Zeolites as potential drug carriers
Abstract
In the last two decades, natural zeolites have emerged in biomedical applications due to their favorable physicochemical characteristics such as high adsorption capacity and specific surface, the cation exchange ability, and good biocompatibility. Although very similar to clays that have been traditionally used in pharmaceutical preparations, these mineral materials also require a comprehensive characterization prior to their use as potential pharmaceutical excipients, that is, drug carriers. In this chapter a brief summary on definitions, properties, functionality-related characteristics, safety, and regulatory aspects of pharmaceutical excipients is given. Special attention is focused on natural and surfactant-modified zeolites; an overview of techniques used for characterization of a starting mineral material as well as drug-modified zeolite composites relevant for their application as pharmaceutical excipients and potential drug carriers is presented.
Keywords:
Zeolites / Pharmaceutical excipients / Modified aluminosilicates / Excipients functionality / Drug delivery/carriers / Cationic surfactantsSource:
Modified Clay and Zeolite Nanocomposite Materials: Environmental and Pharmaceutical Applications, 2018, 27-55Publisher:
- Elsevier
Funding / projects:
- Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-MESTD-Technological Development (TD or TR)-34031)
- Oxide-based environmentally-friendly porous materials for genotoxic substances removal (RS-MESTD-Basic Research (BR or ON)-172018)
Collections
Institution/Community
Institut za tehnologiju nuklearnih i drugih mineralnih sirovinaTY - CHAP AU - Krajišnik, Danina AU - Daković, Aleksandra AU - Milić, Jela AU - Marković, Marija PY - 2018 UR - https://ritnms.itnms.ac.rs/handle/123456789/465 AB - In the last two decades, natural zeolites have emerged in biomedical applications due to their favorable physicochemical characteristics such as high adsorption capacity and specific surface, the cation exchange ability, and good biocompatibility. Although very similar to clays that have been traditionally used in pharmaceutical preparations, these mineral materials also require a comprehensive characterization prior to their use as potential pharmaceutical excipients, that is, drug carriers. In this chapter a brief summary on definitions, properties, functionality-related characteristics, safety, and regulatory aspects of pharmaceutical excipients is given. Special attention is focused on natural and surfactant-modified zeolites; an overview of techniques used for characterization of a starting mineral material as well as drug-modified zeolite composites relevant for their application as pharmaceutical excipients and potential drug carriers is presented. PB - Elsevier T2 - Modified Clay and Zeolite Nanocomposite Materials: Environmental and Pharmaceutical Applications T1 - Zeolites as potential drug carriers EP - 55 SP - 27 DO - 10.1016/B978-0-12-814617-0.00002-5 UR - conv_1027 ER -
@inbook{ author = "Krajišnik, Danina and Daković, Aleksandra and Milić, Jela and Marković, Marija", year = "2018", abstract = "In the last two decades, natural zeolites have emerged in biomedical applications due to their favorable physicochemical characteristics such as high adsorption capacity and specific surface, the cation exchange ability, and good biocompatibility. Although very similar to clays that have been traditionally used in pharmaceutical preparations, these mineral materials also require a comprehensive characterization prior to their use as potential pharmaceutical excipients, that is, drug carriers. In this chapter a brief summary on definitions, properties, functionality-related characteristics, safety, and regulatory aspects of pharmaceutical excipients is given. Special attention is focused on natural and surfactant-modified zeolites; an overview of techniques used for characterization of a starting mineral material as well as drug-modified zeolite composites relevant for their application as pharmaceutical excipients and potential drug carriers is presented.", publisher = "Elsevier", journal = "Modified Clay and Zeolite Nanocomposite Materials: Environmental and Pharmaceutical Applications", booktitle = "Zeolites as potential drug carriers", pages = "55-27", doi = "10.1016/B978-0-12-814617-0.00002-5", url = "conv_1027" }
Krajišnik, D., Daković, A., Milić, J.,& Marković, M.. (2018). Zeolites as potential drug carriers. in Modified Clay and Zeolite Nanocomposite Materials: Environmental and Pharmaceutical Applications Elsevier., 27-55. https://doi.org/10.1016/B978-0-12-814617-0.00002-5 conv_1027
Krajišnik D, Daković A, Milić J, Marković M. Zeolites as potential drug carriers. in Modified Clay and Zeolite Nanocomposite Materials: Environmental and Pharmaceutical Applications. 2018;:27-55. doi:10.1016/B978-0-12-814617-0.00002-5 conv_1027 .
Krajišnik, Danina, Daković, Aleksandra, Milić, Jela, Marković, Marija, "Zeolites as potential drug carriers" in Modified Clay and Zeolite Nanocomposite Materials: Environmental and Pharmaceutical Applications (2018):27-55, https://doi.org/10.1016/B978-0-12-814617-0.00002-5 ., conv_1027 .