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Electrochemical composite bioceramic coatings based on hydroxyapatite, chitosan and polyvinyl alcohol loaded with gentamicin

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2021
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Authors
Jaćimović, Nevena
Đošić, Marija
Janković, Ana
Mišković-Stanković, Vesna
Contributors
Marković, Smilja
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Abstract
Composite bioceramic coatings have been attracting increasing attention of the scientific public in recent decades due to the good potential of their use for medical purposes. The main goal of this scientific research is to show the characterization of the obtained hydroxyapatite (HAP), chitosan (CS) and polyvinyl alcohol (PVA) bioceramic composite coatings loaded with gentamicin (Gent), on titanium (Ti) substrate using the single-step electrophoretic deposition process. Titanium, traditionally used for the purpose of replacing parts of damaged bone tissue, has shown good mechanical properties and biocompatibility through many years of orthopedic practice. Hydroxyapatite provided the HAP/CS/PVA/Gent composite coating with osteoinductivity, while the presence of chitosan and polyvinyl alcohol contributed to its adhesive and mild analgesic properties. The antibacterial agent gentamicin was added to the HAP/CS/PVA composite, which ensured its direct antibacterial effect at the ...implantation site. The coatings were deposited using the cathodic electrophoretic deposition process, with the Ti plate as the cathode, at a constant voltage of 7V, in the range of the deposition time from 5 to 12 min. To demonstrate the presumed bioactivity, HAP/CS/PVA/Gent coatings were immersed in simulated body fluid (SBF) at 37⁰C for periods of 7 and 14 days. Characterization of HAP/CS/PVA/Gent coatings after immersion was performed through employment of Fourier transform infrared spectroscopy (FTIR), Xray diffraction (XRD), and field emission scanning electron microscopy (SEM) techniques. Antibacterial activity was tested by agar diffusion method on two bacterial strains, Echerichia coli and Staphylococcus aureus with a positive response to both bacterial strains. The final conclusions of this research suggest a good potential for utilization of HAP/CS/PVA/Gent bioceramic composite coating, applied through electrophoretic deposition process on Ti substrate, for medical purposes in the replacement and healing of damaged bone tissue." "Composite bioceramic coatings have been attracting increasing attention of the scientific public in recent decades due to the good potential of their use for medical purposes. The main goal of this scientific research is to show the characterization of the obtained hydroxyapatite (HAP), chitosan (CS) and polyvinyl alcohol (PVA) bioceramic composite coatings loaded with gentamicin (Gent), on titanium (Ti) substrate using the single-step electrophoretic deposition process. Titanium, traditionally used for the purpose of replacing parts of damaged bone tissue, has shown good mechanical properties and biocompatibility through many years of orthopedic practice. Hydroxyapatite provided the HAP/CS/PVA/Gent composite coating with osteoinductivity, while the presence of chitosan and polyvinyl alcohol contributed to its adhesive and mild analgesic properties. The antibacterial agent gentamicin was added to the HAP/CS/PVA composite, which ensured its direct antibacterial effect at the implantation site. The coatings were deposited using the cathodic electrophoretic deposition process, with the Ti plate as the cathode, at a constant voltage of 7V, in the range of the deposition time from 5 to 12 min. To demonstrate the presumed bioactivity, HAP/CS/PVA/Gent coatings were immersed in simulated body fluid (SBF) at 37⁰C for periods of 7 and 14 days. Characterization of HAP/CS/PVA/Gent coatings after immersion was performed through employment of Fourier transform infrared spectroscopy (FTIR), Xray diffraction (XRD), and field emission scanning electron microscopy (SEM) techniques. Antibacterial activity was tested by agar diffusion method on two bacterial strains, Echerichia coli and Staphylococcus aureus with a positive response to both bacterial strains. The final conclusions of this research suggest a good potential for utilization of HAP/CS/PVA/Gent bioceramic composite coating, applied through electrophoretic deposition process on Ti substrate, for medical purposes in the replacement and healing of damaged bone tissue.

Source:
Nineteenth Young Researchers’ Conference - Materials Science and Engineering, 2021, 7-7
Publisher:
  • Belgrade : Institute of Technical Sciences of SASA
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-200135)
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200287 (Innovation Center of the Faculty of Technology and Metallurgy) (RS-200287)
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200023 (Institute of Technology of Nuclear and Other Mineral Row Materials - ITNMS, Belgrade) (RS-200023)

