TY  - JOUR
AU  - Izzo, Francesco
AU  - Mercurio, Mariano
AU  - de Gennaro, Bruno
AU  - Aprea, Paolo
AU  - Cappelletti, Piergiulio
AU  - Daković, Aleksandra
AU  - Germinario, Chiara
AU  - Grifa, Celestino
AU  - Smiljanić, Danijela
AU  - Langella, Alessio
PY  - 2019
UR  - https://ritnms.itnms.ac.rs/handle/123456789/496
AB  - The present research deals with the evaluation of a clinoptilolite-rich rock, occurring in the Nizny Hrabovec deposit (Slovakia), for high-value technological applications based on sorption and in vitro release of nonsteroidal anti-inflammatory drugs (i.e., ibuprofen sodium salt). This georesource was surface modified (SMNZ) using four cationic surfactants. Results demonstrate that ibuprofen sorption is very fast and SMZNs can sorb up to (similar to)26 mg/g of drug as a function of the type of counterion and morphology of surfactant, as well as the hydrophobicity and molecular structure of the drug. Maximum sorption capacities observed for all SMNZs are fully comparable to other adsorbent carriers usually used for removal of contaminants in wastewaters. Sorption of ibuprofen is controlled by a dual mechanism: external anionic exchange and partition into the hydrophobic portion of the patchy bilayer. A prompt drug release in simulated intestinal fluid (SIF) was also observed, making this natural material also suitable to provide rapid soothing effects in potential pharmacological applications. Comparing the results of this study with other recent investigations, a good technological performance of clinoptilolite-rich rock can be inferred despite the relatively low zeolite content ((similar to)56 wt.%).
PB  - Elsevier, Amsterdam
T2  - Colloids and Surfaces B-Biointerfaces
T1  - Surface modified natural zeolites (SMNZs) as nanocomposite versatile materials for health and environment
VL  - 182
DO  - 10.1016/j.colsurfb.2019.110380
UR  - conv_861
ER  - 

@article{
author = "Izzo, Francesco and Mercurio, Mariano and de Gennaro, Bruno and Aprea, Paolo and Cappelletti, Piergiulio and Daković, Aleksandra and Germinario, Chiara and Grifa, Celestino and Smiljanić, Danijela and Langella, Alessio",
year = "2019",
abstract = "The present research deals with the evaluation of a clinoptilolite-rich rock, occurring in the Nizny Hrabovec deposit (Slovakia), for high-value technological applications based on sorption and in vitro release of nonsteroidal anti-inflammatory drugs (i.e., ibuprofen sodium salt). This georesource was surface modified (SMNZ) using four cationic surfactants. Results demonstrate that ibuprofen sorption is very fast and SMZNs can sorb up to (similar to)26 mg/g of drug as a function of the type of counterion and morphology of surfactant, as well as the hydrophobicity and molecular structure of the drug. Maximum sorption capacities observed for all SMNZs are fully comparable to other adsorbent carriers usually used for removal of contaminants in wastewaters. Sorption of ibuprofen is controlled by a dual mechanism: external anionic exchange and partition into the hydrophobic portion of the patchy bilayer. A prompt drug release in simulated intestinal fluid (SIF) was also observed, making this natural material also suitable to provide rapid soothing effects in potential pharmacological applications. Comparing the results of this study with other recent investigations, a good technological performance of clinoptilolite-rich rock can be inferred despite the relatively low zeolite content ((similar to)56 wt.%).",
publisher = "Elsevier, Amsterdam",
journal = "Colloids and Surfaces B-Biointerfaces",
title = "Surface modified natural zeolites (SMNZs) as nanocomposite versatile materials for health and environment",
volume = "182",
doi = "10.1016/j.colsurfb.2019.110380",
url = "conv_861"
}

Izzo, F., Mercurio, M., de Gennaro, B., Aprea, P., Cappelletti, P., Daković, A., Germinario, C., Grifa, C., Smiljanić, D.,& Langella, A.. (2019). Surface modified natural zeolites (SMNZs) as nanocomposite versatile materials for health and environment. in Colloids and Surfaces B-Biointerfaces
Elsevier, Amsterdam., 182.
https://doi.org/10.1016/j.colsurfb.2019.110380
conv_861

Izzo F, Mercurio M, de Gennaro B, Aprea P, Cappelletti P, Daković A, Germinario C, Grifa C, Smiljanić D, Langella A. Surface modified natural zeolites (SMNZs) as nanocomposite versatile materials for health and environment. in Colloids and Surfaces B-Biointerfaces. 2019;182.
doi:10.1016/j.colsurfb.2019.110380
conv_861 .

Izzo, Francesco, Mercurio, Mariano, de Gennaro, Bruno, Aprea, Paolo, Cappelletti, Piergiulio, Daković, Aleksandra, Germinario, Chiara, Grifa, Celestino, Smiljanić, Danijela, Langella, Alessio, "Surface modified natural zeolites (SMNZs) as nanocomposite versatile materials for health and environment" in Colloids and Surfaces B-Biointerfaces, 182 (2019),
https://doi.org/10.1016/j.colsurfb.2019.110380 .,
conv_861 .

