TY  - JOUR
AU  - Obradović, Milena
AU  - Daković, Aleksandra
AU  - Smiljanić, Danijela
AU  - Marković, Marija
AU  - Ožegović, Milica
AU  - Krstić, Jugoslav
AU  - Vuković, Nikola
AU  - Milojević-Rakić, Maja
PY  - 2024
UR  - https://ritnms.itnms.ac.rs/handle/123456789/1222
AB  - Organobentonites have been applied for the removal of two common non-steroidal anti-inflammatory drugs, ibuprofen (IBU) and diclofenac sodium (DS), from aqueous solutions. Two surfactants, one with and the other without benzyl group (octadecyldimethylbenzylammonium chloride, ODMBA, and hexadecyltrimethylammonium bromide, HDTMA), in amounts equivalent to 50, 75, and 100% of the cation exchange capacity of bentonite were used for the preparation of organobentonites. Successful modification of bentonite was confirmed by several methods: X-ray powder diffraction (XRPD), point of the zero charge (pHPZC), determination of exchanged inorganic cations in bentonite, determination of textural properties, and scanning electron microscopy (SEM). Kinetic and thermodynamic data on the adsorption of IBU and DS showed that drug adsorption was controlled by the type and the amount of surfactant incorporated into the bentonite and by their arrangement in the interlayer space and at the surface of organobentonites. The adsorption of both drugs increased with an increase in the amount of both surfactants in organobentonites. The presence of the benzyl group in organobentonites enhanced the adsorption of IBU and DS and was more pronounced for IBU. Drug adsorption fits the pseudo-second-order kinetic model the best. The thermodynamic data revealed that the adsorption process was endothermic in nature and with increase of the amount of both surfactants drug adsorption processes were more spontaneous. The results obtained from this study revealed that adsorbents based on surfactants modified bentonite are promising candidates for IBU and DS removal from contaminated water.
PB  - MDPI
T2  - Processes
T1  - Bentonite Modified with Surfactants—Efficient Adsorbents for the Removal of Non-Steroidal Anti-Inflammatory Drugs
IS  - 1
SP  - 96
VL  - 12
DO  - 10.3390/pr12010096
ER  - 

@article{
author = "Obradović, Milena and Daković, Aleksandra and Smiljanić, Danijela and Marković, Marija and Ožegović, Milica and Krstić, Jugoslav and Vuković, Nikola and Milojević-Rakić, Maja",
year = "2024",
abstract = "Organobentonites have been applied for the removal of two common non-steroidal anti-inflammatory drugs, ibuprofen (IBU) and diclofenac sodium (DS), from aqueous solutions. Two surfactants, one with and the other without benzyl group (octadecyldimethylbenzylammonium chloride, ODMBA, and hexadecyltrimethylammonium bromide, HDTMA), in amounts equivalent to 50, 75, and 100% of the cation exchange capacity of bentonite were used for the preparation of organobentonites. Successful modification of bentonite was confirmed by several methods: X-ray powder diffraction (XRPD), point of the zero charge (pHPZC), determination of exchanged inorganic cations in bentonite, determination of textural properties, and scanning electron microscopy (SEM). Kinetic and thermodynamic data on the adsorption of IBU and DS showed that drug adsorption was controlled by the type and the amount of surfactant incorporated into the bentonite and by their arrangement in the interlayer space and at the surface of organobentonites. The adsorption of both drugs increased with an increase in the amount of both surfactants in organobentonites. The presence of the benzyl group in organobentonites enhanced the adsorption of IBU and DS and was more pronounced for IBU. Drug adsorption fits the pseudo-second-order kinetic model the best. The thermodynamic data revealed that the adsorption process was endothermic in nature and with increase of the amount of both surfactants drug adsorption processes were more spontaneous. The results obtained from this study revealed that adsorbents based on surfactants modified bentonite are promising candidates for IBU and DS removal from contaminated water.",
publisher = "MDPI",
journal = "Processes",
title = "Bentonite Modified with Surfactants—Efficient Adsorbents for the Removal of Non-Steroidal Anti-Inflammatory Drugs",
number = "1",
pages = "96",
volume = "12",
doi = "10.3390/pr12010096"
}

