TY  - JOUR
AU  - Krajišnik, Danina
AU  - Milojević, Maja
AU  - Malenović, Anđelija
AU  - Daković, Aleksandra
AU  - Ibrić, Svetlana
AU  - Savić, Snežana
AU  - Dondur, Vera
AU  - Matijašević, Srđan
AU  - Radulović, Aleksandra
AU  - Daniels, Rolf
AU  - Milić, Jela
PY  - 2010
UR  - https://ritnms.itnms.ac.rs/handle/123456789/171
AB  - Context: In this study an investigation of cationic surfactants-modified natural zeolites as drug formulation excipient was performed. Objective: The aim of this work was to carry out a study of the purified natural zeolitic tuff with high amount of clinoptilolite as a potential carrier for molecules of pharmaceutical interest. Materials and methods: Two cationic surfactants (benzalkonium chloride and hexadecyltrimethylammonium bromide) were used for modification of the zeolitic surface in two levels (equal to and twice as external cation-exchange capacity of the zeolitic tuff). Prepared samples were characterized by Fourier transform infrared spectroscopy, thermogravimetric, high-performance liquid chromatography analysis, and powder flow determination. Different surfactant/zeolite composites were used for additional investigation of three model drugs: diclofenac diethylamine, diclofenac sodium, and ibuprofen by means of adsorption isotherm measurements in aqueous solutions. Results: The modified zeolites with two levels of surfactant coverage within the short activation time were prepared. Determination of flow properties showed that modification of zeolitic surface reflected on powder flow characteristics. Investigation of the model drugs adsorption on the obtained composites revealed that a variation between adsorption levels was influenced by the surfactant type and the amount present at the surface of the composites. Discussion and conclusion: In vitro release profiles of the drugs from the zeolite-surfactant-drug composites revealed that sustained drug release could be attained over a period of 8 hours. The presented results for drug uptake by surfactant-zeolite composites and the afterward drug release demonstrated the potential use of investigated modified natural zeolite as excipients for advanced excipients in drug formulations.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Drug Development and Industrial Pharmacy
T1  - Cationic surfactants-modified natural zeolites: improvement of the excipients functionality
EP  - 1224
IS  - 10
SP  - 1215
VL  - 36
DO  - 10.3109/03639041003695121
UR  - conv_588
ER  - 

@article{
author = "Krajišnik, Danina and Milojević, Maja and Malenović, Anđelija and Daković, Aleksandra and Ibrić, Svetlana and Savić, Snežana and Dondur, Vera and Matijašević, Srđan and Radulović, Aleksandra and Daniels, Rolf and Milić, Jela",
year = "2010",
abstract = "Context: In this study an investigation of cationic surfactants-modified natural zeolites as drug formulation excipient was performed. Objective: The aim of this work was to carry out a study of the purified natural zeolitic tuff with high amount of clinoptilolite as a potential carrier for molecules of pharmaceutical interest. Materials and methods: Two cationic surfactants (benzalkonium chloride and hexadecyltrimethylammonium bromide) were used for modification of the zeolitic surface in two levels (equal to and twice as external cation-exchange capacity of the zeolitic tuff). Prepared samples were characterized by Fourier transform infrared spectroscopy, thermogravimetric, high-performance liquid chromatography analysis, and powder flow determination. Different surfactant/zeolite composites were used for additional investigation of three model drugs: diclofenac diethylamine, diclofenac sodium, and ibuprofen by means of adsorption isotherm measurements in aqueous solutions. Results: The modified zeolites with two levels of surfactant coverage within the short activation time were prepared. Determination of flow properties showed that modification of zeolitic surface reflected on powder flow characteristics. Investigation of the model drugs adsorption on the obtained composites revealed that a variation between adsorption levels was influenced by the surfactant type and the amount present at the surface of the composites. Discussion and conclusion: In vitro release profiles of the drugs from the zeolite-surfactant-drug composites revealed that sustained drug release could be attained over a period of 8 hours. The presented results for drug uptake by surfactant-zeolite composites and the afterward drug release demonstrated the potential use of investigated modified natural zeolite as excipients for advanced excipients in drug formulations.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Drug Development and Industrial Pharmacy",
title = "Cationic surfactants-modified natural zeolites: improvement of the excipients functionality",
pages = "1224-1215",
number = "10",
volume = "36",
doi = "10.3109/03639041003695121",
url = "conv_588"
}

Krajišnik, D., Milojević, M., Malenović, A., Daković, A., Ibrić, S., Savić, S., Dondur, V., Matijašević, S., Radulović, A., Daniels, R.,& Milić, J.. (2010). Cationic surfactants-modified natural zeolites: improvement of the excipients functionality. in Drug Development and Industrial Pharmacy
Taylor & Francis Ltd, Abingdon., 36(10), 1215-1224.
https://doi.org/10.3109/03639041003695121
conv_588

Krajišnik D, Milojević M, Malenović A, Daković A, Ibrić S, Savić S, Dondur V, Matijašević S, Radulović A, Daniels R, Milić J. Cationic surfactants-modified natural zeolites: improvement of the excipients functionality. in Drug Development and Industrial Pharmacy. 2010;36(10):1215-1224.
doi:10.3109/03639041003695121
conv_588 .

Krajišnik, Danina, Milojević, Maja, Malenović, Anđelija, Daković, Aleksandra, Ibrić, Svetlana, Savić, Snežana, Dondur, Vera, Matijašević, Srđan, Radulović, Aleksandra, Daniels, Rolf, Milić, Jela, "Cationic surfactants-modified natural zeolites: improvement of the excipients functionality" in Drug Development and Industrial Pharmacy, 36, no. 10 (2010):1215-1224,
https://doi.org/10.3109/03639041003695121 .,
conv_588 .