TY  - JOUR
AU  - Calija, Bojan
AU  - Milić, Jela
AU  - Milasinović, Nikola
AU  - Daković, Aleksandra
AU  - Trifković, Kata
AU  - Stojanović, Jovica
AU  - Krajišnik, Danina
PY  - 2020
UR  - https://ritnms.itnms.ac.rs/handle/123456789/550
AB  - This study was designed to investigate functionality of tetracycline-loaded chitosan-halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 +/- 2.65 to 34.48 +/- 2.34%), tensile strength (from 134.8 +/- 13.21 to 246.36 +/- 14.69 MPa), and elastic modulus (from 633.79 +/- 128.37 to 716.55 +/- 60.76 MPa) of the nanocomposite films. FT-IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan-halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite films released tetracycline in a sustained manner, with the slowest release achieved from the films consisting of low molar mass chitosan. Chitosan molar mass was confirmed to be a functionality-related characteristic of chitosan-halloysite nanocomposite films as potential sustained-release carriers for topical delivery of antibiotics.
PB  - Wiley, Hoboken
T2  - Journal of Applied Polymer Science
T1  - Functionality of chitosan-halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass
IS  - 8
VL  - 137
DO  - 10.1002/app.48406
UR  - conv_858
ER  - 

@article{
author = "Calija, Bojan and Milić, Jela and Milasinović, Nikola and Daković, Aleksandra and Trifković, Kata and Stojanović, Jovica and Krajišnik, Danina",
year = "2020",
abstract = "This study was designed to investigate functionality of tetracycline-loaded chitosan-halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 +/- 2.65 to 34.48 +/- 2.34%), tensile strength (from 134.8 +/- 13.21 to 246.36 +/- 14.69 MPa), and elastic modulus (from 633.79 +/- 128.37 to 716.55 +/- 60.76 MPa) of the nanocomposite films. FT-IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan-halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite films released tetracycline in a sustained manner, with the slowest release achieved from the films consisting of low molar mass chitosan. Chitosan molar mass was confirmed to be a functionality-related characteristic of chitosan-halloysite nanocomposite films as potential sustained-release carriers for topical delivery of antibiotics.",
publisher = "Wiley, Hoboken",
journal = "Journal of Applied Polymer Science",
title = "Functionality of chitosan-halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass",
number = "8",
volume = "137",
doi = "10.1002/app.48406",
url = "conv_858"
}

Calija, B., Milić, J., Milasinović, N., Daković, A., Trifković, K., Stojanović, J.,& Krajišnik, D.. (2020). Functionality of chitosan-halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass. in Journal of Applied Polymer Science
Wiley, Hoboken., 137(8).
https://doi.org/10.1002/app.48406
conv_858

Calija B, Milić J, Milasinović N, Daković A, Trifković K, Stojanović J, Krajišnik D. Functionality of chitosan-halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass. in Journal of Applied Polymer Science. 2020;137(8).
doi:10.1002/app.48406
conv_858 .

Calija, Bojan, Milić, Jela, Milasinović, Nikola, Daković, Aleksandra, Trifković, Kata, Stojanović, Jovica, Krajišnik, Danina, "Functionality of chitosan-halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass" in Journal of Applied Polymer Science, 137, no. 8 (2020),
https://doi.org/10.1002/app.48406 .,
conv_858 .

TY  - CONF
AU  - Marković, Marija
AU  - Daković, Aleksandra
AU  - Rottinghaus, George E.
AU  - Krajišnik, Danina
AU  - Milić, Jela
AU  - Mercurio, Mariano
PY  - 2018
UR  - https://ritnms.itnms.ac.rs/handle/123456789/703
AB  - Introduction
Mycotoxins are secondary metabolites produced by various fungi, primarily belonging to Aspergillus, Fusarium, or Penicillium genera. The most common mycotoxins found in animal feed are the aflatoxins, ochratoxins, trichothecenes, fumonisins, zearalenone and ergot alkaloids. Consumption of mycotoxin-contaminated diet may induce acute and long-term chronic effects in animals and humans, resulting in teratogenic, carcinogenic and oestrogenic or immune-suppressive effects (Zhu et al., 2016).
One approach to reduce deleterious effects of mycotoxins is to use adsorbents in animal feed to bind mycotoxins efficiently in the gastrointestinal tract and prevent their adsorption in the digestive tract. The preferred adsorbents are aluminosilicates (natural zeolites and clay minerals). These adsorbents in their natural form are effective in binding aflatoxins but less effective in binding other mycotoxins. Chemical modification of these minerals with cationic surfactants results in an increased hydrophobicity of the surface and improved adsorption for the majority of the mycotoxins. Clinoptilolite, in its natural form, was effective in adsorbing aflatoxin B1 (AFB1), while clinoptilolite modified with cationic surfactants such as octadecyldimethylbenzyl ammonium chloride and benzalkonium chloride was effective in binding ochratoxin A (OCHRA) and zearalenone (ZEN) (Daković et al., 2005; Marković et al., 2017). Besides clinoptilolite, phillipsite modified with different levels of cetylpyridinium chloride was also shown to be an effective adsorbent for ZEN (Marković et al, 2017). Since adsorption of mycotoxins may be dependent on the type of surfactant, the aim of this research was to investigate how the modification of phillipsite with surfactant hexadecyltrimethyl ammonium bromide (HDTMA) would influence the adsorption of AFB1, OCHRA and ZEN.
Experimental Methods
A sample of Neapolitan Yellow Tuff (Campania, Italy) composed primarily of phillipsite (PHI), was used as starting material. The modified sample was prepared by treatment of a 10% aqueous suspension of starting material with the surfactant hexadecyltrimethyl ammonium bromide (HDTMA) in an amount equivalent to 100% of its external cation exchange capacity (ECEC) and denoted as PHB-100.
Mycotoxins, AFB1, OCHRA and ZEN were obtained from Sigma-Aldrich Co. Adsorption experiments were performed using the following procedure: duplicate aliquots of 0.1M phosphate buffer (pH 3 and 7) containing 2 ppm AFB1, 2 ppm OCHRA and 2 ppm ZEN in solution (10 mL) were added to 15 mL screw cap Falcon polypropylene tubes to which had been added 20, 10, 5 or 2 mg of PHI and PHB-100. In order to eliminate exogenous peaks, controls were prepared by adding 10 mL of 0.1 M phosphate buffer (pH 3 and 7) to Falcon tubes containing 10 mg of each adsorbent. All samples were placed on a rotating shaker for 30 min at room temperature, centrifuged for 5 min at 13000 rpm and 2 mL of the aqueous supernatant was removed for HPLC analysis.
Results and Discussion
Adsorption of AFB1, OCHRA and ZEN by PHI and PHB-100 at different pH values is presented in Figures 1 and 2. Adsorption of each mycotoxin increased with increasing amounts of PHI and PHB-100 in suspension. PHI showed a high adsorption for AFB1 at pH 3 and moderate adsorption at pH 7, while
adsorption of OCHRA and ZEN by PHI was low at both pH values (less than 10% for OCHRA and less than
20% for ZEN). Modified phillipsite showed increased adsorption for each mycotoxin at all investigated
amounts of adsorbents. Compared to the PHI, adsorption of AFB1 by PHB-100 was slightly increased at
pH 3 (from 80.0% for PHI to 85.2% for PHB-100), while a higher increase was observed at pH 7 (from
51.9% for PHI to 81.5% for PHB-100). A much higher increase in adsorption by PHB-100 was observed for
OCHRA and ZEN at both pH values. In conclusion both PHI and PHB-100 were efficient in the adsorption of AFB1 at pH 3, while the
presence of HDTMA at the zeolitic surface increased adsorption of AFB1 at pH 7. Unmodified PHI showed
low adsorption of OCHRA and ZEN at both pH values, while modification of phillipsite with HDTMA ions
significantly increased adsorption of both these mycotoxins.
PB  - Lublin : Lublin University of Technology
C3  - ZEOLITE 2018 - 10th International Conference on the Occurrence, Properties and Utilization of Natural Zeolites
T1  - Adsorption of mycotoxins by unmodified and modified phillipsite
EP  - 62
SP  - 61
ER  - 

@conference{
author = "Marković, Marija and Daković, Aleksandra and Rottinghaus, George E. and Krajišnik, Danina and Milić, Jela and Mercurio, Mariano",
year = "2018",
abstract = "Introduction
Mycotoxins are secondary metabolites produced by various fungi, primarily belonging to Aspergillus, Fusarium, or Penicillium genera. The most common mycotoxins found in animal feed are the aflatoxins, ochratoxins, trichothecenes, fumonisins, zearalenone and ergot alkaloids. Consumption of mycotoxin-contaminated diet may induce acute and long-term chronic effects in animals and humans, resulting in teratogenic, carcinogenic and oestrogenic or immune-suppressive effects (Zhu et al., 2016).
One approach to reduce deleterious effects of mycotoxins is to use adsorbents in animal feed to bind mycotoxins efficiently in the gastrointestinal tract and prevent their adsorption in the digestive tract. The preferred adsorbents are aluminosilicates (natural zeolites and clay minerals). These adsorbents in their natural form are effective in binding aflatoxins but less effective in binding other mycotoxins. Chemical modification of these minerals with cationic surfactants results in an increased hydrophobicity of the surface and improved adsorption for the majority of the mycotoxins. Clinoptilolite, in its natural form, was effective in adsorbing aflatoxin B1 (AFB1), while clinoptilolite modified with cationic surfactants such as octadecyldimethylbenzyl ammonium chloride and benzalkonium chloride was effective in binding ochratoxin A (OCHRA) and zearalenone (ZEN) (Daković et al., 2005; Marković et al., 2017). Besides clinoptilolite, phillipsite modified with different levels of cetylpyridinium chloride was also shown to be an effective adsorbent for ZEN (Marković et al, 2017). Since adsorption of mycotoxins may be dependent on the type of surfactant, the aim of this research was to investigate how the modification of phillipsite with surfactant hexadecyltrimethyl ammonium bromide (HDTMA) would influence the adsorption of AFB1, OCHRA and ZEN.
Experimental Methods
A sample of Neapolitan Yellow Tuff (Campania, Italy) composed primarily of phillipsite (PHI), was used as starting material. The modified sample was prepared by treatment of a 10% aqueous suspension of starting material with the surfactant hexadecyltrimethyl ammonium bromide (HDTMA) in an amount equivalent to 100% of its external cation exchange capacity (ECEC) and denoted as PHB-100.
Mycotoxins, AFB1, OCHRA and ZEN were obtained from Sigma-Aldrich Co. Adsorption experiments were performed using the following procedure: duplicate aliquots of 0.1M phosphate buffer (pH 3 and 7) containing 2 ppm AFB1, 2 ppm OCHRA and 2 ppm ZEN in solution (10 mL) were added to 15 mL screw cap Falcon polypropylene tubes to which had been added 20, 10, 5 or 2 mg of PHI and PHB-100. In order to eliminate exogenous peaks, controls were prepared by adding 10 mL of 0.1 M phosphate buffer (pH 3 and 7) to Falcon tubes containing 10 mg of each adsorbent. All samples were placed on a rotating shaker for 30 min at room temperature, centrifuged for 5 min at 13000 rpm and 2 mL of the aqueous supernatant was removed for HPLC analysis.
Results and Discussion
Adsorption of AFB1, OCHRA and ZEN by PHI and PHB-100 at different pH values is presented in Figures 1 and 2. Adsorption of each mycotoxin increased with increasing amounts of PHI and PHB-100 in suspension. PHI showed a high adsorption for AFB1 at pH 3 and moderate adsorption at pH 7, while
adsorption of OCHRA and ZEN by PHI was low at both pH values (less than 10% for OCHRA and less than
20% for ZEN). Modified phillipsite showed increased adsorption for each mycotoxin at all investigated
amounts of adsorbents. Compared to the PHI, adsorption of AFB1 by PHB-100 was slightly increased at
pH 3 (from 80.0% for PHI to 85.2% for PHB-100), while a higher increase was observed at pH 7 (from
51.9% for PHI to 81.5% for PHB-100). A much higher increase in adsorption by PHB-100 was observed for
OCHRA and ZEN at both pH values. In conclusion both PHI and PHB-100 were efficient in the adsorption of AFB1 at pH 3, while the
presence of HDTMA at the zeolitic surface increased adsorption of AFB1 at pH 7. Unmodified PHI showed
low adsorption of OCHRA and ZEN at both pH values, while modification of phillipsite with HDTMA ions
significantly increased adsorption of both these mycotoxins.",
publisher = "Lublin : Lublin University of Technology",
journal = "ZEOLITE 2018 - 10th International Conference on the Occurrence, Properties and Utilization of Natural Zeolites",
title = "Adsorption of mycotoxins by unmodified and modified phillipsite",
pages = "62-61"
}

