Inorganically modified diatomite as a potential prolonged-release drug carrier
Нема приказа
Аутори
Janićijević, JelenaKrajišnik, Danina
Calija, Bojan
Dobričić, Vladimir
Daković, Aleksandra
Krstić, Jugoslav
Marković, Marija
Milić, Jela
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Inorganic modification of diatomite was performed with the precipitation product of partially neutralized aluminum sulfate solution at three different mass ratios. The starting and the modified diatomites were characterized by SEM-EDS, FTIR, thermal analysis and zeta potential measurements and evaluated for drug loading capacity in adsorption batch experiments using diclofenac sodium (DS) as a model drug. In vitro drug release studies were performed in phosphate buffer pH 6.8 from comprimates containing: the drug adsorbed onto the selected modified diatomite sample (DAMD), physical mixture of the drug with the selected modified diatomite sample (PMDMD) and physical mixture of the drug with the starting diatomite (PMDD). In vivo acute toxicity testing of the modified diatomite samples was performed on mice. High adsorbent loading of the selected modified diatomite sample (similar to 250 mg/g in 2 h) enabled the preparation of comprimates containing adsorbed DS in the amount near to its ...therapeutic dose. Drug release studies demonstrated prolonged release of DS over a period of 8 h from both DAMD comprimates (18% after 8 h) and PMDMD comprimates (45% after 8 h). The release kinetics for DAMD and PMDMD comprimates fitted well with Korsmeyer-Peppas and Bhaskar models, indicating that the release mechanism was a combination of non-Fickian diffusion and ion exchange process.
Кључне речи:
Prolonged drug release / Inorganic modification / Diclofenac sodium / Diatomite / AdsorptionИзвор:
Materials Science & Engineering C-Materials for Biological Applications, 2014, 42, 412-420Издавач:
- Elsevier, Amsterdam
Финансирање / пројекти:
- Развој микро- и наносистема као носача за лекове са антиинфламаторним деловањем и метода за њихову карактеризацију (RS-MESTD-Technological Development (TD or TR)-34031)
- Порозни материјали на бази оксида у заштити животне средине од генотоксичних супстанци (RS-MESTD-Basic Research (BR or ON)-172018)
DOI: 10.1016/j.msec.2014.05.052
ISSN: 0928-4931
PubMed: 25063135
WoS: 000340687400052
Scopus: 2-s2.0-84902655546
Институција/група
Institut za tehnologiju nuklearnih i drugih mineralnih sirovinaTY - JOUR AU - Janićijević, Jelena AU - Krajišnik, Danina AU - Calija, Bojan AU - Dobričić, Vladimir AU - Daković, Aleksandra AU - Krstić, Jugoslav AU - Marković, Marija AU - Milić, Jela PY - 2014 UR - https://ritnms.itnms.ac.rs/handle/123456789/321 AB - Inorganic modification of diatomite was performed with the precipitation product of partially neutralized aluminum sulfate solution at three different mass ratios. The starting and the modified diatomites were characterized by SEM-EDS, FTIR, thermal analysis and zeta potential measurements and evaluated for drug loading capacity in adsorption batch experiments using diclofenac sodium (DS) as a model drug. In vitro drug release studies were performed in phosphate buffer pH 6.8 from comprimates containing: the drug adsorbed onto the selected modified diatomite sample (DAMD), physical mixture of the drug with the selected modified diatomite sample (PMDMD) and physical mixture of the drug with the starting diatomite (PMDD). In vivo acute toxicity testing of the modified diatomite samples was performed on mice. High adsorbent loading of the selected modified diatomite sample (similar to 250 mg/g in 2 h) enabled the preparation of comprimates containing adsorbed DS in the amount near to its therapeutic dose. Drug release studies demonstrated prolonged release of DS over a period of 8 h from both DAMD comprimates (18% after 8 h) and PMDMD comprimates (45% after 8 h). The release kinetics for DAMD and PMDMD comprimates fitted well with Korsmeyer-Peppas and Bhaskar models, indicating that the release mechanism was a combination of non-Fickian diffusion and ion exchange process. PB - Elsevier, Amsterdam T2 - Materials Science & Engineering C-Materials for Biological Applications T1 - Inorganically modified diatomite as a potential prolonged-release drug carrier EP - 420 SP - 412 VL - 42 DO - 10.1016/j.msec.2014.05.052 UR - conv_701 ER -
@article{ author = "Janićijević, Jelena and Krajišnik, Danina and Calija, Bojan and Dobričić, Vladimir and Daković, Aleksandra and Krstić, Jugoslav and Marković, Marija and Milić, Jela", year = "2014", abstract = "Inorganic modification of diatomite was performed with the precipitation product of partially neutralized aluminum sulfate solution at three different mass ratios. The starting and the modified diatomites were characterized by SEM-EDS, FTIR, thermal analysis and zeta potential measurements and evaluated for drug loading capacity in adsorption batch experiments using diclofenac sodium (DS) as a model drug. In vitro drug release studies were performed in phosphate buffer pH 6.8 from comprimates containing: the drug adsorbed onto the selected modified diatomite sample (DAMD), physical mixture of the drug with the selected modified diatomite sample (PMDMD) and physical mixture of the drug with the starting diatomite (PMDD). In vivo acute toxicity testing of the modified diatomite samples was performed on mice. High adsorbent loading of the selected modified diatomite sample (similar to 250 mg/g in 2 h) enabled the preparation of comprimates containing adsorbed DS in the amount near to its therapeutic dose. Drug release studies demonstrated prolonged release of DS over a period of 8 h from both DAMD comprimates (18% after 8 h) and PMDMD comprimates (45% after 8 h). The release kinetics for DAMD and PMDMD comprimates fitted well with Korsmeyer-Peppas and Bhaskar models, indicating that the release mechanism was a combination of non-Fickian diffusion and ion exchange process.", publisher = "Elsevier, Amsterdam", journal = "Materials Science & Engineering C-Materials for Biological Applications", title = "Inorganically modified diatomite as a potential prolonged-release drug carrier", pages = "420-412", volume = "42", doi = "10.1016/j.msec.2014.05.052", url = "conv_701" }
Janićijević, J., Krajišnik, D., Calija, B., Dobričić, V., Daković, A., Krstić, J., Marković, M.,& Milić, J.. (2014). Inorganically modified diatomite as a potential prolonged-release drug carrier. in Materials Science & Engineering C-Materials for Biological Applications Elsevier, Amsterdam., 42, 412-420. https://doi.org/10.1016/j.msec.2014.05.052 conv_701
Janićijević J, Krajišnik D, Calija B, Dobričić V, Daković A, Krstić J, Marković M, Milić J. Inorganically modified diatomite as a potential prolonged-release drug carrier. in Materials Science & Engineering C-Materials for Biological Applications. 2014;42:412-420. doi:10.1016/j.msec.2014.05.052 conv_701 .
Janićijević, Jelena, Krajišnik, Danina, Calija, Bojan, Dobričić, Vladimir, Daković, Aleksandra, Krstić, Jugoslav, Marković, Marija, Milić, Jela, "Inorganically modified diatomite as a potential prolonged-release drug carrier" in Materials Science & Engineering C-Materials for Biological Applications, 42 (2014):412-420, https://doi.org/10.1016/j.msec.2014.05.052 ., conv_701 .