić V, Mišković-Stanković V. Bioaktivne kompozitne prevlake na bazi hidroksiapatita na titanu za primene u ortopediji / Bioactive hydroxyapatite-based composite coatings on titanium for orthopedic applications. in 59. Savetovanje Srpskog hemijskog društva. 2023;:64-64..

Stevanović, Milena, Đošić, Marija, Janković, Ana, Kojić, Vesna, Mišković-Stanković, Vesna, "Bioaktivne kompozitne prevlake na bazi hidroksiapatita na titanu za primene u ortopediji / Bioactive hydroxyapatite-based composite coatings on titanium for orthopedic applications" in 59. Savetovanje Srpskog hemijskog društva (2023):64-64.

TY  - CONF
AU  - Đošić, Marija
AU  - Janković, Ana
AU  - Stevanović, Milena
AU  - Vukašinović-Sekulić, Maja
AU  - Mišković-Stanković, Vesna
PY  - 2023
UR  - https://ritnms.itnms.ac.rs/handle/123456789/749
AB  - Uvođenje antibiotika u polimer/mineralnu kompozitnu prevlaku poboljšava antibakterijska svojstva prevlaka. Kompozitna prevlaka (hidroksiapatit - HAP, poli(vinilalkohol), hitozan, gentamicin) dobijena je elektroforetskim taloženjem iz četvorokomponentne vodene suspenzije. Primenom termogravimetrijske i rendgenske difrakcione analize pokazano je prisustvo karbonatno-supstituisanog HAP. Antibakterijska aktivnost kompozitne prevlake sa gentamicinom potvrđena je protiv soja S. aureus i E. coli, čineći ovu prevlaku pogodnom za potencijalnu primenu u biomedicini.
AB  - Antibiotic introduction in polymer/mineral coating can improve the antibacterial properties of coatings. Composite coating (hydroxyapatite, poly(vinyl alcohol), chitosan, gentamicin) was fabricated from a four-component aqueous suspension using electrophoretic deposition. Structural and morphological characterization of the coating was investigated by X-ray diffraction and thermogravimetric analysis proving carbonate-substituted HAP. The presence of gentamicin contributed to the antibacterial activity of composite coating against S. aureus and E. coli strains, representing a suitable material for possible application in biomedicine.
PB  - Belgrade : Serbian Chemical Society
C3  - 59. Savetovanje Srpskog hemijskog društva
T1  - Elektroforetski taložene kompozitne prevlake sa gentamicinom
T1  - Electrophoretically deposited gentamicin-loaded composite coating
EP  - 58
SP  - 58
ER  - 

@conference{
author = "Đošić, Marija and Janković, Ana and Stevanović, Milena and Vukašinović-Sekulić, Maja and Mišković-Stanković, Vesna",
year = "2023",
abstract = "Uvođenje antibiotika u polimer/mineralnu kompozitnu prevlaku poboljšava antibakterijska svojstva prevlaka. Kompozitna prevlaka (hidroksiapatit - HAP, poli(vinilalkohol), hitozan, gentamicin) dobijena je elektroforetskim taloženjem iz četvorokomponentne vodene suspenzije. Primenom termogravimetrijske i rendgenske difrakcione analize pokazano je prisustvo karbonatno-supstituisanog HAP. Antibakterijska aktivnost kompozitne prevlake sa gentamicinom potvrđena je protiv soja S. aureus i E. coli, čineći ovu prevlaku pogodnom za potencijalnu primenu u biomedicini., Antibiotic introduction in polymer/mineral coating can improve the antibacterial properties of coatings. Composite coating (hydroxyapatite, poly(vinyl alcohol), chitosan, gentamicin) was fabricated from a four-component aqueous suspension using electrophoretic deposition. Structural and morphological characterization of the coating was investigated by X-ray diffraction and thermogravimetric analysis proving carbonate-substituted HAP. The presence of gentamicin contributed to the antibacterial activity of composite coating against S. aureus and E. coli strains, representing a suitable material for possible application in biomedicine.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "59. Savetovanje Srpskog hemijskog društva",
title = "Elektroforetski taložene kompozitne prevlake sa gentamicinom, Electrophoretically deposited gentamicin-loaded composite coating",
pages = "58-58"
}

Đošić, M., Janković, A., Stevanović, M., Vukašinović-Sekulić, M.,& Mišković-Stanković, V.. (2023). Elektroforetski taložene kompozitne prevlake sa gentamicinom. in 59. Savetovanje Srpskog hemijskog društva
Belgrade : Serbian Chemical Society., 58-58.

Đošić M, Janković A, Stevanović M, Vukašinović-Sekulić M, Mišković-Stanković V. Elektroforetski taložene kompozitne prevlake sa gentamicinom. in 59. Savetovanje Srpskog hemijskog društva. 2023;:58-58..

Đošić, Marija, Janković, Ana, Stevanović, Milena, Vukašinović-Sekulić, Maja, Mišković-Stanković, Vesna, "Elektroforetski taložene kompozitne prevlake sa gentamicinom" in 59. Savetovanje Srpskog hemijskog društva (2023):58-58.

TY  - CONF
AU  - Nikolić, Jelena
AU  - Topalović, Vladimir
AU  - Đošić, Marija
AU  - Savić, Veljko
AU  - Obradović, Milena
AU  - Matijašević, Srđan
AU  - Grujić, Snežana
PY  - 2023
UR  - https://ritnms.itnms.ac.rs/handle/123456789/792
AB  - This paper shows the dissolution behavior of polyphosphate glass in demineralized water and 2% citric acid solution at temperatures: 15, 20, 30, 37 and 50 °C. The influence of the solvent type on the diffusion coefficients of the modifying cations, under static conditions, is also presented. The diffusion coefficients, determined from concentration profiles of the modifying cations, are calculated to be in the range of 0.27 to 350x10-14 m2/h for dissolution in demineralized water, and in the range of 3.6 to 148x10-12 m2/h for the dissolution in 2% citric acid solution. The values of activation energy of cations diffusion in demineralized water are in the range from 68.32 to 105.41 kJ/mol, while for 2% citric acid solution they are in the range from 39.28 to 55.34 kJ/mol.
PB  - Belgrade : Association of Metallurgical Engineers of Serbia
C3  - 5th Metallurgical & Materials Engineering Congress of South-East Europe
T1  - Dissolution  of polyphosphate glass: Impact of pH on diffusion coefficients of modifying cations at low temperatures
EP  - 236
SP  - 231
ER  - 

@conference{
author = "Nikolić, Jelena and Topalović, Vladimir and Đošić, Marija and Savić, Veljko and Obradović, Milena and Matijašević, Srđan and Grujić, Snežana",
year = "2023",
abstract = "This paper shows the dissolution behavior of polyphosphate glass in demineralized water and 2% citric acid solution at temperatures: 15, 20, 30, 37 and 50 °C. The influence of the solvent type on the diffusion coefficients of the modifying cations, under static conditions, is also presented. The diffusion coefficients, determined from concentration profiles of the modifying cations, are calculated to be in the range of 0.27 to 350x10-14 m2/h for dissolution in demineralized water, and in the range of 3.6 to 148x10-12 m2/h for the dissolution in 2% citric acid solution. The values of activation energy of cations diffusion in demineralized water are in the range from 68.32 to 105.41 kJ/mol, while for 2% citric acid solution they are in the range from 39.28 to 55.34 kJ/mol.",
publisher = "Belgrade : Association of Metallurgical Engineers of Serbia",
journal = "5th Metallurgical & Materials Engineering Congress of South-East Europe",
title = "Dissolution  of polyphosphate glass: Impact of pH on diffusion coefficients of modifying cations at low temperatures",
pages = "236-231"
}

Nikolić, J., Topalović, V., Đošić, M., Savić, V., Obradović, M., Matijašević, S.,& Grujić, S.. (2023). Dissolution  of polyphosphate glass: Impact of pH on diffusion coefficients of modifying cations at low temperatures. in 5th Metallurgical & Materials Engineering Congress of South-East Europe
Belgrade : Association of Metallurgical Engineers of Serbia., 231-236.