Marković, M., Daković, A., Rottinghaus, G. E., Krajišnik, D., Milić, J.,& Mercurio, M.. (2018). Adsorption of mycotoxins by unmodified and modified phillipsite. in ZEOLITE 2018 - 10th International Conference on the Occurrence, Properties and Utilization of Natural Zeolites
Lublin : Lublin University of Technology., 61-62.

Marković M, Daković A, Rottinghaus GE, Krajišnik D, Milić J, Mercurio M. Adsorption of mycotoxins by unmodified and modified phillipsite. in ZEOLITE 2018 - 10th International Conference on the Occurrence, Properties and Utilization of Natural Zeolites. 2018;:61-62..

Marković, Marija, Daković, Aleksandra, Rottinghaus, George E., Krajišnik, Danina, Milić, Jela, Mercurio, Mariano, "Adsorption of mycotoxins by unmodified and modified phillipsite" in ZEOLITE 2018 - 10th International Conference on the Occurrence, Properties and Utilization of Natural Zeolites (2018):61-62.

TY  - CONF
AU  - Krajišnik, Danina
AU  - Čalija, Bojan
AU  - Djekić, Ljiljana
AU  - Dobričić, Vladimir
AU  - Daković, Aleksandra
AU  - Marković, Marija
AU  - Milić, Jela
PY  - 2018
UR  - https://ritnms.itnms.ac.rs/handle/123456789/702
AB  - Introduction
Interactions of cationic surfactants with natural zeolites have been extensively studied since they proved to be excellent adsorbents for various drug molecules contributing their functionality as drug carriers. Investigations related to nonsteroidal anti-inflammatory drugs (NSAIDs) are particularly interesting, since they are one of the most frequently used medications (Krajišnik et al., 2017). Sorption and release of ibuprofen (IBU) (a representative of NSAIDs; practically insoluble in water) by modified clinoptilolitic zeolitic tuff, in two step preparation procedure, was previously investigated (Krajišnik et al., 2015). According to this procedure, in the first step surfactant modified zeolites were prepared and then in the second step drug-modified zeolite composites were obtained by adsorption of IBU on modified zeolites.
The aim of this work was to carry out a study of direct method of drug-modified zeolite composites preparation and the influence of cationic surfactant:drug molar ratio on adsorption properties of clinoptilolitic zeolitic tuff.
Experimental Methods
In experiments, the initial clinoptilolitic zeolitic tuff from Zlatokop deposit (Serbia) (Krajišnik et al., 2011) was treated with solutions comprising surfactanthexadecyltrimethylammonium bromide (HB) in amounts equivalent to 100, 200 and 300% of its external cation exchange capacity (ECEC). In surfactant solutions (prepared at 40 C) IBU was solubilized at the same drug:surfactant molar ratio. The 10% aqueous suspensions were mixed on a high-speed disperser at 6000 rpm for 10 min. After mixing, the suspensions were filtered and the filtrates were collected for the drug assay by HPLC analysis. The obtained drug/modified zeolites composites, prepared by direct method, were denoted as ZHB-10 IBU/DM, ZHB-20 IBU/DM and ZHB-30 IBU/DM.
The average droplet size (Z-ave) and polydispersity index (PdI) in the starting drug/surfactant solutions were determined by photon correlation spectroscopy (PCS) using a ZetasizerNano ZS90 (Malvern Instruments, Malvern, UK). The zeta potentials of the starting zeolite and the prepared samples (drug/modified zeolites composites) were performed on the same apparatus. FT-IR spectra of the prepared samples and their individual components were recorded using a Nicolet iS50 spectrometer (Thermo Scientific, USA) in the range of 4000–400 cm−1 at a resolution of 2 cm−1.
Results and Discussion
In the starting drug/surfactant solutions, both IBU and HB were used at equimolar concentrations of 0.011 M, 0.022 M and 0.033 M for ZHB-10 IBU/DM, ZHB-20 IBU/DM and ZHB-30 IBU/DM, respectively. The HB concentration in all solutions was higher than its critical micelle concentration (cmc 0.92 mM at 20-25 °C). Instead of an intensive peak pattern associated with HB micelles, a group of very low intensity peaks was observed in a wider size range. The observed changes can be interpreted by disturbing the structure of the micelles under the conditions of agitation and temperature during the preparation of the starting solutions, and the formation of IBU complexes with individual HB molecules (Bunton et al., 1981), as well as their associates.The changes in zeta-potential of clinoptilolitic zeolitic tuff (ZVB) (Fig. 1a) were more pronounced for the samples with higher HB content compared with the sample ZHB-10 IBU/DM. Since the adsorbed amount of IBU on the prepared composites was lower for ZHB-10 IBU/DM ( 20 mg/g) and approximately the same for ZHB-20 IBU/DM and ZHB-30 IBU/DM ( 40 mg/g), increasing zeta potentials probably correspond to different surfactant coverage and organization at the mineral surface.
The bands in FT-IR spectrum of ZHB-30 IBU/DM (Fig. 1b) at 3618, 3420 and 1640 cm−1 are clinoptilolite characteristic bands related to acidic hydroxyls SiO(H)Al, hydrogen-bonding hydroxyl groups, and bending vibration of absorbed water, respectively (Korkuna et al., 2006). Compared to the FT-IR spectrum of ZVB the following bands were observed: the CH2 symmetric and asymmetric stretching vibrations of alkyl chain at 2919 and 2850 cm−1 and C–H scissoring vibrations of CH3–N+ moiety with peak at 1463 cm−1, which evidence the presence of HB (Sui et al., 2006). A weak band at 1384 cm−1 implies the presence of anionic form of adsorbed IBU (Krajišnik et al., 2015). The presented results of drug uptake by surfactant/zeolite composites revealed that drug adsorption from IBU/HB solutions could be successfully performed by the direct method of preparation, while cationic surfactant:drug molar ratio had influence on adsorbed amounts and organization of molecules on the zeolitic surface. Further investigations of pharmaceutical technical characteristics and drug release from the obtained composites would reveal their possible pharmaceutical application.
Acknowledgment
This work was realized within the framework of the projects TR 34031 and OI 172018 supported by the Ministry of Education, Science and Technological Development of Republic of Serbia.
PB  - Lublin : Lublin University of Technology
C3  - ZEOLITE 2018 - 10th International Conference on the Occurrence, Properties and Utilization of Natural Zeolites
T1  - Ibuprofen adsorption on a clinoptilolitic zeolitic tuff modified with cationic surfactant: direct method of composites preparation
EP  - 192
SP  - 191
ER  - 

@conference{
author = "Krajišnik, Danina and Čalija, Bojan and Djekić, Ljiljana and Dobričić, Vladimir and Daković, Aleksandra and Marković, Marija and Milić, Jela",
year = "2018",
abstract = "Introduction
Interactions of cationic surfactants with natural zeolites have been extensively studied since they proved to be excellent adsorbents for various drug molecules contributing their functionality as drug carriers. Investigations related to nonsteroidal anti-inflammatory drugs (NSAIDs) are particularly interesting, since they are one of the most frequently used medications (Krajišnik et al., 2017). Sorption and release of ibuprofen (IBU) (a representative of NSAIDs; practically insoluble in water) by modified clinoptilolitic zeolitic tuff, in two step preparation procedure, was previously investigated (Krajišnik et al., 2015). According to this procedure, in the first step surfactant modified zeolites were prepared and then in the second step drug-modified zeolite composites were obtained by adsorption of IBU on modified zeolites.
The aim of this work was to carry out a study of direct method of drug-modified zeolite composites preparation and the influence of cationic surfactant:drug molar ratio on adsorption properties of clinoptilolitic zeolitic tuff.
Experimental Methods
In experiments, the initial clinoptilolitic zeolitic tuff from Zlatokop deposit (Serbia) (Krajišnik et al., 2011) was treated with solutions comprising surfactanthexadecyltrimethylammonium bromide (HB) in amounts equivalent to 100, 200 and 300% of its external cation exchange capacity (ECEC). In surfactant solutions (prepared at 40 C) IBU was solubilized at the same drug:surfactant molar ratio. The 10% aqueous suspensions were mixed on a high-speed disperser at 6000 rpm for 10 min. After mixing, the suspensions were filtered and the filtrates were collected for the drug assay by HPLC analysis. The obtained drug/modified zeolites composites, prepared by direct method, were denoted as ZHB-10 IBU/DM, ZHB-20 IBU/DM and ZHB-30 IBU/DM.
The average droplet size (Z-ave) and polydispersity index (PdI) in the starting drug/surfactant solutions were determined by photon correlation spectroscopy (PCS) using a ZetasizerNano ZS90 (Malvern Instruments, Malvern, UK). The zeta potentials of the starting zeolite and the prepared samples (drug/modified zeolites composites) were performed on the same apparatus. FT-IR spectra of the prepared samples and their individual components were recorded using a Nicolet iS50 spectrometer (Thermo Scientific, USA) in the range of 4000–400 cm−1 at a resolution of 2 cm−1.
Results and Discussion
In the starting drug/surfactant solutions, both IBU and HB were used at equimolar concentrations of 0.011 M, 0.022 M and 0.033 M for ZHB-10 IBU/DM, ZHB-20 IBU/DM and ZHB-30 IBU/DM, respectively. The HB concentration in all solutions was higher than its critical micelle concentration (cmc 0.92 mM at 20-25 °C). Instead of an intensive peak pattern associated with HB micelles, a group of very low intensity peaks was observed in a wider size range. The observed changes can be interpreted by disturbing the structure of the micelles under the conditions of agitation and temperature during the preparation of the starting solutions, and the formation of IBU complexes with individual HB molecules (Bunton et al., 1981), as well as their associates.The changes in zeta-potential of clinoptilolitic zeolitic tuff (ZVB) (Fig. 1a) were more pronounced for the samples with higher HB content compared with the sample ZHB-10 IBU/DM. Since the adsorbed amount of IBU on the prepared composites was lower for ZHB-10 IBU/DM ( 20 mg/g) and approximately the same for ZHB-20 IBU/DM and ZHB-30 IBU/DM ( 40 mg/g), increasing zeta potentials probably correspond to different surfactant coverage and organization at the mineral surface.
The bands in FT-IR spectrum of ZHB-30 IBU/DM (Fig. 1b) at 3618, 3420 and 1640 cm−1 are clinoptilolite characteristic bands related to acidic hydroxyls SiO(H)Al, hydrogen-bonding hydroxyl groups, and bending vibration of absorbed water, respectively (Korkuna et al., 2006). Compared to the FT-IR spectrum of ZVB the following bands were observed: the CH2 symmetric and asymmetric stretching vibrations of alkyl chain at 2919 and 2850 cm−1 and C–H scissoring vibrations of CH3–N+ moiety with peak at 1463 cm−1, which evidence the presence of HB (Sui et al., 2006). A weak band at 1384 cm−1 implies the presence of anionic form of adsorbed IBU (Krajišnik et al., 2015). The presented results of drug uptake by surfactant/zeolite composites revealed that drug adsorption from IBU/HB solutions could be successfully performed by the direct method of preparation, while cationic surfactant:drug molar ratio had influence on adsorbed amounts and organization of molecules on the zeolitic surface. Further investigations of pharmaceutical technical characteristics and drug release from the obtained composites would reveal their possible pharmaceutical application.
Acknowledgment
This work was realized within the framework of the projects TR 34031 and OI 172018 supported by the Ministry of Education, Science and Technological Development of Republic of Serbia.",
publisher = "Lublin : Lublin University of Technology",
journal = "ZEOLITE 2018 - 10th International Conference on the Occurrence, Properties and Utilization of Natural Zeolites",
title = "Ibuprofen adsorption on a clinoptilolitic zeolitic tuff modified with cationic surfactant: direct method of composites preparation",
pages = "192-191"
}

