Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite
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2018
Authors
Janićijević, JelenaMilić, Jela
Calija, Bojan

Micov, Ana
Stepanović-Petrović, Radica
Tomić, Maja
Daković, Aleksandra

Dobričić, Vladimir

Nedić-Vasiljević, Bojana

Krajišnik, Danina

Article (Published version)

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Refined diatomite from the Kolubara coal basin (Serbia) was inorganically functionalized through a simple, one-pot, non-time-consuming procedure. Model drug ibuprofen was adsorbed on the functionalized diatomite under optimized conditions providing high drug Loading (similar to 201 mg g(-1)). Physicochemical characterization was performed on the starting and modified diatomite before and after ibuprofen adsorption. Dissolution testing was conducted on comprimates containing the drug adsorbed on the modified diatomite (composite) and those containing a physical mixture of the drug with the modified diatomite. The antihyperalgesic and the antiedematous activity of ibuprofen from both composites and physical mixtures were evaluated in vivo employing an inflammatory pain model in rats. Functionalization and subsequent drug adsorption had no significant effect on the diatomite ordered porous structure. Two forms of ibuprofen most likely coexisted in the adsorbed state - the acidic form and ...a salt/complex with aluminium. Both comprimate types showed extended ibuprofen release in vitro, but no significant influence on the duration of the ibuprofen effect was observed upon in vivo application of the composite or physical mixture. However, both the composite and the physical mixture were more effective than equivalent doses of ibuprofen in pain suppression in rats. This potentiation of the ibuprofen antihyperalgesic effect may result from the formation of the drug complex with the carrier and can be of clinical relevance.
Source:
Journal of Materials Chemistry B, 2018, 6, 36, 5812-5822Publisher:
- Royal Soc Chemistry, Cambridge
Funding / projects:
- Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-34031)
- Oxide-based environmentally-friendly porous materials for genotoxic substances removal (RS-172018)
- Examination of mechanisms of action, toxicity and interactions of adjuvant analgesics (RS-175045)
DOI: 10.1039/c8tb01376d
ISSN: 2050-750X
PubMed: 32254988
WoS: 000448413200016
Scopus: 2-s2.0-85053728185
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Institution/Community
Institut za tehnologiju nuklearnih i drugih mineralnih sirovinaTY - JOUR AU - Janićijević, Jelena AU - Milić, Jela AU - Calija, Bojan AU - Micov, Ana AU - Stepanović-Petrović, Radica AU - Tomić, Maja AU - Daković, Aleksandra AU - Dobričić, Vladimir AU - Nedić-Vasiljević, Bojana AU - Krajišnik, Danina PY - 2018 UR - https://ritnms.itnms.ac.rs/handle/123456789/471 AB - Refined diatomite from the Kolubara coal basin (Serbia) was inorganically functionalized through a simple, one-pot, non-time-consuming procedure. Model drug ibuprofen was adsorbed on the functionalized diatomite under optimized conditions providing high drug Loading (similar to 201 mg g(-1)). Physicochemical characterization was performed on the starting and modified diatomite before and after ibuprofen adsorption. Dissolution testing was conducted on comprimates containing the drug adsorbed on the modified diatomite (composite) and those containing a physical mixture of the drug with the modified diatomite. The antihyperalgesic and the antiedematous activity of ibuprofen from both composites and physical mixtures were evaluated in vivo employing an inflammatory pain model in rats. Functionalization and subsequent drug adsorption had no significant effect on the diatomite ordered porous structure. Two forms of ibuprofen most likely coexisted in the adsorbed state - the acidic form and a salt/complex with aluminium. Both comprimate types showed extended ibuprofen release in vitro, but no significant influence on the duration of the ibuprofen effect was observed upon in vivo application of the composite or physical mixture. However, both the composite and the physical mixture were more effective than equivalent doses of ibuprofen in pain suppression in rats. This potentiation of the ibuprofen antihyperalgesic effect may result from the formation of the drug complex with the carrier and can be of clinical relevance. PB - Royal Soc Chemistry, Cambridge T2 - Journal of Materials Chemistry B T1 - Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite EP - 5822 IS - 36 SP - 5812 VL - 6 DO - 10.1039/c8tb01376d UR - conv_835 ER -
@article{ author = "Janićijević, Jelena and Milić, Jela and Calija, Bojan and Micov, Ana and Stepanović-Petrović, Radica and Tomić, Maja and Daković, Aleksandra and Dobričić, Vladimir and Nedić-Vasiljević, Bojana and Krajišnik, Danina", year = "2018", abstract = "Refined diatomite from the Kolubara coal basin (Serbia) was inorganically functionalized through a simple, one-pot, non-time-consuming procedure. Model drug ibuprofen was adsorbed on the functionalized diatomite under optimized conditions providing high drug Loading (similar to 201 mg g(-1)). Physicochemical characterization was performed on the starting and modified diatomite before and after ibuprofen adsorption. Dissolution testing was conducted on comprimates containing the drug adsorbed on the modified diatomite (composite) and those containing a physical mixture of the drug with the modified diatomite. The antihyperalgesic and the antiedematous activity of ibuprofen from both composites and physical mixtures were evaluated in vivo employing an inflammatory pain model in rats. Functionalization and subsequent drug adsorption had no significant effect on the diatomite ordered porous structure. Two forms of ibuprofen most likely coexisted in the adsorbed state - the acidic form and a salt/complex with aluminium. Both comprimate types showed extended ibuprofen release in vitro, but no significant influence on the duration of the ibuprofen effect was observed upon in vivo application of the composite or physical mixture. However, both the composite and the physical mixture were more effective than equivalent doses of ibuprofen in pain suppression in rats. This potentiation of the ibuprofen antihyperalgesic effect may result from the formation of the drug complex with the carrier and can be of clinical relevance.", publisher = "Royal Soc Chemistry, Cambridge", journal = "Journal of Materials Chemistry B", title = "Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite", pages = "5822-5812", number = "36", volume = "6", doi = "10.1039/c8tb01376d", url = "conv_835" }
Janićijević, J., Milić, J., Calija, B., Micov, A., Stepanović-Petrović, R., Tomić, M., Daković, A., Dobričić, V., Nedić-Vasiljević, B.,& Krajišnik, D.. (2018). Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite. in Journal of Materials Chemistry B Royal Soc Chemistry, Cambridge., 6(36), 5812-5822. https://doi.org/10.1039/c8tb01376d conv_835
Janićijević J, Milić J, Calija B, Micov A, Stepanović-Petrović R, Tomić M, Daković A, Dobričić V, Nedić-Vasiljević B, Krajišnik D. Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite. in Journal of Materials Chemistry B. 2018;6(36):5812-5822. doi:10.1039/c8tb01376d conv_835 .
Janićijević, Jelena, Milić, Jela, Calija, Bojan, Micov, Ana, Stepanović-Petrović, Radica, Tomić, Maja, Daković, Aleksandra, Dobričić, Vladimir, Nedić-Vasiljević, Bojana, Krajišnik, Danina, "Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite" in Journal of Materials Chemistry B, 6, no. 36 (2018):5812-5822, https://doi.org/10.1039/c8tb01376d ., conv_835 .