Obradović, M., Daković, A., Smiljanić, D., Marković, M., Ožegović, M., Krstić, J., Vuković, N.,& Milojević-Rakić, M.. (2024). Bentonite Modified with Surfactants—Efficient Adsorbents for the Removal of Non-Steroidal Anti-Inflammatory Drugs. in Processes
MDPI., 12(1), 96.
https://doi.org/10.3390/pr12010096

Obradović M, Daković A, Smiljanić D, Marković M, Ožegović M, Krstić J, Vuković N, Milojević-Rakić M. Bentonite Modified with Surfactants—Efficient Adsorbents for the Removal of Non-Steroidal Anti-Inflammatory Drugs. in Processes. 2024;12(1):96.
doi:10.3390/pr12010096 .

Obradović, Milena, Daković, Aleksandra, Smiljanić, Danijela, Marković, Marija, Ožegović, Milica, Krstić, Jugoslav, Vuković, Nikola, Milojević-Rakić, Maja, "Bentonite Modified with Surfactants—Efficient Adsorbents for the Removal of Non-Steroidal Anti-Inflammatory Drugs" in Processes, 12, no. 1 (2024):96,
https://doi.org/10.3390/pr12010096 . .

TY  - JOUR
AU  - Nedić-Vasiljević, Bojana
AU  - Obradović, Milena
AU  - Bajuk-Bogdanović, Danica
AU  - Milojević-Rakić, Maja
AU  - Jovanović, Zoran
AU  - Gavrilov, Nemanja
AU  - Holclajtner-Antunović, Ivanka
PY  - 2019
UR  - https://ritnms.itnms.ac.rs/handle/123456789/524
AB  - Potassium tungstophosphate is supported on BEA zeolite by in situ synthesis for glyphosate removal. Spectroscopic measurements identified hydrogen bonding as a primal interaction of potassium salt and BEA zeolite. Composites are evaluated for glyphosate herbicide removal and adsorption process is analyzed using two isotherm models. Obtained adsorption capacities for all prepared composites lay between 45.2 and 92.2 mg of glyphosate per gram of investigated composite. Suspension acidity revealed that glyphosate is adsorbed mainly in the zwitter-ion form at the composite surface while the amount of potassium salt in the composites is crucial for the adsorption application. Exceptional adsorption behavior is postulated to come from a high degree of homogeneity among surface active sites which is confirmed by different experimental methods. Temperature programmed desorption of glyphosate coupled with mass spectrometer detected one broad, high-temperature peak which represents overlapped desorption processes from active sights of similar strength. Introduction of potassium tungstophosphate affects active sites present in BEA zeolite for glyphosate desorption and significantly increases the amount of adsorbed pesticide in comparison to BEA zeolite. Supporting of potassium tungstophosphate on BEA zeolite via in situ synthesis procedure enables the formation of highly efficient adsorbents and revealed their perspective environmental application.
PB  - Science Press, Beijing
T2  - Journal of Environmental Sciences
T1  - In situ synthesis of potassium tungstophosphate supported on BEA zeolite and perspective application for pesticide removal
EP  - 147
SP  - 136
VL  - 81
DO  - 10.1016/j.jes.2019.01.018
UR  - conv_846
ER  - 

@article{
author = "Nedić-Vasiljević, Bojana and Obradović, Milena and Bajuk-Bogdanović, Danica and Milojević-Rakić, Maja and Jovanović, Zoran and Gavrilov, Nemanja and Holclajtner-Antunović, Ivanka",
year = "2019",
abstract = "Potassium tungstophosphate is supported on BEA zeolite by in situ synthesis for glyphosate removal. Spectroscopic measurements identified hydrogen bonding as a primal interaction of potassium salt and BEA zeolite. Composites are evaluated for glyphosate herbicide removal and adsorption process is analyzed using two isotherm models. Obtained adsorption capacities for all prepared composites lay between 45.2 and 92.2 mg of glyphosate per gram of investigated composite. Suspension acidity revealed that glyphosate is adsorbed mainly in the zwitter-ion form at the composite surface while the amount of potassium salt in the composites is crucial for the adsorption application. Exceptional adsorption behavior is postulated to come from a high degree of homogeneity among surface active sites which is confirmed by different experimental methods. Temperature programmed desorption of glyphosate coupled with mass spectrometer detected one broad, high-temperature peak which represents overlapped desorption processes from active sights of similar strength. Introduction of potassium tungstophosphate affects active sites present in BEA zeolite for glyphosate desorption and significantly increases the amount of adsorbed pesticide in comparison to BEA zeolite. Supporting of potassium tungstophosphate on BEA zeolite via in situ synthesis procedure enables the formation of highly efficient adsorbents and revealed their perspective environmental application.",
publisher = "Science Press, Beijing",
journal = "Journal of Environmental Sciences",
title = "In situ synthesis of potassium tungstophosphate supported on BEA zeolite and perspective application for pesticide removal",
pages = "147-136",
volume = "81",
doi = "10.1016/j.jes.2019.01.018",
url = "conv_846"
}

