Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release
Abstract
This study investigated the potential of halloysite nanotubes (HNTs) to improve the sustained release properties of chitosan (CS) microparticles cross-linked ionically with tripolyphosphate (TPP). Composite CS-HNTs microparticles were obtained by a simple and eco-friendly procedure based on a coaxial extrusion technique. Prior to encapsulation, a water-soluble model drug, verapamil hydrochloride (VH), was adsorbed successfully on HNTs. The microparticles were characterized by optical microscopy, Fourier transform infrared (FTIR) spectroscopy, differential thermal analysis/thermogravimetric analysis (DTA/TG) and evaluated for encapsulation efficiency and drug-release properties. The composite particles had a slightly deformed spherical shape and micrometric size with average perimeters ranging from 485.4 +/- 13.3 to 492.4 +/- 11.9 mu m. The results of FTIR spectroscopy confirmed non-covalent interactions between CS and HNTs within composite particle structures. The DTA and TG studies re...vealed increased thermal stability of the composite particles in comparison to the CS-TPP particles. Drug adsorption on HNTs prior to encapsulation led to an increase in encapsulation efficiency from 19.6 +/- 2.9 to 84.3 +/- 1.9%. In contrast to the rapid release of encapsulated model drug from CS-TPP microparticles, the composite CS-HNTs microparticles released drug in a sustained manner, showing the best fit to the Bhaskar model. The results presented here imply that HNTs could be used to improve morphology, encapsulation efficiency and sustained drug-release properties of CS microparticles cross-linked ionically with TPP.
Keywords:
microparticles / halloysite / drug delivery / composites / chitosanSource:
Clay Minerals, 2017, 52, 4, 413-426Publisher:
- Mineralogical Soc, Twickenham
Funding / projects:
- Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-34031)
- Oxide-based environmentally-friendly porous materials for genotoxic substances removal (RS-172018)
DOI: 10.1180/claymin.2017.052.04.01
ISSN: 0009-8558
WoS: 000431691500001
Scopus: 2-s2.0-85042654681
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Institution/Community
Institut za tehnologiju nuklearnih i drugih mineralnih sirovinaTY - JOUR AU - Calija, Bojan AU - Milić, Jela AU - Janićijević, Jelena AU - Daković, Aleksandra AU - Krajišnik, Danina PY - 2017 UR - https://ritnms.itnms.ac.rs/handle/123456789/429 AB - This study investigated the potential of halloysite nanotubes (HNTs) to improve the sustained release properties of chitosan (CS) microparticles cross-linked ionically with tripolyphosphate (TPP). Composite CS-HNTs microparticles were obtained by a simple and eco-friendly procedure based on a coaxial extrusion technique. Prior to encapsulation, a water-soluble model drug, verapamil hydrochloride (VH), was adsorbed successfully on HNTs. The microparticles were characterized by optical microscopy, Fourier transform infrared (FTIR) spectroscopy, differential thermal analysis/thermogravimetric analysis (DTA/TG) and evaluated for encapsulation efficiency and drug-release properties. The composite particles had a slightly deformed spherical shape and micrometric size with average perimeters ranging from 485.4 +/- 13.3 to 492.4 +/- 11.9 mu m. The results of FTIR spectroscopy confirmed non-covalent interactions between CS and HNTs within composite particle structures. The DTA and TG studies revealed increased thermal stability of the composite particles in comparison to the CS-TPP particles. Drug adsorption on HNTs prior to encapsulation led to an increase in encapsulation efficiency from 19.6 +/- 2.9 to 84.3 +/- 1.9%. In contrast to the rapid release of encapsulated model drug from CS-TPP microparticles, the composite CS-HNTs microparticles released drug in a sustained manner, showing the best fit to the Bhaskar model. The results presented here imply that HNTs could be used to improve morphology, encapsulation efficiency and sustained drug-release properties of CS microparticles cross-linked ionically with TPP. PB - Mineralogical Soc, Twickenham T2 - Clay Minerals T1 - Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release EP - 426 IS - 4 SP - 413 VL - 52 DO - 10.1180/claymin.2017.052.04.01 UR - conv_823 ER -
@article{ author = "Calija, Bojan and Milić, Jela and Janićijević, Jelena and Daković, Aleksandra and Krajišnik, Danina", year = "2017", abstract = "This study investigated the potential of halloysite nanotubes (HNTs) to improve the sustained release properties of chitosan (CS) microparticles cross-linked ionically with tripolyphosphate (TPP). Composite CS-HNTs microparticles were obtained by a simple and eco-friendly procedure based on a coaxial extrusion technique. Prior to encapsulation, a water-soluble model drug, verapamil hydrochloride (VH), was adsorbed successfully on HNTs. The microparticles were characterized by optical microscopy, Fourier transform infrared (FTIR) spectroscopy, differential thermal analysis/thermogravimetric analysis (DTA/TG) and evaluated for encapsulation efficiency and drug-release properties. The composite particles had a slightly deformed spherical shape and micrometric size with average perimeters ranging from 485.4 +/- 13.3 to 492.4 +/- 11.9 mu m. The results of FTIR spectroscopy confirmed non-covalent interactions between CS and HNTs within composite particle structures. The DTA and TG studies revealed increased thermal stability of the composite particles in comparison to the CS-TPP particles. Drug adsorption on HNTs prior to encapsulation led to an increase in encapsulation efficiency from 19.6 +/- 2.9 to 84.3 +/- 1.9%. In contrast to the rapid release of encapsulated model drug from CS-TPP microparticles, the composite CS-HNTs microparticles released drug in a sustained manner, showing the best fit to the Bhaskar model. The results presented here imply that HNTs could be used to improve morphology, encapsulation efficiency and sustained drug-release properties of CS microparticles cross-linked ionically with TPP.", publisher = "Mineralogical Soc, Twickenham", journal = "Clay Minerals", title = "Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release", pages = "426-413", number = "4", volume = "52", doi = "10.1180/claymin.2017.052.04.01", url = "conv_823" }
Calija, B., Milić, J., Janićijević, J., Daković, A.,& Krajišnik, D.. (2017). Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release. in Clay Minerals Mineralogical Soc, Twickenham., 52(4), 413-426. https://doi.org/10.1180/claymin.2017.052.04.01 conv_823
Calija B, Milić J, Janićijević J, Daković A, Krajišnik D. Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release. in Clay Minerals. 2017;52(4):413-426. doi:10.1180/claymin.2017.052.04.01 conv_823 .
Calija, Bojan, Milić, Jela, Janićijević, Jelena, Daković, Aleksandra, Krajišnik, Danina, "Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release" in Clay Minerals, 52, no. 4 (2017):413-426, https://doi.org/10.1180/claymin.2017.052.04.01 ., conv_823 .