TY  - JOUR
AU  - Milićević, Dragan
AU  - Jurić, Verica
AU  - Daković, Aleksandra
AU  - Jovanović, Miljan
AU  - Stefanović, Srđan
AU  - Petrović, Zoran
PY  - 2009
UR  - https://ritnms.itnms.ac.rs/handle/123456789/152
AB  - U cilju sticanja saznanja o zastupljenosti mikotoksične nefropatije svinja i uticaja OTA na vrstu i lokalizaciju patomorfoloških promena na bubrezima, na liniji klanja tokom veterinarsko-sanitarnog pregleda redovno zaklanih svinja poreklom sa farmi iz Vojvodine i Srbije, uzimani su uzorci bubrega za analizu. Tokom šestomesečnih ispitivanja ukupno je analizirano 90 uzoraka bubrega zaklanih svinja. Prisustvo rezidua OTA u uzorcima bubrega poreklom iz ispitivanih regiona utvrđeno je kod 33,3% ispitanih uzoraka, u količini od 0,17 do 52,5 ng/g. Zastupljenost rezidua OTA bila je najveća u uzorcima bubrega poreklom sa lokaliteta Senta i Bogatić (36,6%), dok je najveći prosečan sadržaj rezidua OTA (-2,2 μg/kg) utvrđen u uzorcima bubrega poreklom sa lokaliteta Bogatić. Patohistološkim pregledom bubrega najčešće su utvrđene tubulopatije sa edemom i vakuolizacijom ćelija. Takođe, utvrđene su hemoragije i nekroza ćelija proksimalnih bubrežnih tubula.
AB  - In order to find information on the occurrence of mycotoxic porcine nephropathy in Serbia, during a six month period (2006/2007) samples of kidney from individual healthy slaughtered pigs were collected (n=90) and analyzed by HPLC for ochratoxin A. In addition, histological examinations were carried out. The incidence of OTA in kidney was 33,3% and varied between 0.17-52.5 ng/g. Histopathological examination of kidneys confirmed tubulopathies with oedema and cell vacuolization. In addition, hemorrhages and necrosis of proximal kidney tubules cells were found. These findings indicate that it is likely that most of the kidney injury is related to ochratoxin A and other nephrotoxic compounds which enhance the toxicity of OTA.
PB  - Matica Srpska, Novi Sad
T2  - Zbornik Matice srpske za prirodne nauke
T1  - Mikotoksična nefropatija svinja i zastupljenost rezidua ohratoksina A u bubrezima zaklanih svinja
T1  - Mycotoxic porcine nephropathy and spontaneous occurrence of ochratoxin A residues in kidneys of slaughtered swine
EP  - 90
IS  - 116
SP  - 81
UR  - conv_166
ER  - 

@article{
author = "Milićević, Dragan and Jurić, Verica and Daković, Aleksandra and Jovanović, Miljan and Stefanović, Srđan and Petrović, Zoran",
year = "2009",
abstract = "U cilju sticanja saznanja o zastupljenosti mikotoksične nefropatije svinja i uticaja OTA na vrstu i lokalizaciju patomorfoloških promena na bubrezima, na liniji klanja tokom veterinarsko-sanitarnog pregleda redovno zaklanih svinja poreklom sa farmi iz Vojvodine i Srbije, uzimani su uzorci bubrega za analizu. Tokom šestomesečnih ispitivanja ukupno je analizirano 90 uzoraka bubrega zaklanih svinja. Prisustvo rezidua OTA u uzorcima bubrega poreklom iz ispitivanih regiona utvrđeno je kod 33,3% ispitanih uzoraka, u količini od 0,17 do 52,5 ng/g. Zastupljenost rezidua OTA bila je najveća u uzorcima bubrega poreklom sa lokaliteta Senta i Bogatić (36,6%), dok je najveći prosečan sadržaj rezidua OTA (-2,2 μg/kg) utvrđen u uzorcima bubrega poreklom sa lokaliteta Bogatić. Patohistološkim pregledom bubrega najčešće su utvrđene tubulopatije sa edemom i vakuolizacijom ćelija. Takođe, utvrđene su hemoragije i nekroza ćelija proksimalnih bubrežnih tubula., In order to find information on the occurrence of mycotoxic porcine nephropathy in Serbia, during a six month period (2006/2007) samples of kidney from individual healthy slaughtered pigs were collected (n=90) and analyzed by HPLC for ochratoxin A. In addition, histological examinations were carried out. The incidence of OTA in kidney was 33,3% and varied between 0.17-52.5 ng/g. Histopathological examination of kidneys confirmed tubulopathies with oedema and cell vacuolization. In addition, hemorrhages and necrosis of proximal kidney tubules cells were found. These findings indicate that it is likely that most of the kidney injury is related to ochratoxin A and other nephrotoxic compounds which enhance the toxicity of OTA.",
publisher = "Matica Srpska, Novi Sad",
journal = "Zbornik Matice srpske za prirodne nauke",
title = "Mikotoksična nefropatija svinja i zastupljenost rezidua ohratoksina A u bubrezima zaklanih svinja, Mycotoxic porcine nephropathy and spontaneous occurrence of ochratoxin A residues in kidneys of slaughtered swine",
pages = "90-81",
number = "116",
url = "conv_166"
}

