TY  - JOUR
AU  - Mišković-Stanković, Vesna
AU  - Janković, Ana
AU  - Grujić, Svetlana
AU  - Matić-Bujagić, Ivana
AU  - Radojević, Vesna
AU  - Vukašinović-Sekulić, Maja
AU  - Kojić, Vesna
AU  - Đošić, Marija
AU  - Atanasković, Teodor
PY  - 2024
UR  - https://ritnms.itnms.ac.rs/handle/123456789/1229
AB  - This study presents comparison of our recently formulated two compartmental model with General fractional derivative (GFD) and Korsmeyer-Peppas, Makoid-Banakar and Kopcha diffusion models. We have used our GFD
model to study the release of gentamicin in poly (vinylalcohol)/chitosan/gentamicin (PVA/CHI/Gent) hydrogel aimed for wound dressing in medical treatment of deep chronical wounds. The PVA/CHI/Gent hydrogel was prepared by physical cross linking of poly(vinyl alcohol)/chitosan dispersion using freezing-thawing method, and then was swollen for 48 h in gentamicin solution, at 37 °C. Different physico-chemical (FTIR, SEM), mechanical and biological (cytotoxicity, antibacterial activity) properties have been determined. The concentration of released gentamicin was determined
using a high-performance liquid chromatography (HPLC) coupled with mass spectrometry (MS). The ratio between concentration of released gentamicin and initial concentration of gentamicin in the hydrogel was monitored for the
prolonged time period in order to obtain gentamicin release profile. It was proven that our novel diffusion GFD model better fitted with experimental data, and enabled the determination of diffusion coefficient precisely for the entire time period.
PB  - Belgrade :  Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel
DO  - 10.2298/JSC231207010M
ER  - 

@article{
author = "Mišković-Stanković, Vesna and Janković, Ana and Grujić, Svetlana and Matić-Bujagić, Ivana and Radojević, Vesna and Vukašinović-Sekulić, Maja and Kojić, Vesna and Đošić, Marija and Atanasković, Teodor",
year = "2024",
abstract = "This study presents comparison of our recently formulated two compartmental model with General fractional derivative (GFD) and Korsmeyer-Peppas, Makoid-Banakar and Kopcha diffusion models. We have used our GFD
model to study the release of gentamicin in poly (vinylalcohol)/chitosan/gentamicin (PVA/CHI/Gent) hydrogel aimed for wound dressing in medical treatment of deep chronical wounds. The PVA/CHI/Gent hydrogel was prepared by physical cross linking of poly(vinyl alcohol)/chitosan dispersion using freezing-thawing method, and then was swollen for 48 h in gentamicin solution, at 37 °C. Different physico-chemical (FTIR, SEM), mechanical and biological (cytotoxicity, antibacterial activity) properties have been determined. The concentration of released gentamicin was determined
using a high-performance liquid chromatography (HPLC) coupled with mass spectrometry (MS). The ratio between concentration of released gentamicin and initial concentration of gentamicin in the hydrogel was monitored for the
prolonged time period in order to obtain gentamicin release profile. It was proven that our novel diffusion GFD model better fitted with experimental data, and enabled the determination of diffusion coefficient precisely for the entire time period.",
publisher = "Belgrade :  Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel",
doi = "10.2298/JSC231207010M"
}

Mišković-Stanković, V., Janković, A., Grujić, S., Matić-Bujagić, I., Radojević, V., Vukašinović-Sekulić, M., Kojić, V., Đošić, M.,& Atanasković, T.. (2024). Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel. in Journal of the Serbian Chemical Society
Belgrade :  Serbian Chemical Society..
https://doi.org/10.2298/JSC231207010M

Mišković-Stanković V, Janković A, Grujić S, Matić-Bujagić I, Radojević V, Vukašinović-Sekulić M, Kojić V, Đošić M, Atanasković T. Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel. in Journal of the Serbian Chemical Society. 2024;.
doi:10.2298/JSC231207010M .

Mišković-Stanković, Vesna, Janković, Ana, Grujić, Svetlana, Matić-Bujagić, Ivana, Radojević, Vesna, Vukašinović-Sekulić, Maja, Kojić, Vesna, Đošić, Marija, Atanasković, Teodor, "Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel" in Journal of the Serbian Chemical Society (2024),
https://doi.org/10.2298/JSC231207010M . .