Krajišnik, D., Čalija, B., Djekić, L., Dobričić, V., Daković, A., Marković, M.,& Milić, J.. (2018). Ibuprofen adsorption on a clinoptilolitic zeolitic tuff modified with cationic surfactant: direct method of composites preparation. in ZEOLITE 2018 - 10th International Conference on the Occurrence, Properties and Utilization of Natural Zeolites
Lublin : Lublin University of Technology., 191-192.

Krajišnik D, Čalija B, Djekić L, Dobričić V, Daković A, Marković M, Milić J. Ibuprofen adsorption on a clinoptilolitic zeolitic tuff modified with cationic surfactant: direct method of composites preparation. in ZEOLITE 2018 - 10th International Conference on the Occurrence, Properties and Utilization of Natural Zeolites. 2018;:191-192..

Krajišnik, Danina, Čalija, Bojan, Djekić, Ljiljana, Dobričić, Vladimir, Daković, Aleksandra, Marković, Marija, Milić, Jela, "Ibuprofen adsorption on a clinoptilolitic zeolitic tuff modified with cationic surfactant: direct method of composites preparation" in ZEOLITE 2018 - 10th International Conference on the Occurrence, Properties and Utilization of Natural Zeolites (2018):191-192.

TY  - JOUR
AU  - Janićijević, Jelena
AU  - Milić, Jela
AU  - Calija, Bojan
AU  - Micov, Ana
AU  - Stepanović-Petrović, Radica
AU  - Tomić, Maja
AU  - Daković, Aleksandra
AU  - Dobričić, Vladimir
AU  - Nedić-Vasiljević, Bojana
AU  - Krajišnik, Danina
PY  - 2018
UR  - https://ritnms.itnms.ac.rs/handle/123456789/471
AB  - Refined diatomite from the Kolubara coal basin (Serbia) was inorganically functionalized through a simple, one-pot, non-time-consuming procedure. Model drug ibuprofen was adsorbed on the functionalized diatomite under optimized conditions providing high drug Loading (similar to 201 mg g(-1)). Physicochemical characterization was performed on the starting and modified diatomite before and after ibuprofen adsorption. Dissolution testing was conducted on comprimates containing the drug adsorbed on the modified diatomite (composite) and those containing a physical mixture of the drug with the modified diatomite. The antihyperalgesic and the antiedematous activity of ibuprofen from both composites and physical mixtures were evaluated in vivo employing an inflammatory pain model in rats. Functionalization and subsequent drug adsorption had no significant effect on the diatomite ordered porous structure. Two forms of ibuprofen most likely coexisted in the adsorbed state - the acidic form and a salt/complex with aluminium. Both comprimate types showed extended ibuprofen release in vitro, but no significant influence on the duration of the ibuprofen effect was observed upon in vivo application of the composite or physical mixture. However, both the composite and the physical mixture were more effective than equivalent doses of ibuprofen in pain suppression in rats. This potentiation of the ibuprofen antihyperalgesic effect may result from the formation of the drug complex with the carrier and can be of clinical relevance.
PB  - Royal Soc Chemistry, Cambridge
T2  - Journal of Materials Chemistry B
T1  - Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite
EP  - 5822
IS  - 36
SP  - 5812
VL  - 6
DO  - 10.1039/c8tb01376d
UR  - conv_835
ER  - 

@article{
author = "Janićijević, Jelena and Milić, Jela and Calija, Bojan and Micov, Ana and Stepanović-Petrović, Radica and Tomić, Maja and Daković, Aleksandra and Dobričić, Vladimir and Nedić-Vasiljević, Bojana and Krajišnik, Danina",
year = "2018",
abstract = "Refined diatomite from the Kolubara coal basin (Serbia) was inorganically functionalized through a simple, one-pot, non-time-consuming procedure. Model drug ibuprofen was adsorbed on the functionalized diatomite under optimized conditions providing high drug Loading (similar to 201 mg g(-1)). Physicochemical characterization was performed on the starting and modified diatomite before and after ibuprofen adsorption. Dissolution testing was conducted on comprimates containing the drug adsorbed on the modified diatomite (composite) and those containing a physical mixture of the drug with the modified diatomite. The antihyperalgesic and the antiedematous activity of ibuprofen from both composites and physical mixtures were evaluated in vivo employing an inflammatory pain model in rats. Functionalization and subsequent drug adsorption had no significant effect on the diatomite ordered porous structure. Two forms of ibuprofen most likely coexisted in the adsorbed state - the acidic form and a salt/complex with aluminium. Both comprimate types showed extended ibuprofen release in vitro, but no significant influence on the duration of the ibuprofen effect was observed upon in vivo application of the composite or physical mixture. However, both the composite and the physical mixture were more effective than equivalent doses of ibuprofen in pain suppression in rats. This potentiation of the ibuprofen antihyperalgesic effect may result from the formation of the drug complex with the carrier and can be of clinical relevance.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Journal of Materials Chemistry B",
title = "Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite",
pages = "5822-5812",
number = "36",
volume = "6",
doi = "10.1039/c8tb01376d",
url = "conv_835"
}

Janićijević, J., Milić, J., Calija, B., Micov, A., Stepanović-Petrović, R., Tomić, M., Daković, A., Dobričić, V., Nedić-Vasiljević, B.,& Krajišnik, D.. (2018). Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite. in Journal of Materials Chemistry B
Royal Soc Chemistry, Cambridge., 6(36), 5812-5822.
https://doi.org/10.1039/c8tb01376d
conv_835

Janićijević J, Milić J, Calija B, Micov A, Stepanović-Petrović R, Tomić M, Daković A, Dobričić V, Nedić-Vasiljević B, Krajišnik D. Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite. in Journal of Materials Chemistry B. 2018;6(36):5812-5822.
doi:10.1039/c8tb01376d
conv_835 .

Janićijević, Jelena, Milić, Jela, Calija, Bojan, Micov, Ana, Stepanović-Petrović, Radica, Tomić, Maja, Daković, Aleksandra, Dobričić, Vladimir, Nedić-Vasiljević, Bojana, Krajišnik, Danina, "Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite" in Journal of Materials Chemistry B, 6, no. 36 (2018):5812-5822,
https://doi.org/10.1039/c8tb01376d .,
conv_835 .

TY  - CHAP
AU  - Krajišnik, Danina
AU  - Daković, Aleksandra
AU  - Milić, Jela
AU  - Marković, Marija
PY  - 2018
UR  - https://ritnms.itnms.ac.rs/handle/123456789/465
AB  - In the last two decades, natural zeolites have emerged in biomedical applications due to their favorable physicochemical characteristics such as high adsorption capacity and specific surface, the cation exchange ability, and good biocompatibility. Although very similar to clays that have been traditionally used in pharmaceutical preparations, these mineral materials also require a comprehensive characterization prior to their use as potential pharmaceutical excipients, that is, drug carriers. In this chapter a brief summary on definitions, properties, functionality-related characteristics, safety, and regulatory aspects of pharmaceutical excipients is given. Special attention is focused on natural and surfactant-modified zeolites; an overview of techniques used for characterization of a starting mineral material as well as drug-modified zeolite composites relevant for their application as pharmaceutical excipients and potential drug carriers is presented.
PB  - Elsevier
T2  - Modified Clay and Zeolite Nanocomposite Materials: Environmental and Pharmaceutical Applications
T1  - Zeolites as potential drug carriers
EP  - 55
SP  - 27
DO  - 10.1016/B978-0-12-814617-0.00002-5
UR  - conv_1027
ER  - 

@inbook{
author = "Krajišnik, Danina and Daković, Aleksandra and Milić, Jela and Marković, Marija",
year = "2018",
abstract = "In the last two decades, natural zeolites have emerged in biomedical applications due to their favorable physicochemical characteristics such as high adsorption capacity and specific surface, the cation exchange ability, and good biocompatibility. Although very similar to clays that have been traditionally used in pharmaceutical preparations, these mineral materials also require a comprehensive characterization prior to their use as potential pharmaceutical excipients, that is, drug carriers. In this chapter a brief summary on definitions, properties, functionality-related characteristics, safety, and regulatory aspects of pharmaceutical excipients is given. Special attention is focused on natural and surfactant-modified zeolites; an overview of techniques used for characterization of a starting mineral material as well as drug-modified zeolite composites relevant for their application as pharmaceutical excipients and potential drug carriers is presented.",
publisher = "Elsevier",
journal = "Modified Clay and Zeolite Nanocomposite Materials: Environmental and Pharmaceutical Applications",
booktitle = "Zeolites as potential drug carriers",
pages = "55-27",
doi = "10.1016/B978-0-12-814617-0.00002-5",
url = "conv_1027"
}

Krajišnik, D., Daković, A., Milić, J.,& Marković, M.. (2018). Zeolites as potential drug carriers. in Modified Clay and Zeolite Nanocomposite Materials: Environmental and Pharmaceutical Applications
Elsevier., 27-55.
https://doi.org/10.1016/B978-0-12-814617-0.00002-5
conv_1027

Krajišnik D, Daković A, Milić J, Marković M. Zeolites as potential drug carriers. in Modified Clay and Zeolite Nanocomposite Materials: Environmental and Pharmaceutical Applications. 2018;:27-55.
doi:10.1016/B978-0-12-814617-0.00002-5
conv_1027 .