Nedić-Vasiljević, B., Obradović, M., Bajuk-Bogdanović, D., Milojević-Rakić, M., Jovanović, Z., Gavrilov, N.,& Holclajtner-Antunović, I.. (2019). In situ synthesis of potassium tungstophosphate supported on BEA zeolite and perspective application for pesticide removal. in Journal of Environmental Sciences
Science Press, Beijing., 81, 136-147.
https://doi.org/10.1016/j.jes.2019.01.018
conv_846

Nedić-Vasiljević B, Obradović M, Bajuk-Bogdanović D, Milojević-Rakić M, Jovanović Z, Gavrilov N, Holclajtner-Antunović I. In situ synthesis of potassium tungstophosphate supported on BEA zeolite and perspective application for pesticide removal. in Journal of Environmental Sciences. 2019;81:136-147.
doi:10.1016/j.jes.2019.01.018
conv_846 .

Nedić-Vasiljević, Bojana, Obradović, Milena, Bajuk-Bogdanović, Danica, Milojević-Rakić, Maja, Jovanović, Zoran, Gavrilov, Nemanja, Holclajtner-Antunović, Ivanka, "In situ synthesis of potassium tungstophosphate supported on BEA zeolite and perspective application for pesticide removal" in Journal of Environmental Sciences, 81 (2019):136-147,
https://doi.org/10.1016/j.jes.2019.01.018 .,
conv_846 .

TY  - JOUR
AU  - Krajišnik, Danina
AU  - Daković, Aleksandra
AU  - Malenović, Anđelija
AU  - Milojević-Rakić, Maja
AU  - Dondur, Vera
AU  - Radulović, Željka
AU  - Millc, Jela
PY  - 2013
UR  - https://ritnms.itnms.ac.rs/handle/123456789/261
AB  - Results on adsorption of diclofenac sodium (DS) by modified natural zeolite composites at three levels (10,20 and 30 mmol/100 g) of cationic surfactant-hexadecyltrimethylammonium bromide (HB), in a buffer solution, were compared. Characterization of composites before and after drug adsorption was performed by determination of electrokinetic mobility, FTIR and thermal analysis. The results indicated interactions between drug and carriers. The pharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments. The results were compared with the drug release from corresponding physical mixtures. Prolonged drug release over a period of 8 h (up to 30%) was achieved with both groups of samples. Furthermore, DS release reached up to 85% from physical mixtures containing drug amount closer to a therapeutic dose.
PB  - Elsevier Science Bv, Amsterdam
T2  - Applied Clay Science
T1  - Investigation of adsorption and release of diclofenac sodium by modified zeolites composites
EP  - 326
SP  - 322
VL  - 83-84
DO  - 10.1016/j.clay.2013.08.011
UR  - conv_671
ER  - 