ISBN: 978-86-80321-36-3

[ Google Scholar ]
URI
https://ritnms.itnms.ac.rs/handle/123456789/756
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Institut za tehnologiju nuklearnih i drugih mineralnih sirovina
TY  - CONF
AU  - Jaćimović, Nevena
AU  - Đošić, Marija
AU  - Janković, Ana
AU  - Mišković-Stanković, Vesna
PY  - 2021
UR  - https://ritnms.itnms.ac.rs/handle/123456789/756
AB  - Composite bioceramic coatings have been attracting increasing attention of the scientific
public in recent decades due to the good potential of their use for medical purposes. The
main goal of this scientific research is to show the characterization of the obtained
hydroxyapatite (HAP), chitosan (CS) and polyvinyl alcohol (PVA) bioceramic composite
coatings loaded with gentamicin (Gent), on titanium (Ti) substrate using the single-step
electrophoretic deposition process. Titanium, traditionally used for the purpose of replacing
parts of damaged bone tissue, has shown good mechanical properties and biocompatibility
through many years of orthopedic practice. Hydroxyapatite provided the HAP/CS/PVA/Gent
composite coating with osteoinductivity, while the presence of chitosan and polyvinyl
alcohol contributed to its adhesive and mild analgesic properties. The antibacterial agent
gentamicin was added to the HAP/CS/PVA composite, which ensured its direct antibacterial
effect at the implantation site. The coatings were deposited using the cathodic electrophoretic
deposition process, with the Ti plate as the cathode, at a constant voltage of 7V, in the range
of the deposition time from 5 to 12 min. To demonstrate the presumed bioactivity,
HAP/CS/PVA/Gent coatings were immersed in simulated body fluid (SBF) at 37⁰C for
periods of 7 and 14 days. Characterization of HAP/CS/PVA/Gent coatings after immersion
was performed through employment of Fourier transform infrared spectroscopy (FTIR), Xray
diffraction (XRD), and field emission scanning electron microscopy (SEM) techniques.
Antibacterial activity was tested by agar diffusion method on two bacterial strains,
Echerichia coli and Staphylococcus aureus with a positive response to both bacterial strains.
The final conclusions of this research suggest a good potential for utilization of
HAP/CS/PVA/Gent bioceramic composite coating, applied through electrophoretic
deposition process on Ti substrate, for medical purposes in the replacement and healing of
damaged bone tissue."















"Composite bioceramic coatings have been attracting increasing attention of the scientific
public in recent decades due to the good potential of their use for medical purposes. The
main goal of this scientific research is to show the characterization of the obtained
hydroxyapatite (HAP), chitosan (CS) and polyvinyl alcohol (PVA) bioceramic composite
coatings loaded with gentamicin (Gent), on titanium (Ti) substrate using the single-step
electrophoretic deposition process. Titanium, traditionally used for the purpose of replacing
parts of damaged bone tissue, has shown good mechanical properties and biocompatibility
through many years of orthopedic practice. Hydroxyapatite provided the HAP/CS/PVA/Gent
composite coating with osteoinductivity, while the presence of chitosan and polyvinyl
alcohol contributed to its adhesive and mild analgesic properties. The antibacterial agent
gentamicin was added to the HAP/CS/PVA composite, which ensured its direct antibacterial
effect at the implantation site. The coatings were deposited using the cathodic electrophoretic
deposition process, with the Ti plate as the cathode, at a constant voltage of 7V, in the range
of the deposition time from 5 to 12 min. To demonstrate the presumed bioactivity,
HAP/CS/PVA/Gent coatings were immersed in simulated body fluid (SBF) at 37⁰C for
periods of 7 and 14 days. Characterization of HAP/CS/PVA/Gent coatings after immersion
was performed through employment of Fourier transform infrared spectroscopy (FTIR), Xray
diffraction (XRD), and field emission scanning electron microscopy (SEM) techniques.
Antibacterial activity was tested by agar diffusion method on two bacterial strains,
Echerichia coli and Staphylococcus aureus with a positive response to both bacterial strains.
The final conclusions of this research suggest a good potential for utilization of
HAP/CS/PVA/Gent bioceramic composite coating, applied through electrophoretic
deposition process on Ti substrate, for medical purposes in the replacement and healing of
damaged bone tissue.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Nineteenth Young Researchers’ Conference - Materials Science and Engineering
T1  - Electrochemical composite bioceramic coatings based on hydroxyapatite, chitosan and polyvinyl alcohol loaded with gentamicin
EP  - 7
SP  - 7
ER  - 
@conference{
author = "Jaćimović, Nevena and Đošić, Marija and Janković, Ana and Mišković-Stanković, Vesna",
year = "2021",
abstract = "Composite bioceramic coatings have been attracting increasing attention of the scientific
public in recent decades due to the good potential of their use for medical purposes. The
main goal of this scientific research is to show the characterization of the obtained
hydroxyapatite (HAP), chitosan (CS) and polyvinyl alcohol (PVA) bioceramic composite
coatings loaded with gentamicin (Gent), on titanium (Ti) substrate using the single-step
electrophoretic deposition process. Titanium, traditionally used for the purpose of replacing
parts of damaged bone tissue, has shown good mechanical properties and biocompatibility
through many years of orthopedic practice. Hydroxyapatite provided the HAP/CS/PVA/Gent
composite coating with osteoinductivity, while the presence of chitosan and polyvinyl
alcohol contributed to its adhesive and mild analgesic properties. The antibacterial agent
gentamicin was added to the HAP/CS/PVA composite, which ensured its direct antibacterial
effect at the implantation site. The coatings were deposited using the cathodic electrophoretic
deposition process, with the Ti plate as the cathode, at a constant voltage of 7V, in the range
of the deposition time from 5 to 12 min. To demonstrate the presumed bioactivity,
HAP/CS/PVA/Gent coatings were immersed in simulated body fluid (SBF) at 37⁰C for
periods of 7 and 14 days. Characterization of HAP/CS/PVA/Gent coatings after immersion
was performed through employment of Fourier transform infrared spectroscopy (FTIR), Xray
diffraction (XRD), and field emission scanning electron microscopy (SEM) techniques.
Antibacterial activity was tested by agar diffusion method on two bacterial strains,
Echerichia coli and Staphylococcus aureus with a positive response to both bacterial strains.
The final conclusions of this research suggest a good potential for utilization of
HAP/CS/PVA/Gent bioceramic composite coating, applied through electrophoretic
deposition process on Ti substrate, for medical purposes in the replacement and healing of
damaged bone tissue."