Krajišnik, Danina, Daković, Aleksandra, Milić, Jela, Marković, Marija, "Zeolites as potential drug carriers" in Modified Clay and Zeolite Nanocomposite Materials: Environmental and Pharmaceutical Applications (2018):27-55,
https://doi.org/10.1016/B978-0-12-814617-0.00002-5 .,
conv_1027 .

TY  - CHAP
AU  - Krajišnik, Danina
AU  - Daković, Aleksandra
AU  - Janićijević, Jelena
AU  - Milić, Jela
PY  - 2017
UR  - https://ritnms.itnms.ac.rs/handle/123456789/442
AB  - In the last two decades several representatives of natural silica-based materials (clays, zeolites, and diatomites) have emerged in biomedical applications due to their favorable physicochemical and functionality-related characteristics along with good biocompatibility. The possibility of their use in drug delivery as carriers for NSAIDs, as one of the most widely prescribed drugs, is particularly interesting since it would overcome some of the therapy-related side effects and improve patience compliance.This chapter gives an overview of natural silica-based materials' characteristics relevant for their pharmaceutical use, along with various examples of their structure modification in order to obtain materials with improved functional properties as potential drug carriers. A review on application of these materials in drug delivery of NSAIDs is presented including evaluation of techniques used for drug silica based carrier characterization in addition to investigation of their biopharmaceutical performances.
PB  - Elsevier Inc.
T2  - Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges and Potential Benefits
T1  - Natural and Modified Silica-Based Materials as Carriers for NSAIDs
EP  - 258
SP  - 219
DO  - 10.1016/B978-0-12-804017-1.00008-X
UR  - conv_1031
ER  - 

@inbook{
author = "Krajišnik, Danina and Daković, Aleksandra and Janićijević, Jelena and Milić, Jela",
year = "2017",
abstract = "In the last two decades several representatives of natural silica-based materials (clays, zeolites, and diatomites) have emerged in biomedical applications due to their favorable physicochemical and functionality-related characteristics along with good biocompatibility. The possibility of their use in drug delivery as carriers for NSAIDs, as one of the most widely prescribed drugs, is particularly interesting since it would overcome some of the therapy-related side effects and improve patience compliance.This chapter gives an overview of natural silica-based materials' characteristics relevant for their pharmaceutical use, along with various examples of their structure modification in order to obtain materials with improved functional properties as potential drug carriers. A review on application of these materials in drug delivery of NSAIDs is presented including evaluation of techniques used for drug silica based carrier characterization in addition to investigation of their biopharmaceutical performances.",
publisher = "Elsevier Inc.",
journal = "Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges and Potential Benefits",
booktitle = "Natural and Modified Silica-Based Materials as Carriers for NSAIDs",
pages = "258-219",
doi = "10.1016/B978-0-12-804017-1.00008-X",
url = "conv_1031"
}

Krajišnik, D., Daković, A., Janićijević, J.,& Milić, J.. (2017). Natural and Modified Silica-Based Materials as Carriers for NSAIDs. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges and Potential Benefits
Elsevier Inc.., 219-258.
https://doi.org/10.1016/B978-0-12-804017-1.00008-X
conv_1031

Krajišnik D, Daković A, Janićijević J, Milić J. Natural and Modified Silica-Based Materials as Carriers for NSAIDs. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges and Potential Benefits. 2017;:219-258.
doi:10.1016/B978-0-12-804017-1.00008-X
conv_1031 .

Krajišnik, Danina, Daković, Aleksandra, Janićijević, Jelena, Milić, Jela, "Natural and Modified Silica-Based Materials as Carriers for NSAIDs" in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges and Potential Benefits (2017):219-258,
https://doi.org/10.1016/B978-0-12-804017-1.00008-X .,
conv_1031 .

TY  - JOUR
AU  - Marković, Marija
AU  - Daković, Aleksandra
AU  - Rottinghaus, George E.
AU  - Petković, Anđela
AU  - Kragović, Milan
AU  - Krajišnik, Danina
AU  - Milić, Jela
PY  - 2017
UR  - https://ritnms.itnms.ac.rs/handle/123456789/438
AB  - Benzalkonium chloride - BC (the mixture of alkylbenzyldimethylammonium chlorides containing the alkyl groups having chain lengths of C8 to C18 and benzyl functional group) was used as a surfactant for production of organozeolites (BZs). The natural zeolite - clinoptilolite was modified with three different levels (2, 5 and 10 mmol/100 g) of BC. FTIR spectroscopy, thermal analysis, zeta potential measurements, determination of the point of zero charge and BET were used to determine the quantity of the surfactant at the zeolitic surface. The main aim was to investigate adsorption properties of BZs towards ochratoxin A (OCHRA) and zearalenone (ZEN) under in vitro conditions. Results showed that adsorption of OCHRA and ZEN by BZs increased with increasing amounts of BC at the zeolitic surface but the adsorption mechanism was different. Adsorption of OCHRA by BZs followed nonlinear isotherms at pH 3 and 7, and higher adsorption capacity was observed at pH 3. This indicates that adsorption was dependent on the form of OCHRA in solution and that the sites at the uncovered zeolitic surface together with the surfactants contributed to OCHRA adsorption. Adsorption of ZEN by BZs showed linear isotherms at pH 3 and 7 and similar amounts were adsorbed at both pH values. This suggests that adsorption is practically independent of the form of ZEN in solution and that organic cations at the zeolitic surface are the active sites relevant for ZEN adsorption.
PB  - Elsevier, Amsterdam
T2  - Colloids and Surfaces A-Physicochemical and Engineering Aspects
T1  - Ochratoxin A and zearalenone adsorption by the natural zeolite treated with benzalkonium chloride
EP  - 17
SP  - 7
VL  - 529
DO  - 10.1016/j.colsurfa.2017.05.054
UR  - conv_802
ER  - 

@article{
author = "Marković, Marija and Daković, Aleksandra and Rottinghaus, George E. and Petković, Anđela and Kragović, Milan and Krajišnik, Danina and Milić, Jela",
year = "2017",
abstract = "Benzalkonium chloride - BC (the mixture of alkylbenzyldimethylammonium chlorides containing the alkyl groups having chain lengths of C8 to C18 and benzyl functional group) was used as a surfactant for production of organozeolites (BZs). The natural zeolite - clinoptilolite was modified with three different levels (2, 5 and 10 mmol/100 g) of BC. FTIR spectroscopy, thermal analysis, zeta potential measurements, determination of the point of zero charge and BET were used to determine the quantity of the surfactant at the zeolitic surface. The main aim was to investigate adsorption properties of BZs towards ochratoxin A (OCHRA) and zearalenone (ZEN) under in vitro conditions. Results showed that adsorption of OCHRA and ZEN by BZs increased with increasing amounts of BC at the zeolitic surface but the adsorption mechanism was different. Adsorption of OCHRA by BZs followed nonlinear isotherms at pH 3 and 7, and higher adsorption capacity was observed at pH 3. This indicates that adsorption was dependent on the form of OCHRA in solution and that the sites at the uncovered zeolitic surface together with the surfactants contributed to OCHRA adsorption. Adsorption of ZEN by BZs showed linear isotherms at pH 3 and 7 and similar amounts were adsorbed at both pH values. This suggests that adsorption is practically independent of the form of ZEN in solution and that organic cations at the zeolitic surface are the active sites relevant for ZEN adsorption.",
publisher = "Elsevier, Amsterdam",
journal = "Colloids and Surfaces A-Physicochemical and Engineering Aspects",
title = "Ochratoxin A and zearalenone adsorption by the natural zeolite treated with benzalkonium chloride",
pages = "17-7",
volume = "529",
doi = "10.1016/j.colsurfa.2017.05.054",
url = "conv_802"
}

Marković, M., Daković, A., Rottinghaus, G. E., Petković, A., Kragović, M., Krajišnik, D.,& Milić, J.. (2017). Ochratoxin A and zearalenone adsorption by the natural zeolite treated with benzalkonium chloride. in Colloids and Surfaces A-Physicochemical and Engineering Aspects
Elsevier, Amsterdam., 529, 7-17.
https://doi.org/10.1016/j.colsurfa.2017.05.054
conv_802

Marković M, Daković A, Rottinghaus GE, Petković A, Kragović M, Krajišnik D, Milić J. Ochratoxin A and zearalenone adsorption by the natural zeolite treated with benzalkonium chloride. in Colloids and Surfaces A-Physicochemical and Engineering Aspects. 2017;529:7-17.
doi:10.1016/j.colsurfa.2017.05.054
conv_802 .

Marković, Marija, Daković, Aleksandra, Rottinghaus, George E., Petković, Anđela, Kragović, Milan, Krajišnik, Danina, Milić, Jela, "Ochratoxin A and zearalenone adsorption by the natural zeolite treated with benzalkonium chloride" in Colloids and Surfaces A-Physicochemical and Engineering Aspects, 529 (2017):7-17,
https://doi.org/10.1016/j.colsurfa.2017.05.054 .,
conv_802 .