@article{
author = "Krajišnik, Danina and Daković, Aleksandra and Malenović, Anđelija and Milojević-Rakić, Maja and Dondur, Vera and Radulović, Željka and Millc, Jela",
year = "2013",
abstract = "Results on adsorption of diclofenac sodium (DS) by modified natural zeolite composites at three levels (10,20 and 30 mmol/100 g) of cationic surfactant-hexadecyltrimethylammonium bromide (HB), in a buffer solution, were compared. Characterization of composites before and after drug adsorption was performed by determination of electrokinetic mobility, FTIR and thermal analysis. The results indicated interactions between drug and carriers. The pharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments. The results were compared with the drug release from corresponding physical mixtures. Prolonged drug release over a period of 8 h (up to 30%) was achieved with both groups of samples. Furthermore, DS release reached up to 85% from physical mixtures containing drug amount closer to a therapeutic dose.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Applied Clay Science",
title = "Investigation of adsorption and release of diclofenac sodium by modified zeolites composites",
pages = "326-322",
volume = "83-84",
doi = "10.1016/j.clay.2013.08.011",
url = "conv_671"
}

Krajišnik, D., Daković, A., Malenović, A., Milojević-Rakić, M., Dondur, V., Radulović, Ž.,& Millc, J.. (2013). Investigation of adsorption and release of diclofenac sodium by modified zeolites composites. in Applied Clay Science
Elsevier Science Bv, Amsterdam., 83-84, 322-326.
https://doi.org/10.1016/j.clay.2013.08.011
conv_671

Krajišnik D, Daković A, Malenović A, Milojević-Rakić M, Dondur V, Radulović Ž, Millc J. Investigation of adsorption and release of diclofenac sodium by modified zeolites composites. in Applied Clay Science. 2013;83-84:322-326.
doi:10.1016/j.clay.2013.08.011
conv_671 .

Krajišnik, Danina, Daković, Aleksandra, Malenović, Anđelija, Milojević-Rakić, Maja, Dondur, Vera, Radulović, Željka, Millc, Jela, "Investigation of adsorption and release of diclofenac sodium by modified zeolites composites" in Applied Clay Science, 83-84 (2013):322-326,
https://doi.org/10.1016/j.clay.2013.08.011 .,
conv_671 .

TY  - JOUR
AU  - Krajišnik, Danina
AU  - Daković, Aleksandra
AU  - Milojević, Maja
AU  - Malenović, Anđelija
AU  - Kragović, Milan
AU  - Bajuk-Bogdanović, Danica
AU  - Dondur, Vera
AU  - Milić, Jela
PY  - 2011
UR  - https://ritnms.itnms.ac.rs/handle/123456789/189
AB  - In this study an investigation of a model drug sorption onto cationic surfactant-modified natural zeolites as a drug formulation excipient was performed. Natural zeolite was modified with cetylpyridinium chloride in amounts equivalent to 100, 200 and 300% of its external cation-exchange capacity. The starting material and obtained organozeolites were characterized by Fourier transform infrared spectroscopy, zeta potential measurements and thermal analysis. In vitro sorption of diclofenac sodium as a model drug was studied for all surfactant/zeolite composites by means of sorption isotherm measurements in aqueous solutions (pH 7.4). The modified zeolites with three levels of surfactant coverage within the short activation time were prepared. Zeta potential measurements and thermal analysis showed that when the surfactant loading level was equal to external cation-exchange value, almost monolayer of organic phase were present at the zeolitic surface while higher amounts of surfactant produced less extended bilayers, ordered bilayers or admicelles at the zeolitic surface. Modified zeolites, obtained in this manner, were effective in diclofenac sodium sorption and the organic phase derived from adsorbed cetylpyridinium chloride was the primary sorption phase for the model drug. The Langmuir isotherm was found to describe the equilibrium sorption data well over the entire concentration range. The separate contributions of the adsorption and partition to the total sorption of DS were analyzed mathematically. Results revealed that that adsorption and partitioning of the model drug take place simultaneously.
PB  - Elsevier, Amsterdam
T2  - Colloids and Surfaces B-Biointerfaces
T1  - Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride
EP  - 172
IS  - 1
SP  - 165
VL  - 83
DO  - 10.1016/j.colsurfb.2010.11.024
UR  - conv_598
ER  - 

