Bone diseases and especially prevalent surgical procedures of total joint replacements in
aging population, cause the need for swift development of new biomaterials for bone tissue
implants. Nowadays, Ti implants are by far most commonly used in orthopedics, due to their
excellent mechanical properties and biocompatibility. Having in mind that biomaterials
should stimulate bone tissue regeneration while providing strong support, the Ti implant
surface requires modifications to facilitate improved osteointegration. In this work,
modification of the titanium surface was carried out by depositing novel composite
hydroxyapatite/chitosan/graphene (HAP/CS/Gr) and
hydroxyapatite/chitosan/graphene/gentamicin (HAP/CS/Gr/Gent) coatings. Deposition was
performed by single-step electrophoretic deposition (EPD) technique from aqueous
suspension at constant voltage on pure titanium plates. X-ray diffraction (XRD), Fourier
transform infrared spectroscopy (FT-IR) and field-emission scanning... electron microscopy
(FE-SEM) were used to characterize obtained composites and to explore the graphene
influence on the composites properties. The results of all performed analyses confirmed the
formation of new composite HAP/CS/Gr and HAP/CS/Gr /Gent coatings on Ti. Antibacterial
activity kinetics against Staphylococcus aureus and Escherichia coli was performed in order
to evaluate the antibacterial properties of obtained composites. HAP/CS/Gr/Gent coating
exhibited excellent antibacterial properties, justifying the gentamicin addition to composites.
Encouraging results for potential applications were obtained for cytotoxicity testing towards
MRC-5 and L929 cell lines. Good biocompatibility of composites was proven towards both
cell lines, with slightly more pronounced effect for human MRC-5 cell line. Summarizing the
obtained results it could be safe to state that HAP/CS/Gr/Gent composite represents a
prospective material for bone implant coating.
Source:
Eighteenth Young Researchers Conference – Materials Science and Engineering, 2019, 18-18
Publisher:
Belgrade : Institute of Technical Sciences of SASA
TY - CONF
AU - Stevanović, Milena
AU - Janković, Ana
AU - Đošić, Marija
AU - Vukašinović-Sekulić, Maja
AU - Kojić, Vesna
AU - Mišković-Stanković, Vesna
PY - 2019
UR - https://ritnms.itnms.ac.rs/handle/123456789/773
AB - Bone diseases and especially prevalent surgical procedures of total joint replacements in
aging population, cause the need for swift development of new biomaterials for bone tissue
implants. Nowadays, Ti implants are by far most commonly used in orthopedics, due to their
excellent mechanical properties and biocompatibility. Having in mind that biomaterials
should stimulate bone tissue regeneration while providing strong support, the Ti implant
surface requires modifications to facilitate improved osteointegration. In this work,
modification of the titanium surface was carried out by depositing novel composite
hydroxyapatite/chitosan/graphene (HAP/CS/Gr) and
hydroxyapatite/chitosan/graphene/gentamicin (HAP/CS/Gr/Gent) coatings. Deposition was
performed by single-step electrophoretic deposition (EPD) technique from aqueous
suspension at constant voltage on pure titanium plates. X-ray diffraction (XRD), Fourier
transform infrared spectroscopy (FT-IR) and field-emission scanning electron microscopy
(FE-SEM) were used to characterize obtained composites and to explore the graphene
influence on the composites properties. The results of all performed analyses confirmed the
formation of new composite HAP/CS/Gr and HAP/CS/Gr /Gent coatings on Ti. Antibacterial
activity kinetics against Staphylococcus aureus and Escherichia coli was performed in order
to evaluate the antibacterial properties of obtained composites. HAP/CS/Gr/Gent coating
exhibited excellent antibacterial properties, justifying the gentamicin addition to composites.
