TY  - JOUR
AU  - Janićijević, Jelena
AU  - Krajišnik, Danina
AU  - Calija, Bojan
AU  - Nedić-Vasiljević, Bojana
AU  - Dobričić, Vladimir
AU  - Daković, Aleksandra
AU  - Antonijević, Milan D.
AU  - Milić, Jela
PY  - 2015
UR  - https://ritnms.itnms.ac.rs/handle/123456789/341
AB  - Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied with the pharmacopoeial requirements for heavy metals content and microbiological quality, was used as a starting material. Inorganic modification of the starting material was performed through a simple, one-step procedure. Significant increase in adsorbent loading with diclofenac sodium (DS) was achieved after the modification process (similar to 373 mg/g) which enabled the preparation of comprimates containing therapeutic dose of the adsorbed drug. Adsorption of DS onto modified diatomite resulted in the alteration of the drug's XRD pattern and FTIR spectrum. In vitro drug release studies in phosphate buffer pH 7.5 demonstrated prolonged DS release over 8 h from comprimates containing DS adsorbed on modified diatomite (up to 37% after 8 h) and those containing physical mixture of the same composition (up to 45% after 8 h). The results of in vivo toxicity testing on mice pointed on potential safety of both unmodified (starting) and modified diatomite. All these findings favor the application of diatomite as a potential functional drug carrier.
PB  - Elsevier, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium
EP  - 474
IS  - 2
SP  - 466
VL  - 496
DO  - 10.1016/j.ijpharm.2015.10.047
UR  - conv_747
ER  - 

@article{
author = "Janićijević, Jelena and Krajišnik, Danina and Calija, Bojan and Nedić-Vasiljević, Bojana and Dobričić, Vladimir and Daković, Aleksandra and Antonijević, Milan D. and Milić, Jela",
year = "2015",
abstract = "Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied with the pharmacopoeial requirements for heavy metals content and microbiological quality, was used as a starting material. Inorganic modification of the starting material was performed through a simple, one-step procedure. Significant increase in adsorbent loading with diclofenac sodium (DS) was achieved after the modification process (similar to 373 mg/g) which enabled the preparation of comprimates containing therapeutic dose of the adsorbed drug. Adsorption of DS onto modified diatomite resulted in the alteration of the drug's XRD pattern and FTIR spectrum. In vitro drug release studies in phosphate buffer pH 7.5 demonstrated prolonged DS release over 8 h from comprimates containing DS adsorbed on modified diatomite (up to 37% after 8 h) and those containing physical mixture of the same composition (up to 45% after 8 h). The results of in vivo toxicity testing on mice pointed on potential safety of both unmodified (starting) and modified diatomite. All these findings favor the application of diatomite as a potential functional drug carrier.",
publisher = "Elsevier, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium",
pages = "474-466",
number = "2",
volume = "496",
doi = "10.1016/j.ijpharm.2015.10.047",
url = "conv_747"
}

Janićijević, J., Krajišnik, D., Calija, B., Nedić-Vasiljević, B., Dobričić, V., Daković, A., Antonijević, M. D.,& Milić, J.. (2015). Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium. in International Journal of Pharmaceutics
Elsevier, Amsterdam., 496(2), 466-474.
https://doi.org/10.1016/j.ijpharm.2015.10.047
conv_747

Janićijević J, Krajišnik D, Calija B, Nedić-Vasiljević B, Dobričić V, Daković A, Antonijević MD, Milić J. Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium. in International Journal of Pharmaceutics. 2015;496(2):466-474.
doi:10.1016/j.ijpharm.2015.10.047
conv_747 .

Janićijević, Jelena, Krajišnik, Danina, Calija, Bojan, Nedić-Vasiljević, Bojana, Dobričić, Vladimir, Daković, Aleksandra, Antonijević, Milan D., Milić, Jela, "Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium" in International Journal of Pharmaceutics, 496, no. 2 (2015):466-474,
https://doi.org/10.1016/j.ijpharm.2015.10.047 .,
conv_747 .