TY  - JOUR
AU  - Krajišnik, Danina
AU  - Daković, Aleksandra
AU  - Malenović, Anđelija
AU  - Đekić, Ljiljana
AU  - Kragović, Milan
AU  - Dobričić, Vladimir
AU  - Milić, Jela
PY  - 2013
UR  - https://ritnms.itnms.ac.rs/handle/123456789/253
AB  - In this paper, investigations of zeolite - cationic surfactant - drug composites as drug carriers were performed. For that purpose, after adsorption of the model drug - diclofenac sodium (DS) onto composites obtained by the modification of natural zeolite (NZ) with cetylpyridinium chloride (CPC) at the three different levels, i.e., 10, 20 and 30 mmol/100 g (ZCPC-10, ZCPC-20 and ZCPC-30, respectively), the release of the drug, at pH 6.8, was studied. The results of DS release from ZCPC-10 composite (DS/ZCPC-10) were compared with the DS release from corresponding physical mixture, as well as from physical mixture of NZ and DS. Characterization of the composites after adsorption of DS and the physical mixtures was realized by zeta potential measurements and by thermal analysis. Results showed that the prolonged release of DS from all the three composites, as well as from physical mixture containing ZCPC-10 and DS was achieved over a period of 8 h. The drug release from both DS/ZCPC-10 (max 55%) and corresponding physical mixture (max 38%) was remarkably lower than that from the physical mixture of NZ and DS (max 85%). The kinetic analysis for all the three composites, as well as for the physical mixture of ZCPC-10 and DS, showed that drug release profiles were best fitted with the Korsmeyer-Peppas and Bhaskar release models, indicating a combination of drug diffusion and ion exchange as the predominant release mechanisms in the dissolution medium.
PB  - Elsevier Science Bv, Amsterdam
T2  - Microporous and Mesoporous Materials
T1  - An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient
EP  - 101
SP  - 94
VL  - 167
DO  - 10.1016/j.micromeso.2012.03.033
UR  - conv_645
ER  - 

@article{
author = "Krajišnik, Danina and Daković, Aleksandra and Malenović, Anđelija and Đekić, Ljiljana and Kragović, Milan and Dobričić, Vladimir and Milić, Jela",
year = "2013",
abstract = "In this paper, investigations of zeolite - cationic surfactant - drug composites as drug carriers were performed. For that purpose, after adsorption of the model drug - diclofenac sodium (DS) onto composites obtained by the modification of natural zeolite (NZ) with cetylpyridinium chloride (CPC) at the three different levels, i.e., 10, 20 and 30 mmol/100 g (ZCPC-10, ZCPC-20 and ZCPC-30, respectively), the release of the drug, at pH 6.8, was studied. The results of DS release from ZCPC-10 composite (DS/ZCPC-10) were compared with the DS release from corresponding physical mixture, as well as from physical mixture of NZ and DS. Characterization of the composites after adsorption of DS and the physical mixtures was realized by zeta potential measurements and by thermal analysis. Results showed that the prolonged release of DS from all the three composites, as well as from physical mixture containing ZCPC-10 and DS was achieved over a period of 8 h. The drug release from both DS/ZCPC-10 (max 55%) and corresponding physical mixture (max 38%) was remarkably lower than that from the physical mixture of NZ and DS (max 85%). The kinetic analysis for all the three composites, as well as for the physical mixture of ZCPC-10 and DS, showed that drug release profiles were best fitted with the Korsmeyer-Peppas and Bhaskar release models, indicating a combination of drug diffusion and ion exchange as the predominant release mechanisms in the dissolution medium.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Microporous and Mesoporous Materials",
title = "An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient",
pages = "101-94",
volume = "167",
doi = "10.1016/j.micromeso.2012.03.033",
url = "conv_645"
}

Krajišnik, D., Daković, A., Malenović, A., Đekić, L., Kragović, M., Dobričić, V.,& Milić, J.. (2013). An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient. in Microporous and Mesoporous Materials
Elsevier Science Bv, Amsterdam., 167, 94-101.
https://doi.org/10.1016/j.micromeso.2012.03.033
conv_645

Krajišnik D, Daković A, Malenović A, Đekić L, Kragović M, Dobričić V, Milić J. An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient. in Microporous and Mesoporous Materials. 2013;167:94-101.
doi:10.1016/j.micromeso.2012.03.033
conv_645 .

Krajišnik, Danina, Daković, Aleksandra, Malenović, Anđelija, Đekić, Ljiljana, Kragović, Milan, Dobričić, Vladimir, Milić, Jela, "An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient" in Microporous and Mesoporous Materials, 167 (2013):94-101,
https://doi.org/10.1016/j.micromeso.2012.03.033 .,
conv_645 .