Nikolić J, Topalović V, Đošić M, Savić V, Obradović M, Matijašević S, Grujić S. Dissolution  of polyphosphate glass: Impact of pH on diffusion coefficients of modifying cations at low temperatures. in 5th Metallurgical & Materials Engineering Congress of South-East Europe. 2023;:231-236..

Nikolić, Jelena, Topalović, Vladimir, Đošić, Marija, Savić, Veljko, Obradović, Milena, Matijašević, Srđan, Grujić, Snežana, "Dissolution  of polyphosphate glass: Impact of pH on diffusion coefficients of modifying cations at low temperatures" in 5th Metallurgical & Materials Engineering Congress of South-East Europe (2023):231-236.

TY  - CONF
AU  - Topalović, Vladimir
AU  - Nikolić, Jelena
AU  - Matijašević, Srđan
AU  - Savić, Veljko
AU  - Đošić, Marija
AU  - Vujošević, Ana
AU  - Grujić, Snežana
PY  - 2022
UR  - https://ritnms.itnms.ac.rs/handle/123456789/801
AB  - The main goal of agricultural production should be the production of a sufficient amount of agricultural products with the least possible impact on the environment. In traditional agricultural production, in order to obtain a satisfactory yield, artificial fertilizers are used, which have multiple negative impacts on the environment. Glassy fertilizers are a type of fertilizer that, at least according to previous research, do not have a negative impact on the environment and the same time the use of these fertilizers yields not less than when using traditional fertilizers. Glassy fertilizers are fertilizers with controlled dissolution, they do not pollute groundwater or surface water, the pH of the soil does not change with their use, by changing the composition they can adapt to the requirements of each crop individually, etc. The paper presents three phosphate glassy fertilizers of different chemical composition, obtained at the Center for Inorganic Technologies, ITNMS. The method of obtaining of glassy fertilizers, their dissolution rates in a medium that simulates soil conditions, the changes in pH values of solutions for different dissolution times and the effect of temperature on dissolution rates are shown. Also, the results of the influence of glass fertilizers on plant cultures in real conditions are presented.
PB  - Banja Luka : University in Banja Luka, Faculty of Technology
C3  - XIV Conference of chemists, technologists and environmentalists of Republic of Srpska
T1  - Phophate glassy fertilizers
EP  - 66
SP  - 62
ER  - 

@conference{
author = "Topalović, Vladimir and Nikolić, Jelena and Matijašević, Srđan and Savić, Veljko and Đošić, Marija and Vujošević, Ana and Grujić, Snežana",
year = "2022",
abstract = "The main goal of agricultural production should be the production of a sufficient amount of agricultural products with the least possible impact on the environment. In traditional agricultural production, in order to obtain a satisfactory yield, artificial fertilizers are used, which have multiple negative impacts on the environment. Glassy fertilizers are a type of fertilizer that, at least according to previous research, do not have a negative impact on the environment and the same time the use of these fertilizers yields not less than when using traditional fertilizers. Glassy fertilizers are fertilizers with controlled dissolution, they do not pollute groundwater or surface water, the pH of the soil does not change with their use, by changing the composition they can adapt to the requirements of each crop individually, etc. The paper presents three phosphate glassy fertilizers of different chemical composition, obtained at the Center for Inorganic Technologies, ITNMS. The method of obtaining of glassy fertilizers, their dissolution rates in a medium that simulates soil conditions, the changes in pH values of solutions for different dissolution times and the effect of temperature on dissolution rates are shown. Also, the results of the influence of glass fertilizers on plant cultures in real conditions are presented.",
publisher = "Banja Luka : University in Banja Luka, Faculty of Technology",
journal = "XIV Conference of chemists, technologists and environmentalists of Republic of Srpska",
title = "Phophate glassy fertilizers",
pages = "66-62"
}

Topalović, V., Nikolić, J., Matijašević, S., Savić, V., Đošić, M., Vujošević, A.,& Grujić, S.. (2022). Phophate glassy fertilizers. in XIV Conference of chemists, technologists and environmentalists of Republic of Srpska
Banja Luka : University in Banja Luka, Faculty of Technology., 62-66.

Topalović V, Nikolić J, Matijašević S, Savić V, Đošić M, Vujošević A, Grujić S. Phophate glassy fertilizers. in XIV Conference of chemists, technologists and environmentalists of Republic of Srpska. 2022;:62-66..

Topalović, Vladimir, Nikolić, Jelena, Matijašević, Srđan, Savić, Veljko, Đošić, Marija, Vujošević, Ana, Grujić, Snežana, "Phophate glassy fertilizers" in XIV Conference of chemists, technologists and environmentalists of Republic of Srpska (2022):62-66.

TY  - CONF
AU  - Topalović, Vladimir
AU  - Nikolić, Jelena
AU  - Savić, Veljko
AU  - Matijašević, Srđan
AU  - Đošić, Marija
AU  - Zildžović, Snežana
AU  - Grujić, Snežana
PY  - 2022
UR  - https://ritnms.itnms.ac.rs/handle/123456789/800
AB  - Global trends are moving towards a circular economy to replace the deeply grounded one linear economics and waste management. Circular economy implies and the protection of human rights through sustainable development, global security natural resources, combating climate change, energy security, insurance sufficient amounts of food, reducing inequalities, preservation of health and a cleaner environment and the rights of future generations to resources, etc. The policy of procurement of raw materials in the circular economy is focused on the use of secondary raw materials. A big challenge for modern production is to use different types of waste to obtain new products without the use of raw materials. This kind of production requires new knowledge, adaptation of existing technologies or new technologies, new jobs, etc. Large amounts of vegetative residues are produced annually by agriculture. Agricultural waste is very often incinerated or disposed of on land and is still not used.  Most of the agricultural waste ashes consist of silicon dioxide along with other oxides which may vary according to region and atmosphere of the local conditions.  This paper gives an overview of the possibilities of using agricultural waste for obtaining glass and glass ceramics.   Previous research has shown that various types of glass and glass-ceramics can be successfully obtained from agricultural waste, which can be used in construction, medicine, various composites, etc.
PB  - Banja Luka : University in Banja Luka, Faculty of Technology
C3  - XIV Conference of chemists, technologists and environmentalists of Republic of srpska
T1  - Use of agricultural waste as raw materials for obtaining glass and glass-ceramics: A review
EP  - 241
SP  - 237
ER  - 

