Surface-modified phillipsite-rich tuff from the Campania region (southern Italy) as a promising drug carrier: An ibuprofen sodium salt trial
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2018
Authors
Mercurio, Mariano
Izzo, Francesco

Langella, Alessio
Grifa, Celestino

Germinario, Chiara

Daković, Aleksandra

Aprea, Paolo
Pasquino, Rossana

Cappelletti, Piergiulio
Graziano, Sossio Fabio

de Gennaro, Bruno

Article (Published version)

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The encapsulation and delivery of drugs often involves the use of expensive microporous materials, and we have investigated the potential for natural zeolites from the widespread volcanic formations of southern Italy as alternatives to these carriers. Surface-modified natural zeolites (SMNZs) with diverse micellar structures (patchy and complete bilayers) were obtained by using different cationic surfactants [cetylpyridinium chloride (CP-Cl), benzalkonium chloride (BC-Cl), hexadecyltrimethylammonium chloride (HDTMA-Cl), and bromide (HDTMA-Br) with phillipsite-rich tuff from the Campania region (southern Italy)]. Loading and release kinetics tests of sodium ibuprofen (IBU) were carried out with organo-phillipsite composites using Fourier transform infrared spectroscopy (FTIR) and thermal analysis coupled with evolved gas analysis (EGA). Results from these tests were mathematically modeled to evaluate IBU adsorption and release mechanisms. The maximum loaded amount of IBU was attained fo...r organo-phillipsite modified with HDTMABr (PHB), which showed a complete bilayer micellar structure. Whenever a patchy bilayer micellar structure formed, the lowest adsorptions of IBU were observed. Equilibrium adsorption results were fit using Langmuir, Sips, and Toth models. Pseudo-first-order and pseudo-second-order fits to the loading kinetic data provided significant goodness of fit. Good fits to the release kinetic data were obtained using first-order and Weibull equations, shedding new light on the release mechanism of IBU from phillipsite. The active amount of IBU on the modified zeolite surface was almost totally available for pharmaceutical purposes.
Keywords:
Toth model / SMNZ / Sips model / Properties / Phillipsite / Neapolitan Yellow Tuff / Microporous Materials: Crystal-Chemistry / ibuprofen sodium salt / functionalization / drug delivery / carrier / and UtilizationsSource:
American Mineralogist, 2018, 103, 5, 700-710Publisher:
- Mineralogical Soc Amer, Chantilly
Funding / projects:
- MIUR (Ministero dell'Istruzione, dell'Universita e della Ricerca) Progetti di Ricerca di Interesse Nazionale (PRIN)
DOI: 10.2138/am-2018-6328
ISSN: 0003-004X
WoS: 000431122500003
Scopus: 2-s2.0-85047188701
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Institution/Community
Institut za tehnologiju nuklearnih i drugih mineralnih sirovinaTY - JOUR AU - Mercurio, Mariano AU - Izzo, Francesco AU - Langella, Alessio AU - Grifa, Celestino AU - Germinario, Chiara AU - Daković, Aleksandra AU - Aprea, Paolo AU - Pasquino, Rossana AU - Cappelletti, Piergiulio AU - Graziano, Sossio Fabio AU - de Gennaro, Bruno PY - 2018 UR - https://ritnms.itnms.ac.rs/handle/123456789/473 AB - The encapsulation and delivery of drugs often involves the use of expensive microporous materials, and we have investigated the potential for natural zeolites from the widespread volcanic formations of southern Italy as alternatives to these carriers. Surface-modified natural zeolites (SMNZs) with diverse micellar structures (patchy and complete bilayers) were obtained by using different cationic surfactants [cetylpyridinium chloride (CP-Cl), benzalkonium chloride (BC-Cl), hexadecyltrimethylammonium chloride (HDTMA-Cl), and bromide (HDTMA-Br) with phillipsite-rich tuff from the Campania region (southern Italy)]. Loading and release kinetics tests of sodium ibuprofen (IBU) were carried out with organo-phillipsite composites using Fourier transform infrared spectroscopy (FTIR) and thermal analysis coupled with evolved gas analysis (EGA). Results from these tests were mathematically modeled to evaluate IBU adsorption and release mechanisms. The maximum loaded amount of IBU was attained for organo-phillipsite modified with HDTMABr (PHB), which showed a complete bilayer micellar structure. Whenever a patchy bilayer micellar structure