An investigation of ibuprofen release from a clinoptilolitic zeolitic tuff modified with cationic surfactant
Autori
Krajišnik, DaninaČalija, Bojan
Djekić, Ljiljana
Dobričić, Vladimir
Daković, Aleksandra
Ostala autorstva
Rakić, VesnaHrenović, Jasna
Ristić, Alenka
Konferencijski prilog (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The biopharmaceutical performance of ibuprofen – surfactant modified zeolitic tuff
composites prepared in a one-step preparation procedure was evaluated by in vitro drug
release experiments. Furthermore, to reveal stability upon desorption, the release of surfactant
was also investigated. Results showed that the prolonged ibuprofen release from the tested
composites was achieved over a period of 8 h. The analysis of the drug release profiles
indicated to a combination of drug diffusion and ion-exchange as predominant release
mechanisms. A negligible surfactant desorption demonstrated during release testing alongside
with non-toxic nature of these materials may encourages further researches of these
functionalized mineral materials as prospective excipients for pharmaceutical application.
Ključne reči:
clinoptilolitic zeolitic tuff / cationic surfactant / ibuprofen / release / mathematical modellingIzvor:
8th Serbian-Croatian-Slovenian Symposium on Zeolites, 2019, 126-129Izdavač:
- Serbian Zeolite Association
Finansiranje / projekti:
- Razvoj mikro- i nanosistema kao nosača za lekove sa antiinflamatornim delovanjem i metoda za njihovu karakterizaciju (RS-MESTD-Technological Development (TD or TR)-34031)
- Porozni materijali na bazi oksida u zaštiti životne sredine od genotoksičnih supstanci (RS-MESTD-Basic Research (BR or ON)-172018)
Institucija/grupa
Institut za tehnologiju nuklearnih i drugih mineralnih sirovinaTY - CONF AU - Krajišnik, Danina AU - Čalija, Bojan AU - Djekić, Ljiljana AU - Dobričić, Vladimir AU - Daković, Aleksandra PY - 2019 UR - https://ritnms.itnms.ac.rs/handle/123456789/738 AB - The biopharmaceutical performance of ibuprofen – surfactant modified zeolitic tuff composites prepared in a one-step preparation procedure was evaluated by in vitro drug release experiments. Furthermore, to reveal stability upon desorption, the release of surfactant was also investigated. Results showed that the prolonged ibuprofen release from the tested composites was achieved over a period of 8 h. The analysis of the drug release profiles indicated to a combination of drug diffusion and ion-exchange as predominant release mechanisms. A negligible surfactant desorption demonstrated during release testing alongside with non-toxic nature of these materials may encourages further researches of these functionalized mineral materials as prospective excipients for pharmaceutical application. PB - Serbian Zeolite Association C3 - 8th Serbian-Croatian-Slovenian Symposium on Zeolites T1 - An investigation of ibuprofen release from a clinoptilolitic zeolitic tuff modified with cationic surfactant EP - 129 SP - 126 ER -
@conference{ author = "Krajišnik, Danina and Čalija, Bojan and Djekić, Ljiljana and Dobričić, Vladimir and Daković, Aleksandra", year = "2019", abstract = "The biopharmaceutical performance of ibuprofen – surfactant modified zeolitic tuff composites prepared in a one-step preparation procedure was evaluated by in vitro drug release experiments. Furthermore, to reveal stability upon desorption, the release of surfactant was also investigated. Results showed that the prolonged ibuprofen release from the tested composites was achieved over a period of 8 h. The analysis of the drug release profiles indicated to a combination of drug diffusion and ion-exchange as predominant release mechanisms. A negligible surfactant desorption demonstrated during release testing alongside with non-toxic nature of these materials may encourages further researches of these functionalized mineral materials as prospective excipients for pharmaceutical application.", publisher = "Serbian Zeolite Association", journal = "8th Serbian-Croatian-Slovenian Symposium on Zeolites", title = "An investigation of ibuprofen release from a clinoptilolitic zeolitic tuff modified with cationic surfactant", pages = "129-126" }
Krajišnik, D., Čalija, B., Djekić, L., Dobričić, V.,& Daković, A.. (2019). An investigation of ibuprofen release from a clinoptilolitic zeolitic tuff modified with cationic surfactant. in 8th Serbian-Croatian-Slovenian Symposium on Zeolites Serbian Zeolite Association., 126-129.
Krajišnik D, Čalija B, Djekić L, Dobričić V, Daković A. An investigation of ibuprofen release from a clinoptilolitic zeolitic tuff modified with cationic surfactant. in 8th Serbian-Croatian-Slovenian Symposium on Zeolites. 2019;:126-129..
Krajišnik, Danina, Čalija, Bojan, Djekić, Ljiljana, Dobričić, Vladimir, Daković, Aleksandra, "An investigation of ibuprofen release from a clinoptilolitic zeolitic tuff modified with cationic surfactant" in 8th Serbian-Croatian-Slovenian Symposium on Zeolites (2019):126-129.