@conference{
author = "Topalović, Vladimir and Nikolić, Jelena and Savić, Veljko and Matijašević, Srđan and Đošić, Marija and Zildžović, Snežana and Grujić, Snežana",
year = "2022",
abstract = "Global trends are moving towards a circular economy to replace the deeply grounded one linear economics and waste management. Circular economy implies and the protection of human rights through sustainable development, global security natural resources, combating climate change, energy security, insurance sufficient amounts of food, reducing inequalities, preservation of health and a cleaner environment and the rights of future generations to resources, etc. The policy of procurement of raw materials in the circular economy is focused on the use of secondary raw materials. A big challenge for modern production is to use different types of waste to obtain new products without the use of raw materials. This kind of production requires new knowledge, adaptation of existing technologies or new technologies, new jobs, etc. Large amounts of vegetative residues are produced annually by agriculture. Agricultural waste is very often incinerated or disposed of on land and is still not used.  Most of the agricultural waste ashes consist of silicon dioxide along with other oxides which may vary according to region and atmosphere of the local conditions.  This paper gives an overview of the possibilities of using agricultural waste for obtaining glass and glass ceramics.   Previous research has shown that various types of glass and glass-ceramics can be successfully obtained from agricultural waste, which can be used in construction, medicine, various composites, etc.",
publisher = "Banja Luka : University in Banja Luka, Faculty of Technology",
journal = "XIV Conference of chemists, technologists and environmentalists of Republic of srpska",
title = "Use of agricultural waste as raw materials for obtaining glass and glass-ceramics: A review",
pages = "241-237"
}

Topalović, V., Nikolić, J., Savić, V., Matijašević, S., Đošić, M., Zildžović, S.,& Grujić, S.. (2022). Use of agricultural waste as raw materials for obtaining glass and glass-ceramics: A review. in XIV Conference of chemists, technologists and environmentalists of Republic of srpska
Banja Luka : University in Banja Luka, Faculty of Technology., 237-241.

Topalović V, Nikolić J, Savić V, Matijašević S, Đošić M, Zildžović S, Grujić S. Use of agricultural waste as raw materials for obtaining glass and glass-ceramics: A review. in XIV Conference of chemists, technologists and environmentalists of Republic of srpska. 2022;:237-241..

Topalović, Vladimir, Nikolić, Jelena, Savić, Veljko, Matijašević, Srđan, Đošić, Marija, Zildžović, Snežana, Grujić, Snežana, "Use of agricultural waste as raw materials for obtaining glass and glass-ceramics: A review" in XIV Conference of chemists, technologists and environmentalists of Republic of srpska (2022):237-241.

TY  - CONF
AU  - Topalović, Vladimir
AU  - Matijašević, Srđan
AU  - Nikolić, Jelena
AU  - Savić, Veljko
AU  - Đošić, Marija
AU  - Grujić, Snežana
PY  - 2022
UR  - https://ritnms.itnms.ac.rs/handle/123456789/779
AB  - The purpose of this study is to investigate the influence of La2O3 addition on the crystallization characteristics of polyphosphate glasses. Differential scanning calorimetry (DSC), and X-ray diffraction (XRD) methods were used to investigate the crystallization behavior of glasses. The addition of La2O3 (1-5%), at the expense of phosphate mole fraction in polyphosphate glass, raises the characteristic temperature of glasses, and resistance to crystallization. The glasses show complex crystallization leading to the formation of several crystalline phases
PB  - Bor : Mining and Metallurgy Institute Bor
C3  - 53rd International October Conference on Mining and Metallurgy IOC 2022
T1  - The efect of La2O3 addition on the crystallization characteristics of polyphosphate glasses
EP  - 142
SP  - 139
ER  - 

@conference{
author = "Topalović, Vladimir and Matijašević, Srđan and Nikolić, Jelena and Savić, Veljko and Đošić, Marija and Grujić, Snežana",
year = "2022",
abstract = "The purpose of this study is to investigate the influence of La2O3 addition on the crystallization characteristics of polyphosphate glasses. Differential scanning calorimetry (DSC), and X-ray diffraction (XRD) methods were used to investigate the crystallization behavior of glasses. The addition of La2O3 (1-5%), at the expense of phosphate mole fraction in polyphosphate glass, raises the characteristic temperature of glasses, and resistance to crystallization. The glasses show complex crystallization leading to the formation of several crystalline phases",
publisher = "Bor : Mining and Metallurgy Institute Bor",
journal = "53rd International October Conference on Mining and Metallurgy IOC 2022",
title = "The efect of La2O3 addition on the crystallization characteristics of polyphosphate glasses",
pages = "142-139"
}

Topalović, V., Matijašević, S., Nikolić, J., Savić, V., Đošić, M.,& Grujić, S.. (2022). The efect of La2O3 addition on the crystallization characteristics of polyphosphate glasses. in 53rd International October Conference on Mining and Metallurgy IOC 2022
Bor : Mining and Metallurgy Institute Bor., 139-142.

Topalović V, Matijašević S, Nikolić J, Savić V, Đošić M, Grujić S. The efect of La2O3 addition on the crystallization characteristics of polyphosphate glasses. in 53rd International October Conference on Mining and Metallurgy IOC 2022. 2022;:139-142..

Topalović, Vladimir, Matijašević, Srđan, Nikolić, Jelena, Savić, Veljko, Đošić, Marija, Grujić, Snežana, "The efect of La2O3 addition on the crystallization characteristics of polyphosphate glasses" in 53rd International October Conference on Mining and Metallurgy IOC 2022 (2022):139-142.

TY  - CONF
AU  - Đošić, Marija
AU  - Janković, Ana
AU  - Vukašinović-Sekulić, Maja
AU  - Mišković-Stanković, Vesna
PY  - 2022
UR  - https://ritnms.itnms.ac.rs/handle/123456789/753
AB  - Multifunkcionalni i višekomponentni biomaterijali se cesto primenjuju u rekonstruktivnoj
hirurgiji zbog sposobnosti da pospešuju osteointegraciju, istovremeno omogucavajuci
primenu antibakterijskih agenasa direktno na mestu intervencije. Primenom
elektroforetskog taloženja, iz cetvorokomponentne vodene suspenzije (hidroksiapatit,
poli(vinilalkohol), hitozan i gentamicin) dobijene su, u jednom koraku, bioaktivne i
antibakterijske kompozitne prevlake na titanu. Karakterizacija prevlaka je izvršena
primenom rendgenske difrakcione analize (XRD), infracrvene spektroskopije sa
Furijeovom transformacijom (FTIR) i skenirajuce elektronske mikroskopije (SEM).
Pracenjem kinetike antibakterijske aktivnosti u suspenziji potvr ena je antibakterijska
efikasnost prevlake sa gentamicinom. Prema dobijenim rezultatima moguce je zakljuciti da
dobijene kompozitne prevlake sa gentamicinom predstavljaju uspešan biomaterijal za
potencijalnu primenu u biomedicini.
AB  - Multifunctional and multicomponent biomaterials are very often the material of choice in
reconstructive surgery, having the ability to promote osteointegration, allowing the
antibacterial agents application directly at the site of intervention. Single-step
electrophoretic deposition was employed to assemble bioactive and antibacterial composite
coatings on titanium, from a four-component aqueous suspension (hydroxyapatite,
poly(vinyl alcohol), chitosan and gentamicin). Physico-chemical characterization of the
coatings was performed using X-ray diffraction (XRD), Fourier transform infrared
spectroscopy (FTIR) and scanning electron microscopy (SEM). Antibacterial activity of
gentamicin loaded coating was confirmed by antibacterial activity kinetics in suspension.
According to the obtained results, it can be concluded that composite coating loaded with
gentamicin represents a successful biomaterial for possible application in biomedicine.
PB  - Belgrade : Serbian Chemical Society
C3  - 58. Savetovanje Srpskog hemijskog društva
T1  - Kompozitne bioaktivne prevlake sa gentamicinom elektroforetski taložene na titanu / Composite bioactive coatings loaded with gentamicin electrophoretically deposited on titanium
EP  - 71
SP  - 71
ER  - 

