Functionality of chitosan-halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass
Authorized Users Only
2020
Authors
Calija, Bojan
Milić, Jela
Milasinović, Nikola
Daković, Aleksandra

Trifković, Kata

Stojanović, Jovica

Krajišnik, Danina

Article (Published version)

Metadata
Show full item recordAbstract
This study was designed to investigate functionality of tetracycline-loaded chitosan-halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 +/- 2.65 to 34.48 +/- 2.34%), tensile strength (from 134.8 +/- 13.21 to 246.36 +/- 14.69 MPa), and elastic modulus (from 633.79 +/- 128.37 to 716.55 +/- 60.76 MPa) of the nanocomposite films. FT-IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan-halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite f...ilms released tetracycline in a sustained manner, with the slowest release achieved from the films consisting of low molar mass chitosan. Chitosan molar mass was confirmed to be a functionality-related characteristic of chitosan-halloysite nanocomposite films as potential sustained-release carriers for topical delivery of antibiotics.
Keywords:
films / drug delivery systems / composites / clay / biopolymers and renewable polymersSource:
Journal of Applied Polymer Science, 2020, 137, 8Publisher:
- Wiley, Hoboken
Funding / projects:
- Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-34031)
- Oxide-based environmentally-friendly porous materials for genotoxic substances removal (RS-172018)
- Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness (RS-46010)
DOI: 10.1002/app.48406
ISSN: 0021-8995
WoS: 000482327700001
Scopus: 2-s2.0-85070936288
Collections
Institution/Community
Institut za tehnologiju nuklearnih i drugih mineralnih sirovinaTY - JOUR AU - Calija, Bojan AU - Milić, Jela AU - Milasinović, Nikola AU - Daković, Aleksandra AU - Trifković, Kata AU - Stojanović, Jovica AU - Krajišnik, Danina PY - 2020 UR - https://ritnms.itnms.ac.rs/handle/123456789/550 AB - This study was designed to investigate functionality of tetracycline-loaded chitosan-halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 +/- 2.65 to 34.48 +/- 2.34%), tensile strength (from 134.8 +/- 13.21 to 246.36 +/- 14.69 MPa), and elastic modulus (from 633.79 +/- 128.37 to 716.55 +/- 60.76 MPa) of the nanocomposite films. FT-IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan-halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite films released tetracycline in a sustained manner, with the slowest release achieved from the films consisting of low molar mass chitosan. Chitosan molar mass was confirmed to be a functionality-related characteristic of chitosan-halloysite nanocomposite films as potential sustained-release carriers for topical delivery of antibiotics. PB - Wiley, Hoboken T2 - Journal of Applied Polymer Science T1 - Functionality of chitosan-halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass IS - 8 VL - 137 DO - 10.1002/app.48406 UR - conv_858 ER -
@article{ author = "Calija, Bojan and Milić, Jela and Milasinović, Nikola and Daković, Aleksandra and Trifković, Kata and Stojanović, Jovica and Krajišnik, Danina", year = "2020", abstract = "This study was designed to investigate functionality of tetracycline-loaded chitosan-halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 +/- 2.65 to 34.48 +/- 2.34%), tensile strength (from 134.8 +/- 13.21 to 246.36 +/- 14.69 MPa), and elastic modulus (from 633.79 +/- 128.37 to 716.55 +/- 60.76 MPa) of the nanocomposite films. FT-IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan-halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite films released tetracycline in a sustained manner, with the slowest release achieved from the films consisting of low molar mass chitosan. Chitosan molar mass was confirmed to be a functionality-related characteristic of chitosan-halloysite nanocomposite films as potential sustained-release carriers for topical delivery of antibiotics.", publisher = "Wiley, Hoboken", journal = "Journal of Applied Polymer Science", title = "Functionality of chitosan-halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass", number = "8", volume = "137", doi = "10.1002/app.48406", url = "conv_858" }
Calija, B., Milić, J., Milasinović, N., Daković, A., Trifković, K., Stojanović, J.,& Krajišnik, D.. (2020). Functionality of chitosan-halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass. in Journal of Applied Polymer Science Wiley, Hoboken., 137(8). https://doi.org/10.1002/app.48406 conv_858
Calija B, Milić J, Milasinović N, Daković A, Trifković K, Stojanović J, Krajišnik D. Functionality of chitosan-halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass. in Journal of Applied Polymer Science. 2020;137(8). doi:10.1002/app.48406 conv_858 .
Calija, Bojan, Milić, Jela, Milasinović, Nikola, Daković, Aleksandra, Trifković, Kata, Stojanović, Jovica, Krajišnik, Danina, "Functionality of chitosan-halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass" in Journal of Applied Polymer Science, 137, no. 8 (2020), https://doi.org/10.1002/app.48406 ., conv_858 .