Bioactive antibiotic-eluting hydroxyapatite-based coatings obtained by electrophoretic deposition on titanium

Abstract

Titanium surface was modified by applying new composite, biocompatible, and bioactive hydroxyapatite/chitosan coatings with and without gentamicin using the electrophoretic deposition technique (HAP/CS, HAP/CS/Gent, HAP/CS/Gr, and HAP/CS/Gr/Gent). HAP/CS/Gent and HAP/CS/Gr/Gent coatings presented strong activity against both bacterial strains tested and even noticeably more against S. aureus, while their counterparts without the antibiotic did not exhibit antibacterial properties. The rapid and strong antibacterial effect monitored during the first 24 h coincides well with the initial burst effect of gentamicin observed on the cumulative release profiles. Presented results are a solid confirmation that bioceramic HAP/CS/Gent and HAP/CS/Gr/Gent composite coatings electrodeposited on Ti are promising biomaterials for further investigation and potential biomedical application as orthopedic and dental implants