@conference{
author = "Đošić, Marija and Janković, Ana and Vukašinović-Sekulić, Maja and Mišković-Stanković, Vesna",
year = "2022",
abstract = "Multifunkcionalni i višekomponentni biomaterijali se cesto primenjuju u rekonstruktivnoj
hirurgiji zbog sposobnosti da pospešuju osteointegraciju, istovremeno omogucavajuci
primenu antibakterijskih agenasa direktno na mestu intervencije. Primenom
elektroforetskog taloženja, iz cetvorokomponentne vodene suspenzije (hidroksiapatit,
poli(vinilalkohol), hitozan i gentamicin) dobijene su, u jednom koraku, bioaktivne i
antibakterijske kompozitne prevlake na titanu. Karakterizacija prevlaka je izvršena
primenom rendgenske difrakcione analize (XRD), infracrvene spektroskopije sa
Furijeovom transformacijom (FTIR) i skenirajuce elektronske mikroskopije (SEM).
Pracenjem kinetike antibakterijske aktivnosti u suspenziji potvr ena je antibakterijska
efikasnost prevlake sa gentamicinom. Prema dobijenim rezultatima moguce je zakljuciti da
dobijene kompozitne prevlake sa gentamicinom predstavljaju uspešan biomaterijal za
potencijalnu primenu u biomedicini., Multifunctional and multicomponent biomaterials are very often the material of choice in
reconstructive surgery, having the ability to promote osteointegration, allowing the
antibacterial agents application directly at the site of intervention. Single-step
electrophoretic deposition was employed to assemble bioactive and antibacterial composite
coatings on titanium, from a four-component aqueous suspension (hydroxyapatite,
poly(vinyl alcohol), chitosan and gentamicin). Physico-chemical characterization of the
coatings was performed using X-ray diffraction (XRD), Fourier transform infrared
spectroscopy (FTIR) and scanning electron microscopy (SEM). Antibacterial activity of
gentamicin loaded coating was confirmed by antibacterial activity kinetics in suspension.
According to the obtained results, it can be concluded that composite coating loaded with
gentamicin represents a successful biomaterial for possible application in biomedicine.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "58. Savetovanje Srpskog hemijskog društva",
title = "Kompozitne bioaktivne prevlake sa gentamicinom elektroforetski taložene na titanu / Composite bioactive coatings loaded with gentamicin electrophoretically deposited on titanium",
pages = "71-71"
}

Đošić, M., Janković, A., Vukašinović-Sekulić, M.,& Mišković-Stanković, V.. (2022). Kompozitne bioaktivne prevlake sa gentamicinom elektroforetski taložene na titanu / Composite bioactive coatings loaded with gentamicin electrophoretically deposited on titanium. in 58. Savetovanje Srpskog hemijskog društva
Belgrade : Serbian Chemical Society., 71-71.

Đošić M, Janković A, Vukašinović-Sekulić M, Mišković-Stanković V. Kompozitne bioaktivne prevlake sa gentamicinom elektroforetski taložene na titanu / Composite bioactive coatings loaded with gentamicin electrophoretically deposited on titanium. in 58. Savetovanje Srpskog hemijskog društva. 2022;:71-71..

Đošić, Marija, Janković, Ana, Vukašinović-Sekulić, Maja, Mišković-Stanković, Vesna, "Kompozitne bioaktivne prevlake sa gentamicinom elektroforetski taložene na titanu / Composite bioactive coatings loaded with gentamicin electrophoretically deposited on titanium" in 58. Savetovanje Srpskog hemijskog društva (2022):71-71.

TY  - CONF
AU  - Nikolić, Jelena
AU  - Topalović, Vladimir
AU  - Matijašević, Srđan
AU  - Savić, Veljko
AU  - Đošić, Marija
AU  - Zildžović, Snežana
AU  - Grujić, Snežana
PY  - 2022
UR  - https://ritnms.itnms.ac.rs/handle/123456789/788
AB  - Fosfatna stakla imaju jedinstveno svojstvo da se mogu potpuno rastvoriti u vodenim rastvorima, a brzina rastvaranja može da se kontroliše. Proces rastvaranja stakla počinje razmenom katjona sa površine stakla sa protonima iz rastvora (H+ ili H3O+) i hidratacijom staklene mreže. Početna brzina rastvaranja je osnovna karakteristika rastvaranja stakla. Analiza početnih brzina rastvaranja fosfatnog stakla, koje je dobijeno topljenjem,  pokazuje da su brzine značajno veće u kiseloj sredini u odnosu na brzine rastvaranja u neutralnoj. Granulacija uzorka ima veći uticaj na početne brzine u neutralnoj sredini. Granulacija uzorka ne utiče na vrednost energije aktivacija početnih brzina rastvaranja u obe sredine. U neutralnoj sredini temperatura manje utiče na hidrolizu, a više na difuziju katjona, dok je u kiseloj sredini suprotno.
PB  - Belgrade : Serbian Chemical Society
C3  - 58. Savetovanje Srpskog hemijskog društva/ 58th Meeting of the Serbian Chemical Society
T1  - Ispitivanje uticaja pH i granulacije na početnu brzinu rastvaranja fosfatnog stakla/ Investigation of the influence of pH and granulation on the initial dissolution rate of phosphate glass
EP  - 119
SP  - 119
ER  - 

@conference{
author = "Nikolić, Jelena and Topalović, Vladimir and Matijašević, Srđan and Savić, Veljko and Đošić, Marija and Zildžović, Snežana and Grujić, Snežana",
year = "2022",
abstract = "Fosfatna stakla imaju jedinstveno svojstvo da se mogu potpuno rastvoriti u vodenim rastvorima, a brzina rastvaranja može da se kontroliše. Proces rastvaranja stakla počinje razmenom katjona sa površine stakla sa protonima iz rastvora (H+ ili H3O+) i hidratacijom staklene mreže. Početna brzina rastvaranja je osnovna karakteristika rastvaranja stakla. Analiza početnih brzina rastvaranja fosfatnog stakla, koje je dobijeno topljenjem,  pokazuje da su brzine značajno veće u kiseloj sredini u odnosu na brzine rastvaranja u neutralnoj. Granulacija uzorka ima veći uticaj na početne brzine u neutralnoj sredini. Granulacija uzorka ne utiče na vrednost energije aktivacija početnih brzina rastvaranja u obe sredine. U neutralnoj sredini temperatura manje utiče na hidrolizu, a više na difuziju katjona, dok je u kiseloj sredini suprotno.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "58. Savetovanje Srpskog hemijskog društva/ 58th Meeting of the Serbian Chemical Society",
title = "Ispitivanje uticaja pH i granulacije na početnu brzinu rastvaranja fosfatnog stakla/ Investigation of the influence of pH and granulation on the initial dissolution rate of phosphate glass",
pages = "119-119"
}