@article{
author = "Krajišnik, Danina and Daković, Aleksandra and Milojević, Maja and Malenović, Anđelija and Kragović, Milan and Bajuk-Bogdanović, Danica and Dondur, Vera and Milić, Jela",
year = "2011",
abstract = "In this study an investigation of a model drug sorption onto cationic surfactant-modified natural zeolites as a drug formulation excipient was performed. Natural zeolite was modified with cetylpyridinium chloride in amounts equivalent to 100, 200 and 300% of its external cation-exchange capacity. The starting material and obtained organozeolites were characterized by Fourier transform infrared spectroscopy, zeta potential measurements and thermal analysis. In vitro sorption of diclofenac sodium as a model drug was studied for all surfactant/zeolite composites by means of sorption isotherm measurements in aqueous solutions (pH 7.4). The modified zeolites with three levels of surfactant coverage within the short activation time were prepared. Zeta potential measurements and thermal analysis showed that when the surfactant loading level was equal to external cation-exchange value, almost monolayer of organic phase were present at the zeolitic surface while higher amounts of surfactant produced less extended bilayers, ordered bilayers or admicelles at the zeolitic surface. Modified zeolites, obtained in this manner, were effective in diclofenac sodium sorption and the organic phase derived from adsorbed cetylpyridinium chloride was the primary sorption phase for the model drug. The Langmuir isotherm was found to describe the equilibrium sorption data well over the entire concentration range. The separate contributions of the adsorption and partition to the total sorption of DS were analyzed mathematically. Results revealed that that adsorption and partitioning of the model drug take place simultaneously.",
publisher = "Elsevier, Amsterdam",
journal = "Colloids and Surfaces B-Biointerfaces",
title = "Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride",
pages = "172-165",
number = "1",
volume = "83",
doi = "10.1016/j.colsurfb.2010.11.024",
url = "conv_598"
}

Krajišnik, D., Daković, A., Milojević, M., Malenović, A., Kragović, M., Bajuk-Bogdanović, D., Dondur, V.,& Milić, J.. (2011). Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride. in Colloids and Surfaces B-Biointerfaces
Elsevier, Amsterdam., 83(1), 165-172.
https://doi.org/10.1016/j.colsurfb.2010.11.024
conv_598

Krajišnik D, Daković A, Milojević M, Malenović A, Kragović M, Bajuk-Bogdanović D, Dondur V, Milić J. Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride. in Colloids and Surfaces B-Biointerfaces. 2011;83(1):165-172.
doi:10.1016/j.colsurfb.2010.11.024
conv_598 .

Krajišnik, Danina, Daković, Aleksandra, Milojević, Maja, Malenović, Anđelija, Kragović, Milan, Bajuk-Bogdanović, Danica, Dondur, Vera, Milić, Jela, "Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride" in Colloids and Surfaces B-Biointerfaces, 83, no. 1 (2011):165-172,
https://doi.org/10.1016/j.colsurfb.2010.11.024 .,
conv_598 .

TY  - JOUR
AU  - Krajišnik, Danina
AU  - Milojević, Maja
AU  - Malenović, Anđelija
AU  - Daković, Aleksandra
AU  - Ibrić, Svetlana
AU  - Savić, Snežana
AU  - Dondur, Vera
AU  - Matijašević, Srđan
AU  - Radulović, Aleksandra
AU  - Daniels, Rolf
AU  - Milić, Jela
PY  - 2010
UR  - https://ritnms.itnms.ac.rs/handle/123456789/171
AB  - Context: In this study an investigation of cationic surfactants-modified natural zeolites as drug formulation excipient was performed. Objective: The aim of this work was to carry out a study of the purified natural zeolitic tuff with high amount of clinoptilolite as a potential carrier for molecules of pharmaceutical interest. Materials and methods: Two cationic surfactants (benzalkonium chloride and hexadecyltrimethylammonium bromide) were used for modification of the zeolitic surface in two levels (equal to and twice as external cation-exchange capacity of the zeolitic tuff). Prepared samples were characterized by Fourier transform infrared spectroscopy, thermogravimetric, high-performance liquid chromatography analysis, and powder flow determination. Different surfactant/zeolite composites were used for additional investigation of three model drugs: diclofenac diethylamine, diclofenac sodium, and ibuprofen by means of adsorption isotherm measurements in aqueous solutions. Results: The modified zeolites with two levels of surfactant coverage within the short activation time were prepared. Determination of flow properties showed that modification of zeolitic surface reflected on powder flow characteristics. Investigation of the model drugs adsorption on the obtained composites revealed that a variation between adsorption levels was influenced by the surfactant type and the amount present at the surface of the composites. Discussion and conclusion: In vitro release profiles of the drugs from the zeolite-surfactant-drug composites revealed that sustained drug release could be attained over a period of 8 hours. The presented results for drug uptake by surfactant-zeolite composites and the afterward drug release demonstrated the potential use of investigated modified natural zeolite as excipients for advanced excipients in drug formulations.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Drug Development and Industrial Pharmacy
T1  - Cationic surfactants-modified natural zeolites: improvement of the excipients functionality
EP  - 1224
IS  - 10
SP  - 1215
VL  - 36
DO  - 10.3109/03639041003695121
UR  - conv_588
ER  - 