Milićević, D., Jurić, V., Daković, A., Jovanović, M., Stefanović, S.,& Petrović, Z.. (2009). Mikotoksična nefropatija svinja i zastupljenost rezidua ohratoksina A u bubrezima zaklanih svinja. in Zbornik Matice srpske za prirodne nauke
Matica Srpska, Novi Sad.(116), 81-90.
conv_166

Milićević D, Jurić V, Daković A, Jovanović M, Stefanović S, Petrović Z. Mikotoksična nefropatija svinja i zastupljenost rezidua ohratoksina A u bubrezima zaklanih svinja. in Zbornik Matice srpske za prirodne nauke. 2009;(116):81-90.
conv_166 .

Milićević, Dragan, Jurić, Verica, Daković, Aleksandra, Jovanović, Miljan, Stefanović, Srđan, Petrović, Zoran, "Mikotoksična nefropatija svinja i zastupljenost rezidua ohratoksina A u bubrezima zaklanih svinja" in Zbornik Matice srpske za prirodne nauke, no. 116 (2009):81-90,
conv_166 .

TY  - JOUR
AU  - Milićević, Dragan
AU  - Jovanović, Milijan
AU  - Jurić, Verica
AU  - Daković, Aleksandra
AU  - Stefanović, Srđan
AU  - Petrović, Zoran
PY  - 2008
UR  - https://ritnms.itnms.ac.rs/handle/123456789/127
AB  - Cilj ovog rada je bio da se utvrdi prisustvo rezidua ohratoksina A (OTA) i toksičnih elemenata (kadmijum, olovo, živa i arsen) u tkivima zaklanih, tovnih svinja, poreklom iz različitih regiona Srbije. Tokom veterinarsko-sanitarnog pregleda zaklanih svinja, na liniji klanja, metodom slučajnog uzorkovanja uzimani su uzorci krvi, a zatim pripadajuća jetra i bubrezi, odgovarajuće životinje (n=90). Prisustvo rezidua OTA utvrđeno je u 26,6% uzoraka jetre u količini od 0,22 do 14,5 ng/g, dok je zastupljenost rezidua OTA u uzorcima krvne plazme i bubrega bila skoro identična (31,1 i 33,3%, ponaosob). Sadržaj OTA u uzorcima krvne plazme kretao se od 0,22 do 220,8 ng/mL, dok se u uzorcima bubrega kretao od 0,17 do 52,5 ng/g. Distribucija OTA u ispitanim tkivima (u %) u odnosu na sadržaj kretala se sledećim redosledom: krvna plazma> bubrezi>jetra (100>34>17), dok se u odnosu na zastupljenost rezidua kretala sledećim redosledom bubrezi>krvna plazma>jetra (100> 93,4>79,9). Rezultati naših istraživanja ukazuju na to da je u 2,2% ispitanih uzoraka bubrega utvrđen sadržaj OTA iznad maksimalno dozvoljene granice (10 ng/g). Nizak stepen pozitivne korelacije utvrđen je između sadržaja OTA u krvnoj plazmi i jetri (r=0,319), kao i između sadržaja OTA u jetri i bubrezima (r=0,341). Vrlo visok stepen pozitivne korelacije utvrđen je između sadržaja OTA u krvnoj plazmi i bubrezima (r=0,973). Prisustvo rezidua žive utvrđeno je u 33,3% uzoraka bubrega, u odnosu na učestalost nalaza rezidua kadmijuma koja je bila nešto manja (27,7%). Sadržaj žive kretao se u granicama predviđenim pravilnikom (0,005-0,055 mg/kg), dok je sadržaj kadmijuma u jednom uzorku bio iznad maksimalno dozvoljene granice (1,23 mg/kg). Prisustvo arsena utvrđeno je samo u jednom uzorku, dok prisustvo olova nije utvrđeno.