"Composite bioceramic coatings have been attracting increasing attention of the scientific
public in recent decades due to the good potential of their use for medical purposes. The
main goal of this scientific research is to show the characterization of the obtained
hydroxyapatite (HAP), chitosan (CS) and polyvinyl alcohol (PVA) bioceramic composite
coatings loaded with gentamicin (Gent), on titanium (Ti) substrate using the single-step
electrophoretic deposition process. Titanium, traditionally used for the purpose of replacing
parts of damaged bone tissue, has shown good mechanical properties and biocompatibility
through many years of orthopedic practice. Hydroxyapatite provided the HAP/CS/PVA/Gent
composite coating with osteoinductivity, while the presence of chitosan and polyvinyl
alcohol contributed to its adhesive and mild analgesic properties. The antibacterial agent
gentamicin was added to the HAP/CS/PVA composite, which ensured its direct antibacterial
effect at the implantation site. The coatings were deposited using the cathodic electrophoretic
deposition process, with the Ti plate as the cathode, at a constant voltage of 7V, in the range
of the deposition time from 5 to 12 min. To demonstrate the presumed bioactivity,
HAP/CS/PVA/Gent coatings were immersed in simulated body fluid (SBF) at 37⁰C for
periods of 7 and 14 days. Characterization of HAP/CS/PVA/Gent coatings after immersion
was performed through employment of Fourier transform infrared spectroscopy (FTIR), Xray
diffraction (XRD), and field emission scanning electron microscopy (SEM) techniques.
Antibacterial activity was tested by agar diffusion method on two bacterial strains,
Echerichia coli and Staphylococcus aureus with a positive response to both bacterial strains.
The final conclusions of this research suggest a good potential for utilization of
HAP/CS/PVA/Gent bioceramic composite coating, applied through electrophoretic
deposition process on Ti substrate, for medical purposes in the replacement and healing of
damaged bone tissue.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Nineteenth Young Researchers’ Conference - Materials Science and Engineering",
title = "Electrochemical composite bioceramic coatings based on hydroxyapatite, chitosan and polyvinyl alcohol loaded with gentamicin",
pages = "7-7"
}
Jaćimović, N., Đošić, M., Janković, A.,& Mišković-Stanković, V.. (2021). Electrochemical composite bioceramic coatings based on hydroxyapatite, chitosan and polyvinyl alcohol loaded with gentamicin. in Nineteenth Young Researchers’ Conference - Materials Science and Engineering
Belgrade : Institute of Technical Sciences of SASA., 7-7.
Jaćimović N, Đošić M, Janković A, Mišković-Stanković V. Electrochemical composite bioceramic coatings based on hydroxyapatite, chitosan and polyvinyl alcohol loaded with gentamicin. in Nineteenth Young Researchers’ Conference - Materials Science and Engineering. 2021;:7-7..
Jaćimović, Nevena, Đošić, Marija, Janković, Ana, Mišković-Stanković, Vesna, "Electrochemical composite bioceramic coatings based on hydroxyapatite, chitosan and polyvinyl alcohol loaded with gentamicin" in Nineteenth Young Researchers’ Conference - Materials Science and Engineering (2021):7-7.

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