Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents
Abstract
Increasing need for improved, compatible bone tissue implants led to the intensive research of novel biomaterials, especially hydroxyapatite (HAP)-based composite materials on titanium and titanium alloy surfaces. Owing to its excellent biocompatibility and osteoinductivity properties, hydroxyapatite is often used as part of composite biomaterials aimed for orthopedic implant applications. In order to overcome persistent problems of bacterial infection, various antimicrobial agents and materials and their incorporation in such medical devices were investigated. This paper represents a comprehensive review of single-step electrodeposition on titanium of hydroxyapatite/chitosan/graphene composite coatings loaded with silver and antibiotic gentamicin as antibacterial agents. The improvement of mechanical and adhesive properties of deposited composite coatings was achieved by graphene and chitosan addition, while desirable antibacterial properties were introduced by including antibiotic ge...ntamicin and silver. The biocompatibility of electrodeposited HAP and HAP-based composite coatings was evaluated by MTT testing, indicating a non-cytotoxic effect and high potential for future medical use as orthopedic implant coating.
Keywords:
hydroxyapatite / electrophoretic deposition / composite / bone implants / antibacterial coatingSource:
Journal of the Serbian Chemical Society, 2019, 84, 11, 1287-1304Publisher:
- Srpsko hemijsko društvo, Beograd
Funding / projects:
- Synthesis, processing and applications of nanostructured multifunctional materials with defined properties (RS-45019)
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2018R1A2B5A02023190]
DOI: 10.2298/JSC190821092S
ISSN: 0352-5139
WoS: 000500748300009
Scopus: 2-s2.0-85076352212
Collections
Institution/Community
Institut za tehnologiju nuklearnih i drugih mineralnih sirovinaTY - JOUR AU - Stevanović, Milena AU - Đošić, Marija AU - Janković, Ana AU - Rhee, Kyong Yop AU - Mišković-Stanković, Vesna PY - 2019 UR - https://ritnms.itnms.ac.rs/handle/123456789/502 AB - Increasing need for improved, compatible bone tissue implants led to the intensive research of novel biomaterials, especially hydroxyapatite (HAP)-based composite materials on titanium and titanium alloy surfaces. Owing to its excellent biocompatibility and osteoinductivity properties, hydroxyapatite is often used as part of composite biomaterials aimed for orthopedic implant applications. In order to overcome persistent problems of bacterial infection, various antimicrobial agents and materials and their incorporation in such medical devices were investigated. This paper represents a comprehensive review of single-step electrodeposition on titanium of hydroxyapatite/chitosan/graphene composite coatings loaded with silver and antibiotic gentamicin as antibacterial agents. The improvement of mechanical and adhesive properties of deposited composite coatings was achieved by graphene and chitosan addition, while desirable antibacterial properties were introduced by including antibiotic gentamicin and silver. The biocompatibility of electrodeposited HAP and HAP-based composite coatings was evaluated by MTT testing, indicating a non-cytotoxic effect and high potential for future medical use as orthopedic implant coating. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents EP - 1304 IS - 11 SP - 1287 VL - 84 DO - 10.2298/JSC190821092S UR - conv_868 ER -
@article{ author = "Stevanović, Milena and Đošić, Marija and Janković, Ana and Rhee, Kyong Yop and Mišković-Stanković, Vesna", year = "2019", abstract = "Increasing need for improved, compatible bone tissue implants led to the intensive research of novel biomaterials, especially hydroxyapatite (HAP)-based composite materials on titanium and titanium alloy surfaces. Owing to its excellent biocompatibility and osteoinductivity properties, hydroxyapatite is often used as part of composite biomaterials aimed for orthopedic implant applications. In order to overcome persistent problems of bacterial infection, various antimicrobial agents and materials and their incorporation in such medical devices were investigated. This paper represents a comprehensive review of single-step electrodeposition on titanium of hydroxyapatite/chitosan/graphene composite coatings loaded with silver and antibiotic gentamicin as antibacterial agents. The improvement of mechanical and adhesive properties of deposited composite coatings was achieved by graphene and chitosan addition, while desirable antibacterial properties were introduced by including antibiotic gentamicin and silver. The biocompatibility of electrodeposited HAP and HAP-based composite coatings was evaluated by MTT testing, indicating a non-cytotoxic effect and high potential for future medical use as orthopedic implant coating.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents", pages = "1304-1287", number = "11", volume = "84", doi = "10.2298/JSC190821092S", url = "conv_868" }
Stevanović, M., Đošić, M., Janković, A., Rhee, K. Y.,& Mišković-Stanković, V.. (2019). Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 84(11), 1287-1304. https://doi.org/10.2298/JSC190821092S conv_868
Stevanović M, Đošić M, Janković A, Rhee KY, Mišković-Stanković V. Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents. in Journal of the Serbian Chemical Society. 2019;84(11):1287-1304. doi:10.2298/JSC190821092S conv_868 .
Stevanović, Milena, Đošić, Marija, Janković, Ana, Rhee, Kyong Yop, Mišković-Stanković, Vesna, "Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents" in Journal of the Serbian Chemical Society, 84, no. 11 (2019):1287-1304, https://doi.org/10.2298/JSC190821092S ., conv_868 .