TY  - JOUR
AU  - Krajišnik, Danina
AU  - Daković, Aleksandra
AU  - Milojević, Maja
AU  - Malenović, Anđelija
AU  - Kragović, Milan
AU  - Bajuk-Bogdanović, Danica
AU  - Dondur, Vera
AU  - Milić, Jela
PY  - 2011
UR  - https://ritnms.itnms.ac.rs/handle/123456789/189
AB  - In this study an investigation of a model drug sorption onto cationic surfactant-modified natural zeolites as a drug formulation excipient was performed. Natural zeolite was modified with cetylpyridinium chloride in amounts equivalent to 100, 200 and 300% of its external cation-exchange capacity. The starting material and obtained organozeolites were characterized by Fourier transform infrared spectroscopy, zeta potential measurements and thermal analysis. In vitro sorption of diclofenac sodium as a model drug was studied for all surfactant/zeolite composites by means of sorption isotherm measurements in aqueous solutions (pH 7.4). The modified zeolites with three levels of surfactant coverage within the short activation time were prepared. Zeta potential measurements and thermal analysis showed that when the surfactant loading level was equal to external cation-exchange value, almost monolayer of organic phase were present at the zeolitic surface while higher amounts of surfactant produced less extended bilayers, ordered bilayers or admicelles at the zeolitic surface. Modified zeolites, obtained in this manner, were effective in diclofenac sodium sorption and the organic phase derived from adsorbed cetylpyridinium chloride was the primary sorption phase for the model drug. The Langmuir isotherm was found to describe the equilibrium sorption data well over the entire concentration range. The separate contributions of the adsorption and partition to the total sorption of DS were analyzed mathematically. Results revealed that that adsorption and partitioning of the model drug take place simultaneously.
PB  - Elsevier, Amsterdam
T2  - Colloids and Surfaces B-Biointerfaces
T1  - Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride
EP  - 172
IS  - 1
SP  - 165
VL  - 83
DO  - 10.1016/j.colsurfb.2010.11.024
UR  - conv_598
ER  - 

@article{
author = "Krajišnik, Danina and Daković, Aleksandra and Milojević, Maja and Malenović, Anđelija and Kragović, Milan and Bajuk-Bogdanović, Danica and Dondur, Vera and Milić, Jela",
year = "2011",
abstract = "In this study an investigation of a model drug sorption onto cationic surfactant-modified natural zeolites as a drug formulation excipient was performed. Natural zeolite was modified with cetylpyridinium chloride in amounts equivalent to 100, 200 and 300% of its external cation-exchange capacity. The starting material and obtained organozeolites were characterized by Fourier transform infrared spectroscopy, zeta potential measurements and thermal analysis. In vitro sorption of diclofenac sodium as a model drug was studied for all surfactant/zeolite composites by means of sorption isotherm measurements in aqueous solutions (pH 7.4). The modified zeolites with three levels of surfactant coverage within the short activation time were prepared. Zeta potential measurements and thermal analysis showed that when the surfactant loading level was equal to external cation-exchange value, almost monolayer of organic phase were present at the zeolitic surface while higher amounts of surfactant produced less extended bilayers, ordered bilayers or admicelles at the zeolitic surface. Modified zeolites, obtained in this manner, were effective in diclofenac sodium sorption and the organic phase derived from adsorbed cetylpyridinium chloride was the primary sorption phase for the model drug. The Langmuir isotherm was found to describe the equilibrium sorption data well over the entire concentration range. The separate contributions of the adsorption and partition to the total sorption of DS were analyzed mathematically. Results revealed that that adsorption and partitioning of the model drug take place simultaneously.",
publisher = "Elsevier, Amsterdam",
journal = "Colloids and Surfaces B-Biointerfaces",
title = "Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride",
pages = "172-165",
number = "1",
volume = "83",
doi = "10.1016/j.colsurfb.2010.11.024",
url = "conv_598"
}

Krajišnik, D., Daković, A., Milojević, M., Malenović, A., Kragović, M., Bajuk-Bogdanović, D., Dondur, V.,& Milić, J.. (2011). Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride. in Colloids and Surfaces B-Biointerfaces
Elsevier, Amsterdam., 83(1), 165-172.
https://doi.org/10.1016/j.colsurfb.2010.11.024
conv_598

Krajišnik D, Daković A, Milojević M, Malenović A, Kragović M, Bajuk-Bogdanović D, Dondur V, Milić J. Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride. in Colloids and Surfaces B-Biointerfaces. 2011;83(1):165-172.
doi:10.1016/j.colsurfb.2010.11.024
conv_598 .

Krajišnik, Danina, Daković, Aleksandra, Milojević, Maja, Malenović, Anđelija, Kragović, Milan, Bajuk-Bogdanović, Danica, Dondur, Vera, Milić, Jela, "Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride" in Colloids and Surfaces B-Biointerfaces, 83, no. 1 (2011):165-172,
https://doi.org/10.1016/j.colsurfb.2010.11.024 .,
conv_598 .