TY  - CONF
AU  - Đošić, Marija
AU  - Nikolić, Jelena
AU  - Stojanović, Jovica
AU  - Vuković, Nikola
AU  - Marković, Marija
AU  - Savić, Veljko
AU  - Topalović, Vladimir
PY  - 2024
UR  - https://ritnms.itnms.ac.rs/handle/123456789/1241
AB  - INTRODUCTION: Owing to its similarity to the inorganic part of the natural bone, excellent bioactivity, biocompatibility,
and ability to stimulate the osteoconductive process, synthetic hydroxyapatite (HAP) is very often the material of
choice for biomedical applications. Diverse ions can be found as substitutes within natural bone structures, each playing
a distinct and crucial role in the physiological processes governing the lifecycle of bones [1]. Among them, strontium ion
has a very important role for the acceleration of osteogenesis and the inhibition of osteoclasts activity [2]. Current
research aims to provide physico-chemical characterization of synthesized HAP and strontium substituted HAP (Sr-HAP)
powders obtained by varying strontium concentration (10, 20 and 40 mol.%) in the starting solutions.
EXPERIMENTAL: HAP powder was synthesized by wet chemical precipitation, using aqueous solutions of Ca(NO3)2
4H2O (Merck, p.a.) and (NH4)2HPO4 (Sigma-Aldrich, ≥99 %). By adding NH4OH (CENTROHEM, p.a.), pH value was adjusted
to 10. The obtained precipitate was heated up to 90 °C. The same procedure was followed for Sr-HAP powder syntheses,
by adding Sr(NO3)2 (Sigma-Aldrich ≥99.0 %) and maintaining the (Ca + Sr)/P ratio at 1.67 in the mixed Ca2+/Sr2+ solution.
Synthesized powders were characterised by FTIR spectroscopy (Nicolet IS-10, Thermo Fisher Scientific), XRD analysis
(Philips PW 1710, Philips, The Netherlands), TG analysis (Netzsch STA 449 F5 Jupiter instrument), and FE-SEM analysis
(JSM-7001F, JEOL Ltd, Japan).
RESULTS AND DISCUSSION: FTIR spectra revealed the presence of carbonate-substituted hydroxyapatite in both pure
and Sr-substituted HAP powders. The powders showed a granular, homogeneous morphology without the Sr separation.
XRD analysis revealed that the amount of incorporated Sr in the HAP structure increased with increased Sr concentration
in the starting solutions. Thermal stability of the Sr-HAP powders decreased with increased Sr concentration.
CONCLUSIONS: Physico-chemical characteristics of Sr-HAP powders are directly dependent on Sr ion concentration
in powders.
PB  - Beograd : Savez hemijskih inženjera Srbije
C3  - ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices
T1  - Characterisation of strontium-substituted hydroxyapatite as potential biomedical material
EP  - 40
IS  - 1s
SP  - 40
VL  - 78
ER  - 

@conference{
author = "Đošić, Marija and Nikolić, Jelena and Stojanović, Jovica and Vuković, Nikola and Marković, Marija and Savić, Veljko and Topalović, Vladimir",
year = "2024",
abstract = "INTRODUCTION: Owing to its similarity to the inorganic part of the natural bone, excellent bioactivity, biocompatibility,
and ability to stimulate the osteoconductive process, synthetic hydroxyapatite (HAP) is very often the material of
choice for biomedical applications. Diverse ions can be found as substitutes within natural bone structures, each playing
a distinct and crucial role in the physiological processes governing the lifecycle of bones [1]. Among them, strontium ion
has a very important role for the acceleration of osteogenesis and the inhibition of osteoclasts activity [2]. Current
research aims to provide physico-chemical characterization of synthesized HAP and strontium substituted HAP (Sr-HAP)
powders obtained by varying strontium concentration (10, 20 and 40 mol.%) in the starting solutions.
EXPERIMENTAL: HAP powder was synthesized by wet chemical precipitation, using aqueous solutions of Ca(NO3)2
4H2O (Merck, p.a.) and (NH4)2HPO4 (Sigma-Aldrich, ≥99 %). By adding NH4OH (CENTROHEM, p.a.), pH value was adjusted
to 10. The obtained precipitate was heated up to 90 °C. The same procedure was followed for Sr-HAP powder syntheses,
by adding Sr(NO3)2 (Sigma-Aldrich ≥99.0 %) and maintaining the (Ca + Sr)/P ratio at 1.67 in the mixed Ca2+/Sr2+ solution.
Synthesized powders were characterised by FTIR spectroscopy (Nicolet IS-10, Thermo Fisher Scientific), XRD analysis
(Philips PW 1710, Philips, The Netherlands), TG analysis (Netzsch STA 449 F5 Jupiter instrument), and FE-SEM analysis
(JSM-7001F, JEOL Ltd, Japan).
RESULTS AND DISCUSSION: FTIR spectra revealed the presence of carbonate-substituted hydroxyapatite in both pure
and Sr-substituted HAP powders. The powders showed a granular, homogeneous morphology without the Sr separation.
XRD analysis revealed that the amount of incorporated Sr in the HAP structure increased with increased Sr concentration
in the starting solutions. Thermal stability of the Sr-HAP powders decreased with increased Sr concentration.
CONCLUSIONS: Physico-chemical characteristics of Sr-HAP powders are directly dependent on Sr ion concentration
in powders.",
publisher = "Beograd : Savez hemijskih inženjera Srbije",
journal = "ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices",
title = "Characterisation of strontium-substituted hydroxyapatite as potential biomedical material",
pages = "40-40",
number = "1s",
volume = "78"
}

Đošić, M., Nikolić, J., Stojanović, J., Vuković, N., Marković, M., Savić, V.,& Topalović, V.. (2024). Characterisation of strontium-substituted hydroxyapatite as potential biomedical material. in ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices
Beograd : Savez hemijskih inženjera Srbije., 78(1s), 40-40.

Đošić M, Nikolić J, Stojanović J, Vuković N, Marković M, Savić V, Topalović V. Characterisation of strontium-substituted hydroxyapatite as potential biomedical material. in ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices. 2024;78(1s):40-40..

Đošić, Marija, Nikolić, Jelena, Stojanović, Jovica, Vuković, Nikola, Marković, Marija, Savić, Veljko, Topalović, Vladimir, "Characterisation of strontium-substituted hydroxyapatite as potential biomedical material" in ExcellMater Conference 2024 - Innovative Biomaterials for Novel Medical Devices, 78, no. 1s (2024):40-40.