Bioactive antibiotic-eluting hydroxyapatite-based coatings obtained by electrophoretic deposition on titanium

Janković, Ana; Đošić, Marija; Mišković-Stanković, Vesna

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Abstract

Titanium surface was modified by applying new composite, biocompatible, and bioactive hydroxyapatite/chitosan coatings with and without gentamicin using the electrophoretic deposition technique (HAP/CS, HAP/CS/Gent, HAP/CS/Gr, and HAP/CS/Gr/Gent). HAP/CS/Gent and HAP/CS/Gr/Gent coatings presented strong activity against both bacterial strains tested and even noticeably more against S. aureus, while their counterparts without the antibiotic did not exhibit antibacterial properties. The rapid and strong antibacterial effect monitored during the first 24 h coincides well with the initial burst effect of gentamicin observed on the cumulative release profiles. Presented results are a solid confirmation that bioceramic HAP/CS/Gent and HAP/CS/Gr/Gent composite coatings electrodeposited on Ti are promising biomaterials for further investigation and potential biomedical application as orthopedic and dental implants

Keywords:

biomaterial / electrophoretic deposition / antibacterial activity / bioactivity

Source:
3rd BIENNIAL CONFERENCE BIOMATERIALS AND NOVEL TECHNOLOGIES FOR HEALTHCARE - BIOMAH 2022, 2022, 216-218

Publisher:

Roma : Consiglio Nazionale delle Ricerche Istituto di Struttura della Materia

Funding / projects:

European Union’s Horizon 2020 research and innovation program under grant agreement No. 952033.
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200287 (Innovation Center of the Faculty of Technology and Metallurgy) (RS-200287)
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200023 (Institute of Technology of Nuclear and Other Mineral Row Materials - ITNMS, Belgrade) (RS-200023)

ISBN: 978 88 8080 500 7

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URI

https://ritnms.itnms.ac.rs/handle/123456789/751

Collections

Radovi istraživača / Researchers’ publications

Institution/Community

Institut za tehnologiju nuklearnih i drugih mineralnih sirovina

TY  - CONF
AU  - Janković, Ana
AU  - Đošić, Marija
AU  - Mišković-Stanković, Vesna
PY  - 2022
UR  - https://ritnms.itnms.ac.rs/handle/123456789/751
AB  - Titanium surface was modified by applying new composite, biocompatible, and bioactive hydroxyapatite/chitosan coatings with and without gentamicin using the electrophoretic deposition technique (HAP/CS, HAP/CS/Gent, HAP/CS/Gr, and HAP/CS/Gr/Gent). HAP/CS/Gent and HAP/CS/Gr/Gent coatings presented strong activity against both bacterial strains tested and even noticeably more against S. aureus, while their counterparts without the antibiotic did not exhibit antibacterial properties. The rapid and strong antibacterial effect monitored during the first 24 h coincides well with the initial burst effect of gentamicin observed on the cumulative release profiles. Presented results are a solid confirmation that bioceramic HAP/CS/Gent and HAP/CS/Gr/Gent composite coatings electrodeposited on Ti are promising biomaterials for further investigation and potential biomedical application as orthopedic and dental implants
PB  - Roma : Consiglio Nazionale delle Ricerche Istituto di Struttura della Materia
C3  - 3rd  BIENNIAL  CONFERENCE BIOMATERIALS AND NOVEL TECHNOLOGIES FOR HEALTHCARE - BIOMAH 2022
T1  - Bioactive antibiotic-eluting hydroxyapatite-based coatings obtained by electrophoretic deposition on titanium
EP  - 218
SP  - 216
ER  -

@conference{
author = "Janković, Ana and Đošić, Marija and Mišković-Stanković, Vesna",
year = "2022",
abstract = "Titanium surface was modified by applying new composite, biocompatible, and bioactive hydroxyapatite/chitosan coatings with and without gentamicin using the electrophoretic deposition technique (HAP/CS, HAP/CS/Gent, HAP/CS/Gr, and HAP/CS/Gr/Gent). HAP/CS/Gent and HAP/CS/Gr/Gent coatings presented strong activity against both bacterial strains tested and even noticeably more against S. aureus, while their counterparts without the antibiotic did not exhibit antibacterial properties. The rapid and strong antibacterial effect monitored during the first 24 h coincides well with the initial burst effect of gentamicin observed on the cumulative release profiles. Presented results are a solid confirmation that bioceramic HAP/CS/Gent and HAP/CS/Gr/Gent composite coatings electrodeposited on Ti are promising biomaterials for further investigation and potential biomedical application as orthopedic and dental implants",
publisher = "Roma : Consiglio Nazionale delle Ricerche Istituto di Struttura della Materia",
journal = "3rd  BIENNIAL  CONFERENCE BIOMATERIALS AND NOVEL TECHNOLOGIES FOR HEALTHCARE - BIOMAH 2022",
title = "Bioactive antibiotic-eluting hydroxyapatite-based coatings obtained by electrophoretic deposition on titanium",
pages = "218-216"
}

Janković, A., Đošić, M.,& Mišković-Stanković, V.. (2022). Bioactive antibiotic-eluting hydroxyapatite-based coatings obtained by electrophoretic deposition on titanium. in 3rd  BIENNIAL  CONFERENCE BIOMATERIALS AND NOVEL TECHNOLOGIES FOR HEALTHCARE - BIOMAH 2022
Roma : Consiglio Nazionale delle Ricerche Istituto di Struttura della Materia., 216-218.

Janković A, Đošić M, Mišković-Stanković V. Bioactive antibiotic-eluting hydroxyapatite-based coatings obtained by electrophoretic deposition on titanium. in 3rd  BIENNIAL  CONFERENCE BIOMATERIALS AND NOVEL TECHNOLOGIES FOR HEALTHCARE - BIOMAH 2022. 2022;:216-218..

Janković, Ana, Đošić, Marija, Mišković-Stanković, Vesna, "Bioactive antibiotic-eluting hydroxyapatite-based coatings obtained by electrophoretic deposition on titanium" in 3rd  BIENNIAL  CONFERENCE BIOMATERIALS AND NOVEL TECHNOLOGIES FOR HEALTHCARE - BIOMAH 2022 (2022):216-218.