TY  - JOUR
AU  - Mercurio, Mariano
AU  - Izzo, Francesco
AU  - Langella, Alessio
AU  - Grifa, Celestino
AU  - Germinario, Chiara
AU  - Daković, Aleksandra
AU  - Aprea, Paolo
AU  - Pasquino, Rossana
AU  - Cappelletti, Piergiulio
AU  - Graziano, Sossio Fabio
AU  - de Gennaro, Bruno
PY  - 2018
UR  - https://ritnms.itnms.ac.rs/handle/123456789/473
AB  - The encapsulation and delivery of drugs often involves the use of expensive microporous materials, and we have investigated the potential for natural zeolites from the widespread volcanic formations of southern Italy as alternatives to these carriers. Surface-modified natural zeolites (SMNZs) with diverse micellar structures (patchy and complete bilayers) were obtained by using different cationic surfactants [cetylpyridinium chloride (CP-Cl), benzalkonium chloride (BC-Cl), hexadecyltrimethylammonium chloride (HDTMA-Cl), and bromide (HDTMA-Br) with phillipsite-rich tuff from the Campania region (southern Italy)]. Loading and release kinetics tests of sodium ibuprofen (IBU) were carried out with organo-phillipsite composites using Fourier transform infrared spectroscopy (FTIR) and thermal analysis coupled with evolved gas analysis (EGA). Results from these tests were mathematically modeled to evaluate IBU adsorption and release mechanisms. The maximum loaded amount of IBU was attained for organo-phillipsite modified with HDTMABr (PHB), which showed a complete bilayer micellar structure. Whenever a patchy bilayer micellar structure formed, the lowest adsorptions of IBU were observed. Equilibrium adsorption results were fit using Langmuir, Sips, and Toth models. Pseudo-first-order and pseudo-second-order fits to the loading kinetic data provided significant goodness of fit. Good fits to the release kinetic data were obtained using first-order and Weibull equations, shedding new light on the release mechanism of IBU from phillipsite. The active amount of IBU on the modified zeolite surface was almost totally available for pharmaceutical purposes.
PB  - Mineralogical Soc Amer, Chantilly
T2  - American Mineralogist
T1  - Surface-modified phillipsite-rich tuff from the Campania region (southern Italy) as a promising drug carrier: An ibuprofen sodium salt trial
EP  - 710
IS  - 5
SP  - 700
VL  - 103
DO  - 10.2138/am-2018-6328
UR  - conv_822
ER  - 

@article{
author = "Mercurio, Mariano and Izzo, Francesco and Langella, Alessio and Grifa, Celestino and Germinario, Chiara and Daković, Aleksandra and Aprea, Paolo and Pasquino, Rossana and Cappelletti, Piergiulio and Graziano, Sossio Fabio and de Gennaro, Bruno",
year = "2018",
abstract = "The encapsulation and delivery of drugs often involves the use of expensive microporous materials, and we have investigated the potential for natural zeolites from the widespread volcanic formations of southern Italy as alternatives to these carriers. Surface-modified natural zeolites (SMNZs) with diverse micellar structures (patchy and complete bilayers) were obtained by using different cationic surfactants [cetylpyridinium chloride (CP-Cl), benzalkonium chloride (BC-Cl), hexadecyltrimethylammonium chloride (HDTMA-Cl), and bromide (HDTMA-Br) with phillipsite-rich tuff from the Campania region (southern Italy)]. Loading and release kinetics tests of sodium ibuprofen (IBU) were carried out with organo-phillipsite composites using Fourier transform infrared spectroscopy (FTIR) and thermal analysis coupled with evolved gas analysis (EGA). Results from these tests were mathematically modeled to evaluate IBU adsorption and release mechanisms. The maximum loaded amount of IBU was attained for organo-phillipsite modified with HDTMABr (PHB), which showed a complete bilayer micellar structure. Whenever a patchy bilayer micellar structure formed, the lowest adsorptions of IBU were observed. Equilibrium adsorption results were fit using Langmuir, Sips, and Toth models. Pseudo-first-order and pseudo-second-order fits to the loading kinetic data provided significant goodness of fit. Good fits to the release kinetic data were obtained using first-order and Weibull equations, shedding new light on the release mechanism of IBU from phillipsite. The active amount of IBU on the modified zeolite surface was almost totally available for pharmaceutical purposes.",
publisher = "Mineralogical Soc Amer, Chantilly",
journal = "American Mineralogist",
title = "Surface-modified phillipsite-rich tuff from the Campania region (southern Italy) as a promising drug carrier: An ibuprofen sodium salt trial",
pages = "710-700",
number = "5",
volume = "103",
doi = "10.2138/am-2018-6328",
url = "conv_822"
}

Mercurio, M., Izzo, F., Langella, A., Grifa, C., Germinario, C., Daković, A., Aprea, P., Pasquino, R., Cappelletti, P., Graziano, S. F.,& de Gennaro, B.. (2018). Surface-modified phillipsite-rich tuff from the Campania region (southern Italy) as a promising drug carrier: An ibuprofen sodium salt trial. in American Mineralogist
Mineralogical Soc Amer, Chantilly., 103(5), 700-710.
https://doi.org/10.2138/am-2018-6328
conv_822

Mercurio M, Izzo F, Langella A, Grifa C, Germinario C, Daković A, Aprea P, Pasquino R, Cappelletti P, Graziano SF, de Gennaro B. Surface-modified phillipsite-rich tuff from the Campania region (southern Italy) as a promising drug carrier: An ibuprofen sodium salt trial. in American Mineralogist. 2018;103(5):700-710.
doi:10.2138/am-2018-6328
conv_822 .

Mercurio, Mariano, Izzo, Francesco, Langella, Alessio, Grifa, Celestino, Germinario, Chiara, Daković, Aleksandra, Aprea, Paolo, Pasquino, Rossana, Cappelletti, Piergiulio, Graziano, Sossio Fabio, de Gennaro, Bruno, "Surface-modified phillipsite-rich tuff from the Campania region (southern Italy) as a promising drug carrier: An ibuprofen sodium salt trial" in American Mineralogist, 103, no. 5 (2018):700-710,
https://doi.org/10.2138/am-2018-6328 .,
conv_822 .