@conference{
author = "Jaćimović, Nevena and Đošić, Marija and Janković, Ana and Mišković-Stanković, Vesna",
year = "2021",
abstract = "Composite bioceramic coatings have been attracting increasing attention of the scientific
public in recent decades due to the good potential of their use for medical purposes. The
main goal of this scientific research is to show the characterization of the obtained
hydroxyapatite (HAP), chitosan (CS) and polyvinyl alcohol (PVA) bioceramic composite
coatings loaded with gentamicin (Gent), on titanium (Ti) substrate using the single-step
electrophoretic deposition process. Titanium, traditionally used for the purpose of replacing
parts of damaged bone tissue, has shown good mechanical properties and biocompatibility
through many years of orthopedic practice. Hydroxyapatite provided the HAP/CS/PVA/Gent
composite coating with osteoinductivity, while the presence of chitosan and polyvinyl
alcohol contributed to its adhesive and mild analgesic properties. The antibacterial agent
gentamicin was added to the HAP/CS/PVA composite, which ensured its direct antibacterial
effect at the implantation site. The coatings were deposited using the cathodic electrophoretic
deposition process, with the Ti plate as the cathode, at a constant voltage of 7V, in the range
of the deposition time from 5 to 12 min. To demonstrate the presumed bioactivity,
HAP/CS/PVA/Gent coatings were immersed in simulated body fluid (SBF) at 37⁰C for
periods of 7 and 14 days. Characterization of HAP/CS/PVA/Gent coatings after immersion
was performed through employment of Fourier transform infrared spectroscopy (FTIR), Xray
diffraction (XRD), and field emission scanning electron microscopy (SEM) techniques.
Antibacterial activity was tested by agar diffusion method on two bacterial strains,
Echerichia coli and Staphylococcus aureus with a positive response to both bacterial strains.
The final conclusions of this research suggest a good potential for utilization of
HAP/CS/PVA/Gent bioceramic composite coating, applied through electrophoretic
deposition process on Ti substrate, for medical purposes in the replacement and healing of
damaged bone tissue."
"Composite bioceramic coatings have been attracting increasing attention of the scientific
public in recent decades due to the good potential of their use for medical purposes. The
main goal of this scientific research is to show the characterization of the obtained
hydroxyapatite (HAP), chitosan (CS) and polyvinyl alcohol (PVA) bioceramic composite
coatings loaded with gentamicin (Gent), on titanium (Ti) substrate using the single-step
electrophoretic deposition process. Titanium, traditionally used for the purpose of replacing
parts of damaged bone tissue, has shown good mechanical properties and biocompatibility
through many years of orthopedic practice. Hydroxyapatite provided the HAP/CS/PVA/Gent
composite coating with osteoinductivity, while the presence of chitosan and polyvinyl
alcohol contributed to its adhesive and mild analgesic properties. The antibacterial agent
gentamicin was added to the HAP/CS/PVA composite, which ensured its direct antibacterial
effect at the implantation site. The coatings were deposited using the cathodic electrophoretic
deposition process, with the Ti plate as the cathode, at a constant voltage of 7V, in the range
of the deposition time from 5 to 12 min. To demonstrate the presumed bioactivity,
HAP/CS/PVA/Gent coatings were immersed in simulated body fluid (SBF) at 37⁰C for
periods of 7 and 14 days. Characterization of HAP/CS/PVA/Gent coatings after immersion
was performed through employment of Fourier transform infrared spectroscopy (FTIR), Xray
diffraction (XRD), and field emission scanning electron microscopy (SEM) techniques.
Antibacterial activity was tested by agar diffusion method on two bacterial strains,
Echerichia coli and Staphylococcus aureus with a positive response to both bacterial strains.
The final conclusions of this research suggest a good potential for utilization of
HAP/CS/PVA/Gent bioceramic composite coating, applied through electrophoretic
deposition process on Ti substrate, for medical purposes in the replacement and healing of
damaged bone tissue.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Nineteenth Young Researchers’ Conference - Materials Science and Engineering",
title = "Electrochemical composite bioceramic coatings based on hydroxyapatite, chitosan and polyvinyl alcohol loaded with gentamicin",
pages = "7-7"
}