TY  - JOUR
AU  - Marković, Marija
AU  - Daković, Aleksandra
AU  - Rottinghaus, George E.
AU  - Kragović, Milan
AU  - Petković, Anđela
AU  - Krajišnik, Danina
AU  - Milić, Jela
AU  - Mercurio, Mariano
AU  - de Gennaro, Bruno
PY  - 2017
UR  - https://ritnms.itnms.ac.rs/handle/123456789/430
AB  - In this study, organozeolites were prepared by treatment of the natural zeolites (clinoptilolite and phillipsite) with cetylpyridinium chloride (CP) equivalent to 50 and 100% of their external cation exchange capacities (ECEC). Organoclinoptilolites (ZCPs) and organophillipsites (PCPs) were characterized by FTIR spectroscopy, thermal analysis, determination of the point of zero charge and zeta potential. Adsorption of zearalenone (ZEN) by ZCPs and PCPs at pH 3 and 7 was investigated. Results showed that adsorption of ZEN increases with increasing amounts of CP at the zeolitic surfaces for both ZCPs and PCPs but the adsorption mechanism was different. Adsorption of ZEN by ZCPs followed a linear type of isotherm at pH 3 and 7 while ZEN adsorption by PCPs showed non linear (Langmuir and Freundlich) type of isotherm at both pH values. Different interactions between the ZEN molecule (or ion) and ZCPs and PCPs occurred: partition (linear isotherms) and adsorption in addition to partition (non linear isotherms), respectively. For the highest level of organic phase at the zeolitic surfaces, the maximum adsorbed amount of ZEN was 5.73 mg/g for organoclinoptilolite and 6.86 mg/g for organophillipsite at pH 3. Slightly higher adsorption: 6.98 mg/g for organoclinoptilolite and 7.54 mg/g for organophillipsite was achieved at pH 7. The results confirmed that CP ions at both zeolitic surfaces are responsible for ZEN adsorption and that organophillipsites are as effective in ZEN adsorption as organoclinoptilolites.
PB  - Elsevier, Amsterdam
T2  - Colloids and Surfaces B-Biointerfaces
T1  - Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant
EP  - 332
SP  - 324
VL  - 151
DO  - 10.1016/j.colsurfb.2016.12.033
UR  - conv_788
ER  - 

@article{
author = "Marković, Marija and Daković, Aleksandra and Rottinghaus, George E. and Kragović, Milan and Petković, Anđela and Krajišnik, Danina and Milić, Jela and Mercurio, Mariano and de Gennaro, Bruno",
year = "2017",
abstract = "In this study, organozeolites were prepared by treatment of the natural zeolites (clinoptilolite and phillipsite) with cetylpyridinium chloride (CP) equivalent to 50 and 100% of their external cation exchange capacities (ECEC). Organoclinoptilolites (ZCPs) and organophillipsites (PCPs) were characterized by FTIR spectroscopy, thermal analysis, determination of the point of zero charge and zeta potential. Adsorption of zearalenone (ZEN) by ZCPs and PCPs at pH 3 and 7 was investigated. Results showed that adsorption of ZEN increases with increasing amounts of CP at the zeolitic surfaces for both ZCPs and PCPs but the adsorption mechanism was different. Adsorption of ZEN by ZCPs followed a linear type of isotherm at pH 3 and 7 while ZEN adsorption by PCPs showed non linear (Langmuir and Freundlich) type of isotherm at both pH values. Different interactions between the ZEN molecule (or ion) and ZCPs and PCPs occurred: partition (linear isotherms) and adsorption in addition to partition (non linear isotherms), respectively. For the highest level of organic phase at the zeolitic surfaces, the maximum adsorbed amount of ZEN was 5.73 mg/g for organoclinoptilolite and 6.86 mg/g for organophillipsite at pH 3. Slightly higher adsorption: 6.98 mg/g for organoclinoptilolite and 7.54 mg/g for organophillipsite was achieved at pH 7. The results confirmed that CP ions at both zeolitic surfaces are responsible for ZEN adsorption and that organophillipsites are as effective in ZEN adsorption as organoclinoptilolites.",
publisher = "Elsevier, Amsterdam",
journal = "Colloids and Surfaces B-Biointerfaces",
title = "Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant",
pages = "332-324",
volume = "151",
doi = "10.1016/j.colsurfb.2016.12.033",
url = "conv_788"
}

Marković, M., Daković, A., Rottinghaus, G. E., Kragović, M., Petković, A., Krajišnik, D., Milić, J., Mercurio, M.,& de Gennaro, B.. (2017). Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant. in Colloids and Surfaces B-Biointerfaces
Elsevier, Amsterdam., 151, 324-332.
https://doi.org/10.1016/j.colsurfb.2016.12.033
conv_788

Marković M, Daković A, Rottinghaus GE, Kragović M, Petković A, Krajišnik D, Milić J, Mercurio M, de Gennaro B. Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant. in Colloids and Surfaces B-Biointerfaces. 2017;151:324-332.
doi:10.1016/j.colsurfb.2016.12.033
conv_788 .

Marković, Marija, Daković, Aleksandra, Rottinghaus, George E., Kragović, Milan, Petković, Anđela, Krajišnik, Danina, Milić, Jela, Mercurio, Mariano, de Gennaro, Bruno, "Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant" in Colloids and Surfaces B-Biointerfaces, 151 (2017):324-332,
https://doi.org/10.1016/j.colsurfb.2016.12.033 .,
conv_788 .

TY  - JOUR
AU  - Calija, Bojan
AU  - Milić, Jela
AU  - Janićijević, Jelena
AU  - Daković, Aleksandra
AU  - Krajišnik, Danina
PY  - 2017
UR  - https://ritnms.itnms.ac.rs/handle/123456789/429
AB  - This study investigated the potential of halloysite nanotubes (HNTs) to improve the sustained release properties of chitosan (CS) microparticles cross-linked ionically with tripolyphosphate (TPP). Composite CS-HNTs microparticles were obtained by a simple and eco-friendly procedure based on a coaxial extrusion technique. Prior to encapsulation, a water-soluble model drug, verapamil hydrochloride (VH), was adsorbed successfully on HNTs. The microparticles were characterized by optical microscopy, Fourier transform infrared (FTIR) spectroscopy, differential thermal analysis/thermogravimetric analysis (DTA/TG) and evaluated for encapsulation efficiency and drug-release properties. The composite particles had a slightly deformed spherical shape and micrometric size with average perimeters ranging from 485.4 +/- 13.3 to 492.4 +/- 11.9 mu m. The results of FTIR spectroscopy confirmed non-covalent interactions between CS and HNTs within composite particle structures. The DTA and TG studies revealed increased thermal stability of the composite particles in comparison to the CS-TPP particles. Drug adsorption on HNTs prior to encapsulation led to an increase in encapsulation efficiency from 19.6 +/- 2.9 to 84.3 +/- 1.9%. In contrast to the rapid release of encapsulated model drug from CS-TPP microparticles, the composite CS-HNTs microparticles released drug in a sustained manner, showing the best fit to the Bhaskar model. The results presented here imply that HNTs could be used to improve morphology, encapsulation efficiency and sustained drug-release properties of CS microparticles cross-linked ionically with TPP.
PB  - Mineralogical Soc, Twickenham
T2  - Clay Minerals
T1  - Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release
EP  - 426
IS  - 4
SP  - 413
VL  - 52
DO  - 10.1180/claymin.2017.052.04.01
UR  - conv_823
ER  - 

@article{
author = "Calija, Bojan and Milić, Jela and Janićijević, Jelena and Daković, Aleksandra and Krajišnik, Danina",
year = "2017",
abstract = "This study investigated the potential of halloysite nanotubes (HNTs) to improve the sustained release properties of chitosan (CS) microparticles cross-linked ionically with tripolyphosphate (TPP). Composite CS-HNTs microparticles were obtained by a simple and eco-friendly procedure based on a coaxial extrusion technique. Prior to encapsulation, a water-soluble model drug, verapamil hydrochloride (VH), was adsorbed successfully on HNTs. The microparticles were characterized by optical microscopy, Fourier transform infrared (FTIR) spectroscopy, differential thermal analysis/thermogravimetric analysis (DTA/TG) and evaluated for encapsulation efficiency and drug-release properties. The composite particles had a slightly deformed spherical shape and micrometric size with average perimeters ranging from 485.4 +/- 13.3 to 492.4 +/- 11.9 mu m. The results of FTIR spectroscopy confirmed non-covalent interactions between CS and HNTs within composite particle structures. The DTA and TG studies revealed increased thermal stability of the composite particles in comparison to the CS-TPP particles. Drug adsorption on HNTs prior to encapsulation led to an increase in encapsulation efficiency from 19.6 +/- 2.9 to 84.3 +/- 1.9%. In contrast to the rapid release of encapsulated model drug from CS-TPP microparticles, the composite CS-HNTs microparticles released drug in a sustained manner, showing the best fit to the Bhaskar model. The results presented here imply that HNTs could be used to improve morphology, encapsulation efficiency and sustained drug-release properties of CS microparticles cross-linked ionically with TPP.",
publisher = "Mineralogical Soc, Twickenham",
journal = "Clay Minerals",
title = "Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release",
pages = "426-413",
number = "4",
volume = "52",
doi = "10.1180/claymin.2017.052.04.01",
url = "conv_823"
}

Calija, B., Milić, J., Janićijević, J., Daković, A.,& Krajišnik, D.. (2017). Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release. in Clay Minerals
Mineralogical Soc, Twickenham., 52(4), 413-426.
https://doi.org/10.1180/claymin.2017.052.04.01
conv_823

Calija B, Milić J, Janićijević J, Daković A, Krajišnik D. Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release. in Clay Minerals. 2017;52(4):413-426.
doi:10.1180/claymin.2017.052.04.01
conv_823 .

Calija, Bojan, Milić, Jela, Janićijević, Jelena, Daković, Aleksandra, Krajišnik, Danina, "Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release" in Clay Minerals, 52, no. 4 (2017):413-426,
https://doi.org/10.1180/claymin.2017.052.04.01 .,
conv_823 .

TY  - JOUR
AU  - Marković, Marija
AU  - Daković, Aleksandra
AU  - Krajišnik, Danina
AU  - Kragović, Milan
AU  - Milić, Jela
AU  - Langella, Alessio
AU  - de Gennaro, Bruno
AU  - Cappelletti, Piergiulio
AU  - Mercurio, Mariano
PY  - 2016
UR  - https://ritnms.itnms.ac.rs/handle/123456789/400
AB  - Incorporation of diclofenac sodium into phillipsite modified with cetylpyridinium chloride (CP-Cl) or hexadecyltrimethyl ammonium bromide (HDTMA-Br) was followed by batch equilibrium adsorption studies in buffer solution at pH = 7.4. Characteristics of the drug/surfactant/zeolite complexes were investigated by UV/VIS, FTIR spectroscopy, thermal (DTA/TG) analysis and-potential measurements. The obtained data confirmed that organic cations at phillipsite surface were responsible for incorporation of diclofenac sodium. Diclofenac sodium incorporated amounts increased with increasing the amount of each surfactant as well as with increasing the initial drug concentration. Langmuir model was the best model for fitting the experimental data of diclofenac adsorption on surfactant/phillipsite composites, suggesting complex adsorption mechanism. The physico-chemical properties of surfactant/phillipsite composites and enhanced incorporation of diclofenac sodium suggests that it might be possible to use these materials as drug carriers.
PB  - Elsevier, Amsterdam
T2  - Journal of Molecular Liquids
T1  - Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium
EP  - 716
SP  - 711
VL  - 222
DO  - 10.1016/j.molliq.2016.07.127
UR  - conv_772
ER  - 

@article{
author = "Marković, Marija and Daković, Aleksandra and Krajišnik, Danina and Kragović, Milan and Milić, Jela and Langella, Alessio and de Gennaro, Bruno and Cappelletti, Piergiulio and Mercurio, Mariano",
year = "2016",
abstract = "Incorporation of diclofenac sodium into phillipsite modified with cetylpyridinium chloride (CP-Cl) or hexadecyltrimethyl ammonium bromide (HDTMA-Br) was followed by batch equilibrium adsorption studies in buffer solution at pH = 7.4. Characteristics of the drug/surfactant/zeolite complexes were investigated by UV/VIS, FTIR spectroscopy, thermal (DTA/TG) analysis and-potential measurements. The obtained data confirmed that organic cations at phillipsite surface were responsible for incorporation of diclofenac sodium. Diclofenac sodium incorporated amounts increased with increasing the amount of each surfactant as well as with increasing the initial drug concentration. Langmuir model was the best model for fitting the experimental data of diclofenac adsorption on surfactant/phillipsite composites, suggesting complex adsorption mechanism. The physico-chemical properties of surfactant/phillipsite composites and enhanced incorporation of diclofenac sodium suggests that it might be possible to use these materials as drug carriers.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Molecular Liquids",
title = "Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium",
pages = "716-711",
volume = "222",
doi = "10.1016/j.molliq.2016.07.127",
url = "conv_772"
}

Marković, M., Daković, A., Krajišnik, D., Kragović, M., Milić, J., Langella, A., de Gennaro, B., Cappelletti, P.,& Mercurio, M.. (2016). Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium. in Journal of Molecular Liquids
Elsevier, Amsterdam., 222, 711-716.
https://doi.org/10.1016/j.molliq.2016.07.127
conv_772

Marković M, Daković A, Krajišnik D, Kragović M, Milić J, Langella A, de Gennaro B, Cappelletti P, Mercurio M. Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium. in Journal of Molecular Liquids. 2016;222:711-716.
doi:10.1016/j.molliq.2016.07.127
conv_772 .