formed, the lowest adsorptions of IBU were observed. Equilibrium adsorption results were fit using Langmuir, Sips, and Toth models. Pseudo-first-order and pseudo-second-order fits to the loading kinetic data provided significant goodness of fit. Good fits to the release kinetic data were obtained using first-order and Weibull equations, shedding new light on the release mechanism of IBU from phillipsite. The active amount of IBU on the modified zeolite surface was almost totally available for pharmaceutical purposes. PB - Mineralogical Soc Amer, Chantilly T2 - American Mineralogist T1 - Surface-modified phillipsite-rich tuff from the Campania region (southern Italy) as a promising drug carrier: An ibuprofen sodium salt trial EP - 710 IS - 5 SP - 700 VL - 103 DO - 10.2138/am-2018-6328 UR - conv_822 ER -
@article{ author = "Mercurio, Mariano and Izzo, Francesco and Langella, Alessio and Grifa, Celestino and Germinario, Chiara and Daković, Aleksandra and Aprea, Paolo and Pasquino, Rossana and Cappelletti, Piergiulio and Graziano, Sossio Fabio and de Gennaro, Bruno", year = "2018", abstract = "The encapsulation and delivery of drugs often involves the use of expensive microporous materials, and we have investigated the potential for natural zeolites from the widespread volcanic formations of southern Italy as alternatives to these carriers. Surface-modified natural zeolites (SMNZs) with diverse micellar structures (patchy and complete bilayers) were obtained by using different cationic surfactants [cetylpyridinium chloride (CP-Cl), benzalkonium chloride (BC-Cl), hexadecyltrimethylammonium chloride (HDTMA-Cl), and bromide (HDTMA-Br) with phillipsite-rich tuff from the Campania region (southern Italy)]. Loading and release kinetics tests of sodium ibuprofen (IBU) were carried out with organo-phillipsite composites using Fourier transform infrared spectroscopy (FTIR) and thermal analysis coupled with evolved gas analysis (EGA). Results from these tests were mathematically modeled to evaluate IBU adsorption and release mechanisms. The maximum loaded amount of IBU was attained for organo-phillipsite modified with HDTMABr (PHB), which showed a complete bilayer micellar structure. Whenever a patchy bilayer micellar structure formed, the lowest adsorptions of IBU were observed. Equilibrium adsorption results were fit using Langmuir, Sips, and Toth models. Pseudo-first-order and pseudo-second-order fits to the loading kinetic data provided significant goodness of fit. Good fits to the release kinetic data were obtained using first-order and Weibull equations, shedding new light on the release mechanism of IBU from phillipsite. The active amount of IBU on the modified zeolite surface was almost totally available for pharmaceutical purposes.", publisher = "Mineralogical Soc Amer, Chantilly", journal = "American Mineralogist", title = "Surface-modified phillipsite-rich tuff from the Campania region (southern Italy) as a promising drug carrier: An ibuprofen sodium salt trial", pages = "710-700", number = "5", volume = "103", doi = "10.2138/am-2018-6328", url = "conv_822" }
Mercurio, M., Izzo, F., Langella, A., Grifa, C., Germinario, C., Daković, A., Aprea, P., Pasquino, R., Cappelletti, P., Graziano, S. F.,& de Gennaro, B.. (2018). Surface-modified phillipsite-rich tuff from the Campania region (southern Italy) as a promising drug carrier: An ibuprofen sodium salt trial. in American Mineralogist Mineralogical Soc Amer, Chantilly., 103(5), 700-710. https://doi.org/10.2138/am-2018-6328 conv_822
Mercurio M, Izzo F, Langella A, Grifa C, Germinario C, Daković A, Aprea P, Pasquino R, Cappelletti P, Graziano SF, de Gennaro B. Surface-modified phillipsite-rich tuff from the Campania region (southern Italy) as a promising drug carrier: An ibuprofen sodium salt trial. in American Mineralogist. 2018;103(5):700-710. doi:10.2138/am-2018-6328 conv_822 .
Mercurio, Mariano, Izzo, Francesco, Langella, Alessio, Grifa, Celestino, Germinario, Chiara, Daković, Aleksandra, Aprea, Paolo, Pasquino, Rossana, Cappelletti, Piergiulio, Graziano, Sossio Fabio, de Gennaro, Bruno, "Surface-modified phillipsite-rich tuff from the Campania region (southern Italy) as a promising drug carrier: An ibuprofen sodium salt trial" in American Mineralogist, 103, no. 5 (2018):700-710, https://doi.org/10.2138/am-2018-6328 ., conv_822 .