Elektroforetski taložene kompozitne prevlake kao nosaci lekova / Electrophoretically deposited composite coatings as drug carriers
Authors
Janković, Ana
Đošić, Marija

Jaćimović, Nevena
Kojić, Vesna

Mišković-Stanković, Vesna

Contributors
Šolaja, BogdanConference object (Published version)

Metadata
Show full item recordAbstract
Metoda elektroforetskog taloženja (EPD)se koristi za sintezu biokompatibilnih
kompozitnih materijala za medicinsku primenu kao antibakterijske prevlake za koštane
implantate. Taloženjem pri konstantnom naponu je uspešno dobijena kompozitna prevlaka
hidroksiapatit/hitozan/poli(vinilalkohol) (HAP/CS/PVA) koja sadrži gentamicin (Gent).
Bioaktivnost prevlake je dokazana formiranjem novonastalog apatitnog sloja u simuliranoj
telesnoj tecnosti i karakterisana primenom skenirajuce elektronske mikroskopije (SEM) I
infracrvene spektroskopije sa Furijeovom transformacijom (FTIR). Sposobnost
oseointegracije dalje je potvr ena merenjem aktivnosti alkalne fosfataze (ALP), što
ukazuje na povoljna oseopromotivna svojstva taloženih prevlaka. Kada su testirane
humane i mišje fibroblastne celijske linije (MRC-5 i L929), kompozitne prevlake nisu
pokazale citotoksicni efekat
The electrophoretic deposition (EPD) method isused for the synthesis of biocompatible
composite materials for medical use as antibacterial coatings for bone implants. Deposition
at the constant voltage yielded composite coating hydroxyapatite/chitosan/poly(vinyl
alcohol)(HAP/CS/PVA) loaded with gentamicin (Gent). Bioactivity of the coating was
proved by a newly formed apatite layer in simulated body fluid and characterized
usingscanning electron microscopy (SEM) and Fourier transform infrared spectroscopy
(FTIR). The osseointegration ability was validated by measuring the alkaline phosphatase
activity (ALP) indicating the favorable osseopromotive properties of deposited coatings.
When tested against human and mice fibroblast cells lines (MRC-5 and L929), composite
coatings did not exhibit cytotoxic effect.
Source:
58. Savetovanje Srpskog hemijskog društva, 2022, 72-72Publisher:
- Belgrade : Serbian Chemical Society
Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-200135)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200287 (Innovation Center of the Faculty of Technology and Metallurgy) (RS-200287)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200023 (Institute of Technology of Nuclear and Other Mineral Row Materials - ITNMS, Belgrade) (RS-200023)
Collections
Institution/Community
Institut za tehnologiju nuklearnih i drugih mineralnih sirovinaTY - CONF AU - Janković, Ana AU - Đošić, Marija AU - Jaćimović, Nevena AU - Kojić, Vesna AU - Mišković-Stanković, Vesna PY - 2022 UR - https://ritnms.itnms.ac.rs/handle/123456789/754 AB - Metoda elektroforetskog taloženja (EPD)se koristi za sintezu biokompatibilnih kompozitnih materijala za medicinsku primenu kao antibakterijske prevlake za koštane implantate. Taloženjem pri konstantnom naponu je uspešno dobijena kompozitna prevlaka hidroksiapatit/hitozan/poli(vinilalkohol) (HAP/CS/PVA) koja sadrži gentamicin (Gent). Bioaktivnost prevlake je dokazana formiranjem novonastalog apatitnog sloja u simuliranoj telesnoj tecnosti i karakterisana primenom skenirajuce elektronske mikroskopije (SEM) I infracrvene spektroskopije sa Furijeovom transformacijom (FTIR). Sposobnost oseointegracije dalje je potvr ena merenjem aktivnosti alkalne fosfataze (ALP), što ukazuje na povoljna oseopromotivna svojstva taloženih prevlaka. Kada su testirane humane i mišje fibroblastne celijske linije (MRC-5 i L929), kompozitne prevlake nisu pokazale citotoksicni efekat AB - The electrophoretic deposition (EPD) method isused for the synthesis of biocompatible composite materials for medical use as antibacterial coatings for bone