Marković, Marija, Daković, Aleksandra, Krajišnik, Danina, Kragović, Milan, Milić, Jela, Langella, Alessio, de Gennaro, Bruno, Cappelletti, Piergiulio, Mercurio, Mariano, "Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium" in Journal of Molecular Liquids, 222 (2016):711-716,
https://doi.org/10.1016/j.molliq.2016.07.127 .,
conv_772 .

TY  - JOUR
AU  - Krajišnik, Danina
AU  - Daković, Aleksandra
AU  - Malenović, Anđelija
AU  - Kragović, Milan
AU  - Milić, Jela
PY  - 2015
UR  - https://ritnms.itnms.ac.rs/handle/123456789/348
AB  - The sorption of ibuprofen by modified natural zeolite composites at three concentration levels (10, 20 and 30 mmol/100 g) of cationic surfactants - benzalkonium chloride and cetylpyridinium chloride, in a buffer solution (pH 7.4), was studied. Characterization of the composites before and after ibuprofen sorption was performed by drug sorption and isotherm studies, zeta potential and Fourier Transform infrared spectroscopic analysis. The biopharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments from the composites with medium surfactant contents. The drug sorption was influenced by the surfactant type and amount used for the zeolite modification. Prolonged drug release over a period of 8 h (up to similar to 40%) was achieved with both groups of samples. The kinetic analysis showed that the drug release profiles were best fitted with the Higuchi and the Bhaskar models, indicating a combination of drug diffusion and ion exchange as the predominant release mechanisms.
PB  - Mineralogical Soc, Twickenham
T2  - Clay Minerals
T1  - Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers
EP  - 22
IS  - 1
SP  - 11
VL  - 50
DO  - 10.1180/claymin.2015.050.1.02
UR  - conv_740
ER  - 

@article{
author = "Krajišnik, Danina and Daković, Aleksandra and Malenović, Anđelija and Kragović, Milan and Milić, Jela",
year = "2015",
abstract = "The sorption of ibuprofen by modified natural zeolite composites at three concentration levels (10, 20 and 30 mmol/100 g) of cationic surfactants - benzalkonium chloride and cetylpyridinium chloride, in a buffer solution (pH 7.4), was studied. Characterization of the composites before and after ibuprofen sorption was performed by drug sorption and isotherm studies, zeta potential and Fourier Transform infrared spectroscopic analysis. The biopharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments from the composites with medium surfactant contents. The drug sorption was influenced by the surfactant type and amount used for the zeolite modification. Prolonged drug release over a period of 8 h (up to similar to 40%) was achieved with both groups of samples. The kinetic analysis showed that the drug release profiles were best fitted with the Higuchi and the Bhaskar models, indicating a combination of drug diffusion and ion exchange as the predominant release mechanisms.",
publisher = "Mineralogical Soc, Twickenham",
journal = "Clay Minerals",
title = "Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers",
pages = "22-11",
number = "1",
volume = "50",
doi = "10.1180/claymin.2015.050.1.02",
url = "conv_740"
}

Krajišnik, D., Daković, A., Malenović, A., Kragović, M.,& Milić, J.. (2015). Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers. in Clay Minerals
Mineralogical Soc, Twickenham., 50(1), 11-22.
https://doi.org/10.1180/claymin.2015.050.1.02
conv_740

Krajišnik D, Daković A, Malenović A, Kragović M, Milić J. Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers. in Clay Minerals. 2015;50(1):11-22.
doi:10.1180/claymin.2015.050.1.02
conv_740 .

Krajišnik, Danina, Daković, Aleksandra, Malenović, Anđelija, Kragović, Milan, Milić, Jela, "Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers" in Clay Minerals, 50, no. 1 (2015):11-22,
https://doi.org/10.1180/claymin.2015.050.1.02 .,
conv_740 .

TY  - JOUR
AU  - Janićijević, Jelena
AU  - Krajišnik, Danina
AU  - Calija, Bojan
AU  - Nedić-Vasiljević, Bojana
AU  - Dobričić, Vladimir
AU  - Daković, Aleksandra
AU  - Antonijević, Milan D.
AU  - Milić, Jela
PY  - 2015
UR  - https://ritnms.itnms.ac.rs/handle/123456789/341
AB  - Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied with the pharmacopoeial requirements for heavy metals content and microbiological quality, was used as a starting material. Inorganic modification of the starting material was performed through a simple, one-step procedure. Significant increase in adsorbent loading with diclofenac sodium (DS) was achieved after the modification process (similar to 373 mg/g) which enabled the preparation of comprimates containing therapeutic dose of the adsorbed drug. Adsorption of DS onto modified diatomite resulted in the alteration of the drug's XRD pattern and FTIR spectrum. In vitro drug release studies in phosphate buffer pH 7.5 demonstrated prolonged DS release over 8 h from comprimates containing DS adsorbed on modified diatomite (up to 37% after 8 h) and those containing physical mixture of the same composition (up to 45% after 8 h). The results of in vivo toxicity testing on mice pointed on potential safety of both unmodified (starting) and modified diatomite. All these findings favor the application of diatomite as a potential functional drug carrier.
PB  - Elsevier, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium
EP  - 474
IS  - 2
SP  - 466
VL  - 496
DO  - 10.1016/j.ijpharm.2015.10.047
UR  - conv_747
ER  - 

@article{
author = "Janićijević, Jelena and Krajišnik, Danina and Calija, Bojan and Nedić-Vasiljević, Bojana and Dobričić, Vladimir and Daković, Aleksandra and Antonijević, Milan D. and Milić, Jela",
year = "2015",
abstract = "Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied with the pharmacopoeial requirements for heavy metals content and microbiological quality, was used as a starting material. Inorganic modification of the starting material was performed through a simple, one-step procedure. Significant increase in adsorbent loading with diclofenac sodium (DS) was achieved after the modification process (similar to 373 mg/g) which enabled the preparation of comprimates containing therapeutic dose of the adsorbed drug. Adsorption of DS onto modified diatomite resulted in the alteration of the drug's XRD pattern and FTIR spectrum. In vitro drug release studies in phosphate buffer pH 7.5 demonstrated prolonged DS release over 8 h from comprimates containing DS adsorbed on modified diatomite (up to 37% after 8 h) and those containing physical mixture of the same composition (up to 45% after 8 h). The results of in vivo toxicity testing on mice pointed on potential safety of both unmodified (starting) and modified diatomite. All these findings favor the application of diatomite as a potential functional drug carrier.",
publisher = "Elsevier, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium",
pages = "474-466",
number = "2",
volume = "496",
doi = "10.1016/j.ijpharm.2015.10.047",
url = "conv_747"
}

Janićijević, J., Krajišnik, D., Calija, B., Nedić-Vasiljević, B., Dobričić, V., Daković, A., Antonijević, M. D.,& Milić, J.. (2015). Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium. in International Journal of Pharmaceutics
Elsevier, Amsterdam., 496(2), 466-474.
https://doi.org/10.1016/j.ijpharm.2015.10.047
conv_747

Janićijević J, Krajišnik D, Calija B, Nedić-Vasiljević B, Dobričić V, Daković A, Antonijević MD, Milić J. Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium. in International Journal of Pharmaceutics. 2015;496(2):466-474.
doi:10.1016/j.ijpharm.2015.10.047
conv_747 .

Janićijević, Jelena, Krajišnik, Danina, Calija, Bojan, Nedić-Vasiljević, Bojana, Dobričić, Vladimir, Daković, Aleksandra, Antonijević, Milan D., Milić, Jela, "Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium" in International Journal of Pharmaceutics, 496, no. 2 (2015):466-474,
https://doi.org/10.1016/j.ijpharm.2015.10.047 .,
conv_747 .

TY  - JOUR
AU  - Janićijević, Jelena
AU  - Krajišnik, Danina
AU  - Calija, Bojan
AU  - Dobričić, Vladimir
AU  - Daković, Aleksandra
AU  - Krstić, Jugoslav
AU  - Marković, Marija
AU  - Milić, Jela
PY  - 2014
UR  - https://ritnms.itnms.ac.rs/handle/123456789/321
AB  - Inorganic modification of diatomite was performed with the precipitation product of partially neutralized aluminum sulfate solution at three different mass ratios. The starting and the modified diatomites were characterized by SEM-EDS, FTIR, thermal analysis and zeta potential measurements and evaluated for drug loading capacity in adsorption batch experiments using diclofenac sodium (DS) as a model drug. In vitro drug release studies were performed in phosphate buffer pH 6.8 from comprimates containing: the drug adsorbed onto the selected modified diatomite sample (DAMD), physical mixture of the drug with the selected modified diatomite sample (PMDMD) and physical mixture of the drug with the starting diatomite (PMDD). In vivo acute toxicity testing of the modified diatomite samples was performed on mice. High adsorbent loading of the selected modified diatomite sample (similar to 250 mg/g in 2 h) enabled the preparation of comprimates containing adsorbed DS in the amount near to its therapeutic dose. Drug release studies demonstrated prolonged release of DS over a period of 8 h from both DAMD comprimates (18% after 8 h) and PMDMD comprimates (45% after 8 h). The release kinetics for DAMD and PMDMD comprimates fitted well with Korsmeyer-Peppas and Bhaskar models, indicating that the release mechanism was a combination of non-Fickian diffusion and ion exchange process.
PB  - Elsevier, Amsterdam
T2  - Materials Science & Engineering C-Materials for Biological Applications
T1  - Inorganically modified diatomite as a potential prolonged-release drug carrier
EP  - 420
SP  - 412
VL  - 42
DO  - 10.1016/j.msec.2014.05.052
UR  - conv_701
ER  - 

