Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel
Authors
Mišković-Stanković, VesnaJanković, Ana
Grujić, Svetlana
Matić-Bujagić, Ivana
Radojević, Vesna
Vukašinović-Sekulić, Maja
Kojić, Vesna
Đošić, Marija
Atanasković, Teodor
Article (Published version)
Metadata
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This study presents comparison of our recently formulated two compartmental model with General fractional derivative (GFD) and Korsmeyer-Peppas, Makoid-Banakar and Kopcha diffusion models. We have used our GFD
model to study the release of gentamicin in poly (vinylalcohol)/chitosan/gentamicin (PVA/CHI/Gent) hydrogel aimed for wound dressing in medical treatment of deep chronical wounds. The PVA/CHI/Gent hydrogel was prepared by physical cross linking of poly(vinyl alcohol)/chitosan dispersion using freezing-thawing method, and then was swollen for 48 h in gentamicin solution, at 37 °C. Different physico-chemical (FTIR, SEM), mechanical and biological (cytotoxicity, antibacterial activity) properties have been determined. The concentration of released gentamicin was determined
using a high-performance liquid chromatography (HPLC) coupled with mass spectrometry (MS). The ratio between concentration of released gentamicin and initial concentration of gentamicin in the hydrogel was monit...ored for the
prolonged time period in order to obtain gentamicin release profile. It was proven that our novel diffusion GFD model better fitted with experimental data, and enabled the determination of diffusion coefficient precisely for the entire time period.
Keywords:
drug release / diffusion / pharmacokinetics / cytotoxicity / antibacterial activity / mechanical propertiesSource:
Journal of the Serbian Chemical Society, 2024Publisher:
- Belgrade : Serbian Chemical Society
Funding / projects:
- info:eu-repo/grantAgreement/MESTD/inst-2020/20023/RS// (RS-MESTD-inst-2020-20023)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200135)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200287 (Innovation Center of the Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200287)
- „Twinning to excel materials engineering for medical devices ExcellMater“ grant no. 952033
- Transnational Network of cooperation for WIDESPREAD NCPs (EU-H2020-639034)
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Institution/Community
Institut za tehnologiju nuklearnih i drugih mineralnih sirovinaTY - JOUR AU - Mišković-Stanković, Vesna AU - Janković, Ana AU - Grujić, Svetlana AU - Matić-Bujagić, Ivana AU - Radojević, Vesna AU - Vukašinović-Sekulić, Maja AU - Kojić, Vesna AU - Đošić, Marija AU - Atanasković, Teodor PY - 2024 UR - https://ritnms.itnms.ac.rs/handle/123456789/1229 AB - This study presents comparison of our recently formulated two compartmental model with General fractional derivative (GFD) and Korsmeyer-Peppas, Makoid-Banakar and Kopcha diffusion models. We have used our GFD model to study the release of gentamicin in poly (vinylalcohol)/chitosan/gentamicin (PVA/CHI/Gent) hydrogel aimed for wound dressing in medical treatment of deep chronical wounds. The PVA/CHI/Gent hydrogel was prepared by physical cross linking of poly(vinyl alcohol)/chitosan dispersion using freezing-thawing method, and then was swollen for 48 h in gentamicin solution, at 37 °C. Different physico-chemical (FTIR, SEM), mechanical and biological (cytotoxicity, antibacterial activity) properties have been determined. The concentration of released gentamicin was determined using a high-performance liquid chromatography (HPLC) coupled with mass spectrometry (MS). The ratio between concentration of released gentamicin and initial concentration of gentamicin in the hydrogel was monitored for the prolonged time period in order to obtain gentamicin release profile. It was proven that our novel diffusion GFD model better fitted with experimental data, and enabled the determination of diffusion coefficient precisely for the entire time period. PB - Belgrade : Serbian Chemical Society T2 - Journal of the Serbian Chemical Society T1 - Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel DO - 10.2298/JSC231207010M ER -
@article{ author = "Mišković-Stanković, Vesna and Janković, Ana and Grujić, Svetlana and Matić-Bujagić, Ivana and Radojević, Vesna and Vukašinović-Sekulić, Maja and Kojić, Vesna and Đošić, Marija and Atanasković, Teodor", year = "2024", abstract = "This study presents comparison of our recently formulated two compartmental model with General fractional derivative (GFD) and Korsmeyer-Peppas, Makoid-Banakar and Kopcha diffusion models. We have used our GFD model to study the release of gentamicin in poly (vinylalcohol)/chitosan/gentamicin (PVA/CHI/Gent) hydrogel aimed for wound dressing in medical treatment of deep chronical wounds. The PVA/CHI/Gent hydrogel was prepared by physical cross linking of poly(vinyl alcohol)/chitosan dispersion using freezing-thawing method, and then was swollen for 48 h in gentamicin solution, at 37 °C. Different physico-chemical (FTIR, SEM), mechanical and biological (cytotoxicity, antibacterial activity) properties have been determined. The concentration of released gentamicin was determined using a high-performance liquid chromatography (HPLC) coupled with mass spectrometry (MS). The ratio between concentration of released gentamicin and initial concentration of gentamicin in the hydrogel was monitored for the prolonged time period in order to obtain gentamicin release profile. It was proven that our novel diffusion GFD model better fitted with experimental data, and enabled the determination of diffusion coefficient precisely for the entire time period.", publisher = "Belgrade : Serbian Chemical Society", journal = "Journal of the Serbian Chemical Society", title = "Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel", doi = "10.2298/JSC231207010M" }
Mišković-Stanković, V., Janković, A., Grujić, S., Matić-Bujagić, I., Radojević, V., Vukašinović-Sekulić, M., Kojić, V., Đošić, M.,& Atanasković, T.. (2024). Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel. in Journal of the Serbian Chemical Society Belgrade : Serbian Chemical Society.. https://doi.org/10.2298/JSC231207010M
Mišković-Stanković V, Janković A, Grujić S, Matić-Bujagić I, Radojević V, Vukašinović-Sekulić M, Kojić V, Đošić M, Atanasković T. Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel. in Journal of the Serbian Chemical Society. 2024;. doi:10.2298/JSC231207010M .
Mišković-Stanković, Vesna, Janković, Ana, Grujić, Svetlana, Matić-Bujagić, Ivana, Radojević, Vesna, Vukašinović-Sekulić, Maja, Kojić, Vesna, Đošić, Marija, Atanasković, Teodor, "Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel" in Journal of the Serbian Chemical Society (2024), https://doi.org/10.2298/JSC231207010M . .