TY  - JOUR
AU  - Stojanović, Jevrem
AU  - Milojević-Rakić, Maja
AU  - Bajuk-Bogdanović, Danica
AU  - Ranđelović, Dragana
AU  - Sokić, Miroslav
AU  - Otašević, Biljana
AU  - Malenović, Anđelija
AU  - Janošević Ležajić, Aleksandra
AU  - Protić, Ana
PY  - 2024
UR  - https://ritnms.itnms.ac.rs/handle/123456789/1277
AB  - A chemometrically based approach was applied to select the most efficient drug adsorbent among the biochars obtained from the novel feedstock, the leaves of the invasive plant (Ailanthus altissima). The representative target adsorbates (atenolol, paracetamol, ketorolac and tetracycline) were selected on the basis of their physicochemical properties to cover a wide chemical space, which is the usual analytical challenge. Their adsorption was investigated using design of experiments as a comprehensive approach to optimise the performance of the adsorption system, rationalise the procedure and overcome common drawbacks. Among the response surface designs, the central composite design was selected as it allows the identification of important experimental factors (solid-to-liquid ratio, pH, ionic strength) and their interactions, and allows the selection of optimal experimental conditions to maximise adsorption performance. The biochars were prepared by pyrolysis at 500 °C and 800 °C (BC-500 and BC-800) and the ZnCl2-activated biochars were prepared at 650 °C and 800 °C (AcBC-650 and AcBC-800). The FTIR spectra revealed that increasing the pyrolysis temperature without activator decreases the intensity of all bands, while activation preserves functional groups, as evidenced by the spectra of AcBC-650 and AcBC-800. High temperatures during activation promoted the development of an efficient surface area, with the maximum observed for AcBC-800 reaching 347 m2 g−1. AcBC-800 was found to be the most efficient adsorbent with removal efficiencies of 34.1, 51.3, 55.9 and 38.2 % for atenolol, paracetamol, ketorolac and tetracycline, respectively. The models describing the relationship between the removal efficiency of AcBC-800 and the experimental factors studied, showed satisfactory predictive ability (predicted R2 > 0.8) and no significant lack-of-fit was observed. The results obtained, including the mathematical models, the properties of the adsorbates and the adsorbents, clearly indicate that the adsorption mechanisms of activated biochars are mainly based on hydrophobic interactions, pore filling and hydrogen bonding.
PB  - Elsevier
T2  - Heliyon
T1  - Chemometrically-aided general approach to novel adsorbents studies: Case study on the adsorption of pharmaceuticals by the carbonized Ailanthus altissima leaves
IS  - 14
SP  - e34841
VL  - 10
DO  - 10.1016/j.heliyon.2024.e34841
ER  - 

@article{
author = "Stojanović, Jevrem and Milojević-Rakić, Maja and Bajuk-Bogdanović, Danica and Ranđelović, Dragana and Sokić, Miroslav and Otašević, Biljana and Malenović, Anđelija and Janošević Ležajić, Aleksandra and Protić, Ana",
year = "2024",
abstract = "A chemometrically based approach was applied to select the most efficient drug adsorbent among the biochars obtained from the novel feedstock, the leaves of the invasive plant (Ailanthus altissima). The representative target adsorbates (atenolol, paracetamol, ketorolac and tetracycline) were selected on the basis of their physicochemical properties to cover a wide chemical space, which is the usual analytical challenge. Their adsorption was investigated using design of experiments as a comprehensive approach to optimise the performance of the adsorption system, rationalise the procedure and overcome common drawbacks. Among the response surface designs, the central composite design was selected as it allows the identification of important experimental factors (solid-to-liquid ratio, pH, ionic strength) and their interactions, and allows the selection of optimal experimental conditions to maximise adsorption performance. The biochars were prepared by pyrolysis at 500 °C and 800 °C (BC-500 and BC-800) and the ZnCl2-activated biochars were prepared at 650 °C and 800 °C (AcBC-650 and AcBC-800). The FTIR spectra revealed that increasing the pyrolysis temperature without activator decreases the intensity of all bands, while activation preserves functional groups, as evidenced by the spectra of AcBC-650 and AcBC-800. High temperatures during activation promoted the development of an efficient surface area, with the maximum observed for AcBC-800 reaching 347 m2 g−1. AcBC-800 was found to be the most efficient adsorbent with removal efficiencies of 34.1, 51.3, 55.9 and 38.2 % for atenolol, paracetamol, ketorolac and tetracycline, respectively. The models describing the relationship between the removal efficiency of AcBC-800 and the experimental factors studied, showed satisfactory predictive ability (predicted R2 > 0.8) and no significant lack-of-fit was observed. The results obtained, including the mathematical models, the properties of the adsorbates and the adsorbents, clearly indicate that the adsorption mechanisms of activated biochars are mainly based on hydrophobic interactions, pore filling and hydrogen bonding.",
publisher = "Elsevier",
journal = "Heliyon",
title = "Chemometrically-aided general approach to novel adsorbents studies: Case study on the adsorption of pharmaceuticals by the carbonized Ailanthus altissima leaves",
number = "14",
pages = "e34841",
volume = "10",
doi = "10.1016/j.heliyon.2024.e34841"
}