@article{
author = "Krajišnik, Danina and Milojević, Maja and Malenović, Anđelija and Daković, Aleksandra and Ibrić, Svetlana and Savić, Snežana and Dondur, Vera and Matijašević, Srđan and Radulović, Aleksandra and Daniels, Rolf and Milić, Jela",
year = "2010",
abstract = "Context: In this study an investigation of cationic surfactants-modified natural zeolites as drug formulation excipient was performed. Objective: The aim of this work was to carry out a study of the purified natural zeolitic tuff with high amount of clinoptilolite as a potential carrier for molecules of pharmaceutical interest. Materials and methods: Two cationic surfactants (benzalkonium chloride and hexadecyltrimethylammonium bromide) were used for modification of the zeolitic surface in two levels (equal to and twice as external cation-exchange capacity of the zeolitic tuff). Prepared samples were characterized by Fourier transform infrared spectroscopy, thermogravimetric, high-performance liquid chromatography analysis, and powder flow determination. Different surfactant/zeolite composites were used for additional investigation of three model drugs: diclofenac diethylamine, diclofenac sodium, and ibuprofen by means of adsorption isotherm measurements in aqueous solutions. Results: The modified zeolites with two levels of surfactant coverage within the short activation time were prepared. Determination of flow properties showed that modification of zeolitic surface reflected on powder flow characteristics. Investigation of the model drugs adsorption on the obtained composites revealed that a variation between adsorption levels was influenced by the surfactant type and the amount present at the surface of the composites. Discussion and conclusion: In vitro release profiles of the drugs from the zeolite-surfactant-drug composites revealed that sustained drug release could be attained over a period of 8 hours. The presented results for drug uptake by surfactant-zeolite composites and the afterward drug release demonstrated the potential use of investigated modified natural zeolite as excipients for advanced excipients in drug formulations.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Drug Development and Industrial Pharmacy",
title = "Cationic surfactants-modified natural zeolites: improvement of the excipients functionality",
pages = "1224-1215",
number = "10",
volume = "36",
doi = "10.3109/03639041003695121",
url = "conv_588"
}

Krajišnik, D., Milojević, M., Malenović, A., Daković, A., Ibrić, S., Savić, S., Dondur, V., Matijašević, S., Radulović, A., Daniels, R.,& Milić, J.. (2010). Cationic surfactants-modified natural zeolites: improvement of the excipients functionality. in Drug Development and Industrial Pharmacy
Taylor & Francis Ltd, Abingdon., 36(10), 1215-1224.
https://doi.org/10.3109/03639041003695121
conv_588

Krajišnik D, Milojević M, Malenović A, Daković A, Ibrić S, Savić S, Dondur V, Matijašević S, Radulović A, Daniels R, Milić J. Cationic surfactants-modified natural zeolites: improvement of the excipients functionality. in Drug Development and Industrial Pharmacy. 2010;36(10):1215-1224.
doi:10.3109/03639041003695121
conv_588 .

Krajišnik, Danina, Milojević, Maja, Malenović, Anđelija, Daković, Aleksandra, Ibrić, Svetlana, Savić, Snežana, Dondur, Vera, Matijašević, Srđan, Radulović, Aleksandra, Daniels, Rolf, Milić, Jela, "Cationic surfactants-modified natural zeolites: improvement of the excipients functionality" in Drug Development and Industrial Pharmacy, 36, no. 10 (2010):1215-1224,
https://doi.org/10.3109/03639041003695121 .,
conv_588 .