Nikolić, J., Topalović, V., Matijašević, S., Savić, V., Đošić, M., Zildžović, S.,& Grujić, S.. (2022). Ispitivanje uticaja pH i granulacije na početnu brzinu rastvaranja fosfatnog stakla/ Investigation of the influence of pH and granulation on the initial dissolution rate of phosphate glass. in 58. Savetovanje Srpskog hemijskog društva/ 58th Meeting of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 119-119.

Nikolić J, Topalović V, Matijašević S, Savić V, Đošić M, Zildžović S, Grujić S. Ispitivanje uticaja pH i granulacije na početnu brzinu rastvaranja fosfatnog stakla/ Investigation of the influence of pH and granulation on the initial dissolution rate of phosphate glass. in 58. Savetovanje Srpskog hemijskog društva/ 58th Meeting of the Serbian Chemical Society. 2022;:119-119..

Nikolić, Jelena, Topalović, Vladimir, Matijašević, Srđan, Savić, Veljko, Đošić, Marija, Zildžović, Snežana, Grujić, Snežana, "Ispitivanje uticaja pH i granulacije na početnu brzinu rastvaranja fosfatnog stakla/ Investigation of the influence of pH and granulation on the initial dissolution rate of phosphate glass" in 58. Savetovanje Srpskog hemijskog društva/ 58th Meeting of the Serbian Chemical Society (2022):119-119.

TY  - CONF
AU  - Janković, Ana
AU  - Đošić, Marija
AU  - Mišković-Stanković, Vesna
PY  - 2022
UR  - https://ritnms.itnms.ac.rs/handle/123456789/751
AB  - Titanium surface was modified by applying new composite, biocompatible, and bioactive hydroxyapatite/chitosan coatings with and without gentamicin using the electrophoretic deposition technique (HAP/CS, HAP/CS/Gent, HAP/CS/Gr, and HAP/CS/Gr/Gent). HAP/CS/Gent and HAP/CS/Gr/Gent coatings presented strong activity against both bacterial strains tested and even noticeably more against S. aureus, while their counterparts without the antibiotic did not exhibit antibacterial properties. The rapid and strong antibacterial effect monitored during the first 24 h coincides well with the initial burst effect of gentamicin observed on the cumulative release profiles. Presented results are a solid confirmation that bioceramic HAP/CS/Gent and HAP/CS/Gr/Gent composite coatings electrodeposited on Ti are promising biomaterials for further investigation and potential biomedical application as orthopedic and dental implants
PB  - Roma : Consiglio Nazionale delle Ricerche Istituto di Struttura della Materia
C3  - 3rd  BIENNIAL  CONFERENCE BIOMATERIALS AND NOVEL TECHNOLOGIES FOR HEALTHCARE - BIOMAH 2022
T1  - Bioactive antibiotic-eluting hydroxyapatite-based coatings obtained by electrophoretic deposition on titanium
EP  - 218
SP  - 216
ER  - 

@conference{
author = "Janković, Ana and Đošić, Marija and Mišković-Stanković, Vesna",
year = "2022",
abstract = "Titanium surface was modified by applying new composite, biocompatible, and bioactive hydroxyapatite/chitosan coatings with and without gentamicin using the electrophoretic deposition technique (HAP/CS, HAP/CS/Gent, HAP/CS/Gr, and HAP/CS/Gr/Gent). HAP/CS/Gent and HAP/CS/Gr/Gent coatings presented strong activity against both bacterial strains tested and even noticeably more against S. aureus, while their counterparts without the antibiotic did not exhibit antibacterial properties. The rapid and strong antibacterial effect monitored during the first 24 h coincides well with the initial burst effect of gentamicin observed on the cumulative release profiles. Presented results are a solid confirmation that bioceramic HAP/CS/Gent and HAP/CS/Gr/Gent composite coatings electrodeposited on Ti are promising biomaterials for further investigation and potential biomedical application as orthopedic and dental implants",
publisher = "Roma : Consiglio Nazionale delle Ricerche Istituto di Struttura della Materia",
journal = "3rd  BIENNIAL  CONFERENCE BIOMATERIALS AND NOVEL TECHNOLOGIES FOR HEALTHCARE - BIOMAH 2022",
title = "Bioactive antibiotic-eluting hydroxyapatite-based coatings obtained by electrophoretic deposition on titanium",
pages = "218-216"
}

Janković, A., Đošić, M.,& Mišković-Stanković, V.. (2022). Bioactive antibiotic-eluting hydroxyapatite-based coatings obtained by electrophoretic deposition on titanium. in 3rd  BIENNIAL  CONFERENCE BIOMATERIALS AND NOVEL TECHNOLOGIES FOR HEALTHCARE - BIOMAH 2022
Roma : Consiglio Nazionale delle Ricerche Istituto di Struttura della Materia., 216-218.

Janković A, Đošić M, Mišković-Stanković V. Bioactive antibiotic-eluting hydroxyapatite-based coatings obtained by electrophoretic deposition on titanium. in 3rd  BIENNIAL  CONFERENCE BIOMATERIALS AND NOVEL TECHNOLOGIES FOR HEALTHCARE - BIOMAH 2022. 2022;:216-218..

Janković, Ana, Đošić, Marija, Mišković-Stanković, Vesna, "Bioactive antibiotic-eluting hydroxyapatite-based coatings obtained by electrophoretic deposition on titanium" in 3rd  BIENNIAL  CONFERENCE BIOMATERIALS AND NOVEL TECHNOLOGIES FOR HEALTHCARE - BIOMAH 2022 (2022):216-218.