AB  - The aim and task of this study was to determine the presence of ochratoxin A (OTA) in blood serum, liver and kidneys of fattening swine, slaughtered regularly, originating from different areas of Serbia. During meat inspection on the slaughterhouse line samples of blood, kidney and liver per animal were randomly sampled (n=90) and analyzed by HPLC for ochratoxin A. Also, the presence of nephrotoxic (cadmium, lead, mercury and arsenic) elements in kidneys was carried out. Of the 90 liver samples, 26.6% contained OTA in the range of 0.22-14.5 ng/g, while the incidence of OTA in serum and kidney samples were very similar (31 and 33.3%, respectively). The analyses showed that serum samples were positive in the range of 0.22-221 ng/mL, while ochratoxin A concentrations in the kidney were between 0.17 and 52.5 ng/g. The mean distribution of OTA residue followed the pattern: serum>kidneys>liver (100>34>17), while in respect to occurrence it followed the pattern: kidneys>serum>liver (100>93.4>79.9). The results of this study showed that 2.2% of kidney sample had a content of ochratoxin A above the maximum permitted limit in Serbia of 10 ng/g. The results from this survey indicated that there was a low correlation between the OTA level in serum and liver as well as in the OTA level in kidney and liver (r=0.319 and 0.341, respectively) while the strongest correlation was found between the OTA level in serum and in kidney (r=0.973). The presence of mercury was found in 33.3% of kidney samples in the range of 0.005-0.055 mg/kg, while the presence of cadmium was found to a lesser degree (27.7%). The Hg concentrations in the kidney samples were lower than 0.10 mg/kg and did not exceed the guideline level established in Serbia, while concentration of cadmium in only one kidney sample was greater than 1.0 mg/kg, and exceeded the limit proposed by the Serbian Rule Book. The presence of arsenic was found only in one sample, while the presence of lead was not established. This study shows the presence of OTA in Serbian slaughtered pigs at levels comparable to those reported in other countries.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski glasnik
T1  - Uticaj prisustva rezidua ohratoksina A i toksičnih elemenata u tkivima na bezbednost svinjskog mesa
T1  - Presence of ochratoxin A and toxic elements residue in tissues and their impact on safety of pork
EP  - 371
IS  - 5-6
SP  - 359
VL  - 62
DO  - 10.2298/VETGL0806359M
UR  - conv_51
ER  - 