implants. Deposition at the constant voltage yielded composite coating hydroxyapatite/chitosan/poly(vinyl alcohol)(HAP/CS/PVA) loaded with gentamicin (Gent). Bioactivity of the coating was proved by a newly formed apatite layer in simulated body fluid and characterized usingscanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The osseointegration ability was validated by measuring the alkaline phosphatase activity (ALP) indicating the favorable osseopromotive properties of deposited coatings. When tested against human and mice fibroblast cells lines (MRC-5 and L929), composite coatings did not exhibit cytotoxic effect. PB - Belgrade : Serbian Chemical Society C3 - 58. Savetovanje Srpskog hemijskog društva T1 - Elektroforetski taložene kompozitne prevlake kao nosaci lekova / Electrophoretically deposited composite coatings as drug carriers EP - 72 SP - 72 ER -
@conference{ author = "Janković, Ana and Đošić, Marija and Jaćimović, Nevena and Kojić, Vesna and Mišković-Stanković, Vesna", year = "2022", abstract = "Metoda elektroforetskog taloženja (EPD)se koristi za sintezu biokompatibilnih kompozitnih materijala za medicinsku primenu kao antibakterijske prevlake za koštane implantate. Taloženjem pri konstantnom naponu je uspešno dobijena kompozitna prevlaka hidroksiapatit/hitozan/poli(vinilalkohol) (HAP/CS/PVA) koja sadrži gentamicin (Gent). Bioaktivnost prevlake je dokazana formiranjem novonastalog apatitnog sloja u simuliranoj telesnoj tecnosti i karakterisana primenom skenirajuce elektronske mikroskopije (SEM) I infracrvene spektroskopije sa Furijeovom transformacijom (FTIR). Sposobnost oseointegracije dalje je potvr ena merenjem aktivnosti alkalne fosfataze (ALP), što ukazuje na povoljna oseopromotivna svojstva taloženih prevlaka. Kada su testirane humane i mišje fibroblastne celijske linije (MRC-5 i L929), kompozitne prevlake nisu pokazale citotoksicni efekat, The electrophoretic deposition (EPD) method isused for the synthesis of biocompatible composite materials for medical use as antibacterial coatings for bone implants. Deposition at the constant voltage yielded composite coating hydroxyapatite/chitosan/poly(vinyl alcohol)(HAP/CS/PVA) loaded with gentamicin (Gent). Bioactivity of the coating was proved by a newly formed apatite layer in simulated body fluid and characterized usingscanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The osseointegration ability was validated by measuring the alkaline phosphatase activity (ALP) indicating the favorable osseopromotive properties of deposited coatings. When tested against human and mice fibroblast cells lines (MRC-5 and L929), composite coatings did not exhibit cytotoxic effect.", publisher = "Belgrade : Serbian Chemical Society", journal = "58. Savetovanje Srpskog hemijskog društva", title = "Elektroforetski taložene kompozitne prevlake kao nosaci lekova / Electrophoretically deposited composite coatings as drug carriers", pages = "72-72" }
Janković, A., Đošić, M., Jaćimović, N., Kojić, V.,& Mišković-Stanković, V.. (2022). Elektroforetski taložene kompozitne prevlake kao nosaci lekova / Electrophoretically deposited composite coatings as drug carriers. in 58. Savetovanje Srpskog hemijskog društva Belgrade : Serbian Chemical Society., 72-72.
Janković A, Đošić M, Jaćimović N, Kojić V, Mišković-Stanković V. Elektroforetski taložene kompozitne prevlake kao nosaci lekova / Electrophoretically deposited composite coatings as drug carriers. in 58. Savetovanje Srpskog hemijskog društva. 2022;:72-72..
Janković, Ana, Đošić, Marija, Jaćimović, Nevena, Kojić, Vesna, Mišković-Stanković, Vesna, "Elektroforetski taložene kompozitne prevlake kao nosaci lekova / Electrophoretically deposited composite coatings as drug carriers" in 58. Savetovanje Srpskog hemijskog društva (2022):72-72.