TY  - CONF
AU  - Stevanović, Milena
AU  - Janković, Ana
AU  - Đošić, Marija
AU  - Vukašinović-Sekulić, Maja
AU  - Kojić, Vesna
AU  - Mišković-Stanković, Vesna
PY  - 2022
UR  - https://ritnms.itnms.ac.rs/handle/123456789/752
AB  - Titanium (Ti) is an implant material widely used in orthopedics due to its high corrosion
resistance (naturally forms a passive oxide layer) and good mechanical properties. Although
Ti has certain ability to osseointegrate, the biocompatibility and bioactivity of Ti can be
significantly improved by modifying its surface. In order to improve antibacterial properties
a broad spectrum antibiotic gentamicin was loaded in a composite coating of hydroxyapatite
(HAP) with natural polymers chitosan (CS) and poly(vinyl alcohol (PVA) and was deposited
on Ti using electrophoretic deposition (EPD) technique. EPD was carried out at the constant
voltage on pure titanium plates from an aqueous suspension. Deposited HAP/CS/PVA and
HAP/CS/PVA/Gent coating were characterized by X-ray diffraction (XRD), Fourier
transform infrared spectroscopy (FT-IR), and field emission scanning electron microscopy
(FE-SEM). The obtained results confirmed the formation of new composite coatings.
Cytotoxicity against two types of cell lines (MRC-5 and L929) was investigated using trypan
blue dye-exclusion test (DET) and MTT assay for assessing cell metabolic activity. The
antibiotic loaded coating (HAP/CS/PVA/Gent) exhibited good antibacterial activity against
Staphylococcus aureus and Escherichia coli, while preserving low cytotoxicity, indicating
the high potential for biomedical applications. Excellent osteogenic properties, through the
promotion of osteoblast differentiation were confirmed by ALP assay. Results were much
more pronounced for HAP/CS/PVA/Gent coating. Therefore, HAP/CS/PVA/Gent coating
can be considered as an excellent promising candidate for biomedical hard tissue implants.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Twentieth Young Researchers Conference – Materials Science and Engineering
T1  - Bioactive hydroxyapatite/chitosan/poly(vinyl alcohol)/gentamicin composite coating electrodeposited on titanium
EP  - 15
SP  - 15
ER  - 

@conference{
author = "Stevanović, Milena and Janković, Ana and Đošić, Marija and Vukašinović-Sekulić, Maja and Kojić, Vesna and Mišković-Stanković, Vesna",
year = "2022",
abstract = "Titanium (Ti) is an implant material widely used in orthopedics due to its high corrosion
resistance (naturally forms a passive oxide layer) and good mechanical properties. Although
Ti has certain ability to osseointegrate, the biocompatibility and bioactivity of Ti can be
significantly improved by modifying its surface. In order to improve antibacterial properties
a broad spectrum antibiotic gentamicin was loaded in a composite coating of hydroxyapatite
(HAP) with natural polymers chitosan (CS) and poly(vinyl alcohol (PVA) and was deposited
on Ti using electrophoretic deposition (EPD) technique. EPD was carried out at the constant
voltage on pure titanium plates from an aqueous suspension. Deposited HAP/CS/PVA and
HAP/CS/PVA/Gent coating were characterized by X-ray diffraction (XRD), Fourier
transform infrared spectroscopy (FT-IR), and field emission scanning electron microscopy
(FE-SEM). The obtained results confirmed the formation of new composite coatings.
Cytotoxicity against two types of cell lines (MRC-5 and L929) was investigated using trypan
blue dye-exclusion test (DET) and MTT assay for assessing cell metabolic activity. The
antibiotic loaded coating (HAP/CS/PVA/Gent) exhibited good antibacterial activity against
Staphylococcus aureus and Escherichia coli, while preserving low cytotoxicity, indicating
the high potential for biomedical applications. Excellent osteogenic properties, through the
promotion of osteoblast differentiation were confirmed by ALP assay. Results were much
more pronounced for HAP/CS/PVA/Gent coating. Therefore, HAP/CS/PVA/Gent coating
can be considered as an excellent promising candidate for biomedical hard tissue implants.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Twentieth Young Researchers Conference – Materials Science and Engineering",
title = "Bioactive hydroxyapatite/chitosan/poly(vinyl alcohol)/gentamicin composite coating electrodeposited on titanium",
pages = "15-15"
}

Stevanović, M., Janković, A., Đošić, M., Vukašinović-Sekulić, M., Kojić, V.,& Mišković-Stanković, V.. (2022). Bioactive hydroxyapatite/chitosan/poly(vinyl alcohol)/gentamicin composite coating electrodeposited on titanium. in Twentieth Young Researchers Conference – Materials Science and Engineering
Belgrade : Institute of Technical Sciences of SASA., 15-15.

Stevanović M, Janković A, Đošić M, Vukašinović-Sekulić M, Kojić V, Mišković-Stanković V. Bioactive hydroxyapatite/chitosan/poly(vinyl alcohol)/gentamicin composite coating electrodeposited on titanium. in Twentieth Young Researchers Conference – Materials Science and Engineering. 2022;:15-15..

Stevanović, Milena, Janković, Ana, Đošić, Marija, Vukašinović-Sekulić, Maja, Kojić, Vesna, Mišković-Stanković, Vesna, "Bioactive hydroxyapatite/chitosan/poly(vinyl alcohol)/gentamicin composite coating electrodeposited on titanium" in Twentieth Young Researchers Conference – Materials Science and Engineering (2022):15-15.

TY  - CONF
AU  - Topalović, Vladimir
AU  - Savić, Veljko
AU  - Nikolić, Jelena
AU  - Matijašević, Srđan
AU  - Đošić, Marija
AU  - Zildžović, Snežana
AU  - Grujić, Snežana
PY  - 2022
UR  - https://ritnms.itnms.ac.rs/handle/123456789/787
AB  - Staklokeramički nosači koji oponašaju strukturu kostiju dobijeni su korišćenjem poliuretanske (PU) pene i polifosfatnog stakla u prahu. Osnovno staklo je pripremljeno standardnom tehnikom izlivanja rastopa i njegovog hlađenja na sobnoj temperaturi. Kocke pene su potapane u koloidni rastvor stakla, presovane i osušene. Poliuretanska pena obložena staklenim česticama je termički obrađena i staklo je sinterovano 3 h na 620 ⁰C. Mikrostruktura, morfologija i fazni sastav pripremljenih staklokeramičkih nosača ispitivani su metodama skenirajuće elektronske mikroskopije (SEM) i rendgenske difrakcije (XRD). Dobijeni su 3D porozni staklokeramički nosači koji sadrže bioaktivne kristalne faze β-Ca3(PO4)2 i β-Ca2P2O7. Struktura sinterovanih nosača je veoma porozna, a stubovi između pora su dobro sinterovani. Dobijeni fazni sastav i mikrostruktura nosača ukazuju na mogućnost njihove primene kao bioaktivnih materijala za inženjering koštanih tkiva.
PB  - Belgrade : Serbian Chemical Society
C3  - 58. Savetovanje Srpskog hemijskog društva/ 58th Meeting of the Serbian Chemical Society
T1  - Dobijanje poroznih 3D bioaktivnih staklokeramičkih nosača/Fabrication of porous 3D bioactive phosphate glass-ceramic scaffolds
EP  - 108
SP  - 108
ER  - 