@article{
author = "Milićević, Dragan and Jovanović, Milijan and Jurić, Verica and Daković, Aleksandra and Stefanović, Srđan and Petrović, Zoran",
year = "2008",
abstract = "Cilj ovog rada je bio da se utvrdi prisustvo rezidua ohratoksina A (OTA) i toksičnih elemenata (kadmijum, olovo, živa i arsen) u tkivima zaklanih, tovnih svinja, poreklom iz različitih regiona Srbije. Tokom veterinarsko-sanitarnog pregleda zaklanih svinja, na liniji klanja, metodom slučajnog uzorkovanja uzimani su uzorci krvi, a zatim pripadajuća jetra i bubrezi, odgovarajuće životinje (n=90). Prisustvo rezidua OTA utvrđeno je u 26,6% uzoraka jetre u količini od 0,22 do 14,5 ng/g, dok je zastupljenost rezidua OTA u uzorcima krvne plazme i bubrega bila skoro identična (31,1 i 33,3%, ponaosob). Sadržaj OTA u uzorcima krvne plazme kretao se od 0,22 do 220,8 ng/mL, dok se u uzorcima bubrega kretao od 0,17 do 52,5 ng/g. Distribucija OTA u ispitanim tkivima (u %) u odnosu na sadržaj kretala se sledećim redosledom: krvna plazma> bubrezi>jetra (100>34>17), dok se u odnosu na zastupljenost rezidua kretala sledećim redosledom bubrezi>krvna plazma>jetra (100> 93,4>79,9). Rezultati naših istraživanja ukazuju na to da je u 2,2% ispitanih uzoraka bubrega utvrđen sadržaj OTA iznad maksimalno dozvoljene granice (10 ng/g). Nizak stepen pozitivne korelacije utvrđen je između sadržaja OTA u krvnoj plazmi i jetri (r=0,319), kao i između sadržaja OTA u jetri i bubrezima (r=0,341). Vrlo visok stepen pozitivne korelacije utvrđen je između sadržaja OTA u krvnoj plazmi i bubrezima (r=0,973). Prisustvo rezidua žive utvrđeno je u 33,3% uzoraka bubrega, u odnosu na učestalost nalaza rezidua kadmijuma koja je bila nešto manja (27,7%). Sadržaj žive kretao se u granicama predviđenim pravilnikom (0,005-0,055 mg/kg), dok je sadržaj kadmijuma u jednom uzorku bio iznad maksimalno dozvoljene granice (1,23 mg/kg). Prisustvo arsena utvrđeno je samo u jednom uzorku, dok prisustvo olova nije utvrđeno., The aim and task of this study was to determine the presence of ochratoxin A (OTA) in blood serum, liver and kidneys of fattening swine, slaughtered regularly, originating from different areas of Serbia. During meat inspection on the slaughterhouse line samples of blood, kidney and liver per animal were randomly sampled (n=90) and analyzed by HPLC for ochratoxin A. Also, the presence of nephrotoxic (cadmium, lead, mercury and arsenic) elements in kidneys was carried out. Of the 90 liver samples, 26.6% contained OTA in the range of 0.22-14.5 ng/g, while the incidence of OTA in serum and kidney samples were very similar (31 and 33.3%, respectively). The analyses showed that serum samples were positive in the range of 0.22-221 ng/mL, while ochratoxin A concentrations in the kidney were between 0.17 and 52.5 ng/g. The mean distribution of OTA residue followed the pattern: serum>kidneys>liver (100>34>17), while in respect to occurrence it followed the pattern: kidneys>serum>liver (100>93.4>79.9). The results of this study showed that 2.2% of kidney sample had a content of ochratoxin A above the maximum permitted limit in Serbia of 10 ng/g. The results from this survey indicated that there was a low correlation between the OTA level in serum and liver as well as in the OTA level in kidney and liver (r=0.319 and 0.341, respectively) while the strongest correlation was found between the OTA level in serum and in kidney (r=0.973). The presence of mercury was found in 33.3% of kidney samples in the range of 0.005-0.055 mg/kg, while the presence of cadmium was found to a lesser degree (27.7%). The Hg concentrations in the kidney samples were lower than 0.10 mg/kg and did not exceed the guideline level established in Serbia, while concentration of cadmium in only one kidney sample was greater than 1.0 mg/kg, and exceeded the limit proposed by the Serbian Rule Book. The presence of arsenic was found only in one sample, while the presence of lead was not established. This study shows the presence of OTA in Serbian slaughtered pigs at levels comparable to those reported in other countries.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski glasnik",
title = "Uticaj prisustva rezidua ohratoksina A i toksičnih elemenata u tkivima na bezbednost svinjskog mesa, Presence of ochratoxin A and toxic elements residue in tissues and their impact on safety of pork",
pages = "371-359",
number = "5-6",
volume = "62",
doi = "10.2298/VETGL0806359M",
url = "conv_51"
}

Milićević, D., Jovanović, M., Jurić, V., Daković, A., Stefanović, S.,& Petrović, Z.. (2008). Uticaj prisustva rezidua ohratoksina A i toksičnih elemenata u tkivima na bezbednost svinjskog mesa. in Veterinarski glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 62(5-6), 359-371.
https://doi.org/10.2298/VETGL0806359M
conv_51

Milićević D, Jovanović M, Jurić V, Daković A, Stefanović S, Petrović Z. Uticaj prisustva rezidua ohratoksina A i toksičnih elemenata u tkivima na bezbednost svinjskog mesa. in Veterinarski glasnik. 2008;62(5-6):359-371.
doi:10.2298/VETGL0806359M
conv_51 .

Milićević, Dragan, Jovanović, Milijan, Jurić, Verica, Daković, Aleksandra, Stefanović, Srđan, Petrović, Zoran, "Uticaj prisustva rezidua ohratoksina A i toksičnih elemenata u tkivima na bezbednost svinjskog mesa" in Veterinarski glasnik, 62, no. 5-6 (2008):359-371,
https://doi.org/10.2298/VETGL0806359M .,
conv_51 .