Investigation of adsorption and release of diclofenac sodium by modified zeolites composites
Само за регистроване кориснике
2013
Аутори
Krajišnik, DaninaDaković, Aleksandra
Malenović, Anđelija
Milojević-Rakić, Maja
Dondur, Vera
Radulović, Željka
Millc, Jela
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Results on adsorption of diclofenac sodium (DS) by modified natural zeolite composites at three levels (10,20 and 30 mmol/100 g) of cationic surfactant-hexadecyltrimethylammonium bromide (HB), in a buffer solution, were compared. Characterization of composites before and after drug adsorption was performed by determination of electrokinetic mobility, FTIR and thermal analysis. The results indicated interactions between drug and carriers. The pharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments. The results were compared with the drug release from corresponding physical mixtures. Prolonged drug release over a period of 8 h (up to 30%) was achieved with both groups of samples. Furthermore, DS release reached up to 85% from physical mixtures containing drug amount closer to a therapeutic dose.
Кључне речи:
Excipient / Dissolution / Diclofenac sodium / Clinoptilolite / Cationic surfactant / AdsorptionИзвор:
Applied Clay Science, 2013, 83-84, 322-326Издавач:
- Elsevier Science Bv, Amsterdam
Финансирање / пројекти:
- Развој микро- и наносистема као носача за лекове са антиинфламаторним деловањем и метода за њихову карактеризацију (RS-MESTD-Technological Development (TD or TR)-34031)
- Порозни материјали на бази оксида у заштити животне средине од генотоксичних супстанци (RS-MESTD-Basic Research (BR or ON)-172018)
DOI: 10.1016/j.clay.2013.08.011
ISSN: 0169-1317
WoS: 000326661300043
Scopus: 2-s2.0-84885078956
Институција/група
Institut za tehnologiju nuklearnih i drugih mineralnih sirovinaTY - JOUR AU - Krajišnik, Danina AU - Daković, Aleksandra AU - Malenović, Anđelija AU - Milojević-Rakić, Maja AU - Dondur, Vera AU - Radulović, Željka AU - Millc, Jela PY - 2013 UR - https://ritnms.itnms.ac.rs/handle/123456789/261 AB - Results on adsorption of diclofenac sodium (DS) by modified natural zeolite composites at three levels (10,20 and 30 mmol/100 g) of cationic surfactant-hexadecyltrimethylammonium bromide (HB), in a buffer solution, were compared. Characterization of composites before and after drug adsorption was performed by determination of electrokinetic mobility, FTIR and thermal analysis. The results indicated interactions between drug and carriers. The pharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments. The results were compared with the drug release from corresponding physical mixtures. Prolonged drug release over a period of 8 h (up to 30%) was achieved with both groups of samples. Furthermore, DS release reached up to 85% from physical mixtures containing drug amount closer to a therapeutic dose. PB - Elsevier Science Bv, Amsterdam T2 - Applied Clay Science T1 - Investigation of adsorption and release of diclofenac sodium by modified zeolites composites EP - 326 SP - 322 VL - 83-84 DO - 10.1016/j.clay.2013.08.011 UR - conv_671 ER -
@article{ author = "Krajišnik, Danina and Daković, Aleksandra and Malenović, Anđelija and Milojević-Rakić, Maja and Dondur, Vera and Radulović, Željka and Millc, Jela", year = "2013", abstract = "Results on adsorption of diclofenac sodium (DS) by modified natural zeolite composites at three levels (10,20 and 30 mmol/100 g) of cationic surfactant-hexadecyltrimethylammonium bromide (HB), in a buffer solution, were compared. Characterization of composites before and after drug adsorption was performed by determination of electrokinetic mobility, FTIR and thermal analysis. The results indicated interactions between drug and carriers. The pharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments. The results were compared with the drug release from corresponding physical mixtures. Prolonged drug release over a period of 8 h (up to 30%) was achieved with both groups of samples. Furthermore, DS release reached up to 85% from physical mixtures containing drug amount closer to a therapeutic dose.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Applied Clay Science", title = "Investigation of adsorption and release of diclofenac sodium by modified zeolites composites", pages = "326-322", volume = "83-84", doi = "10.1016/j.clay.2013.08.011", url = "conv_671" }
Krajišnik, D., Daković, A., Malenović, A., Milojević-Rakić, M., Dondur, V., Radulović, Ž.,& Millc, J.. (2013). Investigation of adsorption and release of diclofenac sodium by modified zeolites composites. in Applied Clay Science Elsevier Science Bv, Amsterdam., 83-84, 322-326. https://doi.org/10.1016/j.clay.2013.08.011 conv_671
Krajišnik D, Daković A, Malenović A, Milojević-Rakić M, Dondur V, Radulović Ž, Millc J. Investigation of adsorption and release of diclofenac sodium by modified zeolites composites. in Applied Clay Science. 2013;83-84:322-326. doi:10.1016/j.clay.2013.08.011 conv_671 .
Krajišnik, Danina, Daković, Aleksandra, Malenović, Anđelija, Milojević-Rakić, Maja, Dondur, Vera, Radulović, Željka, Millc, Jela, "Investigation of adsorption and release of diclofenac sodium by modified zeolites composites" in Applied Clay Science, 83-84 (2013):322-326, https://doi.org/10.1016/j.clay.2013.08.011 ., conv_671 .