@conference{
author = "Topalović, Vladimir and Savić, Veljko and Nikolić, Jelena and Matijašević, Srđan and Đošić, Marija and Zildžović, Snežana and Grujić, Snežana",
year = "2022",
abstract = "Staklokeramički nosači koji oponašaju strukturu kostiju dobijeni su korišćenjem poliuretanske (PU) pene i polifosfatnog stakla u prahu. Osnovno staklo je pripremljeno standardnom tehnikom izlivanja rastopa i njegovog hlađenja na sobnoj temperaturi. Kocke pene su potapane u koloidni rastvor stakla, presovane i osušene. Poliuretanska pena obložena staklenim česticama je termički obrađena i staklo je sinterovano 3 h na 620 ⁰C. Mikrostruktura, morfologija i fazni sastav pripremljenih staklokeramičkih nosača ispitivani su metodama skenirajuće elektronske mikroskopije (SEM) i rendgenske difrakcije (XRD). Dobijeni su 3D porozni staklokeramički nosači koji sadrže bioaktivne kristalne faze β-Ca3(PO4)2 i β-Ca2P2O7. Struktura sinterovanih nosača je veoma porozna, a stubovi između pora su dobro sinterovani. Dobijeni fazni sastav i mikrostruktura nosača ukazuju na mogućnost njihove primene kao bioaktivnih materijala za inženjering koštanih tkiva.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "58. Savetovanje Srpskog hemijskog društva/ 58th Meeting of the Serbian Chemical Society",
title = "Dobijanje poroznih 3D bioaktivnih staklokeramičkih nosača/Fabrication of porous 3D bioactive phosphate glass-ceramic scaffolds",
pages = "108-108"
}

Topalović, V., Savić, V., Nikolić, J., Matijašević, S., Đošić, M., Zildžović, S.,& Grujić, S.. (2022). Dobijanje poroznih 3D bioaktivnih staklokeramičkih nosača/Fabrication of porous 3D bioactive phosphate glass-ceramic scaffolds. in 58. Savetovanje Srpskog hemijskog društva/ 58th Meeting of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 108-108.

Topalović V, Savić V, Nikolić J, Matijašević S, Đošić M, Zildžović S, Grujić S. Dobijanje poroznih 3D bioaktivnih staklokeramičkih nosača/Fabrication of porous 3D bioactive phosphate glass-ceramic scaffolds. in 58. Savetovanje Srpskog hemijskog društva/ 58th Meeting of the Serbian Chemical Society. 2022;:108-108..

Topalović, Vladimir, Savić, Veljko, Nikolić, Jelena, Matijašević, Srđan, Đošić, Marija, Zildžović, Snežana, Grujić, Snežana, "Dobijanje poroznih 3D bioaktivnih staklokeramičkih nosača/Fabrication of porous 3D bioactive phosphate glass-ceramic scaffolds" in 58. Savetovanje Srpskog hemijskog društva/ 58th Meeting of the Serbian Chemical Society (2022):108-108.

TY  - CONF
AU  - Janković, Ana
AU  - Đošić, Marija
AU  - Jaćimović, Nevena
AU  - Kojić, Vesna
AU  - Mišković-Stanković, Vesna
PY  - 2022
UR  - https://ritnms.itnms.ac.rs/handle/123456789/754
AB  - Metoda elektroforetskog taloženja (EPD)se koristi za sintezu biokompatibilnih
kompozitnih materijala za medicinsku primenu kao antibakterijske prevlake za koštane
implantate. Taloženjem pri konstantnom naponu je uspešno dobijena kompozitna prevlaka
hidroksiapatit/hitozan/poli(vinilalkohol) (HAP/CS/PVA) koja sadrži gentamicin (Gent).
Bioaktivnost prevlake je dokazana formiranjem novonastalog apatitnog sloja u simuliranoj
telesnoj tecnosti i karakterisana primenom skenirajuce elektronske mikroskopije (SEM) I
infracrvene spektroskopije sa Furijeovom transformacijom (FTIR). Sposobnost
oseointegracije dalje je potvr ena merenjem aktivnosti alkalne fosfataze (ALP), što
ukazuje na povoljna oseopromotivna svojstva taloženih prevlaka. Kada su testirane
humane i mišje fibroblastne celijske linije (MRC-5 i L929), kompozitne prevlake nisu
pokazale citotoksicni efekat
AB  - The electrophoretic deposition (EPD) method isused for the synthesis of biocompatible
composite materials for medical use as antibacterial coatings for bone implants. Deposition
at the constant voltage yielded composite coating hydroxyapatite/chitosan/poly(vinyl
alcohol)(HAP/CS/PVA) loaded with gentamicin (Gent). Bioactivity of the coating was
proved by a newly formed apatite layer in simulated body fluid and characterized
usingscanning electron microscopy (SEM) and Fourier transform infrared spectroscopy
(FTIR). The osseointegration ability was validated by measuring the alkaline phosphatase
activity (ALP) indicating the favorable osseopromotive properties of deposited coatings.
When tested against human and mice fibroblast cells lines (MRC-5 and L929), composite
coatings did not exhibit cytotoxic effect.
PB  - Belgrade : Serbian Chemical Society
C3  - 58. Savetovanje Srpskog hemijskog društva
T1  - Elektroforetski taložene kompozitne prevlake kao nosaci lekova / Electrophoretically deposited composite coatings as drug carriers
EP  - 72
SP  - 72
ER  - 

@conference{
author = "Janković, Ana and Đošić, Marija and Jaćimović, Nevena and Kojić, Vesna and Mišković-Stanković, Vesna",
year = "2022",
abstract = "Metoda elektroforetskog taloženja (EPD)se koristi za sintezu biokompatibilnih
kompozitnih materijala za medicinsku primenu kao antibakterijske prevlake za koštane
implantate. Taloženjem pri konstantnom naponu je uspešno dobijena kompozitna prevlaka
hidroksiapatit/hitozan/poli(vinilalkohol) (HAP/CS/PVA) koja sadrži gentamicin (Gent).
Bioaktivnost prevlake je dokazana formiranjem novonastalog apatitnog sloja u simuliranoj
telesnoj tecnosti i karakterisana primenom skenirajuce elektronske mikroskopije (SEM) I
infracrvene spektroskopije sa Furijeovom transformacijom (FTIR). Sposobnost
oseointegracije dalje je potvr ena merenjem aktivnosti alkalne fosfataze (ALP), što
ukazuje na povoljna oseopromotivna svojstva taloženih prevlaka. Kada su testirane
humane i mišje fibroblastne celijske linije (MRC-5 i L929), kompozitne prevlake nisu
pokazale citotoksicni efekat, The electrophoretic deposition (EPD) method isused for the synthesis of biocompatible
composite materials for medical use as antibacterial coatings for bone implants. Deposition
at the constant voltage yielded composite coating hydroxyapatite/chitosan/poly(vinyl
alcohol)(HAP/CS/PVA) loaded with gentamicin (Gent). Bioactivity of the coating was
proved by a newly formed apatite layer in simulated body fluid and characterized
usingscanning electron microscopy (SEM) and Fourier transform infrared spectroscopy
(FTIR). The osseointegration ability was validated by measuring the alkaline phosphatase
activity (ALP) indicating the favorable osseopromotive properties of deposited coatings.
When tested against human and mice fibroblast cells lines (MRC-5 and L929), composite
coatings did not exhibit cytotoxic effect.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "58. Savetovanje Srpskog hemijskog društva",
title = "Elektroforetski taložene kompozitne prevlake kao nosaci lekova / Electrophoretically deposited composite coatings as drug carriers",
pages = "72-72"
}

Janković, A., Đošić, M., Jaćimović, N., Kojić, V.,& Mišković-Stanković, V.. (2022). Elektroforetski taložene kompozitne prevlake kao nosaci lekova / Electrophoretically deposited composite coatings as drug carriers. in 58. Savetovanje Srpskog hemijskog društva
Belgrade : Serbian Chemical Society., 72-72.

