Bioaktivne kompozitne prevlake na bazi hidroksiapatita na titanu za primene u ortopediji / Bioactive hydroxyapatite-based composite coatings on titanium for orthopedic applications

Stevanović, Milena; Đošić, Marija; Janković, Ana; Kojić, Vesna; Mišković-Stanković, Vesna

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Abstract

Kompozitna prevlaka hidroksiapatita (HAP) sa prirodnim polimerima hitozanom (CS) i polivinil-alkoholom (PVA), kao i sa antibiotikom gentamicinom (Gent) je elektroforetski taložena na titanu, pri konstantnom naponu. Formiranje nove kompozitne HAP/PVA/CS/Gent prevlake je potvrđeno infracrvenom spektroskopijom sa Furijeovom transformacijom. Necitotoksični efekat istaložene HAP/PVA/CS/Gent prevlake je dokazan MTT testom prema dve ćelijske linije (MRC-5 i L929). Sposobnost HAP/PVA/CS/Gent prevlake da indukuje i promoviše osteointegraciju je pokazana ALP testom.

Composite coating of hydroxyapatite (HAP) with natural polymers chitosan (CS) and poly(vinyl alcohol) (PVA) with the antibiotic gentamicin (Gent) was electrophoretically deposited on titanium from an aqueous suspension, at a constant voltage. Formation of a new composite HAP/PVA/CS/Gent coating was confirmed by Fourier transform infrared spectroscopy. Non-cytotoxicity of deposited HAP/PVA/CS/Gent coating was demonstrated by MTT assay towards two types of cell lines (MRC-5 and L929). HAP/PVA/CS/Gent coating ability to induce and promote the osseointegration process was proved by the ALP assay.

Source:
59. Savetovanje Srpskog hemijskog društva, 2023, 64-64

Publisher:

Belgrade : Serbian Chemical Society

Funding / projects:

Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200287 (Innovation Center of the Faculty of Technology and Metallurgy) (RS-200287)
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200023 (Institute of Technology of Nuclear and Other Mineral Row Materials - ITNMS, Belgrade) (RS-200023)
European Union’s Horizon 2020 research and innovation program under grant agreement No. 952033.

ISBN: 978-86-7132-081-8

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URI

https://ritnms.itnms.ac.rs/handle/123456789/750

Collections

Radovi istraživača / Researchers’ publications

Institution/Community

Institut za tehnologiju nuklearnih i drugih mineralnih sirovina

TY - CONF
AU - Stevanović, Milena
AU - Đošić, Marija
AU - Janković, Ana
AU - Kojić, Vesna
AU - Mišković-Stanković, Vesna
PY - 2023
UR - https://ritnms.itnms.ac.rs/handle/123456789/750
AB - Kompozitna prevlaka hidroksiapatita (HAP) sa prirodnim polimerima hitozanom (CS) i polivinil-alkoholom (PVA), kao i sa antibiotikom gentamicinom (Gent) je elektroforetski taložena na titanu, pri konstantnom naponu. Formiranje nove kompozitne HAP/PVA/CS/Gent prevlake je potvrđeno infracrvenom spektroskopijom sa Furijeovom transformacijom. Necitotoksični efekat istaložene HAP/PVA/CS/Gent prevlake je dokazan MTT testom prema dve ćelijske linije (MRC-5 i L929). Sposobnost HAP/PVA/CS/Gent prevlake da indukuje i promoviše osteointegraciju je pokazana ALP testom.
AB - Composite coating of hydroxyapatite (HAP) with natural polymers chitosan (CS) and poly(vinyl alcohol) (PVA) with the antibiotic gentamicin (Gent) was electrophoretically deposited on titanium from an aqueous suspension, at a constant voltage. Formation of a new composite HAP/PVA/CS/Gent coating was confirmed by Fourier transform infrared spectroscopy. Non-cytotoxicity of deposited HAP/PVA/CS/Gent coating was demonstrated by MTT assay towards two types of cell lines (MRC-5 and L929). HAP/PVA/CS/Gent coating ability to induce and promote the osseointegration process was proved by the ALP assay.
PB - Belgrade : Serbian Chemical Society
C3 - 59. Savetovanje Srpskog hemijskog društva
T1 - Bioaktivne kompozitne prevlake na bazi hidroksiapatita na titanu za primene u ortopediji / Bioactive hydroxyapatite-based composite coatings on titanium for orthopedic applications
EP - 64
SP - 64
ER -

@conference{
author = "Stevanović, Milena and Đošić, Marija and Janković, Ana and Kojić, Vesna and Mišković-Stanković, Vesna",
year = "2023",
abstract = "Kompozitna prevlaka hidroksiapatita (HAP) sa prirodnim polimerima hitozanom (CS) i polivinil-alkoholom (PVA), kao i sa antibiotikom gentamicinom (Gent) je elektroforetski taložena na titanu, pri konstantnom naponu. Formiranje nove kompozitne HAP/PVA/CS/Gent prevlake je potvrđeno infracrvenom spektroskopijom sa Furijeovom transformacijom. Necitotoksični efekat istaložene HAP/PVA/CS/Gent prevlake je dokazan MTT testom prema dve ćelijske linije (MRC-5 i L929). Sposobnost HAP/PVA/CS/Gent prevlake da indukuje i promoviše osteointegraciju je pokazana ALP testom., Composite coating of hydroxyapatite (HAP) with natural polymers chitosan (CS) and poly(vinyl alcohol) (PVA) with the antibiotic gentamicin (Gent) was electrophoretically deposited on titanium from an aqueous suspension, at a constant voltage. Formation of a new composite HAP/PVA/CS/Gent coating was confirmed by Fourier transform infrared spectroscopy. Non-cytotoxicity of deposited HAP/PVA/CS/Gent coating was demonstrated by MTT assay towards two types of cell lines (MRC-5 and L929). HAP/PVA/CS/Gent coating ability to induce and promote the osseointegration process was proved by the ALP assay.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "59. Savetovanje Srpskog hemijskog društva",
title = "Bioaktivne kompozitne prevlake na bazi hidroksiapatita na titanu za primene u ortopediji / Bioactive hydroxyapatite-based composite coatings on titanium for orthopedic applications",
pages = "64-64"
}

Stevanović, M., Đošić, M., Janković, A., Kojić, V.,& Mišković-Stanković, V.. (2023). Bioaktivne kompozitne prevlake na bazi hidroksiapatita na titanu za primene u ortopediji / Bioactive hydroxyapatite-based composite coatings on titanium for orthopedic applications. in 59. Savetovanje Srpskog hemijskog društva
Belgrade : Serbian Chemical Society., 64-64.

Stevanović M, Đošić M, Janković A, Kojić V, Mišković-Stanković V. Bioaktivne kompozitne prevlake na bazi hidroksiapatita na titanu za primene u ortopediji / Bioactive hydroxyapatite-based composite coatings on titanium for orthopedic applications. in 59. Savetovanje Srpskog hemijskog društva. 2023;:64-64..

Stevanović, Milena, Đošić, Marija, Janković, Ana, Kojić, Vesna, Mišković-Stanković, Vesna, "Bioaktivne kompozitne prevlake na bazi hidroksiapatita na titanu za primene u ortopediji / Bioactive hydroxyapatite-based composite coatings on titanium for orthopedic applications" in 59. Savetovanje Srpskog hemijskog društva (2023):64-64.