@article{
author = "Janićijević, Jelena and Krajišnik, Danina and Calija, Bojan and Dobričić, Vladimir and Daković, Aleksandra and Krstić, Jugoslav and Marković, Marija and Milić, Jela",
year = "2014",
abstract = "Inorganic modification of diatomite was performed with the precipitation product of partially neutralized aluminum sulfate solution at three different mass ratios. The starting and the modified diatomites were characterized by SEM-EDS, FTIR, thermal analysis and zeta potential measurements and evaluated for drug loading capacity in adsorption batch experiments using diclofenac sodium (DS) as a model drug. In vitro drug release studies were performed in phosphate buffer pH 6.8 from comprimates containing: the drug adsorbed onto the selected modified diatomite sample (DAMD), physical mixture of the drug with the selected modified diatomite sample (PMDMD) and physical mixture of the drug with the starting diatomite (PMDD). In vivo acute toxicity testing of the modified diatomite samples was performed on mice. High adsorbent loading of the selected modified diatomite sample (similar to 250 mg/g in 2 h) enabled the preparation of comprimates containing adsorbed DS in the amount near to its therapeutic dose. Drug release studies demonstrated prolonged release of DS over a period of 8 h from both DAMD comprimates (18% after 8 h) and PMDMD comprimates (45% after 8 h). The release kinetics for DAMD and PMDMD comprimates fitted well with Korsmeyer-Peppas and Bhaskar models, indicating that the release mechanism was a combination of non-Fickian diffusion and ion exchange process.",
publisher = "Elsevier, Amsterdam",
journal = "Materials Science & Engineering C-Materials for Biological Applications",
title = "Inorganically modified diatomite as a potential prolonged-release drug carrier",
pages = "420-412",
volume = "42",
doi = "10.1016/j.msec.2014.05.052",
url = "conv_701"
}

Janićijević, J., Krajišnik, D., Calija, B., Dobričić, V., Daković, A., Krstić, J., Marković, M.,& Milić, J.. (2014). Inorganically modified diatomite as a potential prolonged-release drug carrier. in Materials Science & Engineering C-Materials for Biological Applications
Elsevier, Amsterdam., 42, 412-420.
https://doi.org/10.1016/j.msec.2014.05.052
conv_701

Janićijević J, Krajišnik D, Calija B, Dobričić V, Daković A, Krstić J, Marković M, Milić J. Inorganically modified diatomite as a potential prolonged-release drug carrier. in Materials Science & Engineering C-Materials for Biological Applications. 2014;42:412-420.
doi:10.1016/j.msec.2014.05.052
conv_701 .

Janićijević, Jelena, Krajišnik, Danina, Calija, Bojan, Dobričić, Vladimir, Daković, Aleksandra, Krstić, Jugoslav, Marković, Marija, Milić, Jela, "Inorganically modified diatomite as a potential prolonged-release drug carrier" in Materials Science & Engineering C-Materials for Biological Applications, 42 (2014):412-420,
https://doi.org/10.1016/j.msec.2014.05.052 .,
conv_701 .

TY  - CHAP
AU  - Milić, Jela
AU  - Daković, Aleksandra
AU  - Krajišnik, Danina
AU  - Rottinghaus, George E.
PY  - 2014
UR  - https://ritnms.itnms.ac.rs/handle/123456789/288
AB  - Natural and synthetic zeolites have emerged as potential materials for biomedical application in recent years. Zeolites are hydrated microporous tektoaluminosilicates consisting of three-dimensional frameworks of SiO4 and AlO4 tetrahedra linked through shared oxygen atoms. Clinoptilolite, a mineral from the heulandite group of zeolites, ((Na,K)6(Al6Si3O)O72·nH2O), is the most abundant sedimentary zeolite in nature. In this chapter an overview of surface modifi cation of clinoptilolite by interaction with cationic surfactants is given alongside with the methods used for characterization of the surfactant modifi ed zeolites (organozeolites/composites). Diff erent organozeolites were tested under conditions for adsorption of several mycotoxins commonly found in animal feed. Study of in vitro surfactant desorption in vitro followed by in vivo acute toxicity testing was used to demonstrate the nontoxic nature of these improved mineral materials. Functionality related characteristics of modifi ed natural zeolites were analyzed for investigation of their potential use as pharmaceutical excipients for modifi ed release of active pharmaceutical ingredients.
PB  - Wiley Blackwell
T2  - Advanced Healthcare Materials
T1  - Modified Natural Zeolites-Functional Characterization and Biomedical Application
EP  - 403
SP  - 359
VL  - 9781118773598
DO  - 10.1002/9781118774205.ch10
UR  - conv_1041
ER  - 

@inbook{
author = "Milić, Jela and Daković, Aleksandra and Krajišnik, Danina and Rottinghaus, George E.",
year = "2014",
abstract = "Natural and synthetic zeolites have emerged as potential materials for biomedical application in recent years. Zeolites are hydrated microporous tektoaluminosilicates consisting of three-dimensional frameworks of SiO4 and AlO4 tetrahedra linked through shared oxygen atoms. Clinoptilolite, a mineral from the heulandite group of zeolites, ((Na,K)6(Al6Si3O)O72·nH2O), is the most abundant sedimentary zeolite in nature. In this chapter an overview of surface modifi cation of clinoptilolite by interaction with cationic surfactants is given alongside with the methods used for characterization of the surfactant modifi ed zeolites (organozeolites/composites). Diff erent organozeolites were tested under conditions for adsorption of several mycotoxins commonly found in animal feed. Study of in vitro surfactant desorption in vitro followed by in vivo acute toxicity testing was used to demonstrate the nontoxic nature of these improved mineral materials. Functionality related characteristics of modifi ed natural zeolites were analyzed for investigation of their potential use as pharmaceutical excipients for modifi ed release of active pharmaceutical ingredients.",
publisher = "Wiley Blackwell",
journal = "Advanced Healthcare Materials",
booktitle = "Modified Natural Zeolites-Functional Characterization and Biomedical Application",
pages = "403-359",
volume = "9781118773598",
doi = "10.1002/9781118774205.ch10",
url = "conv_1041"
}

Milić, J., Daković, A., Krajišnik, D.,& Rottinghaus, G. E.. (2014). Modified Natural Zeolites-Functional Characterization and Biomedical Application. in Advanced Healthcare Materials
Wiley Blackwell., 9781118773598, 359-403.
https://doi.org/10.1002/9781118774205.ch10
conv_1041

Milić J, Daković A, Krajišnik D, Rottinghaus GE. Modified Natural Zeolites-Functional Characterization and Biomedical Application. in Advanced Healthcare Materials. 2014;9781118773598:359-403.
doi:10.1002/9781118774205.ch10
conv_1041 .

Milić, Jela, Daković, Aleksandra, Krajišnik, Danina, Rottinghaus, George E., "Modified Natural Zeolites-Functional Characterization and Biomedical Application" in Advanced Healthcare Materials, 9781118773598 (2014):359-403,
https://doi.org/10.1002/9781118774205.ch10 .,
conv_1041 .

TY  - JOUR
AU  - Krajišnik, Danina
AU  - Daković, Aleksandra
AU  - Malenović, Anđelija
AU  - Đekić, Ljiljana
AU  - Kragović, Milan
AU  - Dobričić, Vladimir
AU  - Milić, Jela
PY  - 2013
UR  - https://ritnms.itnms.ac.rs/handle/123456789/253
AB  - In this paper, investigations of zeolite - cationic surfactant - drug composites as drug carriers were performed. For that purpose, after adsorption of the model drug - diclofenac sodium (DS) onto composites obtained by the modification of natural zeolite (NZ) with cetylpyridinium chloride (CPC) at the three different levels, i.e., 10, 20 and 30 mmol/100 g (ZCPC-10, ZCPC-20 and ZCPC-30, respectively), the release of the drug, at pH 6.8, was studied. The results of DS release from ZCPC-10 composite (DS/ZCPC-10) were compared with the DS release from corresponding physical mixture, as well as from physical mixture of NZ and DS. Characterization of the composites after adsorption of DS and the physical mixtures was realized by zeta potential measurements and by thermal analysis. Results showed that the prolonged release of DS from all the three composites, as well as from physical mixture containing ZCPC-10 and DS was achieved over a period of 8 h. The drug release from both DS/ZCPC-10 (max 55%) and corresponding physical mixture (max 38%) was remarkably lower than that from the physical mixture of NZ and DS (max 85%). The kinetic analysis for all the three composites, as well as for the physical mixture of ZCPC-10 and DS, showed that drug release profiles were best fitted with the Korsmeyer-Peppas and Bhaskar release models, indicating a combination of drug diffusion and ion exchange as the predominant release mechanisms in the dissolution medium.
PB  - Elsevier Science Bv, Amsterdam
T2  - Microporous and Mesoporous Materials
T1  - An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient
EP  - 101
SP  - 94
VL  - 167
DO  - 10.1016/j.micromeso.2012.03.033
UR  - conv_645
ER  - 

@article{
author = "Krajišnik, Danina and Daković, Aleksandra and Malenović, Anđelija and Đekić, Ljiljana and Kragović, Milan and Dobričić, Vladimir and Milić, Jela",
year = "2013",
abstract = "In this paper, investigations of zeolite - cationic surfactant - drug composites as drug carriers were performed. For that purpose, after adsorption of the model drug - diclofenac sodium (DS) onto composites obtained by the modification of natural zeolite (NZ) with cetylpyridinium chloride (CPC) at the three different levels, i.e., 10, 20 and 30 mmol/100 g (ZCPC-10, ZCPC-20 and ZCPC-30, respectively), the release of the drug, at pH 6.8, was studied. The results of DS release from ZCPC-10 composite (DS/ZCPC-10) were compared with the DS release from corresponding physical mixture, as well as from physical mixture of NZ and DS. Characterization of the composites after adsorption of DS and the physical mixtures was realized by zeta potential measurements and by thermal analysis. Results showed that the prolonged release of DS from all the three composites, as well as from physical mixture containing ZCPC-10 and DS was achieved over a period of 8 h. The drug release from both DS/ZCPC-10 (max 55%) and corresponding physical mixture (max 38%) was remarkably lower than that from the physical mixture of NZ and DS (max 85%). The kinetic analysis for all the three composites, as well as for the physical mixture of ZCPC-10 and DS, showed that drug release profiles were best fitted with the Korsmeyer-Peppas and Bhaskar release models, indicating a combination of drug diffusion and ion exchange as the predominant release mechanisms in the dissolution medium.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Microporous and Mesoporous Materials",
title = "An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient",
pages = "101-94",
volume = "167",
doi = "10.1016/j.micromeso.2012.03.033",
url = "conv_645"
}

Krajišnik, D., Daković, A., Malenović, A., Đekić, L., Kragović, M., Dobričić, V.,& Milić, J.. (2013). An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient. in Microporous and Mesoporous Materials
Elsevier Science Bv, Amsterdam., 167, 94-101.
https://doi.org/10.1016/j.micromeso.2012.03.033
conv_645

Krajišnik D, Daković A, Malenović A, Đekić L, Kragović M, Dobričić V, Milić J. An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient. in Microporous and Mesoporous Materials. 2013;167:94-101.
doi:10.1016/j.micromeso.2012.03.033
conv_645 .