Stojanović, J., Milojević-Rakić, M., Bajuk-Bogdanović, D., Ranđelović, D., Sokić, M., Otašević, B., Malenović, A., Janošević Ležajić, A.,& Protić, A.. (2024). Chemometrically-aided general approach to novel adsorbents studies: Case study on the adsorption of pharmaceuticals by the carbonized Ailanthus altissima leaves. in Heliyon
Elsevier., 10(14), e34841.
https://doi.org/10.1016/j.heliyon.2024.e34841

Stojanović J, Milojević-Rakić M, Bajuk-Bogdanović D, Ranđelović D, Sokić M, Otašević B, Malenović A, Janošević Ležajić A, Protić A. Chemometrically-aided general approach to novel adsorbents studies: Case study on the adsorption of pharmaceuticals by the carbonized Ailanthus altissima leaves. in Heliyon. 2024;10(14):e34841.
doi:10.1016/j.heliyon.2024.e34841 .

Stojanović, Jevrem, Milojević-Rakić, Maja, Bajuk-Bogdanović, Danica, Ranđelović, Dragana, Sokić, Miroslav, Otašević, Biljana, Malenović, Anđelija, Janošević Ležajić, Aleksandra, Protić, Ana, "Chemometrically-aided general approach to novel adsorbents studies: Case study on the adsorption of pharmaceuticals by the carbonized Ailanthus altissima leaves" in Heliyon, 10, no. 14 (2024):e34841,
https://doi.org/10.1016/j.heliyon.2024.e34841 . .

TY  - CONF
AU  - Stojanović, Jevrem
AU  - Zalewski, Przemysław
AU  - Otašević, Biljana
AU  - Zečević, Mira
AU  - Malenović, Anđelija
AU  - Janošević Ležaić, Aleksandra
AU  - Ranđelović, Dragana
AU  - Protić, Ana
PY  - 2023
UR  - http://analityka2023.bok-ump.pl/
UR  - https://ritnms.itnms.ac.rs/handle/123456789/1218
AB  - In the last two decades, there has been a growing awareness of the presence of pharmaceuticals in the aquatic
environment. Antibiotics are particularly alarming because their occurrence may result in increased antibiotic
resistance. Difficulties in sample preparation and removal of low concentrations of pharmaceuticals from
environmental water could be overcome by their adsorption onto novel, non-polluting, and inexpensive
materials.
In this study, biochar prepared by pirolysis of biomass at 500°C (BC500) and 800°C (BC800) and activated
carbon prepared upon treatment with ZnCl2 at 800°C (AC800) were evaluated as potential adsorbents. Ailanthus
altissima was selected as a source of raw material, leaf, because it is a widespread invasive tree that negatively
affects biodiversity. Tetracycline hydrochloride was selected as a model substance, since it is an antibiotic
widely present in environmental water. Central composite design was employed to simultaneously investigate
the effects of adsorbate solution pH, ionic strength (KCl concentration), and adsorbent mass on removal
efficiency of all three adsorbents, and to find optimal conditions for studying adsorption kinetics and equilibrium
on the most promising adsorbent. The removal efficiency and adsorbed mass were calculated from the HPLCUV
determined concentration of tetracycline post-adsorption.
Under optimal conditions (10.18 mg of adsorbent, pH 4.42, and ionic strength 165mM), AC800 showed the
highest affinity for tetracycline, i.e. 38.22% removal and adsorbed mass of 56.32 mg g-1 compared to 14.57%
and 21.48 mg g-1 (BC500) and 18.82% and 27.73 mg g-1 (BC800). Removal efficiency of AC800 was strongly
influenced by the adsorbent mass and solution pH. The kinetics study showed a rapid adsorption process
(equilibrium attained in 120 minutes), while equilibrium studies revealed a high adsorption capacity for
tetracycline (131.55 mg g-1). AC800 has been shown to be a promising novel drug adsorbent and should be
further tested for its suitability in water treatment and sample preparation.
C3  - IV Poznańska Konferencja Naukowo – Szkoleniowej - „Modern pharmaceutical and biomedical analytics in health care”
T1  - Adsorption of pharmaceuticals by novel carbonaceous materials from the leaves of Ailanthus altissima (Mill.) Swingle - Case study on the adsorption of tetracycline
EP  - 55
SP  - 55
ER  - 

