Incorporation of diclofenac sodium into phillipsite modified with cetylpyridinium chloride (CP-Cl) or hexadecyltrimethyl ammonium bromide (HDTMA-Br) was followed by batch equilibrium adsorption studies in buffer solution at pH = 7.4. Characteristics of the drug/surfactant/zeolite complexes were investigated by UV/VIS, FTIR spectroscopy, thermal (DTA/TG) analysis and-potential measurements. The obtained data confirmed that organic cations at phillipsite surface were responsible for incorporation of diclofenac sodium. Diclofenac sodium incorporated amounts increased with increasing the amount of each surfactant as well as with increasing the initial drug concentration. Langmuir model was the best model for fitting the experimental data of diclofenac adsorption on surfactant/phillipsite composites, suggesting complex adsorption mechanism. The physico-chemical properties of surfactant/phillipsite composites and enhanced incorporation of diclofenac sodium suggests that it might be possible ...to use these materials as drug carriers.
TY - JOUR
AU - Marković, Marija
AU - Daković, Aleksandra
AU - Krajišnik, Danina
AU - Kragović, Milan
AU - Milić, Jela
AU - Langella, Alessio
AU - de Gennaro, Bruno
AU - Cappelletti, Piergiulio
AU - Mercurio, Mariano
PY - 2016
UR - https://ritnms.itnms.ac.rs/handle/123456789/400
AB - Incorporation of diclofenac sodium into phillipsite modified with cetylpyridinium chloride (CP-Cl) or hexadecyltrimethyl ammonium bromide (HDTMA-Br) was followed by batch equilibrium adsorption studies in buffer solution at pH = 7.4. Characteristics of the drug/surfactant/zeolite complexes were investigated by UV/VIS, FTIR spectroscopy, thermal (DTA/TG) analysis and-potential measurements. The obtained data confirmed that organic cations at phillipsite surface were responsible for incorporation of diclofenac sodium. Diclofenac sodium incorporated amounts increased with increasing the amount of each surfactant as well as with increasing the initial drug concentration. Langmuir model was the best model for fitting the experimental data of diclofenac adsorption on surfactant/phillipsite composites, suggesting complex adsorption mechanism. The physico-chemical properties of surfactant/phillipsite composites and enhanced incorporation of diclofenac sodium suggests that it might be possible to use these materials as drug carriers.
PB - Elsevier, Amsterdam
T2 - Journal of Molecular Liquids
T1 - Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium
EP - 716
SP - 711
VL - 222
DO - 10.1016/j.molliq.2016.07.127
UR - conv_772
ER -
@article{
author = "Marković, Marija and Daković, Aleksandra and Krajišnik, Danina and Kragović, Milan and Milić, Jela and Langella, Alessio and de Gennaro, Bruno and Cappelletti, Piergiulio and Mercurio, Mariano",
year = "2016",
abstract = "Incorporation of diclofenac sodium into phillipsite modified with cetylpyridinium chloride (CP-Cl) or hexadecyltrimethyl ammonium bromide (HDTMA-Br) was followed by batch equilibrium adsorption studies in buffer solution at pH = 7.4. Characteristics of the drug/surfactant/zeolite complexes were investigated by UV/VIS, FTIR spectroscopy, thermal (DTA/TG) analysis and-potential measurements. The obtained data confirmed that organic cations at phillipsite surface were responsible for incorporation of diclofenac sodium. Diclofenac sodium incorporated amounts increased with increasing the amount of each surfactant as well as with increasing the initial drug concentration. Langmuir model was the best model for fitting the experimental data of diclofenac adsorption on surfactant/phillipsite composites, suggesting complex adsorption mechanism. The physico-chemical properties of surfactant/phillipsite composites and enhanced incorporation of diclofenac sodium suggests that it might be possible to use these materials as drug carriers.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Molecular Liquids",
title = "Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium",
pages = "716-711",
volume = "222",
doi = "10.1016/j.molliq.2016.07.127",
url = "conv_772"
}
Marković, M., Daković, A., Krajišnik, D., Kragović, M., Milić, J., Langella, A., de Gennaro, B., Cappelletti, P.,& Mercurio, M.. (2016). Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium. in Journal of Molecular Liquids
Elsevier, Amsterdam., 222, 711-716.
https://doi.org/10.1016/j.molliq.2016.07.127
conv_772
Marković M, Daković A, Krajišnik D, Kragović M, Milić J, Langella A, de Gennaro B, Cappelletti P, Mercurio M. Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium. in Journal of Molecular Liquids. 2016;222:711-716.
doi:10.1016/j.molliq.2016.07.127
conv_772 .
Marković, Marija, Daković, Aleksandra, Krajišnik, Danina, Kragović, Milan, Milić, Jela, Langella, Alessio, de Gennaro, Bruno, Cappelletti, Piergiulio, Mercurio, Mariano, "Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium" in Journal of Molecular Liquids, 222 (2016):711-716,
https://doi.org/10.1016/j.molliq.2016.07.127 .,
conv_772 .
