@conference{
author = "Topalović, Vladimir and Matijašević, Srđan and Nikolić, Jelena and Đošić, Marija and Savić, Veljko and Smiljanić, Sonja and Grujić, Snežana",
year = "2018",
abstract = "In recent years, because of dissolution behavior, bioactivity and biocompatibility, there is an expanding interest in the development and application of phosphate-based glasses as biomaterials in medicine [1, 2]. These glasses are preferable to silica-based glasses because of their more controllable dissolution rate [3, 4]. Several techniques have been developed to fabricate bioactive porous glass-ceramic scaffolds for application in bone tissue engineering [5-7]. In this paper, the 3D macroporous bioactive glass-ceramic scaffolds based on 42P2O5•40CaO•5SrO•10Na2O•3TiO2 (mol %) glass were prepared by polyurethane (PU) foam replication technique and analyzed. The appropriate batch composition of raw materials was melted at 1250 °C for 0.5 h in a Pt crucible. Obtained glass samples were transparent, without visible residual gas bubbles. To obtain desired particle size (< 5μm), the glass sample was ground at 400 rpm for 1h in an SFM-1 Desk-Top Planetary Ball Miller, MTI Corporation. The polymeric template used for scaffold preparation was a commercial PU sponge. The sponge cubes were soaked into the glass slurry, compressed, dried, and thermally treated (650 °C, 1h) to remove the organic phase and to obtain macroporous glass-ceramic scaffolds. The sintering temperature for glass was chosen according to DTA and HSM experiment performed previously [8]. Scaffolds structure and morphology were analyzed by stereo microscope (EU Instruments) and a scanning electron microscope (MIRA X 3 TESCAN). The phase composition of the sintered scaffold was determined by XRD analysis using a Philips PW-1710 automated diffractometer. Figure 1, shows the structure of the PU sponge, used as a scaffold template that exhibits a 3D network of pores, which vary in size from 100 to 600 µm. In Figure 2, the SEM micrograph of the PU skeleton coated with glass particles is shown. As may be seen in Figure 3, the morphology of the scaffold sintered at T = 650 °C for 1h remains highly porous without a significant decrease in the pore size. The images revealed that the pore struts are well sintered. XRD analysis of the powdered scaffold showed that during sintering the glass particles crystallized and the crystalline phases determined are: Ca(PO3)2, β-Ca3(PO4)2, α-Ca2P2O7 and β-Ca2P2O7 (Figure 4). For β-Ca3(PO4)2 and β-Ca2P2O7 the bioactivity, i.e. the ability to promote the formation of apatite (HAP) layer after reaction with the surrounding body fluid has been reported [9]. The obtained phase composition and the microstructure of the as-prepared scaffold indicated its possible application as a bioactive material for bone tissue engineering [10].",
publisher = "Belgrade : Serbian Academy of Sciences and Arts",
journal = "First International Conference on Electron Microscopy ELMINA2018",
title = "Synthesis of Phosphate Based Bioactive Glass-ceramics Scaffolds",
pages = "251-249"
}