@conference{
author = "Stojanović, Jevrem and Zalewski, Przemysław and Otašević, Biljana and Zečević, Mira and Malenović, Anđelija and Janošević Ležaić, Aleksandra and Ranđelović, Dragana and Protić, Ana",
year = "2023",
abstract = "In the last two decades, there has been a growing awareness of the presence of pharmaceuticals in the aquatic
environment. Antibiotics are particularly alarming because their occurrence may result in increased antibiotic
resistance. Difficulties in sample preparation and removal of low concentrations of pharmaceuticals from
environmental water could be overcome by their adsorption onto novel, non-polluting, and inexpensive
materials.
In this study, biochar prepared by pirolysis of biomass at 500°C (BC500) and 800°C (BC800) and activated
carbon prepared upon treatment with ZnCl2 at 800°C (AC800) were evaluated as potential adsorbents. Ailanthus
altissima was selected as a source of raw material, leaf, because it is a widespread invasive tree that negatively
affects biodiversity. Tetracycline hydrochloride was selected as a model substance, since it is an antibiotic
widely present in environmental water. Central composite design was employed to simultaneously investigate
the effects of adsorbate solution pH, ionic strength (KCl concentration), and adsorbent mass on removal
efficiency of all three adsorbents, and to find optimal conditions for studying adsorption kinetics and equilibrium
on the most promising adsorbent. The removal efficiency and adsorbed mass were calculated from the HPLCUV
determined concentration of tetracycline post-adsorption.
Under optimal conditions (10.18 mg of adsorbent, pH 4.42, and ionic strength 165mM), AC800 showed the
highest affinity for tetracycline, i.e. 38.22% removal and adsorbed mass of 56.32 mg g-1 compared to 14.57%
and 21.48 mg g-1 (BC500) and 18.82% and 27.73 mg g-1 (BC800). Removal efficiency of AC800 was strongly
influenced by the adsorbent mass and solution pH. The kinetics study showed a rapid adsorption process
(equilibrium attained in 120 minutes), while equilibrium studies revealed a high adsorption capacity for
tetracycline (131.55 mg g-1). AC800 has been shown to be a promising novel drug adsorbent and should be
further tested for its suitability in water treatment and sample preparation.",
journal = "IV Poznańska Konferencja Naukowo – Szkoleniowej - „Modern pharmaceutical and biomedical analytics in health care”",
title = "Adsorption of pharmaceuticals by novel carbonaceous materials from the leaves of Ailanthus altissima (Mill.) Swingle - Case study on the adsorption of tetracycline",
pages = "55-55"
}

Stojanović, J., Zalewski, P., Otašević, B., Zečević, M., Malenović, A., Janošević Ležaić, A., Ranđelović, D.,& Protić, A.. (2023). Adsorption of pharmaceuticals by novel carbonaceous materials from the leaves of Ailanthus altissima (Mill.) Swingle - Case study on the adsorption of tetracycline. in IV Poznańska Konferencja Naukowo – Szkoleniowej - „Modern pharmaceutical and biomedical analytics in health care”, 55-55.

Stojanović J, Zalewski P, Otašević B, Zečević M, Malenović A, Janošević Ležaić A, Ranđelović D, Protić A. Adsorption of pharmaceuticals by novel carbonaceous materials from the leaves of Ailanthus altissima (Mill.) Swingle - Case study on the adsorption of tetracycline. in IV Poznańska Konferencja Naukowo – Szkoleniowej - „Modern pharmaceutical and biomedical analytics in health care”. 2023;:55-55..

Stojanović, Jevrem, Zalewski, Przemysław, Otašević, Biljana, Zečević, Mira, Malenović, Anđelija, Janošević Ležaić, Aleksandra, Ranđelović, Dragana, Protić, Ana, "Adsorption of pharmaceuticals by novel carbonaceous materials from the leaves of Ailanthus altissima (Mill.) Swingle - Case study on the adsorption of tetracycline" in IV Poznańska Konferencja Naukowo – Szkoleniowej - „Modern pharmaceutical and biomedical analytics in health care” (2023):55-55.