Janković A, Đošić M, Jaćimović N, Kojić V, Mišković-Stanković V. Elektroforetski taložene kompozitne prevlake kao nosaci lekova / Electrophoretically deposited composite coatings as drug carriers. in 58. Savetovanje Srpskog hemijskog društva. 2022;:72-72..

Janković, Ana, Đošić, Marija, Jaćimović, Nevena, Kojić, Vesna, Mišković-Stanković, Vesna, "Elektroforetski taložene kompozitne prevlake kao nosaci lekova / Electrophoretically deposited composite coatings as drug carriers" in 58. Savetovanje Srpskog hemijskog društva (2022):72-72.

TY  - JOUR
AU  - Prokić, B.B.
AU  - Božinovski, T.L.
AU  - Gajdov, V.
AU  - Milošević, I.
AU  - Todorović, V.
AU  - Đošić, Marija
AU  - Mišković-Stanković, Vesna
AU  - Marković, D.
PY  - 2022
UR  - https://ritnms.itnms.ac.rs/handle/123456789/624
AB  - The ethical dilemmas of using animals as in vivo models in preclinical and clinical examinations have been increasingly present in recent decades. Small laboratory animals (rats, rabbits) will continue to be used because they are cost-effective and permit the formation of statistically testable cohort groups; a task that, for financial, maintenance and care reasons, is almost prohibitive for larger animals. Technological advances in the production of new biomaterials for clinical use are enormous, but screening tests and methods used to assess biocompatibility lag behind these advances. The assessment of biological responses is slow and based on millennial recovery mechanisms in eukaryotic organisms. Therefore, the goal of researchers in this field is to re-evaluate old methods of biocompatibility assessment and introduce new methods of evaluation, especially for in vivo testing. In that sense, a revision of the ISO standards was planned and conducted in 2017, which insisted on cytotoxicity testing in cell lines and produced concrete proposals on how biocompatibility should be quantified. In vivo biocompatibility evaluation of biomaterials used for soft tissue recovery commonly utilises rats. Rabbits are recommended for implants used for hard tissues, because of the rabbit’s size, the possibility of implanting the biomaterials on a larger bone surface, and because of the peculiarities of rabbit bone tissue that favours rapid recovery after bone defects and enables easy reading of the results
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski glasnik
T1  - Animal models in bicompatibility assessments of implants in soft and hard tissues
IS  - 1
VL  - 76
DO  - 10.2298/VETGL210322005P
UR  - conv_1002
ER  - 

@article{
author = "Prokić, B.B. and Božinovski, T.L. and Gajdov, V. and Milošević, I. and Todorović, V. and Đošić, Marija and Mišković-Stanković, Vesna and Marković, D.",
year = "2022",
abstract = "The ethical dilemmas of using animals as in vivo models in preclinical and clinical examinations have been increasingly present in recent decades. Small laboratory animals (rats, rabbits) will continue to be used because they are cost-effective and permit the formation of statistically testable cohort groups; a task that, for financial, maintenance and care reasons, is almost prohibitive for larger animals. Technological advances in the production of new biomaterials for clinical use are enormous, but screening tests and methods used to assess biocompatibility lag behind these advances. The assessment of biological responses is slow and based on millennial recovery mechanisms in eukaryotic organisms. Therefore, the goal of researchers in this field is to re-evaluate old methods of biocompatibility assessment and introduce new methods of evaluation, especially for in vivo testing. In that sense, a revision of the ISO standards was planned and conducted in 2017, which insisted on cytotoxicity testing in cell lines and produced concrete proposals on how biocompatibility should be quantified. In vivo biocompatibility evaluation of biomaterials used for soft tissue recovery commonly utilises rats. Rabbits are recommended for implants used for hard tissues, because of the rabbit’s size, the possibility of implanting the biomaterials on a larger bone surface, and because of the peculiarities of rabbit bone tissue that favours rapid recovery after bone defects and enables easy reading of the results",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski glasnik",
title = "Animal models in bicompatibility assessments of implants in soft and hard tissues",
number = "1",
volume = "76",
doi = "10.2298/VETGL210322005P",
url = "conv_1002"
}

Prokić, B.B., Božinovski, T.L., Gajdov, V., Milošević, I., Todorović, V., Đošić, M., Mišković-Stanković, V.,& Marković, D.. (2022). Animal models in bicompatibility assessments of implants in soft and hard tissues. in Veterinarski glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 76(1).
https://doi.org/10.2298/VETGL210322005P
conv_1002

Prokić B, Božinovski T, Gajdov V, Milošević I, Todorović V, Đošić M, Mišković-Stanković V, Marković D. Animal models in bicompatibility assessments of implants in soft and hard tissues. in Veterinarski glasnik. 2022;76(1).
doi:10.2298/VETGL210322005P
conv_1002 .

Prokić, B.B., Božinovski, T.L., Gajdov, V., Milošević, I., Todorović, V., Đošić, Marija, Mišković-Stanković, Vesna, Marković, D., "Animal models in bicompatibility assessments of implants in soft and hard tissues" in Veterinarski glasnik, 76, no. 1 (2022),
https://doi.org/10.2298/VETGL210322005P .,
conv_1002 .

TY  - CONF
AU  - Stevanović, Milena
AU  - Đošić, Marija
AU  - Janković, Ana
AU  - Nesović, Katarina
AU  - Mišković-Stanković, Vesna
PY  - 2022
UR  - https://ritnms.itnms.ac.rs/handle/123456789/644
PB  - Mary Ann Liebert, Inc, New Rochelle
C3  - Tissue Engineering Part A
T1  - Graphene-loaded bioactive hydroxyapatite coatings on titanium substrate - fundamental in vitro investigations
EP  - S132
SP  - S132
VL  - 28
UR  - conv_946
ER  - 

@conference{
author = "Stevanović, Milena and Đošić, Marija and Janković, Ana and Nesović, Katarina and Mišković-Stanković, Vesna",
year = "2022",
publisher = "Mary Ann Liebert, Inc, New Rochelle",
journal = "Tissue Engineering Part A",
title = "Graphene-loaded bioactive hydroxyapatite coatings on titanium substrate - fundamental in vitro investigations",
pages = "S132-S132",
volume = "28",
url = "conv_946"
}

Stevanović, M., Đošić, M., Janković, A., Nesović, K.,& Mišković-Stanković, V.. (2022). Graphene-loaded bioactive hydroxyapatite coatings on titanium substrate - fundamental in vitro investigations. in Tissue Engineering Part A
Mary Ann Liebert, Inc, New Rochelle., 28, S132-S132.
conv_946

Stevanović M, Đošić M, Janković A, Nesović K, Mišković-Stanković V. Graphene-loaded bioactive hydroxyapatite coatings on titanium substrate - fundamental in vitro investigations. in Tissue Engineering Part A. 2022;28:S132-S132.
conv_946 .

Stevanović, Milena, Đošić, Marija, Janković, Ana, Nesović, Katarina, Mišković-Stanković, Vesna, "Graphene-loaded bioactive hydroxyapatite coatings on titanium substrate - fundamental in vitro investigations" in Tissue Engineering Part A, 28 (2022):S132-S132,
conv_946 .