Krajišnik, Danina, Daković, Aleksandra, Malenović, Anđelija, Đekić, Ljiljana, Kragović, Milan, Dobričić, Vladimir, Milić, Jela, "An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient" in Microporous and Mesoporous Materials, 167 (2013):94-101,
https://doi.org/10.1016/j.micromeso.2012.03.033 .,
conv_645 .

TY  - JOUR
AU  - Krajišnik, Danina
AU  - Daković, Aleksandra
AU  - Milojević, Maja
AU  - Malenović, Anđelija
AU  - Kragović, Milan
AU  - Bajuk-Bogdanović, Danica
AU  - Dondur, Vera
AU  - Milić, Jela
PY  - 2011
UR  - https://ritnms.itnms.ac.rs/handle/123456789/189
AB  - In this study an investigation of a model drug sorption onto cationic surfactant-modified natural zeolites as a drug formulation excipient was performed. Natural zeolite was modified with cetylpyridinium chloride in amounts equivalent to 100, 200 and 300% of its external cation-exchange capacity. The starting material and obtained organozeolites were characterized by Fourier transform infrared spectroscopy, zeta potential measurements and thermal analysis. In vitro sorption of diclofenac sodium as a model drug was studied for all surfactant/zeolite composites by means of sorption isotherm measurements in aqueous solutions (pH 7.4). The modified zeolites with three levels of surfactant coverage within the short activation time were prepared. Zeta potential measurements and thermal analysis showed that when the surfactant loading level was equal to external cation-exchange value, almost monolayer of organic phase were present at the zeolitic surface while higher amounts of surfactant produced less extended bilayers, ordered bilayers or admicelles at the zeolitic surface. Modified zeolites, obtained in this manner, were effective in diclofenac sodium sorption and the organic phase derived from adsorbed cetylpyridinium chloride was the primary sorption phase for the model drug. The Langmuir isotherm was found to describe the equilibrium sorption data well over the entire concentration range. The separate contributions of the adsorption and partition to the total sorption of DS were analyzed mathematically. Results revealed that that adsorption and partitioning of the model drug take place simultaneously.
PB  - Elsevier, Amsterdam
T2  - Colloids and Surfaces B-Biointerfaces
T1  - Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride
EP  - 172
IS  - 1
SP  - 165
VL  - 83
DO  - 10.1016/j.colsurfb.2010.11.024
UR  - conv_598
ER  - 

@article{
author = "Krajišnik, Danina and Daković, Aleksandra and Milojević, Maja and Malenović, Anđelija and Kragović, Milan and Bajuk-Bogdanović, Danica and Dondur, Vera and Milić, Jela",
year = "2011",
abstract = "In this study an investigation of a model drug sorption onto cationic surfactant-modified natural zeolites as a drug formulation excipient was performed. Natural zeolite was modified with cetylpyridinium chloride in amounts equivalent to 100, 200 and 300% of its external cation-exchange capacity. The starting material and obtained organozeolites were characterized by Fourier transform infrared spectroscopy, zeta potential measurements and thermal analysis. In vitro sorption of diclofenac sodium as a model drug was studied for all surfactant/zeolite composites by means of sorption isotherm measurements in aqueous solutions (pH 7.4). The modified zeolites with three levels of surfactant coverage within the short activation time were prepared. Zeta potential measurements and thermal analysis showed that when the surfactant loading level was equal to external cation-exchange value, almost monolayer of organic phase were present at the zeolitic surface while higher amounts of surfactant produced less extended bilayers, ordered bilayers or admicelles at the zeolitic surface. Modified zeolites, obtained in this manner, were effective in diclofenac sodium sorption and the organic phase derived from adsorbed cetylpyridinium chloride was the primary sorption phase for the model drug. The Langmuir isotherm was found to describe the equilibrium sorption data well over the entire concentration range. The separate contributions of the adsorption and partition to the total sorption of DS were analyzed mathematically. Results revealed that that adsorption and partitioning of the model drug take place simultaneously.",
publisher = "Elsevier, Amsterdam",
journal = "Colloids and Surfaces B-Biointerfaces",
title = "Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride",
pages = "172-165",
number = "1",
volume = "83",
doi = "10.1016/j.colsurfb.2010.11.024",
url = "conv_598"
}

Krajišnik, D., Daković, A., Milojević, M., Malenović, A., Kragović, M., Bajuk-Bogdanović, D., Dondur, V.,& Milić, J.. (2011). Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride. in Colloids and Surfaces B-Biointerfaces
Elsevier, Amsterdam., 83(1), 165-172.
https://doi.org/10.1016/j.colsurfb.2010.11.024
conv_598

Krajišnik D, Daković A, Milojević M, Malenović A, Kragović M, Bajuk-Bogdanović D, Dondur V, Milić J. Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride. in Colloids and Surfaces B-Biointerfaces. 2011;83(1):165-172.
doi:10.1016/j.colsurfb.2010.11.024
conv_598 .

Krajišnik, Danina, Daković, Aleksandra, Milojević, Maja, Malenović, Anđelija, Kragović, Milan, Bajuk-Bogdanović, Danica, Dondur, Vera, Milić, Jela, "Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride" in Colloids and Surfaces B-Biointerfaces, 83, no. 1 (2011):165-172,
https://doi.org/10.1016/j.colsurfb.2010.11.024 .,
conv_598 .

TY  - JOUR
AU  - Krajišnik, Danina
AU  - Milojević, Maja
AU  - Malenović, Anđelija
AU  - Daković, Aleksandra
AU  - Ibrić, Svetlana
AU  - Savić, Snežana
AU  - Dondur, Vera
AU  - Matijašević, Srđan
AU  - Radulović, Aleksandra
AU  - Daniels, Rolf
AU  - Milić, Jela
PY  - 2010
UR  - https://ritnms.itnms.ac.rs/handle/123456789/171
AB  - Context: In this study an investigation of cationic surfactants-modified natural zeolites as drug formulation excipient was performed. Objective: The aim of this work was to carry out a study of the purified natural zeolitic tuff with high amount of clinoptilolite as a potential carrier for molecules of pharmaceutical interest. Materials and methods: Two cationic surfactants (benzalkonium chloride and hexadecyltrimethylammonium bromide) were used for modification of the zeolitic surface in two levels (equal to and twice as external cation-exchange capacity of the zeolitic tuff). Prepared samples were characterized by Fourier transform infrared spectroscopy, thermogravimetric, high-performance liquid chromatography analysis, and powder flow determination. Different surfactant/zeolite composites were used for additional investigation of three model drugs: diclofenac diethylamine, diclofenac sodium, and ibuprofen by means of adsorption isotherm measurements in aqueous solutions. Results: The modified zeolites with two levels of surfactant coverage within the short activation time were prepared. Determination of flow properties showed that modification of zeolitic surface reflected on powder flow characteristics. Investigation of the model drugs adsorption on the obtained composites revealed that a variation between adsorption levels was influenced by the surfactant type and the amount present at the surface of the composites. Discussion and conclusion: In vitro release profiles of the drugs from the zeolite-surfactant-drug composites revealed that sustained drug release could be attained over a period of 8 hours. The presented results for drug uptake by surfactant-zeolite composites and the afterward drug release demonstrated the potential use of investigated modified natural zeolite as excipients for advanced excipients in drug formulations.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Drug Development and Industrial Pharmacy
T1  - Cationic surfactants-modified natural zeolites: improvement of the excipients functionality
EP  - 1224
IS  - 10
SP  - 1215
VL  - 36
DO  - 10.3109/03639041003695121
UR  - conv_588
ER  - 

@article{
author = "Krajišnik, Danina and Milojević, Maja and Malenović, Anđelija and Daković, Aleksandra and Ibrić, Svetlana and Savić, Snežana and Dondur, Vera and Matijašević, Srđan and Radulović, Aleksandra and Daniels, Rolf and Milić, Jela",
year = "2010",
abstract = "Context: In this study an investigation of cationic surfactants-modified natural zeolites as drug formulation excipient was performed. Objective: The aim of this work was to carry out a study of the purified natural zeolitic tuff with high amount of clinoptilolite as a potential carrier for molecules of pharmaceutical interest. Materials and methods: Two cationic surfactants (benzalkonium chloride and hexadecyltrimethylammonium bromide) were used for modification of the zeolitic surface in two levels (equal to and twice as external cation-exchange capacity of the zeolitic tuff). Prepared samples were characterized by Fourier transform infrared spectroscopy, thermogravimetric, high-performance liquid chromatography analysis, and powder flow determination. Different surfactant/zeolite composites were used for additional investigation of three model drugs: diclofenac diethylamine, diclofenac sodium, and ibuprofen by means of adsorption isotherm measurements in aqueous solutions. Results: The modified zeolites with two levels of surfactant coverage within the short activation time were prepared. Determination of flow properties showed that modification of zeolitic surface reflected on powder flow characteristics. Investigation of the model drugs adsorption on the obtained composites revealed that a variation between adsorption levels was influenced by the surfactant type and the amount present at the surface of the composites. Discussion and conclusion: In vitro release profiles of the drugs from the zeolite-surfactant-drug composites revealed that sustained drug release could be attained over a period of 8 hours. The presented results for drug uptake by surfactant-zeolite composites and the afterward drug release demonstrated the potential use of investigated modified natural zeolite as excipients for advanced excipients in drug formulations.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Drug Development and Industrial Pharmacy",
title = "Cationic surfactants-modified natural zeolites: improvement of the excipients functionality",
pages = "1224-1215",
number = "10",
volume = "36",
doi = "10.3109/03639041003695121",
url = "conv_588"
}

Krajišnik, D., Milojević, M., Malenović, A., Daković, A., Ibrić, S., Savić, S., Dondur, V., Matijašević, S., Radulović, A., Daniels, R.,& Milić, J.. (2010). Cationic surfactants-modified natural zeolites: improvement of the excipients functionality. in Drug Development and Industrial Pharmacy
Taylor & Francis Ltd, Abingdon., 36(10), 1215-1224.
https://doi.org/10.3109/03639041003695121
conv_588

Krajišnik D, Milojević M, Malenović A, Daković A, Ibrić S, Savić S, Dondur V, Matijašević S, Radulović A, Daniels R, Milić J. Cationic surfactants-modified natural zeolites: improvement of the excipients functionality. in Drug Development and Industrial Pharmacy. 2010;36(10):1215-1224.
doi:10.3109/03639041003695121
conv_588 .

Krajišnik, Danina, Milojević, Maja, Malenović, Anđelija, Daković, Aleksandra, Ibrić, Svetlana, Savić, Snežana, Dondur, Vera, Matijašević, Srđan, Radulović, Aleksandra, Daniels, Rolf, Milić, Jela, "Cationic surfactants-modified natural zeolites: improvement of the excipients functionality" in Drug Development and Industrial Pharmacy, 36, no. 10 (2010):1215-1224,
https://doi.org/10.3109/03639041003695121 .,
conv_588 .