Encouraging results for potential applications were obtained for cytotoxicity testing towards
MRC-5 and L929 cell lines. Good biocompatibility of composites was proven towards both
cell lines, with slightly more pronounced effect for human MRC-5 cell line. Summarizing the
obtained results it could be safe to state that HAP/CS/Gr/Gent composite represents a
prospective material for bone implant coating.
PB - Belgrade : Institute of Technical Sciences of SASA
C3 - Eighteenth Young Researchers Conference – Materials Science and Engineering
T1 - Surface modification of Ti implants by electrophoretic deposition of hydroxyapatite/chitosan/graphene/gentamicin coating
EP - 18
SP - 18
ER -
@conference{
author = "Stevanović, Milena and Janković, Ana and Đošić, Marija and Vukašinović-Sekulić, Maja and Kojić, Vesna and Mišković-Stanković, Vesna",
year = "2019",
abstract = "Bone diseases and especially prevalent surgical procedures of total joint replacements in
aging population, cause the need for swift development of new biomaterials for bone tissue
implants. Nowadays, Ti implants are by far most commonly used in orthopedics, due to their
excellent mechanical properties and biocompatibility. Having in mind that biomaterials
should stimulate bone tissue regeneration while providing strong support, the Ti implant
surface requires modifications to facilitate improved osteointegration. In this work,
modification of the titanium surface was carried out by depositing novel composite
hydroxyapatite/chitosan/graphene (HAP/CS/Gr) and
hydroxyapatite/chitosan/graphene/gentamicin (HAP/CS/Gr/Gent) coatings. Deposition was
performed by single-step electrophoretic deposition (EPD) technique from aqueous
suspension at constant voltage on pure titanium plates. X-ray diffraction (XRD), Fourier
transform infrared spectroscopy (FT-IR) and field-emission scanning electron microscopy
(FE-SEM) were used to characterize obtained composites and to explore the graphene
influence on the composites properties. The results of all performed analyses confirmed the
formation of new composite HAP/CS/Gr and HAP/CS/Gr /Gent coatings on Ti. Antibacterial
activity kinetics against Staphylococcus aureus and Escherichia coli was performed in order
to evaluate the antibacterial properties of obtained composites. HAP/CS/Gr/Gent coating
exhibited excellent antibacterial properties, justifying the gentamicin addition to composites.
Encouraging results for potential applications were obtained for cytotoxicity testing towards
MRC-5 and L929 cell lines. Good biocompatibility of composites was proven towards both
cell lines, with slightly more pronounced effect for human MRC-5 cell line. Summarizing the
obtained results it could be safe to state that HAP/CS/Gr/Gent composite represents a
prospective material for bone implant coating.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Eighteenth Young Researchers Conference – Materials Science and Engineering",
title = "Surface modification of Ti implants by electrophoretic deposition of hydroxyapatite/chitosan/graphene/gentamicin coating",
pages = "18-18"
}
Stevanović, M., Janković, A., Đošić, M., Vukašinović-Sekulić, M., Kojić, V.,& Mišković-Stanković, V.. (2019). Surface modification of Ti implants by electrophoretic deposition of hydroxyapatite/chitosan/graphene/gentamicin coating. in Eighteenth Young Researchers Conference – Materials Science and Engineering
Belgrade : Institute of Technical Sciences of SASA., 18-18.
Stevanović M, Janković A, Đošić M, Vukašinović-Sekulić M, Kojić V, Mišković-Stanković V. Surface modification of Ti implants by electrophoretic deposition of hydroxyapatite/chitosan/graphene/gentamicin coating. in Eighteenth Young Researchers Conference – Materials Science and Engineering. 2019;:18-18..
Stevanović, Milena, Janković, Ana, Đošić, Marija, Vukašinović-Sekulić, Maja, Kojić, Vesna, Mišković-Stanković, Vesna, "Surface modification of Ti implants by electrophoretic deposition of hydroxyapatite/chitosan/graphene/gentamicin coating" in Eighteenth Young Researchers Conference – Materials Science and Engineering (2019):18-18.
