Graphene-reinforced composite hydroxyapatite/chitosan and hydroxyapatite/chitosan/gentamicin coatings
Аутори
Stevanović, MilenaĐošić, Marija
Janković, Ana
Mišković-Stanković, Vesna
Остала ауторства
Todorović, TamaraVujisić, Ljubodrag
Radivojević, Jelena
Filipović, Vuk
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Graphene (Gr) is a superior material with favorable mechanical and thermal properties,
predominately utilized as a component of exceptional composites [1]. In this work
graphene-reinforced composite coatings based on hydroxyapatite (HAP) and chitosan
(CS), with and without antibiotic gentamicin (Gent) were investigated.
Composite HAP/CS/Gr and HAP/CS/Gr/Gent coatings were electrophoretically
deposited in a single step process from aqueous suspension on pure titanium foils.
Detailed physico-chemical and biological characterization analyses were performed in
order to evaluate the influence of graphene on the properties of newly formed
composites. The formation of HAP/CS/Gr and HAP/CS/Gr/Gent composite coatings
was confirmed by X-ray diffraction, field emission scanning electron microscopy and
Fourier transform infrared spectroscopy. On micro level, composite coatings exhibited
porous, homogenous surfaces suggesting strong interfacial interactions between HAP,
CS and Gr.
Agar... diffusion testing was performed against Staphylococcus aureus and Escherichia
coli in order to evaluate the antibacterial potential and possible medical applications of
obtained composite coatings. The results indicated excellent antibacterial properties of
the gentamicin-containing coating (HAP/CS/Gr/Gent) with a slightly more pronounced
effect against S. aureus compared to E. coli. Composite coatings were also subjected to
cytotoxicity MTT assay to prove the biocompatibility and non-cytotoxic effect towards
MRC-5 and L292 cell lines. Obtained results indicated the high potential of HAP/CS/Gr/Gent coating for use in medicine as a part of bone implants.
Извор:
Seventh Conference of the Young Chemists of Serbia, 2019, 140-140Издавач:
- Belgrade : Serbian Chemical Society
Финансирање / пројекти:
- Синтеза, развој технологија добијања и примена наноструктурних мултифункционалних материјала дефинисаних својстава (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45019)
Институција/група
Institut za tehnologiju nuklearnih i drugih mineralnih sirovinaTY - CONF AU - Stevanović, Milena AU - Đošić, Marija AU - Janković, Ana AU - Mišković-Stanković, Vesna PY - 2019 UR - https://ritnms.itnms.ac.rs/handle/123456789/772 AB - Graphene (Gr) is a superior material with favorable mechanical and thermal properties, predominately utilized as a component of exceptional composites [1]. In this work graphene-reinforced composite coatings based on hydroxyapatite (HAP) and chitosan (CS), with and without antibiotic gentamicin (Gent) were investigated. Composite HAP/CS/Gr and HAP/CS/Gr/Gent coatings were electrophoretically deposited in a single step process from aqueous suspension on pure titanium foils. Detailed physico-chemical and biological characterization analyses were performed in order to evaluate the influence of graphene on the properties of newly formed composites. The formation of HAP/CS/Gr and HAP/CS/Gr/Gent composite coatings was confirmed by X-ray diffraction, field emission scanning electron microscopy and Fourier transform infrared spectroscopy. On micro level, composite coatings exhibited porous, homogenous surfaces suggesting strong interfacial interactions between HAP, CS and Gr. Agar diffusion testing was performed against Staphylococcus aureus and Escherichia coli in order to evaluate the antibacterial potential and possible medical applications of obtained composite coatings. The results indicated excellent antibacterial properties of the gentamicin-containing coating (HAP/CS/Gr/Gent) with a slightly more pronounced effect against S. aureus compared to E. coli. Composite coatings were also subjected to cytotoxicity MTT assay to prove the biocompatibility and non-cytotoxic effect towards MRC-5 and L292 cell lines. Obtained results indicated the high potential of HAP/CS/Gr/Gent coating for use in medicine as a part of bone implants. PB - Belgrade : Serbian Chemical Society C3 - Seventh Conference of the Young Chemists of Serbia T1 - Graphene-reinforced composite hydroxyapatite/chitosan and hydroxyapatite/chitosan/gentamicin coatings EP - 140 SP - 140 ER -
@conference{ author = "Stevanović, Milena and Đošić, Marija and Janković, Ana and Mišković-Stanković, Vesna", year = "2019", abstract = "Graphene (Gr) is a superior material with favorable mechanical and thermal properties, predominately utilized as a component of exceptional composites [1]. In this work graphene-reinforced composite coatings based on hydroxyapatite (HAP) and chitosan (CS), with and without antibiotic gentamicin (Gent) were investigated. Composite HAP/CS/Gr and HAP/CS/Gr/Gent coatings were electrophoretically deposited in a single step process from aqueous suspension on pure titanium foils. Detailed physico-chemical and biological characterization analyses were performed in order to evaluate the influence of graphene on the properties of newly formed composites. The formation of HAP/CS/Gr and HAP/CS/Gr/Gent composite coatings was confirmed by X-ray diffraction, field emission scanning electron microscopy and Fourier transform infrared spectroscopy. On micro level, composite coatings exhibited porous, homogenous surfaces suggesting strong interfacial interactions between HAP, CS and Gr. Agar diffusion testing was performed against Staphylococcus aureus and Escherichia coli in order to evaluate the antibacterial potential and possible medical applications of obtained composite coatings. The results indicated excellent antibacterial properties of the gentamicin-containing coating (HAP/CS/Gr/Gent) with a slightly more pronounced effect against S. aureus compared to E. coli. Composite coatings were also subjected to cytotoxicity MTT assay to prove the biocompatibility and non-cytotoxic effect towards MRC-5 and L292 cell lines. Obtained results indicated the high potential of HAP/CS/Gr/Gent coating for use in medicine as a part of bone implants.", publisher = "Belgrade : Serbian Chemical Society", journal = "Seventh Conference of the Young Chemists of Serbia", title = "Graphene-reinforced composite hydroxyapatite/chitosan and hydroxyapatite/chitosan/gentamicin coatings", pages = "140-140" }
Stevanović, M., Đošić, M., Janković, A.,& Mišković-Stanković, V.. (2019). Graphene-reinforced composite hydroxyapatite/chitosan and hydroxyapatite/chitosan/gentamicin coatings. in Seventh Conference of the Young Chemists of Serbia Belgrade : Serbian Chemical Society., 140-140.
Stevanović M, Đošić M, Janković A, Mišković-Stanković V. Graphene-reinforced composite hydroxyapatite/chitosan and hydroxyapatite/chitosan/gentamicin coatings. in Seventh Conference of the Young Chemists of Serbia. 2019;:140-140..
Stevanović, Milena, Đošić, Marija, Janković, Ana, Mišković-Stanković, Vesna, "Graphene-reinforced composite hydroxyapatite/chitosan and hydroxyapatite/chitosan/gentamicin coatings" in Seventh Conference of the Young Chemists of Serbia (2019):140-140.